-
1
-
-
0344622606
-
The serial cultivation of human diploid cell strains
-
Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res 1961;25:585-621.
-
(1961)
Exp Cell Res
, vol.25
, pp. 585-621
-
-
Hayflick, L.1
Moorhead, P.S.2
-
2
-
-
0021810432
-
Restriction enzyme analysis of mitochondrial DNA in aging human cells
-
White FA, Bunn CL. Restriction enzyme analysis of mitochondrial DNA in aging human cells. Mech Ageing Dev 1985;30:153-168.
-
(1985)
Mech Ageing Dev
, vol.30
, pp. 153-168
-
-
White, F.A.1
Bunn, C.L.2
-
3
-
-
0025279931
-
Telomeres shorten during aging of human fibroblasts
-
Harley CB, Futcher AB, Greider CW. Telomeres shorten during aging of human fibroblasts. Nature 1990;345:458-160.
-
(1990)
Nature
, vol.345
, pp. 458-1160
-
-
Harley, C.B.1
Futcher, A.B.2
Greider, C.W.3
-
4
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
Bodnar AG, Ouellette M, Frolkis M, et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998;279:349-352.
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
Ouellette, M.2
Frolkis, M.3
-
5
-
-
0034695436
-
Accumulation of defective mitochondria through delayed degradation of damaged organelles and its possible role in the ageing of post-mitotic and dividing cells
-
Kowald A, Kirkwood T. Accumulation of defective mitochondria through delayed degradation of damaged organelles and its possible role in the ageing of post-mitotic and dividing cells. J Theoret Biol 2000;202:145-160.
-
(2000)
J Theoret Biol
, vol.202
, pp. 145-160
-
-
Kowald, A.1
Kirkwood, T.2
-
6
-
-
0346256784
-
Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence
-
Zwerschke W, Mazurek S, Stockl P, et al. Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence. Biochem J 2003;376:403-111.
-
(2003)
Biochem J
, vol.376
, pp. 403-1111
-
-
Zwerschke, W.1
Mazurek, S.2
Stockl, P.3
-
7
-
-
0033004248
-
Differences in electron transport potential, antioxidant defenses, and oxidant generation in young and senescent fetal lung fibroblasts (WI-38)
-
Allen RG, Tresini M, Keogh BP, et al. Differences in electron transport potential, antioxidant defenses, and oxidant generation in young and senescent fetal lung fibroblasts (WI-38). J Cell Physiol 1999;180:114-122.
-
(1999)
J Cell Physiol
, vol.180
, pp. 114-122
-
-
Allen, R.G.1
Tresini, M.2
Keogh, B.P.3
-
8
-
-
3042781117
-
Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts
-
Hutter E, Renner K, Pfister G, et al. Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts. Biochem J 2004;380:919-928.
-
(2004)
Biochem J
, vol.380
, pp. 919-928
-
-
Hutter, E.1
Renner, K.2
Pfister, G.3
-
9
-
-
0034117954
-
Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts
-
Sitte N, Merker K, von Zglinicki T, et al. Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts. Free Radic Biol Med 2000;28:701-708.
-
(2000)
Free Radic Biol Med
, vol.28
, pp. 701-708
-
-
Sitte, N.1
Merker, K.2
Von Zglinicki, T.3
-
10
-
-
0035092972
-
Lipofuscin accumulation in proliferating fibroblasts in vitro: An indicator of oxidative stress
-
Sitte N, Merker K, Grune T, et al. Lipofuscin accumulation in proliferating fibroblasts in vitro: an indicator of oxidative stress. Exp Gerontol 2001;36:475-486.
-
(2001)
Exp Gerontol
, vol.36
, pp. 475-486
-
-
Sitte, N.1
Merker, K.2
Grune, T.3
-
12
-
-
21244431867
-
Mitochondria, telomeres and cell senescence
-
Passos JF, von Zglinicki T. Mitochondria, telomeres and cell senescence. Exp Gerontol 2005;40:466-172.
-
(2005)
Exp Gerontol
, vol.40
, pp. 466-1172
-
-
Passos, J.F.1
Von Zglinicki, T.2
-
13
-
-
2642580016
-
Premature aging in mice expressing defective mitochondrial DNA polymerase
-
Trifunovic A, Wredenberg A, Falkenberg M, et al. Premature aging in mice expressing defective mitochondrial DNA polymerase. Nature 2004;429:417-123.
