-
1
-
-
0033004248
-
Differences in electron transport potential, antioxidant defenses, and oxidant generation in young and senescent fetal lung fibroblasts (WI-38)
-
Allen RG, Tresini M, Keogh BP, Doggett DL. Cristofalo VJ (1999) Differences in electron transport potential, antioxidant defenses, and oxidant generation in young and senescent fetal lung fibroblasts (WI-38). J Cell Physiol 180(1):114-22
-
(1999)
J Cell Physiol
, vol.180
, Issue.1
, pp. 114-122
-
-
Allen, R.G.1
Tresini, M.2
Keogh, B.P.3
Doggett, D.L.4
Cristofalo, V.J.5
-
2
-
-
33745532801
-
Increased cell-to-cell variation in gene expression in ageing mouse heart
-
Bahar R, Hartmann CH, Rodriguez KA, Denny AD, Busuttil RA, Dolle MET, Calder RB, Chisholm GB, Pollock BH, Klein CA, Vijg J (2006) Increased cell-to-cell variation in gene expression in ageing mouse heart. Nature 441(7096):1011-14
-
(2006)
Nature
, vol.441
, Issue.7096
, pp. 1011-1014
-
-
Bahar, R.1
Hartmann, C.H.2
Rodriguez, K.A.3
Denny, A.D.4
Busuttil, R.A.5
Dolle, M.E.T.6
Calder, R.B.7
Chisholm, G.B.8
Pollock, B.H.9
Klein, C.A.10
Vijg, J.11
-
3
-
-
0037313185
-
Extensive allelic variation and ultrashort telomeres in senescent human cells
-
Baird DM, Rowson J, Wynford-Thomas D, Kipling D (2003) Extensive allelic variation and ultrashort telomeres in senescent human cells. Nat Genet 33(2):203-07
-
(2003)
Nat Genet
, vol.33
, Issue.2
, pp. 203-207
-
-
Baird, D.M.1
Rowson, J.2
Wynford-Thomas, D.3
Kipling, D.4
-
4
-
-
1642355129
-
Normal human fibroblasts are resistant to RAS-induced senescence
-
Benanti JA, Galloway DA (2004) Normal human fibroblasts are resistant to RAS-induced senescence Mol Cell Biol 24(7):2842-52
-
(2004)
Mol Cell Biol
, vol.24
, Issue.7
, pp. 2842-2852
-
-
Benanti, J.A.1
Galloway, D.A.2
-
5
-
-
33646375711
-
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease
-
Bender A, Krishnan KJ, Morris CM, Taylor GA, Reeve AK, Perry RH, Jaros E, Hersheson JS, Betts J, Klopstock T, Taylor RW, Turnbull DM (2006) High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nat Genet 38(5):515-17
-
(2006)
Nat Genet
, vol.38
, Issue.5
, pp. 515-517
-
-
Bender, A.1
Krishnan, K.J.2
Morris, C.M.3
Taylor, G.A.4
Reeve, A.K.5
Perry, R.H.6
Jaros, E.7
Hersheson, J.S.8
Betts, J.9
Klopstock, T.10
Taylor, R.W.11
Turnbull, D.M.12
-
6
-
-
0034597794
-
Telomere states and cell fates
-
Blackburn EH (2000) Telomere states and cell fates. Nature 408(6808):53-56
-
(2000)
Nature
, vol.408
, Issue.6808
, pp. 53-56
-
-
Blackburn, E.H.1
-
7
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Harley CB, Shay JW, Lichtsteiner S, Wright WE (1998) Extension of life-span by introduction of telomerase into normal human cells. Science 279(5349):349-52
-
(1998)
Science
, vol.279
, Issue.5349
, pp. 349-352
-
-
Bodnar, A.G.1
Ouellette, M.2
Frolkis, M.3
Holt, S.E.4
Chiu, C.P.5
Morin, G.B.6
Harley, C.B.7
Shay, J.W.8
Lichtsteiner, S.9
Wright, W.E.10
-
8
-
-
0028261160
-
Escape from senescence in human diploid fibroblasts induced directly by mutant p53
-
Bond, JA, Wyllie FS. and Wynford-Thomas, D. (1994) 'Escape from senescence in human diploid fibroblasts induced directly by mutant p53', Oncogene, 9, (7), pp. 1885-89
-
(1994)
Oncogene
, vol.9
, Issue.7
, pp. 1885-1889
-
-
Bond, J.A.1
Wyllie, F.S.2
Wynford-Thomas, D.3
-
9
-
-
33749136403
-
Roles of Pif1-like helicases in the maintenance of genomic stability
-
Boule, J-B. and Zakian, VA. (2006) 'Roles of Pif1-like helicases in the maintenance of genomic stability', Nucl. Acids Res., 34, (15), pp. 4147-4153.
-
(2006)
Nucl. Acids Res.
, vol.34
, Issue.15
, pp. 4147-4153
-
-
Boule, J.-B.1
Zakian, V.A.2
-
10
-
-
9644282890
-
Identification of subpopulations of cells with differing telomere lengths in mouse and human cell lines by flow FISH
-
Cabuy, E, Newton C, Roberts, T, Newbold, R. and Slijepcevic, P. (2004) 'Identification of subpopulations of cells with differing telomere lengths in mouse and human cell lines by flow FISH', Cytometry Part A, 62A, (2), pp. 150-161.
