메뉴 건너뛰기




Volumn 9, Issue 1, 2006, Pages 64-68

Mitochondrial dysfunction and cell senescence: Cause or consequence?

Author keywords

[No Author keywords available]

Indexed keywords

CELL AGING; CELL DIVISION; CELL IMMORTALIZATION; CONFERENCE PAPER; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENE EXPRESSION; GENETIC VARIABILITY; HUMAN; MITOCHONDRION; PRIORITY JOURNAL; SENESCENCE; SOMATIC CELL; TELOMERE;

EID: 33646056352     PISSN: 15491684     EISSN: None     Source Type: Journal    
DOI: 10.1089/rej.2006.9.64     Document Type: Conference Paper
Times cited : (39)

References (34)
  • 1
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res 1961;25:585-621.
    • (1961) Exp Cell Res , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 2
    • 0021810432 scopus 로고
    • Restriction enzyme analysis of mitochondrial DNA in aging human cells
    • White FA, Bunn CL. Restriction enzyme analysis of mitochondrial DNA in aging human cells. Mech Ageing Dev 1985;30:153-168.
    • (1985) Mech Ageing Dev , vol.30 , pp. 153-168
    • White, F.A.1    Bunn, C.L.2
  • 3
    • 0025279931 scopus 로고
    • Telomeres shorten during aging of human fibroblasts
    • Harley CB, Futcher AB, Greider CW. Telomeres shorten during aging of human fibroblasts. Nature 1990;345:458-160.
    • (1990) Nature , vol.345 , pp. 458-1160
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 4
    • 0010045614 scopus 로고    scopus 로고
    • Extension of life-span by introduction of telomerase into normal human cells
    • Bodnar AG, Ouellette M, Frolkis M, et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998;279:349-352.
    • (1998) Science , vol.279 , pp. 349-352
    • Bodnar, A.G.1    Ouellette, M.2    Frolkis, M.3
  • 5
    • 0034695436 scopus 로고    scopus 로고
    • Accumulation of defective mitochondria through delayed degradation of damaged organelles and its possible role in the ageing of post-mitotic and dividing cells
    • Kowald A, Kirkwood T. Accumulation of defective mitochondria through delayed degradation of damaged organelles and its possible role in the ageing of post-mitotic and dividing cells. J Theoret Biol 2000;202:145-160.
    • (2000) J Theoret Biol , vol.202 , pp. 145-160
    • Kowald, A.1    Kirkwood, T.2
  • 6
    • 0346256784 scopus 로고    scopus 로고
    • Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence
    • Zwerschke W, Mazurek S, Stockl P, et al. Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence. Biochem J 2003;376:403-111.
    • (2003) Biochem J , vol.376 , pp. 403-1111
    • Zwerschke, W.1    Mazurek, S.2    Stockl, P.3
  • 7
    • 0033004248 scopus 로고    scopus 로고
    • Differences in electron transport potential, antioxidant defenses, and oxidant generation in young and senescent fetal lung fibroblasts (WI-38)
    • Allen RG, Tresini M, Keogh BP, et al. Differences in electron transport potential, antioxidant defenses, and oxidant generation in young and senescent fetal lung fibroblasts (WI-38). J Cell Physiol 1999;180:114-122.
    • (1999) J Cell Physiol , vol.180 , pp. 114-122
    • Allen, R.G.1    Tresini, M.2    Keogh, B.P.3
  • 8
    • 3042781117 scopus 로고    scopus 로고
    • Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts
    • Hutter E, Renner K, Pfister G, et al. Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts. Biochem J 2004;380:919-928.
    • (2004) Biochem J , vol.380 , pp. 919-928
    • Hutter, E.1    Renner, K.2    Pfister, G.3
  • 9
    • 0034117954 scopus 로고    scopus 로고
    • Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts
    • Sitte N, Merker K, von Zglinicki T, et al. Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts. Free Radic Biol Med 2000;28:701-708.
    • (2000) Free Radic Biol Med , vol.28 , pp. 701-708
    • Sitte, N.1    Merker, K.2    Von Zglinicki, T.3
  • 10
    • 0035092972 scopus 로고    scopus 로고
    • Lipofuscin accumulation in proliferating fibroblasts in vitro: An indicator of oxidative stress
    • Sitte N, Merker K, Grune T, et al. Lipofuscin accumulation in proliferating fibroblasts in vitro: an indicator of oxidative stress. Exp Gerontol 2001;36:475-486.
    • (2001) Exp Gerontol , vol.36 , pp. 475-486
    • Sitte, N.1    Merker, K.2    Grune, T.3
  • 12
    • 21244431867 scopus 로고    scopus 로고
