메뉴 건너뛰기




Volumn 369, Issue 1645, 2014, Pages

Immune responses during spontaneous control of HIV and AIDS: What is the hope for a cure?

Author keywords

Eradication; HIV controllers; Inflammation; Natural hosts of simian human immunodeficiency virus; Post treatment controllers

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; DISEASE; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE RESPONSE; RESEARCH; VACCINE;

EID: 84900312727     PISSN: 09628436     EISSN: 14712970     Source Type: Journal    
DOI: 10.1098/rstb.2013.0436     Document Type: Review
Times cited : (22)

References (251)
  • 1
    • 0020596551 scopus 로고
    • Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS)
    • (doi:10.1126/science. 6189183)
    • Barre-Sinoussi F et al. 1983 Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science 220, 868-871. (doi:10.1126/science. 6189183)
    • (1983) Science , vol.220 , pp. 868-871
    • Barre-Sinoussi, F.1
  • 2
    • 84864345953 scopus 로고    scopus 로고
    • Towards an HIV cure: A global scientific strategy
    • (doi:10.1038/nri3262)
    • Deeks SG et al. 2012 Towards an HIV cure: a global scientific strategy. Nat. Rev. Immunol. 12, 607-614. (doi:10.1038/nri3262)
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 607-614
    • Deeks, S.G.1
  • 3
    • 60549090253 scopus 로고    scopus 로고
    • Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation
    • (doi:10.1056/ NEJMoa0802905)
    • Hutter G et al. 2009 Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N. Engl. J. Med. 360, 692-698. (doi:10.1056/ NEJMoa0802905)
    • (2009) N. Engl. J. Med. , vol.360 , pp. 692-698
    • Hutter, G.1
  • 4
    • 79953117041 scopus 로고    scopus 로고
    • Evidence for the cure of HIV infection by CCR5D32/D32 stem cell transplantation
    • (doi:10. 1182/blood-2010-09-309591)
    • Allers K, Hutter G, Hofmann J, Loddenkemper C, Rieger K, Thiel E, Schneider T. 2011 Evidence for the cure of HIV infection by CCR5D32/D32 stem cell transplantation. Blood 117, 2791-2799. (doi:10. 1182/blood-2010-09-309591)
    • (2011) Blood , vol.117 , pp. 2791-2799
    • Allers, K.1    Hutter, G.2    Hofmann, J.3    Loddenkemper, C.4    Rieger, K.5    Thiel, E.6    Schneider, T.7
  • 5
    • 84878503062 scopus 로고    scopus 로고
    • Challenges in detecting HIV persistence during potentially curative interventions: A study of the Berlin patient
    • (doi:10.1371/journal.ppat.1003347)
    • Yukl SA et al. 2013 Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient. PLoS Pathog. 9, e1003347. (doi:10.1371/journal.ppat.1003347)
    • (2013) PLoS Pathog. , vol.9
    • Yukl, S.A.1
  • 6
    • 84879320681 scopus 로고    scopus 로고
    • HIV controllers: A genetically determined or inducible phenotype?
    • (doi:10.1111/imr. 12076)
    • Saez-Cirion A, Pancino G. 2013 HIV controllers: a genetically determined or inducible phenotype? Immunol. Rev. 254, 281-294. (doi:10.1111/imr. 12076)
    • (2013) Immunol. Rev. , vol.254 , pp. 281-294
    • Saez-Cirion, A.1    Pancino, G.2
  • 7
    • 0030070991 scopus 로고    scopus 로고
    • Prognosis in HIV-1 infection predicted by the quantity of virus in plasma
    • (doi:10.1126/science.272. 5265.1167)
    • Mellors JW, Rinaldo Jr CR, Gupta P, White RM, Todd JA, Kingsley LA. 1996 Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science 272, 1167-1170. (doi:10.1126/science.272. 5265.1167)
    • (1996) Science , vol.272 , pp. 1167-1170
    • Mellors, J.W.1    Rinaldo Jr., C.R.2    Gupta, P.3    White, R.M.4    Todd, J.A.5    Kingsley, L.A.6
  • 8
    • 0032955651 scopus 로고    scopus 로고
    • Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage
    • (doi:10.1086/314660)
    • Giorgi JV et al. 1999 Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J. Infect. Dis. 179, 859-870. (doi:10.1086/314660)
    • (1999) J. Infect. Dis. , vol.179 , pp. 859-870
    • Giorgi, J.V.1
  • 9
    • 0037105617 scopus 로고    scopus 로고
    • CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load
    • Sousa AE, Carneiro J, Meier-Schellersheim M, Grossman Z, Victorino RM. 2002 CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load. J. Immunol. 169, 3400-3406.