-
(2004)
Cytometry Part A
, vol.62 A
, Issue.2
, pp. 150-161
-
-
Cabuy, E.1
Newton, C.2
Roberts, T.3
Newbold, R.4
Slijepcevic, P.5
-
11
-
-
0035504933
-
Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: Analysis by laser-capture microdissection
-
Cao, Z, Wanagat, J, McKiernan, SH. and Aiken, JM. (2001) 'Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection', Nucleic Acids Res, 29, (21), pp. 4502-8
-
(2001)
Nucleic Acids Res
, vol.29
, Issue.21
, pp. 4502-4508
-
-
Cao, Z.1
Wanagat, J.2
McKiernan, S.H.3
Aiken, J.M.4
-
12
-
-
33846652598
-
Mammalian telomeres
-
de lange, T., Lundbard, V. and Blackburn, E. H. eds, Cold Spring Harbour Laboratory Press: New York
-
De Lange, T. (2006) 'Mammalian Telomeres', in de lange, T., Lundbard, V. and Blackburn, E. H. (eds) Telomeres. Cold Spring Harbour Laboratory Press: New York, pp. 387-431.
-
(2006)
Telomeres
, pp. 387-431
-
-
De Lange, T.1
-
13
-
-
0033963144
-
Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast
-
Dumont P, Burton M, Chen QM, Gonos ES, Frippiat C, Mazarati, JB, Eliaers, F, Remacle, J. and Toussaint, O. (2000) 'Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast', Free Radical Biology and Medicine, 28, (3), pp. 361-373
-
(2000)
Free Radical Biology and Medicine
, vol.28
, Issue.3
, pp. 361-373
-
-
Dumont, P.1
Burton, M.2
Chen, Q.M.3
Gonos, E.S.4
Frippiat, C.5
Mazarati, J.B.6
Eliaers, F.7
Remacle, J.8
Toussaint, O.9
-
14
-
-
10344229954
-
Accelerated telomere shortening in response to life stress
-
Epel, E. S., Blackburn, E. H., Lin, J., Dhabhar, F. S., Adler, N. E., Morrow, J. D. and Cawthon, R. M. (2004) 'Accelerated telomere shortening in response to life stress', PNAS, 101, (49), pp. 17312-17315.
-
(2004)
PNAS
, vol.101
, Issue.49
, pp. 17312-17315
-
-
Epel, E.S.1
Blackburn, E.H.2
Lin, J.3
Dhabhar, F.S.4
Adler, N.E.5
Morrow, J.D.6
Cawthon, R.M.7
-
15
-
-
0344441890
-
A DNA damage checkpoint response in telomere-initiated senescence
-
Fagagna FDAD, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, Von Zglinicki T, Saretzki G, Carter NP, Jackson SP (2003) A DNA damage checkpoint response in telomere-initiated senescence. Nature 426(6963):194-98
-
(2003)
Nature
, vol.426
, Issue.6963
, pp. 194-198
-
-
Fagagna, F.D.A.D.1
Reaper, P.M.2
Clay-Farrace, L.3
Fiegler, H.4
Carr, P.5
Von Zglinicki, T.6
Saretzki, G.7
Carter, N.P.8
Jackson, S.P.9
-
16
-
-
0036237039
-
Oncogenic ras and p53 cooperate to induce cellular senescence
-
Ferbeyre G, De Stanchina E, Lin AW, Querido E, McCurrach ME, Hannon GJ, Lowe SW (2002) Oncogenic ras and p53 cooperate to induce cellular senescence. Mol Cell Biol 22(10):3497-3508
-
(2002)
Mol Cell Biol
, vol.22
, Issue.10
, pp. 3497-3508
-
-
Ferbeyre, G.1
De Stanchina, E.2
Lin, A.W.3
Querido, E.4
McCurrach, M.E.5
Hannon, G.J.6
Lowe, S.W.7
-
17
-
-
23844540299
-
Effects of telomerase and telomere length on epidermal stem cell behavior
-
Flores I, Cayuela ML, Blasco MA (2005) Effects of telomerase and telomere length on epidermal stem cell behavior. Science 309(5738):1253-56
-
(2005)
Science
, vol.309
, Issue.5738
, pp. 1253-1256
-
-
Flores, I.1
Cayuela, M.L.2
Blasco, M.A.3
-
18
-
-
3242885366
-
The relative lengths of individual telomeres are defined in the zygote and strictly maintained during life
-
Graakjaer J, Pascoe L, Der-Sarkissian H, Thomas G, Kolvraa S, Christensen K, Londono-Vallejo J.-A (2004) The relative lengths of individual telomeres are defined in the zygote and strictly maintained during life. Aging Cell 3(3):97-102
-
(2004)
Aging Cell
, vol.3
, Issue.3
, pp. 97-102
-
-
Graakjaer, J.1
Pascoe, L.2
Der-Sarkissian, H.3
Thomas, G.4
Kolvraa, S.5
Christensen, K.6
Londono-Vallejo, J.-A.7
-
19
-
-
0033553536
-
Mammalian telomeres end in a large duplex loop
-
Griffith JD, Comeau L, Rosenfield S, Stansel RM, Bianchi A, Moss H, De Lange T (1999) Mammalian telomeres end in a large duplex loop. Cell 97(4):503-14
-
(1999)
Cell
, vol.97
, Issue.4
, pp. 503-514
-
-
Griffith, J.D.1
Comeau, L.2
Rosenfield, S.3
Stansel, R.M.4
Bianchi, A.5
Moss, H.6
De Lange, T.7
-
20
-
-
0025279931
-
Telomeres shorten during ageing of human fibroblasts
-
Harley CB, Futcher AB, Greider CW (1990) Telomeres shorten during ageing of human fibroblasts. Nature 345(6274):458-60
-
(1990)
Nature
, vol.345
, Issue.6274
, pp. 458-460
-
-
Harley, C.B.1
Futcher, A.B.2
Greider, C.W.3
-
21
-
-
77049308856
-
Aging: A theory based on free radical and radiation chemistry
-
Harman D (1956) Aging: A theory based on free radical and radiation chemistry. J Gerontol 11:298-300
-
(1956)
J Gerontol
, vol.11
, pp. 298-300
-
-
Harman, D.1
-
22
-
-
0015319592
-
The biologic clock: The mitochondria?