-
(2004)
Nature
, vol.429
, pp. 417-1123
-
-
Trifunovic, A.1
Wredenberg, A.2
Falkenberg, M.3
-
14
-
-
22344456832
-
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
-
Kujoth GC, Hiona A, Pugh TD, et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 2005;309:481-184.
-
(2005)
Science
, vol.309
, pp. 481-1184
-
-
Kujoth, G.C.1
Hiona, A.2
Pugh, T.D.3
-
15
-
-
12144288373
-
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging
-
Van Remmen H, Ikeno Y, Hamilton M, et al. Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genom 2003;16:29-37.
-
(2003)
Physiol Genom
, vol.16
, pp. 29-37
-
-
Van Remmen, H.1
Ikeno, Y.2
Hamilton, M.3
-
16
-
-
21144434217
-
Extension of murine life span by overexpression of catalase targeted to mitochondria
-
Schriner SE, Linford NJ, Martin GM, et al. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 2005;308:1909-1911.
-
(2005)
Science
, vol.308
, pp. 1909-1911
-
-
Schriner, S.E.1
Linford, N.J.2
Martin, G.M.3
-
17
-
-
0029127226
-
Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: A model for senescence?
-
von Zglinicki T, Saretzki G, Docke W, et al. Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? Exp Cell Res 1995;220:186-193.
-
(1995)
Exp Cell Res
, vol.220
, pp. 186-193
-
-
Von Zglinicki, T.1
Saretzki, G.2
Docke, W.3
-
18
-
-
0017738651
-
The effect of oxygen and vitamin E on the lifespan of human diploid cells in vitro
-
Balin AK, Goodman DB, Rasmussen H, et al. The effect of oxygen and vitamin E on the lifespan of human diploid cells in vitro. J Cell Biol 1977;74:58-67.
-
(1977)
J Cell Biol
, vol.74
, pp. 58-67
-
-
Balin, A.K.1
Goodman, D.B.2
Rasmussen, H.3
-
19
-
-
0028345161
-
Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblasts F65 cells
-
Chen Q, Ames BN. Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblasts F65 cells. Proc Natl Acad Sci USA 1994;91:4130-4134.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 4130-4134
-
-
Chen, Q.1
Ames, B.N.2
-
20
-
-
0033963144
-
Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast
-
Dumont P, Burton M, Chen QM, et al. Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast. Free Radic Biol Med 2000;28:361-373.
-
(2000)
Free Radic Biol Med
, vol.28
, pp. 361-373
-
-
Dumont, P.1
Burton, M.2
Chen, Q.M.3
-
21
-
-
0036629255
-
Oxidative stress shortens telomeres
-
von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem Sci 2002;27:339-344.
-
(2002)
Trends Biochem Sci
, vol.27
, pp. 339-344
-
-
Von Zglinicki, T.1
-
22
-
-
0018890645
-
Intraclonal variation in proliferative potential of human diploid fibroblasts: Stochastic mechanism for cellular ageing
-
Smith JR, Whitney RG. Intraclonal variation in proliferative potential of human diploid fibroblasts: stochastic mechanism for cellular ageing. Science 1980;207:82-84.
-
(1980)
Science
, vol.207
, pp. 82-84
-
-
Smith, J.R.1
Whitney, R.G.2
-
23
-
-
0035930836
-
A stochastic model of cell replicative senescence based on telomere shortening, oxidative stress, and somatic mutations in nuclear and mitochondrial DNA
-
Sozou PD, Kirkwood T. A stochastic model of cell replicative senescence based on telomere shortening, oxidative stress, and somatic mutations in nuclear and mitochondrial DNA. J Theoret Biol 2001;213:573-586.
-
(2001)
J Theoret Biol
, vol.213
, pp. 573-586
-
-
Sozou, P.D.1
Kirkwood, T.2
-
24
-
-
2342435511
-
Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span
-
Martin-Ruiz C, Saretzki G, Petrie J, et al. Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span. J Biol Chem 2004;279:17826-17833.