    • (2002) J. Immunol. , vol.169 , pp. 3400-3406
    • Sousa, A.E.1    Carneiro, J.2    Meier-Schellersheim, M.3    Grossman, Z.4    Victorino, R.M.5
  • 11
    • 55949084601 scopus 로고    scopus 로고
    • Inflammatory and coagulation biomarkers and mortality in patients with HIV infection
    • (doi:10.1371/journal. pmed.0050203)
    • Kuller LH et al. 2008 Inflammatory and coagulation biomarkers and mortality in patients with HIV infection. PLoS Med. 5, e203. (doi:10.1371/journal. pmed.0050203)
    • (2008) PLoS Med. , vol.5
    • Kuller, L.H.1
  • 12
    • 84879295275 scopus 로고    scopus 로고
    • HIV-associated chronic immune activation
    • (doi:10.1111/imr.12079)
    • Paiardini M, Müller-Trutwin M. 2013 HIV-associated chronic immune activation. Immunol. Rev. 254, 78-101. (doi:10.1111/imr.12079)
    • (2013) Immunol. Rev. , vol.254 , pp. 78-101
    • Paiardini, M.1    Müller-Trutwin, M.2
  • 13
    • 84866978487 scopus 로고    scopus 로고
    • Acute plasma biomarkers of T cell activation set-point levels and of disease progression in HIV-1 infection
    • (doi:10.1371/journal.pone.0046143)
    • Liovat AS et al. 2012 Acute plasma biomarkers of T cell activation set-point levels and of disease progression in HIV-1 infection. PLoS ONE 7, e46143. (doi:10.1371/journal.pone.0046143)
    • (2012) PLoS ONE , vol.7
    • Liovat, A.S.1
  • 14
    • 0242410967 scopus 로고    scopus 로고
    • Differential induction of TGF-beta regulates proinflammatory cytokine production and determines the outcome of lethal and nonlethal Plasmodium yoelii infections
    • Omer FM, de Souza JB, Riley EM. 2003 Differential induction of TGF-beta regulates proinflammatory cytokine production and determines the outcome of lethal and nonlethal Plasmodium yoelii infections. J. Immunol. 171, 5430-5436.
    • (2003) J. Immunol. , vol.171 , pp. 5430-5436
    • Omer, F.M.1    de Souza, J.B.2    Riley, E.M.3
  • 15
    • 53349143044 scopus 로고    scopus 로고
    • Persistent virus infection inhibits type I interferon production by plasmacytoid dendritic cells to facilitate opportunistic infections
    • (doi:10.1016/j.chom.2008.08.016)
    • Zuniga EI, Liou LY, Mack L, Mendoza M, Oldstone MB. 2008 Persistent virus infection inhibits type I interferon production by plasmacytoid dendritic cells to facilitate opportunistic infections. Cell Host Microbe 4, 374-386. (doi:10.1016/j.chom.2008.08.016)
    • (2008) Cell Host Microbe , vol.4 , pp. 374-386
    • Zuniga, E.I.1    Liou, L.Y.2    Mack, L.3    Mendoza, M.4    Oldstone, M.B.5
  • 16
    • 84892372311 scopus 로고    scopus 로고
    • Can early therapy reduce inflammation?
    • (doi:10.1097/COH.0000000000000020)
    • Sandler NG, Sereti I. 2014 Can early therapy reduce inflammation? Curr. Opin. HIV AIDS 9, 72-79. (doi:10.1097/COH.0000000000000020)
    • (2014) Curr. Opin. HIV AIDS , vol.9 , pp. 72-79
    • Sandler, N.G.1    Sereti, I.2
  • 17
    • 84875985311 scopus 로고    scopus 로고
    • Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI study
    • (doi:10.1371/journal.ppat.1003211)
    • Saez-Cirion A et al. 2013 Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI study. PLoS Pathog. 9, e1003211. (doi:10.1371/journal.ppat.1003211)
    • (2013) PLoS Pathog. , vol.9
    • Saez-Cirion, A.1
  • 18
    • 77953916829 scopus 로고    scopus 로고
    • Long-term immunovirologic control following antiretroviral therapy interruption in patients treated at the time of primary HIV-1 infection
    • (doi:10.1097/QAD.0b013e32833b61ba)
    • Hocqueloux L, Prazuck T, Avettand-Fenoel V, Lafeuillade A, Cardon B, Viard JP, Rouzioux C. 2010 Long-term immunovirologic control following antiretroviral therapy interruption in patients treated at the time of primary HIV-1 infection. AIDS 24, 1598-1601. (doi:10.1097/QAD.0b013e32833b61ba)
    • (2010) AIDS , vol.24 , pp. 1598-1601
    • Hocqueloux, L.1    Prazuck, T.2    Avettand-Fenoel, V.3    Lafeuillade, A.4    Cardon, B.5    Viard, J.P.6    Rouzioux, C.7