-
Harman D (1972) The biologic clock: the mitochondria? J Am Geriatr Soc 20(4):145-47
-
(1972)
J Am Geriatr Soc
, vol.20
, Issue.4
, pp. 145-147
-
-
Harman, D.1
-
23
-
-
0344622606
-
The serial cultivation of human diploid cell strains
-
Hayflick L, Moorhead PS (1961) The serial cultivation of human diploid cell strains, Exp Cell Res 25:585-621
-
(1961)
Exp Cell Res
, vol.25
, pp. 585-621
-
-
Hayflick, L.1
Moorhead, P.S.2
-
24
-
-
0037167855
-
Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans
-
Herndon LA, Schmeissner PJ, Dudaronek JM, Brown PA, Listner KM, Sakano Y, Paupard MC, Hall DH, Driscoll M (2002) Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 419(6909):808-14
-
(2002)
Nature
, vol.419
, Issue.6909
, pp. 808-814
-
-
Herndon, L.A.1
Schmeissner, P.J.2
Dudaronek, J.M.3
Brown, P.A.4
Listner, K.M.5
Sakano, Y.6
Paupard, M.C.7
Hall, D.H.8
Driscoll, M.9
-
25
-
-
0033789360
-
Spontaneous and radiation-induced differentiation of fibroblasts
-
Herskind C, Rodemann HP (2000) Spontaneous and radiation-induced differentiation of fibroblasts. Exp Gerontol 35(6-7):747-55
-
(2000)
Exp Gerontol
, vol.35
, Issue.6-7
, pp. 747-755
-
-
Herskind, C.1
Rodemann, H.P.2
-
26
-
-
0036814967
-
Replicative senescence of human fibroblasts: The role of Ras-dependent signaling and oxidative stress
-
Hutter E, Unterluggauer H, Uberall F, Schramek H, and Jansen-Durr P (2002) Replicative senescence of human fibroblasts: the role of Ras-dependent signaling and oxidative stress. Exp Gerontol 37(10-11):1165-74
-
(2002)
Exp Gerontol
, vol.37
, Issue.10-11
, pp. 1165-1174
-
-
Hutter, E.1
Unterluggauer, H.2
Uberall, F.3
Schramek, H.4
Jansen-Durr, P.5
-
27
-
-
13944281338
-
The role of telomeres in Etoposide induced tumor cell death
-
Jeyapalan J, Leake A, Ahmed S, Saretzki G, Tilby M, Von Zglinicki T (2004) The role of telomeres in Etoposide induced tumor cell death. Cell Cycle 3(9):1169-76
-
(2004)
Cell Cycle
, vol.3
, Issue.9
, pp. 1169-1176
-
-
Jeyapalan, J.1
Leake, A.2
Ahmed, S.3
Saretzki, G.4
Tilby, M.5
Von Zglinicki, T.6
-
28
-
-
10744219690
-
Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity
-
Kang HJ, Choi YS, Hong S-B, Kim K-W, Woo R-S, Won SJ, Kim EJ, Jeon HK, Jo S-Y, Kim TK, Bachoo R, Reynolds I J, Gwag BJ, Lee H-W (2004) Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity. J Neurosci 24(6):1280-87
-
(2004)
J Neurosci
, vol.24
, Issue.6
, pp. 1280-1287
-
-
Kang, H.J.1
Choi, Y.S.2
Hong, S.-B.3
Kim, K.-W.4
Woo, R.-S.5
Won, S.J.6
Kim, E.J.7
Jeon, H.K.8
Jo, S.-Y.9
Kim, T.K.10
Bachoo, R.11
Reynolds, I.J.12
Gwag, B.J.13
Lee, H.-W.14
-
29
-
-
33748306003
-
Nicotinamide extends replicative life span of human cells
-
Kang HT, Lee HI, Hwang ES (2006) Nicotinamide extends replicative life span of human cells. Aging Cell 5(5):423-36
-
(2006)
Aging Cell
, vol.5
, Issue.5
, pp. 423-436
-
-
Kang, H.T.1
Lee, H.I.2
Hwang, E.S.3
-
30
-
-
0028295472
-
The expression of proliferation-dependent antigens during the life span of normal and progeroid human fibroblasts in culture
-
Kill IR, Faragher RG, Lawrence K, Shall S (1994) The expression of proliferation-dependent antigens during the life span of normal and progeroid human fibroblasts in culture. J Cell Sci 107:571-79
-
(1994)
J Cell Sci
, vol.107
, pp. 571-579
-
-
Kill, I.R.1
Faragher, R.G.2
Lawrence, K.3
Shall, S.4
-
31
-
-
0020070207
-
Cytogerontology since 1881: A reappraisal of August Weissmann and a review of modern progress
-
Kirkwood T, Cremer T (1982) Cytogerontology since 1881: a reappraisal of August Weissmann and a review of modern progress. Hum Genet 60:101-21
-
(1982)
Hum Genet
, vol.60
, pp. 101-121
-
-
Kirkwood, T.1
Cremer, T.2
-
32
-
-
0037167844
-