-
(2004)
J Biol Chem
, vol.279
, pp. 17826-17833
-
-
Martin-Ruiz, C.1
Saretzki, G.2
Petrie, J.3
-
25
-
-
23244458528
-
Early-senescing human skin fibroblasts do not demonstrate accelerated telomere shortening
-
Ferenac M, Polancec D, Huzak M, Pet al. Early-senescing human skin fibroblasts do not demonstrate accelerated telomere shortening. J Gerontol A Biol Sci Med Sci 2005;60:820-829.
-
(2005)
J Gerontol A Biol Sci Med Sci
, vol.60
, pp. 820-829
-
-
Ferenac, M.1
Polancec, D.2
Huzak, M.P.3
-
26
-
-
0037470062
-
Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening
-
Serra V, von Zglinicki T, Lorenz M, et al. Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening. J Biol Chem 2003;278:6824-6830.
-
(2003)
J Biol Chem
, vol.278
, pp. 6824-6830
-
-
Serra, V.1
Von Zglinicki, T.2
Lorenz, M.3
-
27
-
-
0038331337
-
Mitochondrial dysfunction leads to telomere attrition and genomic instability
-
Liu L, Trimarchi JR, Smith PJ, et al. Mitochondrial dysfunction leads to telomere attrition and genomic instability. Aging Cell 2002;1:40-46.
-
(2002)
Aging Cell
, vol.1
, pp. 40-46
-
-
Liu, L.1
Trimarchi, J.R.2
Smith, P.J.3
-
28
-
-
0041419866
-
Mito Q counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress
-
Saretzki G, Murphy MP, von Zglinicki T. Mito Q counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress. Aging Cell 2003;2:141-143.
-
(2003)
Aging Cell
, vol.2
, pp. 141-143
-
-
Saretzki, G.1
Murphy, M.P.2
Von Zglinicki, T.3
-
29
-
-
0032923742
-
Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype
-
Jiang X-R, Jimenez G, Chang E, et al. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nat Genet 1999;21:111-114.
-
(1999)
Nat Genet
, vol.21
, pp. 111-114
-
-
Jiang, X.-R.1
Jimenez, G.2
Chang, E.3
-
30
-
-
0037390962
-
TERT suppresses apoptosis at a premitochondrial step by a mechanism requiring reverse transcriptase activity and 14-3-3 protein binding ability
-
Zhang P, Chan SL, Fu W, et al. TERT suppresses apoptosis at a premitochondrial step by a mechanism requiring reverse transcriptase activity and 14-3-3 protein binding ability. FASEB J 2003;17:767-769.
-
(2003)
FASEB J
, vol.17
, pp. 767-769
-
-
Zhang, P.1
Chan, S.L.2
Fu, W.3
-
31
-
-
16444384725
-
Overexpression of telomerase confers growth advantage, stress resistance, and enhanced differentiation of ESCs toward the hematopoietic lineage
-
Armstrong L, Saretzki G, Peters H, et al. Overexpression of telomerase confers growth advantage, stress resistance, and enhanced differentiation of ESCs toward the hematopoietic lineage. Stem Cells 2005;23:516-529.
-
(2005)
Stem Cells
, vol.23
, pp. 516-529
-
-
Armstrong, L.1
Saretzki, G.2
Peters, H.3
-
32
-
-
23944516520
-
Conditional telomerase induction causes proliferation of hair follicle stem cells
-
Sarin KY, Cheung P, Gilison D, et al. Conditional telomerase induction causes proliferation of hair follicle stem cells. Nature 2005;436:1048-1052.
-
(2005)
Nature
, vol.436
, pp. 1048-1052
-
-
Sarin, K.Y.1
Cheung, P.2
Gilison, D.3
-
33
-
-
10744219690
-
Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity
-
Kang HJ, Choi YS, Hong S-B, et al. Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity. J Neurosci 2004;24:1280-1287.
-
(2004)
J Neurosci
, vol.24
, pp. 1280-1287
-
-
Kang, H.J.1
Choi, Y.S.2
Hong, S.-B.3
-
34
-
-
8644232705
-
Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells
-
Saretzki G, Armstrong L, Leake A, et al. Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells. Stem Cells 2004;22:962-971.
-
(2004)
Stem Cells
, vol.22
, pp. 962-971
-
-
Saretzki, G.1
Armstrong, L.2
Leake, A.3
|