  • 19
    • 84866130614 scopus 로고    scopus 로고
    • Immunovirologic control 24 months after interruption of antiretroviral therapy initiated close to HIV seroconversion
    • (doi:10.1001/ archinternmed.2012.2719)
    • Lodi S, Meyer L, Kelleher AD, Rosinska M, Ghosn J, Sannes M, Porter K. 2012 Immunovirologic control 24 months after interruption of antiretroviral therapy initiated close to HIV seroconversion. Arch. Intern. Med. 172, 1252-1255. (doi:10.1001/ archinternmed.2012.2719)
    • (2012) Arch. Intern. Med. , vol.172 , pp. 1252-1255
    • Lodi, S.1    Meyer, L.2    Kelleher, A.D.3    Rosinska, M.4    Ghosn, J.5    Sannes, M.6    Porter, K.7
  • 20
    • 84866735012 scopus 로고    scopus 로고
    • Continuous versus intermittent treatment strategies during primary HIV-1 infection: The randomized ANRS INTERPRIM trial
    • (doi:10.1097/QAD. 0b013e32835844d9)
    • Goujard C et al. 2012 Continuous versus intermittent treatment strategies during primary HIV-1 infection: the randomized ANRS INTERPRIM trial. AIDS 26, 1895-1905. (doi:10.1097/QAD. 0b013e32835844d9)
    • (2012) AIDS , vol.26 , pp. 1895-1905
    • Goujard, C.1
  • 21
    • 17644385926 scopus 로고    scopus 로고
    • Undetectable viremia without antiretroviral therapy in patients with HIV seroconversion: An uncommon phenomenon?
    • (doi:10.1086/429318)
    • Madec Y, Boufassa F, Rouzioux C, Delfraissy JF, Meyer L. 2005 Undetectable viremia without antiretroviral therapy in patients with HIV seroconversion: an uncommon phenomenon? Clin. Infect. Dis. 40, 1350-1354. (doi:10.1086/429318)
    • (2005) Clin. Infect. Dis. , vol.40 , pp. 1350-1354
    • Madec, Y.1    Boufassa, F.2    Rouzioux, C.3    Delfraissy, J.F.4    Meyer, L.5
  • 22
    • 70049106041 scopus 로고    scopus 로고
    • Spontaneous control of viral replication during primary HIV infection: When is 'HIV controller' status established?
    • (doi:10.1086/605504)
    • Goujard C et al. 2009 Spontaneous control of viral replication during primary HIV infection: when is 'HIV controller' status established? Clin. Infect. Dis. 49, 982-986. (doi:10.1086/605504)
    • (2009) Clin. Infect. Dis. , vol.49 , pp. 982-986
    • Goujard, C.1
  • 23
    • 84861606706 scopus 로고    scopus 로고
    • Immune and viral correlates of 'secondary viral control' after treatment interruption in chronically HIV-1 infected patients
    • (doi:10.1371/journal.pone.0037792)
    • Van Gulck E, Bracke L, Heyndrickx L, Coppens S, Atkinson D, Merlin C, Pasternak A, Florence E, Vanham G. 2012 Immune and viral correlates of 'secondary viral control' after treatment interruption in chronically HIV-1 infected patients. PLoS ONE 7, e37792. (doi:10.1371/journal.pone.0037792)
    • (2012) PLoS ONE , vol.7
    • Van Gulck, E.1    Bracke, L.2    Heyndrickx, L.3    Coppens, S.4    Atkinson, D.5    Merlin, C.6    Pasternak, A.7    Florence, E.8    Vanham, G.9
  • 24
    • 33751515147 scopus 로고    scopus 로고
    • + count-guided interruption of antiretroviral treatment
    • (doi:10.1056/ NEJMoa062360)
    • + count-guided interruption of antiretroviral treatment. N. Engl. J. Med. 355, 2283-2296. (doi:10.1056/ NEJMoa062360)
    • (2006) N. Engl. J. Med. , vol.355 , pp. 2283-2296
    • El-Sadr, W.M.1
  • 25
    • 0027043276 scopus 로고
    • Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene
    • (doi:10.1126/science.1470917)
    • Daniel MD, Kirchhoff F, Czajak SC, Sehgal PK, Desrosiers RC. 1992 Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene. Science 258, 1938-1941. (doi:10.1126/science.1470917)
    • (1992) Science , vol.258 , pp. 1938-1941
    • Daniel, M.D.1    Kirchhoff, F.2    Czajak, S.C.3    Sehgal, P.K.4    Desrosiers, R.C.5
  • 26
    • 33745070227 scopus 로고    scopus 로고
    • Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1
    • (doi:10.1016/j.cell.2006.04.033)