Ageing: The old worm turns more slowly
-
Kirkwood TB, Finch CE (2002) Ageing: the old worm turns more slowly. Nature 419(6909):794-95
-
(2002)
Nature
, vol.419
, Issue.6909
, pp. 794-795
-
-
Kirkwood, T.B.1
Finch, C.E.2
-
33
-
-
13944262937
-
Understanding the odd science of aging
-
Kirkwood TBL (2005) Understanding the odd science of aging. Cell 120(4):437-447
-
(2005)
Cell
, vol.120
, Issue.4
, pp. 437-447
-
-
Kirkwood, T.B.L.1
-
34
-
-
33646351299
-
Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons
-
Kraytsberg Y, Kudryavtseva E, McKee AC, Geula C, Kowall NW, Khrapko K (2006) Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons. Nat Genet 38(5):518-20
-
(2006)
Nat Genet
, vol.38
, Issue.5
, pp. 518-520
-
-
Kraytsberg, Y.1
Kudryavtseva, E.2
McKee, A.C.3
Geula, C.4
Kowall, N.W.5
Khrapko, K.6
-
35
-
-
3042591085
-
Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells
-
Kurz DJ, Decary S, Hong Y, Trivier E, Akhmedov A, Erusalimsky JD (2004) Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells. J Cell Sci 117(11):2417-26
-
(2004)
J Cell Sci
, vol.117
, Issue.11
, pp. 2417-2426
-
-
Kurz, D.J.1
Decary, S.2
Hong, Y.3
Trivier, E.4
Akhmedov, A.5
Erusalimsky, J.D.6
-
36
-
-
0030059079
-
Agingdependent functional alterations of mitochondrial DNA (mtDNA) from human fibroblasts transferred into mtDNA-less cells
-
Laderman KA, Penny JR, Mazzucchelli F, Bresolin N, Scarlato G, Attardi G (1996) Agingdependent functional alterations of mitochondrial DNA (mtDNA) from human fibroblasts transferred into mtDNA-less cells. J Biol Chem 271(27):15891-97
-
(1996)
J Biol Chem
, vol.271
, Issue.27
, pp. 15891-15897
-
-
Laderman, K.A.1
Penny, J.R.2
Mazzucchelli, F.3
Bresolin, N.4
Scarlato, G.5
Attardi, G.6
-
37
-
-
0029939848
-
Heterogeneity in telomere length of human chromosomes
-
Lansdorp PM, Verwoerd NP, Van De Rijke FM, Dragowska V, Little MT, Dirks RW, Raap AK, Tanke HJ (1996) Heterogeneity in telomere length of human chromosomes. Hum Mol Genet 5(5):685-91
-
(1996)
Hum Mol Genet
, vol.5
, Issue.5
, pp. 685-691
-
-
Lansdorp, P.M.1
Verwoerd, N.P.2
Van De Rijke, F.M.3
Dragowska, V.4
Little, M.T.5
Dirks, R.W.6
Raap, A.K.7
Tanke, H.J.8
-
38
-
-
0032533691
-
Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy
-
Lee CM, Lopez ME, Weindruch R, Aiken JM (1998) Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy. Free Rad Biol Med 25(8):964-72
-
(1998)
Free Rad Biol Med
, vol.25
, Issue.8
, pp. 964-972
-
-
Lee, C.M.1
Lopez, M.E.2
Weindruch, R.3
Aiken, J.M.4
-
39
-
-
0032190629
-
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
-
Lin AW, Barradas M, Stone JC, Van Aelst L, Serrano M, Lowe SW (1998) Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev 12(19):3008-19
-
(1998)
Genes Dev
, vol.12
, Issue.19
, pp. 3008-3019
-
-
Lin, A.W.1
Barradas, M.2
Stone, J.C.3
Van Aelst, L.4
Serrano, M.5
Lowe, S.W.6
-
40
-
-
0038331337
-
Mitochondrial dysfunction leads to telomere attrition and genomic instability
-
Liu L, Trimarchi JR, Smith PJ, Keefe DL (2002) Mitochondrial dysfunction leads to telomere attrition and genomic instability. Aging Cell 1(1):40-46
-
(2002)
Aging Cell
, vol.1
, Issue.1
, pp. 40-46
-
-
Liu, L.1
Trimarchi, J.R.2
Smith, P.J.3
Keefe, D.L.4
-
41
-
-
0035300424
-
Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase
-
Ludwig A, Saretzki G, Holm PS, Tiemann F, Lorenz M, Emrich T, Harley CB, Von Zglinicki T (2001) Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase. Cancer Res 61(7):3053-61
-
(2001)
Cancer Res
, vol.61
, Issue.7
, pp. 3053-3061
-
-
Ludwig, A.1
Saretzki, G.2
Holm, P.S.3
Tiemann, F.4
Lorenz, M.5
Emrich, T.6
Harley, C.B.7
Von Zglinicki, T.8
-
42
-
-
2342435511
-
Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span
-
Martin-Ruiz C, Saretzki G, Petrie J, Ladhoff J, Jeyapalan J, Wei W, Sedivy J, Von Zglinicki T (2004) Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span. J Biol Chem 279(17):17826-33
-
(2004)
J Biol Chem
, vol.279
, Issue.17
, pp. 17826-17833
-
-
Martin-Ruiz, C.1
Saretzki, G.2
Petrie, J.3
Ladhoff, J.4
Jeyapalan, J.5
Wei, W.6
Sedivy, J.7
Von Zglinicki, T.8
-
43
-
-
0036671827
-
Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span
-
Mitsui A, Hamuro J, Nakamura H, Kondo N, Hirabayashi Y, Ishizaki-Koizumi S, Hirakawa T, Inoue T, Yodoi J (2002) Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span. Antioxidants Redox Signal 4(4):693-96
-
(2002)
Antioxidants Redox Signal
, vol.4
, Issue.4
, pp. 693-696
-
-
Mitsui, A.1
Hamuro, J.2
Nakamura, H.3
Kondo, N.4
Hirabayashi, Y.5
Ishizaki-Koizumi, S.6
Hirakawa, T.7
Inoue, T.8
Yodoi, J.9
-
44
-
-
0024366601
-
Cytochrome-c-oxidase deficient cardiomyocytes in the human heart-an agerelated phenomenon. A histochemical ultracytochemical study
-
Muller-Hocker J (1989) Cytochrome-c-oxidase deficient cardiomyocytes in the human heart-an agerelated phenomenon. A histochemical ultracytochemical study. Am J Pathol 134(5):1167-73
-
(1989)
Am J Pathol
, vol.134
, Issue.5
, pp. 1167-1173
-
-
Muller-Hocker, J.1
-
45
-
-
0030916581
-
Advanced telomere shortening in respiratory chain disorders
-
Oexle K, Zwirner A (1997) Advanced telomere shortening in respiratory chain disorders. Hum Mol Genet 6(6):905-8
-
(1997)
Hum Mol Genet
, vol.6
, Issue.6
, pp. 905-908
-
-
Oexle, K.1
Zwirner, A.2
-
46
-
-
0029778901
-
Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent
-
Ogryzko V, Hirai T, Russanova V, Barbie D, Howard B (1996) Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent. Mol Cell Biol 16(9):5210-18
-
(1996)
Mol Cell Biol
, vol.16
, Issue.9
, pp. 5210-5218
-
-
Ogryzko, V.1
Hirai, T.2
Russanova, V.3
Barbie, D.4
Howard, B.5
-
47
-
-
0142027772
-
Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction
-
Oh H, Bradfute SB, Gallardo TD, Nakamura T, Gaussin V, Mishina Y, Pocius J, Michael LH, Behringer RR, Garry D J, Entman ML, Schneider MD (2003) Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. PNAS 100(21):12313-18
-
(2003)
PNAS
, vol.100
, Issue.21
, pp. 12313-12318
-
-
Oh, H.1
Bradfute, S.B.2
Gallardo, T.D.3
Nakamura, T.4
Gaussin, V.5
Mishina, Y.6
Pocius, J.7
Michael, L.H.8
Behringer, R.R.9
Garry, D.J.10
Entman, M.L.11
Schneider, M.D.12
-
48
-
-
0015184804
-
Principle of marginotomy in template synthesis of polynucleotides
-
Olovnikov AM (1971) [Principle of marginotomy in template synthesis of polynucleotides]. Dokl Akad Nauk SSSR 201(6):1496-99
-
(1971)
Dokl Akad Nauk SSSR
, vol.201
, Issue.6
, pp. 1496-1499
-
-
Olovnikov, A.M.1
-
49
-
-
34249028642
-
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence
-
Passos JF, Saretzki G, Ahmed S, Nelson G, Richter T, Peters H, Wappler I, Birkett M, Harold G, Schaeuble K, Birch-Machin M, Kirkwood T, Von Zglinicki T (2007) Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence. PLoS Biol 5(5):e110
-
(2007)
PLoS Biol
, vol.5
, Issue.5
-
-
Passos, J.F.1
Saretzki, G.2
Ahmed, S.3
Nelson, G.4
Richter, T.5
Peters, H.6
Wappler, I.7
Birkett, M.8
Harold, G.9
Schaeuble, K.10
Birch-Machin, M.11
Kirkwood, T.12
Von Zglinicki, T.13
-
50
-
-
21244431867
-
Mitochondria, telomeres and cell senescence
-
Passos JF, Von Zglinicki T (2005) Mitochondria, telomeres and cell senescence. Exp Gerontol 40(6):466-72
-
(2005)
Exp Gerontol
, vol.40
, Issue.6
, pp. 466-472
-
-
Passos, J.F.1
Von Zglinicki, T.2
-
51
-
-
33646056352
-
Mitochondrial dysfunction and cell senescence: Cause or consequence?