    • Mitochondria, telomeres and cell senescence
    • Passos JF, von Zglinicki T. Mitochondria, telomeres and cell senescence. Exp Gerontol 2005;40:466-172.
    • (2005) Exp Gerontol , vol.40 , pp. 466-1172
    • Passos, J.F.1    Von Zglinicki, T.2
  • 13
    • 2642580016 scopus 로고    scopus 로고
    • Premature aging in mice expressing defective mitochondrial DNA polymerase
    • Trifunovic A, Wredenberg A, Falkenberg M, et al. Premature aging in mice expressing defective mitochondrial DNA polymerase. Nature 2004;429:417-123.
    • (2004) Nature , vol.429 , pp. 417-1123
    • Trifunovic, A.1    Wredenberg, A.2    Falkenberg, M.3
  • 14
    • 22344456832 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
    • Kujoth GC, Hiona A, Pugh TD, et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 2005;309:481-184.
    • (2005) Science , vol.309 , pp. 481-1184
    • Kujoth, G.C.1    Hiona, A.2    Pugh, T.D.3
  • 15
    • 12144288373 scopus 로고    scopus 로고
    • Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging
    • Van Remmen H, Ikeno Y, Hamilton M, et al. Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genom 2003;16:29-37.
    • (2003) Physiol Genom , vol.16 , pp. 29-37
    • Van Remmen, H.1    Ikeno, Y.2    Hamilton, M.3
  • 16
    • 21144434217 scopus 로고    scopus 로고
    • Extension of murine life span by overexpression of catalase targeted to mitochondria
    • Schriner SE, Linford NJ, Martin GM, et al. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 2005;308:1909-1911.
    • (2005) Science , vol.308 , pp. 1909-1911
    • Schriner, S.E.1    Linford, N.J.2    Martin, G.M.3
  • 17
    • 0029127226 scopus 로고
    • Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: A model for senescence?
    • von Zglinicki T, Saretzki G, Docke W, et al. Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? Exp Cell Res 1995;220:186-193.
    • (1995) Exp Cell Res , vol.220 , pp. 186-193
    • Von Zglinicki, T.1    Saretzki, G.2    Docke, W.3
  • 18
    • 0017738651 scopus 로고
    • The effect of oxygen and vitamin E on the lifespan of human diploid cells in vitro
    • Balin AK, Goodman DB, Rasmussen H, et al. The effect of oxygen and vitamin E on the lifespan of human diploid cells in vitro. J Cell Biol 1977;74:58-67.
    • (1977) J Cell Biol , vol.74 , pp. 58-67
    • Balin, A.K.1    Goodman, D.B.2    Rasmussen, H.3
  • 19
    • 0028345161 scopus 로고
    • Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblasts F65 cells
    • Chen Q, Ames BN. Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblasts F65 cells. Proc Natl Acad Sci USA 1994;91:4130-4134.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 4130-4134
    • Chen, Q.1    Ames, B.N.2
  • 20
    • 0033963144 scopus 로고    scopus 로고
    • Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast
    • Dumont P, Burton M, Chen QM, et al. Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast. Free Radic Biol Med 2000;28:361-373.
    • (2000) Free Radic Biol Med , vol.28 , pp. 361-373
    • Dumont, P.1    Burton, M.2    Chen, Q.M.3
  • 21
    • 0036629255 scopus 로고    scopus 로고
    • Oxidative stress shortens telomeres
    • von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem Sci 2002;27:339-344.
    • (2002) Trends Biochem Sci , vol.27 , pp. 339-344
    • Von Zglinicki, T.1
  • 22
    • 0018890645 scopus 로고
    • Intraclonal variation in proliferative potential of human diploid fibroblasts: Stochastic mechanism for cellular ageing
    • Smith JR, Whitney RG. Intraclonal variation in proliferative potential of human diploid fibroblasts: stochastic mechanism for cellular ageing. Science 1980;207:82-84.
    • (1980) Science , vol.207 , pp. 82-84
    • Smith, J.R.1    Whitney, R.G.2
  • 23
    • 0035930836 scopus 로고    scopus 로고
    • A stochastic model of cell replicative senescence based on telomere shortening, oxidative stress, and somatic mutations in nuclear and mitochondrial DNA
    • Sozou PD, Kirkwood T. A stochastic model of cell replicative senescence based on telomere shortening, oxidative stress, and somatic mutations in nuclear and mitochondrial DNA. J Theoret Biol 2001;213:573-586.
    • (2001) J Theoret Biol , vol.213 , pp. 573-586
    • Sozou, P.D.1    Kirkwood, T.2
  • 24
    • 2342435511 scopus 로고    scopus 로고
    • Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span
    • Martin-Ruiz C, Saretzki G, Petrie J, et al. Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span. J Biol Chem 2004;279:17826-17833.
    • (2004) J Biol Chem , vol.279 , pp. 17826-17833
    • Martin-Ruiz, C.1    Saretzki, G.2    Petrie, J.3
  • 25
    • 23244458528 scopus 로고    scopus 로고
    • Early-senescing human skin fibroblasts do not demonstrate accelerated telomere shortening
    • Ferenac M, Polancec D, Huzak M, Pet al. Early-senescing human skin fibroblasts do not demonstrate accelerated telomere shortening. J Gerontol A Biol Sci Med Sci 2005;60:820-829.
    • (2005) J Gerontol A Biol Sci Med Sci , vol.60 , pp. 820-829
    • Ferenac, M.1    Polancec, D.2    Huzak, M.P.3
  • 26
    • 0037470062 scopus 로고    scopus 로고
    • Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening
    • Serra V, von Zglinicki T, Lorenz M, et al. Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening. J Biol Chem 2003;278:6824-6830.
    • (2003) J Biol Chem , vol.278 , pp. 6824-6830
    • Serra, V.1    Von Zglinicki, T.2    Lorenz, M.3
  • 27
    • 0038331337 scopus 로고    scopus 로고
    • Mitochondrial dysfunction leads to telomere attrition and genomic instability
    • Liu L, Trimarchi JR, Smith PJ, et al. Mitochondrial dysfunction leads to telomere attrition and genomic instability. Aging Cell 2002;1:40-46.
    • (2002) Aging Cell , vol.1 , pp. 40-46
    • Liu, L.1    Trimarchi, J.R.2    Smith, P.J.3
  • 28
    • 0041419866 scopus 로고    scopus 로고
    • Mito Q counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress
    • Saretzki G, Murphy MP, von Zglinicki T. Mito Q counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress. Aging Cell 2003;2:141-143.
    • (2003) Aging Cell , vol.2 , pp. 141-143
    • Saretzki, G.1    Murphy, M.P.2    Von Zglinicki, T.3
  • 29
    • 0032923742 scopus 로고    scopus 로고
    • Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype
    • Jiang X-R, Jimenez G, Chang E, et al. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nat Genet 1999;21:111-114.
    • (1999) Nat Genet , vol.21 , pp. 111-114
    • Jiang, X.-R.1    Jimenez, G.2    Chang, E.3
  • 30
    • 0037390962 scopus 로고    scopus 로고
    • TERT suppresses apoptosis at a premitochondrial step by a mechanism requiring reverse transcriptase activity and 14-3-3 protein binding ability
    • Zhang P, Chan SL, Fu W, et al. TERT suppresses apoptosis at a premitochondrial step by a mechanism requiring reverse transcriptase activity and 14-3-3 protein binding ability. FASEB J 2003;17:767-769.
    • (2003) FASEB J , vol.17 , pp. 767-769
    • Zhang, P.1    Chan, S.L.2    Fu, W.3
  • 31
    • 16444384725 scopus 로고    scopus 로고
    • Overexpression of telomerase confers growth advantage, stress resistance, and enhanced differentiation of ESCs toward the hematopoietic lineage
    • Armstrong L, Saretzki G, Peters H, et al. Overexpression of telomerase confers growth advantage, stress resistance, and enhanced differentiation of ESCs toward the hematopoietic lineage. Stem Cells 2005;23:516-529.
    • (2005) Stem Cells , vol.23 , pp. 516-529
    • Armstrong, L.1    Saretzki, G.2    Peters, H.3
  • 32
    • 23944516520 scopus 로고    scopus 로고
    • Conditional telomerase induction causes proliferation of hair follicle stem cells
    • Sarin KY, Cheung P, Gilison D, et al. Conditional telomerase induction causes proliferation of hair follicle stem cells. Nature 2005;436:1048-1052.
    • (2005) Nature , vol.436 , pp. 1048-1052
    • Sarin, K.Y.1    Cheung, P.2    Gilison, D.3
  • 33
    • 10744219690 scopus 로고    scopus 로고
    • Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity
    • Kang HJ, Choi YS, Hong S-B, et al. Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity. J Neurosci 2004;24:1280-1287.
    • (2004) J Neurosci , vol.24 , pp. 1280-1287
    • Kang, H.J.1    Choi, Y.S.2    Hong, S.-B.3
  • 34
    • 8644232705 scopus 로고    scopus 로고
    • Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells
    • Saretzki G, Armstrong L, Leake A, et al. Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells. Stem Cells 2004;22:962-971.
    • (2004) Stem Cells , vol.22 , pp. 962-971
    • Saretzki, G.1    Armstrong, L.2    Leake, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.