    • Schindler M et al. 2006 Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1. Cell 125, 1055-1067. (doi:10.1016/j.cell.2006.04.033)
    • (2006) Cell , vol.125 , pp. 1055-1067
    • Schindler, M.1
  • 27
    • 17844376742 scopus 로고    scopus 로고
    • + T cells
    • (doi:10. 1038/nature03513)
    • + T cells. Nature 434, 1148-1152. (doi:10. 1038/nature03513)
    • (2005) Nature , vol.434 , pp. 1148-1152
    • Li, Q.1
  • 29
    • 9244220630 scopus 로고    scopus 로고
    • + memory T cells in rapidly progressive simian immunodeficiency virus infection
    • (doi:10. 1084/jem.20041049)
    • + memory T cells in rapidly progressive simian immunodeficiency virus infection. J. Exp. Med. 200, 1299-1314. (doi:10. 1084/jem.20041049)
    • (2004) J. Exp. Med. , vol.200 , pp. 1299-1314
    • Picker, L.J.1
  • 30
    • 18844375363 scopus 로고    scopus 로고
    • HIV swiftly guts the immune system
    • (doi:10. 1038/nm0505-469)
    • Veazey RS, Lackner AA. 2005 HIV swiftly guts the immune system. Nat. Med. 11, 469-470. (doi:10. 1038/nm0505-469)
    • (2005) Nat. Med. , vol.11 , pp. 469-470
    • Veazey, R.S.1    Lackner, A.A.2
  • 31
    • 33845532053 scopus 로고    scopus 로고
    • Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    • (doi:10.1038/ nm1511)
    • Brenchley JM et al. 2006 Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat. Med. 12, 1365-1371. (doi:10.1038/ nm1511)
    • (2006) Nat. Med. , vol.12 , pp. 1365-1371
    • Brenchley, J.M.1
  • 33
    • 84867544493 scopus 로고    scopus 로고
    • SIV infection induces accumulation of plasmacytoid dendritic cells in the gut mucosa
    • (doi:10.1093/infdis/jis408)
    • Reeves RK, Evans TI, Gillis J, Wong FE, Kang G, Li Q, Johnson RP. 2012 SIV infection induces accumulation of plasmacytoid dendritic cells in the gut mucosa. J. Infect. Dis. 206, 1462-1468. (doi:10.1093/infdis/jis408)
    • (2012) J. Infect. Dis. , vol.206 , pp. 1462-1468
    • Reeves, R.K.1    Evans, T.I.2    Gillis, J.3    Wong, F.E.4    Kang, G.5    Li, Q.6    Johnson, R.P.7
  • 34
    • 79251555316 scopus 로고    scopus 로고
    • Blocking of alpha4beta7 guthoming integrin during acute infection leads to decreased plasma and gastrointestinal tissue viral loads in simian immunodeficiency virus-infected rhesus macaques
    • (doi:10.4049/jimmunol.1003052)
    • Ansari AA et al. 2011 Blocking of alpha4beta7 guthoming integrin during acute infection leads to decreased plasma and gastrointestinal tissue viral loads in simian immunodeficiency virus-infected rhesus macaques. J. Immunol. 186, 1044-1059. (doi:10.4049/jimmunol.1003052)
    • (2011) J. Immunol. , vol.186 , pp. 1044-1059
    • Ansari, A.A.1
  • 35
    • 79953815415 scopus 로고    scopus 로고
    • Influence of the MHC genotype on the progression of experimental SIV infection in the Mauritian cynomolgus macaque
    • (doi:10.1007/s00251-010-0504-6)
    • Aarnink A, Dereuddre-Bosquet N, Vaslin B, Le Grand R, Winterton P, Apoil PA, Blancher A. 2011 Influence of the MHC genotype on the progression of experimental SIV infection in the Mauritian cynomolgus macaque. Immunogenetics 63, 267-274. (doi:10.1007/s00251-010-0504-6)
    • (2011) Immunogenetics , vol.63 , pp. 267-274
    • Aarnink, A.1    Dereuddre-Bosquet, N.2    Vaslin, B.3    Le Grand, R.4    Winterton, P.5    Apoil, P.A.6    Blancher, A.7
  • 37
    • 84883435285 scopus 로고    scopus 로고
    • TRIM5 alpha drives SIVsmm evolution in rhesus macaques
    • (doi:10.1371/journal.ppat.1003577)
    • Wu F et al. 2013 TRIM5 alpha drives SIVsmm evolution in rhesus macaques. PLoS Pathog. 9, e1003577. (doi:10.1371/journal.ppat.1003577)
    • (2013) PLoS Pathog. , vol.9
    • Wu, F.1
  • 38
    • 16244408954 scopus 로고    scopus 로고
    • +-T-cell loss in simian immunodeficiency virus SIVagm-infected pigtailed macaques: Variable pathogenicity of natural SIVagm isolates
    • (doi:10.1128/JVI.79.8.5153-5162.2005)