-
Passos JF, Von Zglinicki T, Saretzki G (2006) Mitochondrial dysfunction and cell senescence: cause or consequence? Rejuv Res 9(1):64-68
-
(2006)
Rejuv Res
, vol.9
, Issue.1
, pp. 64-68
-
-
Passos, J.F.1
Von Zglinicki, T.2
Saretzki, G.3
-
52
-
-
0031821009
-
Preferential accumulation of single-stranded regions in telomeres of human fibroblasts
-
Petersen S, Saretzki G, Von Zglinicki T (1998) Preferential accumulation of single-stranded regions in telomeres of human fibroblasts. Exp Cell Res 239(1):152-60
-
(1998)
Exp Cell Res
, vol.239
, Issue.1
, pp. 152-160
-
-
Petersen, S.1
Saretzki, G.2
Von Zglinicki, T.3
-
53
-
-
33750533387
-
ROS as a tumour suppressor?
-
Ramsey M, Sharpless N (2006) ROS as a tumour suppressor? Nat Cell Biol. 8(11):1213-15
-
(2006)
Nat Cell Biol.
, vol.8
, Issue.11
, pp. 1213-1215
-
-
Ramsey, M.1
Sharpless, N.2
-
54
-
-
23044445756
-
A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans
-
Rea SL, Wu D, Cypser JR, Vaupel JW, Johnson TE (2005) A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans. Nat Genet 37(8):894-98
-
(2005)
Nat Genet
, vol.37
, Issue.8
, pp. 894-898
-
-
Rea, S.L.1
Wu, D.2
Cypser, J.R.3
Vaupel, J.W.4
Johnson, T.E.5
-
55
-
-
0032485213
-
Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts'
-
Robles S, Adami G (1998) Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts.' Oncogene 16(9):1113-23
-
(1998)
Oncogene
, vol.16
, Issue.9
, pp. 1113-1123
-
-
Robles, S.1
Adami, G.2
-
56
-
-
0037449724
-
Cell sorting experiments link persistent mitochondrial DNA damage with loss of mitochondrial membrane potential and apoptotic cell death
-
Santos JH, Hunakova L, Chen Y, Bortner C, Van Houten B (2003) Cell sorting experiments link persistent mitochondrial DNA damage with loss of mitochondrial membrane potential and apoptotic cell death. J Biol Chem 278(3):1728-34
-
(2003)
J Biol Chem
, vol.278
, Issue.3
, pp. 1728-1734
-
-
Santos, J.H.1
Hunakova, L.2
Chen, Y.3
Bortner, C.4
Van Houten, B.5
-
57
-
-
33744745014
-
Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis
-
Santos JH, Meyer JN, Van Houten B (2006) Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis. Hum Mol Genet 15(11):1757-68
-
(2006)
Hum Mol Genet
, vol.15
, Issue.11
, pp. 1757-1768
-
-
Santos, J.H.1
Meyer, J.N.2
Van Houten, B.3
-
58
-
-
0041419866
-
MitoQ counteracts telomere shortening and elongates life span of fibroblasts under mild oxidative stress
-
Saretzki G, Murphy MP, Von Zglinicki T (2003) MitoQ counteracts telomere shortening and elongates life span of fibroblasts under mild oxidative stress. Aging Cell 2(2):141-43
-
(2003)
Aging Cell
, vol.2
, Issue.2
, pp. 141-143
-
-
Saretzki, G.1
Murphy, M.P.2
Von Zglinicki, T.3
-
59
-
-
23944516520
-
-
Sarin KY, Cheung P, Gilison D, Lee E, Tennen RI, Wang E, Artandi MK, Oro AE, Artandi SE (2005) Conditional telomerase induction causes proliferation of hair follicle stem cells. 436(7053):1048-52
-
(2005)
Conditional Telomerase Induction Causes Proliferation of Hair Follicle Stem Cells
, vol.436
, Issue.7053
, pp. 1048-1052
-
-
Sarin, K.Y.1
Cheung, P.2
Gilison, D.3
Lee, E.4
Tennen, R.I.5
Wang, E.6
Artandi, M.K.7
Oro, A.E.8
Artandi, S.E.9
-
60
-
-
21144434217
-
Extension of murine life span by overexpression of catalase targeted to mitochondria
-
Schriner SE, Linford NJ, Martin GM, Treuting P, Ogburn CE, Emond M, Coskun PE, Ladiges W, Wolf N, Van Remmen H, Wallace DC, Rabinovitch PS (2005) Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 308(5730):1909-11
-
(2005)
Science
, vol.308
, Issue.5730
, pp. 1909-1911
-
-
Schriner, S.E.1
Linford, N.J.2
Martin, G.M.3
Treuting, P.4
Ogburn, C.E.5
Emond, M.6
Coskun, P.E.7
Ladiges, W.8
Wolf, N.9
Van Remmen, H.10
Wallace, D.C.11