    • +-T-cell loss in simian immunodeficiency virus SIVagm-infected pigtailed macaques: variable pathogenicity of natural SIVagm isolates. J. Virol. 79, 5153-5162. (doi:10.1128/JVI.79.8.5153-5162.2005)
    • (2005) J. Virol. , vol.79 , pp. 5153-5162
    • Goldstein, S.1    Ourmanov, I.2    Brown, C.R.3    Plishka, R.4    Buckler-White, A.5    Byrum, R.6    Hirsch, V.M.7
  • 39
    • 80052314332 scopus 로고    scopus 로고
    • + cell depletion
    • (doi:10. 1371/journal.ppat.1002170)
    • + cell depletion. PLoS Pathog. 7, e1002170. (doi:10. 1371/journal.ppat.1002170)
    • (2011) PLoS Pathog. , vol.7
    • Pandrea, I.1
  • 40
    • 0033861039 scopus 로고    scopus 로고
    • High levels of viral replication during primary simian immunodeficiency virus SIVagm infection are rapidly and strongly controlled in African green monkeys
    • (doi:10.1128/JVI.74.16.7538-7547.2000)
    • Diop OM et al. 2000 High levels of viral replication during primary simian immunodeficiency virus SIVagm infection are rapidly and strongly controlled in African green monkeys. J. Virol. 74, 7538-7547. (doi:10.1128/JVI.74.16.7538-7547.2000)
    • (2000) J. Virol. , vol.74 , pp. 7538-7547
    • Diop, O.M.1
  • 42
    • 50949097030 scopus 로고    scopus 로고
    • Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel
    • (doi:10.1371/ journal.pmed.0050157)
    • Cranage M et al. 2008 Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel. PLoS Med. 5, e157. (doi:10.1371/ journal.pmed.0050157)
    • (2008) PLoS Med. , vol.5
    • Cranage, M.1
  • 43
    • 84866150865 scopus 로고    scopus 로고
    • Nonhuman primate models for HIV cure research
    • (doi:10.1371/journal.ppat.1002892)
    • Apetrei C, Pandrea I, Mellors JW. 2012 Nonhuman primate models for HIV cure research. PLoS Pathog. 8, e1002892. (doi:10.1371/journal.ppat.1002892)
    • (2012) PLoS Pathog. , vol.8
    • Apetrei, C.1    Pandrea, I.2    Mellors, J.W.3
  • 44
    • 84864051807 scopus 로고    scopus 로고
    • A highly intensified ART regimen induces long-term viral suppression and restriction of the viral reservoir in a simian AIDS model
    • (doi:10.1371/journal.ppat.1002774)
    • Shytaj IL. 2012 A highly intensified ART regimen induces long-term viral suppression and restriction of the viral reservoir in a simian AIDS model. PLoS Pathog. 8, e1002774. (doi:10.1371/journal.ppat.1002774)
    • (2012) PLoS Pathog. , vol.8
    • Shytaj, I.L.1
  • 45
    • 68349157582 scopus 로고    scopus 로고
    • Toward an AIDS vaccine: Lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts
    • (doi:10.1038/nm.2013)
    • Sodora DL et al. 2009 Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts. Nat. Med. 15, 861-865. (doi:10.1038/nm.2013)
    • (2009) Nat. Med. , vol.15 , pp. 861-865
    • Sodora, D.L.1
  • 46
    • 59649097925 scopus 로고    scopus 로고
    • African non human primates infected by SIV-why don't they get sick? Lessons from studies on the early phase of nonpathogenic SIV infection
    • (doi:10.2174/157016209787048546)
    • Liovat AS, Jacquelin B, Ploquin MJ, Barre-Sinoussi F, Muller-Trutwin MC. 2009 African non human primates infected by SIV-why don't they get sick? Lessons from studies on the early phase of nonpathogenic SIV infection. Curr. HIV Res. 7, 39-50. (doi:10.2174/157016209787048546)
    • (2009) Curr. HIV Res. , vol.7 , pp. 39-50
    • Liovat, A.S.1    Jacquelin, B.2    Ploquin, M.J.3    Barre-Sinoussi, F.4    Muller-Trutwin, M.C.5
  • 47
    • 20144387661 scopus 로고    scopus 로고
    • Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS
    • (doi:10.1172/ JCI23006)
    • Kornfeld C et al. 2005 Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS. J. Clin. Invest. 115, 1082-1091. (doi:10.1172/ JCI23006)
    • (2005) J. Clin. Invest. , vol.115 , pp. 1082-1091
    • Kornfeld, C.1
  • 48
    • 84887160135 scopus 로고    scopus 로고
    • Immune activation, HIV persistence, and the cure
    • Douek DC. 2013 Immune activation, HIV persistence, and the cure. Top. Antiviral Med. 21, 128-132.
    • (2013) Top. Antiviral Med. , vol.21 , pp. 128-132
    • Douek, D.C.1
  • 49
    • 43149099234 scopus 로고    scopus 로고
    • Increased proportion of KIR3DS1 homozygotes in HIV-exposed uninfected individuals
    • (doi:10.1097/QAD. 0b013e3282f56b23)
    • Boulet S, Sharafi S, Simic N, Bruneau J, Routy JP, Tsoukas CM, Bernard NF. 2008 Increased proportion of KIR3DS1 homozygotes in HIV-exposed uninfected individuals. AIDS 22, 595-599. (doi:10.1097/QAD. 0b013e3282f56b23)
    • (2008) AIDS , vol.22 , pp. 595-599
    • Boulet, S.1    Sharafi, S.2    Simic, N.3    Bruneau, J.4    Routy, J.P.5    Tsoukas, C.M.6    Bernard, N.F.7
  • 50
    • 33750802673 scopus 로고    scopus 로고
    • Cutting edge: Resistance to HIV-1 infection among African female sex workers is associated with inhibitory KIR in the absence of their HLA ligands
    • Jennes W, Verheyden S, Demanet C, Adje-Toure CA, Vuylsteke B, Nkengasong JN, Kestens L. 2006 Cutting edge: resistance to HIV-1 infection among African female sex workers is associated with inhibitory KIR in the absence of their HLA ligands. J. Immunol. 177, 6588-6592.
    • (2006) J. Immunol. , vol.177 , pp. 6588-6592
    • Jennes, W.1    Verheyden, S.2    Demanet, C.3    Adje-Toure, C.A.4    Vuylsteke, B.5    Nkengasong, J.N.6    Kestens, L.7
  • 52
    • 34248368553 scopus 로고    scopus 로고
    • Distinctive NK-cell receptor repertoires sustain high-level constitutive NK-cell activation in HIV-exposed uninfected individuals
    • (doi:10.1182/blood-2006-08-040238)
    • Ravet S et al. 2007 Distinctive NK-cell receptor repertoires sustain high-level constitutive NK-cell activation in HIV-exposed uninfected individuals. Blood 109, 4296-4305. (doi:10.1182/blood-2006-08-040238)
    • (2007) Blood , vol.109 , pp. 4296-4305
    • Ravet, S.1
  • 54
    • 34248140162 scopus 로고    scopus 로고
    • Evolution of innate and adaptive effector cell functions during acute HIV-1 infection
    • (doi:10.1086/513878)
    • Alter G, Teigen N, Ahern R, Streeck H, Meier A, Rosenberg ES, Altfeld M. 2007 Evolution of innate and adaptive effector cell functions during acute HIV-1 infection. J. Infect. Dis. 195, 1452-1460. (doi:10.1086/513878)
    • (2007) J. Infect. Dis. , vol.195 , pp. 1452-1460
    • Alter, G.1    Teigen, N.2    Ahern, R.3    Streeck, H.4    Meier, A.5    Rosenberg, E.S.6    Altfeld, M.7
  • 55
    • 27744464537 scopus 로고    scopus 로고
    • Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection
    • (doi:10.1182/blood-2005-03-1100)
    • Alter G et al. 2005 Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection. Blood 106, 3366-3369. (doi:10.1182/blood-2005-03-1100)
    • (2005) Blood , vol.106 , pp. 3366-3369
    • Alter, G.1
  • 56
    • 84865560190 scopus 로고    scopus 로고
    • Evasion from NK cell-mediated immune responses by HIV-1
    • (doi:10.1016/j.micinf.2012.05.001)
    • Jost S, Altfeld M. 2012 Evasion from NK cell-mediated immune responses by HIV-1. Microbes Infect. 14, 904-915. (doi:10.1016/j.micinf.2012.05.001)
    • (2012) Microbes Infect. , vol.14 , pp. 904-915
    • Jost, S.1    Altfeld, M.2
  • 57
    • 0036699528 scopus 로고    scopus 로고
    • Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS
    • (doi:10.1038/ng934)
    • Martin MP et al. 2002 Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat. Genet. 31, 429-434. (doi:10.1038/ng934)
    • (2002) Nat. Genet. , vol.31 , pp. 429-434
    • Martin, M.P.1
  • 58
    • 34249802335 scopus 로고    scopus 로고
    • Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1
    • (doi:10.1038/ng2035)
    • Martin MP et al. 2007 Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1. Nat. Genet. 39, 733-740. (doi:10.1038/ng2035)
    • (2007) Nat. Genet. , vol.39 , pp. 733-740
    • Martin, M.P.1
  • 60
    • 42949129193 scopus 로고    scopus 로고