Rabinovitch, P.S.12
-
61
-
-
0037470062
-
Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening
-
Serra V, Von Zglinicki T, Lorenz M, Saretzki G (2003) Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening. J Biol Chem 278(9):6824-30
-
(2003)
J Biol Chem
, vol.278
, Issue.9
, pp. 6824-6830
-
-
Serra, V.1
Von Zglinicki, T.2
Lorenz, M.3
Saretzki, G.4
-
62
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
-
Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88(5):593-602
-
(1997)
Cell
, vol.88
, Issue.5
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
63
-
-
0035092972
-
Lipofuscin accumulation in proliferating fibroblasts in vitro: An indicator of oxidative stress
-
Sitte N, Merker K, Grune T. Von Zglinicki T (2001) Lipofuscin accumulation in proliferating fibroblasts in vitro: an indicator of oxidative stress. Exper Gerontol 36(3):475-86
-
(2001)
Exper Gerontol
, vol.36
, Issue.3
, pp. 475-486
-
-
Sitte, N.1
Merker, K.2
Grune, T.3
Von Zglinicki, T.4
-
64
-
-
0034117954
-
Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts
-
Sitte N, Merker K, Von Zglinicki T, Grune T (2000) Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts. Free Rad Biol Med 28(5):701-08
-
(2000)
Free Rad Biol Med
, vol.28
, Issue.5
, pp. 701-708
-
-
Sitte, N.1
Merker, K.2
Von Zglinicki, T.3
Grune, T.4
-
65
-
-
0032054781
-
Accelerated telomere shortening in fibroblasts after extended periods of confluency
-
Sitte N, Saretzki G, Von Zglinicki T (1998) Accelerated telomere shortening in fibroblasts after extended periods of confluency. Free Rad Biol Med 24(6):885-93
-
(1998)
Free Rad Biol Med
, vol.24
, Issue.6
, pp. 885-893
-
-
Sitte, N.1
Saretzki, G.2
Von Zglinicki, T.3
-
66
-
-
0016177201
-
Variation in the life-span of clones derived from human diploid cell strains
-
Smith JR, Hayflick L (1974) Variation in the life-span of clones derived from human diploid cell strains. J Cell Biol 62(1):48-53
-
(1974)
J Cell Biol
, vol.62
, Issue.1
, pp. 48-53
-
-
Smith, J.R.1
Hayflick, L.2
-
67
-
-
0018890645
-
Intraclonal variation in proliferative potential of human diploid fibroblasts: Stochastic mechanism for cellular aging
-
Smith JR, Whitney RG (1980) Intraclonal variation in proliferative potential of human diploid fibroblasts: stochastic mechanism for cellular aging. Science 207(4426):82-84
-
(1980)
Science
, vol.207
, Issue.4426
, pp. 82-84
-
-
Smith, J.R.1
Whitney, R.G.2
-
68
-
-
0035930836
-
A stochastic model of cell replicative senescence based on telomere shortening, oxidative stress, and somatic mutations in nuclear and mitochondrial DNA
-
Sozou PD, Kirkwood T (2001) A stochastic model of cell replicative senescence based on telomere shortening, oxidative stress, and somatic mutations in nuclear and mitochondrial DNA. J Theor Biol 213:573-86
-
(2001)
J Theor Biol
, vol.213
, pp. 573-586
-
-
Sozou, P.D.1
Kirkwood, T.2
-
69
-
-
0037687519
-
Human epithelial cell immortalization as a step in carcinogenesis
-
Stampfer MR, Yaswen P (2003) Human epithelial cell immortalization as a step in carcinogenesis. Cancer Lett 194(2):199-208
-
(2003)
Cancer Lett
, vol.194
, Issue.2
, pp. 199-208
-
-
Stampfer, M.R.1
Yaswen, P.2
-
70
-
-
0347600946
-
Mitochondrial DNA mutations in human colonic crypt stem cells
-
Taylor RW, Barron MJ, Borthwick GM, Gospel A, Chinnery PF, Samuels DC, Taylor GA, Plusa SM, Needham SJ, Greaves LC, Kirkwood T, Turnbull DM (2003) Mitochondrial DNA mutations in human colonic crypt stem cells. J Clin Inv 112(9):1351-60
-
(2003)
J Clin Inv
, vol.112
, Issue.9
, pp. 1351-1360
-
-
Taylor, R.W.1
Barron, M.J.2
Borthwick, G.M.3
Gospel, A.4
Chinnery, P.F.5
Samuels, D.C.6
Taylor, G.A.7
Plusa, S.M.8
Needham, S.J.9
Greaves, L.C.10