    • HLA alleles determine differences in human natural killer cell responsiveness and potency
    • (doi:10.1073/pnas.0712229105)
    • Kim S et al. 2008 HLA alleles determine differences in human natural killer cell responsiveness and potency. Proc. Natl Acad. Sci. USA 105, 3053-3058. (doi:10.1073/pnas.0712229105)
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 3053-3058
    • Kim, S.1
  • 61
    • 77953414590 scopus 로고    scopus 로고
    • Peptide antagonism as a mechanism for NK cell activation
    • (doi:10.1073/pnas. 0913745107)
    • Fadda L et al. 2010 Peptide antagonism as a mechanism for NK cell activation. Proc. Natl Acad. Sci. USA 107, 10 160-10 165. (doi:10.1073/pnas. 0913745107)
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 10160-10165
    • Fadda, L.1
  • 62
    • 33845953843 scopus 로고    scopus 로고
    • Cutting edge: Allelespecific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B
    • Thananchai H et al. 2007 Cutting edge: allelespecific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B. J. Immunol. 178, 33-37.
    • (2007) J. Immunol. , vol.178 , pp. 33-37
    • Thananchai, H.1
  • 63
    • 81555213587 scopus 로고    scopus 로고
    • Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B
    • (doi:10. 1038/nature10517)
    • Vivian JP et al. 2011 Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B. Nature 479, 401-405. (doi:10. 1038/nature10517)
    • (2011) Nature , vol.479 , pp. 401-405
    • Vivian, J.P.1
  • 64
    • 79961138654 scopus 로고    scopus 로고
    • HIV-1 adaptation to NK-cellmediated immune pressure
    • (doi:10.1038/nature10237)
    • Alter G et al. 2011 HIV-1 adaptation to NK-cellmediated immune pressure. Nature 476, 96-100. (doi:10.1038/nature10237)
    • (2011) Nature , vol.476 , pp. 96-100
    • Alter, G.1
  • 65
    • 0034646143 scopus 로고    scopus 로고
    • HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors
    • (doi:10. 1073/pnas.050567397)
    • Migueles SA et al. 2000 HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors. Proc. Natl Acad. Sci. USA 97, 2709-2714. (doi:10. 1073/pnas.050567397)
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 2709-2714
    • Migueles, S.A.1
  • 66
    • 78650084232 scopus 로고    scopus 로고
    • The major genetic determinants of HIV-1 control affect HLA class I peptide presentation
    • (doi:10.1126/science.1195271)
    • Pereyra F et al. 2010 The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science 330, 1551-1557. (doi:10.1126/science.1195271)
    • (2010) Science , vol.330 , pp. 1551-1557
    • Pereyra, F.1
  • 67
    • 34249852256 scopus 로고    scopus 로고
    • HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype
    • (doi:10.1073/pnas. 0611244104)
    • Saez-Cirion A et al. 2007 HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype. Proc. Natl Acad. Sci. USA 104, 6776-6781. (doi:10.1073/pnas. 0611244104)
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 6776-6781
    • Saez-Cirion, A.1
  • 68
    • 0035942184 scopus 로고    scopus 로고
    • Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity
    • (doi:10.1073/pnas. 071548198)
    • Flores-Villanueva PO et al. 2001 Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity. Proc. Natl Acad. Sci. USA 98, 5140-5145. (doi:10.1073/pnas. 071548198)
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 5140-5145
    • Flores-Villanueva, P.O.1
  • 69
    • 84880351147 scopus 로고    scopus 로고
    • Natural killer cells in HIV controller patients express an activated effector phenotype and do not up-regulate NKp44 on IL-2 stimulation
    • (doi:10.1073/pnas.1302090110)
    • Marras F et al. 2013 Natural killer cells in HIV controller patients express an activated effector phenotype and do not up-regulate NKp44 on IL-2 stimulation. Proc. Natl Acad. Sci. USA 110, 11 970-11 975. (doi:10.1073/pnas.1302090110)