Kirkwood, T.11
Turnbull, D.M.12
-
71
-
-
0031563829
-
Different kinetics of senescence in human fibroblasts and peritoneal mesothelial cells
-
Thomas E, Al-Baker E, Dropcova S, Denyer S, Ostad N, Lloyd A, Kill IR, Faragher RGA (1997) Different kinetics of senescence in human fibroblasts and peritoneal mesothelial cells. Exper Cell Res 236(1):355-58
-
(1997)
Exper Cell Res
, vol.236
, Issue.1
, pp. 355-358
-
-
Thomas, E.1
Al-Baker, E.2
Dropcova, S.3
Denyer, S.4
Ostad, N.5
Lloyd, A.6
Kill, I.R.7
Faragher, R.G.A.8
-
72
-
-
12144288373
-
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging
-
Van Remmen H, Ikeno Y, Hamilton M, Pahlavani M, Wolf N, Thorpe SR, Alderson NL, Baynes JW, Epstein CJ., Huang TT, Nelson J, Strong R, Richardson A (2003) Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genom 16:29-37
-
(2003)
Physiol Genom
, vol.16
, pp. 29-37
-
-
Van Remmen, H.1
Ikeno, Y.2
Hamilton, M.3
Pahlavani, M.4
Wolf, N.5
Thorpe, S.R.6
Alderson, N.L.7
Baynes, J.W.8
Epstein, C.J.9
Huang, T.T.10
Nelson, J.11
Strong, R.12
Richardson, A.13
-
73
-
-
0036629255
-
Oxidative stress shortens telomeres
-
Von Zglinicki T (2002) Oxidative stress shortens telomeres. Trends Biochem Sci 27(7):339-44
-
(2002)
Trends Biochem Sci
, vol.27
, Issue.7
, pp. 339-344
-
-
Von Zglinicki, T.1
-
74
-
-
0037335554
-
Telomere-driven replicative senescence is a stress response
-
Von Zglinicki T, Petrie J, Kirkwood TB (2003) Telomere-driven replicative senescence is a stress response. Nat Biotechnol 21(3):229-30
-
(2003)
Nat Biotechnol
, vol.21
, Issue.3
, pp. 229-230
-
-
Von Zglinicki, T.1
Petrie, J.2
Kirkwood, T.B.3
-
75
-
-
0035127889
-
Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia
-
Wanagat J, Cao Z, Pathare P, Aiken JM (2001) Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia. Faseb J 15(2):322-32
-
(2001)
Faseb J
, vol.15
, Issue.2
, pp. 322-332
-
-
Wanagat, J.1
Cao, Z.2
Pathare, P.3
Aiken, J.M.4
-
76
-
-
0015515155
-
Origin of concatemeric T7 DNA
-
Watson JD (1972) Origin of concatemeric T7 DNA. Nat New Biol 239(94):197-201
-
(1972)
Nat New Biol
, vol.239
, Issue.94
, pp. 197-201
-
-
Watson, J.D.1
-
77
-
-
0031032817
-
Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
-
Yakes FM, Van Houten B (1997) Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci U S A 94(2):514-49
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, Issue.2
, pp. 514-549
-
-
Yakes, F.M.1
Van Houten, B.2
-
78
-
-
84900924517
-
TERT suppresses apoptosis at a premitochondrial step by a mechanism requiring reverse transcriptase activity and 14-3-3 protein binding ability
-
Zhang P, Chan SL, Fu W, Mendoza M, Mattson MP (2003) TERT suppresses apoptosis at a premitochondrial step by a mechanism requiring reverse transcriptase activity and 14-3-3 protein binding ability. FASEB J pp. 02-0603
-
(2003)
FASEB J
, pp. 02-0603
-
-
Zhang, P.1
Chan, S.L.2
Fu, W.3
Mendoza, M.4
Mattson, M.P.5
-
79
-
-
3342972121
-
Does a sentinel or a subset of short telomeres determine replicative senescence?
-
Zou Y, Sfeir A, Gryaznov SM, Shay JW, Wright WE (2004) Does a sentinel or a subset of short telomeres determine replicative senescence? Mol Biol Cell 15(8):3709-18
-
(2004)
Mol Biol Cell
, vol.15
, Issue.8
, pp. 3709-3718
-
-
Zou, Y.1
Sfeir, A.2
Gryaznov, S.M.3
Shay, J.W.4
Wright, W.E.5
-
80
-
-
0346256784
-
Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence
-
Zwerschke W, Mazurek S, Stockl P, Hutter E, Eigenbrodt E, Jansen-Durr P (2003) Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence. Biochem J 376(Pt 2):403-11
-
(2003)
Biochem J
, vol.376
, Issue.PART 2
, pp. 403-411
-
-
Zwerschke, W.1
Mazurek, S.2
Stockl, P.3
Hutter, E.4
Eigenbrodt, E.5
Jansen-Durr, P.6
|