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 11970-11975
    • Marras, F.1
  • 70
    • 84866735381 scopus 로고    scopus 로고
    • Impact of protective killer inhibitory receptor/ human leukocyte antigen genotypes on natural killer cell and T-cell function in HIV-1-infected controllers
    • (doi:10.1097/ QAD.0b013e32835861b0)
    • Tomescu C, Duh FM, Hoh R, Viviani A, Harvill K, Martin MP, Carrington M, Deeks SG, Montaner LJ. 2012 Impact of protective killer inhibitory receptor/ human leukocyte antigen genotypes on natural killer cell and T-cell function in HIV-1-infected controllers. AIDS 26, 1869-1878. (doi:10.1097/ QAD.0b013e32835861b0)
    • (2012) AIDS , vol.26 , pp. 1869-1878
    • Tomescu, C.1    Duh, F.M.2    Hoh, R.3    Viviani, A.4    Harvill, K.5    Martin, M.P.6    Carrington, M.7    Deeks, S.G.8    Montaner, L.J.9
  • 71
    • 77950210095 scopus 로고    scopus 로고
    • Specific phenotypic and functional features of natural killer cells from HIV-infected long-term nonprogressors and HIV controllers
    • (doi:10.1097/ QAI.0b013e3181d0c5b4)
    • Vieillard V, Fausther-Bovendo H, Samri A, Debre P. 2010 Specific phenotypic and functional features of natural killer cells from HIV-infected long-term nonprogressors and HIV controllers. J. Acquir. Immune Defic. Syndr. 53, 564-573. (doi:10.1097/ QAI.0b013e3181d0c5b4)
    • (2010) J. Acquir. Immune Defic. Syndr. , vol.53 , pp. 564-573
    • Vieillard, V.1    Fausther-Bovendo, H.2    Samri, A.3    Debre, P.4
  • 72
    • 65349168831 scopus 로고    scopus 로고
    • Role of natural killer cells in a cohort of elite suppressors: Low frequency of the protective KIR3DS1 allele and limited inhibition of human immunodeficiency virus type 1 replication in vitro
    • (doi:10.1128/JVI. 02551-08)
    • O'Connell KA, Han Y, Williams TM, Siliciano RF, Blankson JN. 2009 Role of natural killer cells in a cohort of elite suppressors: low frequency of the protective KIR3DS1 allele and limited inhibition of human immunodeficiency virus type 1 replication in vitro. J. Virol. 83, 5028-5034. (doi:10.1128/JVI. 02551-08)
    • (2009) J. Virol. , vol.83 , pp. 5028-5034
    • O'Connell, K.A.1    Han, Y.2    Williams, T.M.3    Siliciano, R.F.4    Blankson, J.N.5
  • 73
    • 29144467887 scopus 로고    scopus 로고
    • Role for plasmacytoid dendritic cells in anti-HIV innate immunity
    • (doi:10.1111/j.1440-1711.2005.01394.x)
    • Muller-Trutwin M, Hosmalin A. 2005 Role for plasmacytoid dendritic cells in anti-HIV innate immunity. Immunol. Cell Biol. 83, 578-583. (doi:10.1111/j.1440-1711.2005.01394.x)
    • (2005) Immunol. Cell Biol. , vol.83 , pp. 578-583
    • Muller-Trutwin, M.1    Hosmalin, A.2
  • 74
    • 84857374815 scopus 로고    scopus 로고
    • Role of retroviral restriction factors in the interferon-alpha-mediated suppression of HIV-1 in vivo
    • (doi:10.1073/pnas. 1111573109)
    • Pillai SK et al. 2012 Role of retroviral restriction factors in the interferon-alpha-mediated suppression of HIV-1 in vivo. Proc. Natl Acad. Sci. USA 109, 3035-3040. (doi:10.1073/pnas. 1111573109)
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 3035-3040
    • Pillai, S.K.1
  • 75
    • 0024364803 scopus 로고
    • Interferon-alpha but not AZT suppresses HIV expression in chronically infected cell lines
    • (doi:10.1126/science.2470148)
    • Poli G, Orenstein JM, Kinter A, Folks TM, Fauci AS. 1989 Interferon-alpha but not AZT suppresses HIV expression in chronically infected cell lines. Science 244, 575-577. (doi:10.1126/science.2470148)
    • (1989) Science , vol.244 , pp. 575-577
    • Poli, G.1    Orenstein, J.M.2    Kinter, A.3    Folks, T.M.4    Fauci, A.S.5
  • 76
    • 3343012408 scopus 로고    scopus 로고
    • Peginterferon Alfa-2a plus ribavirin for chronic hepatitis C virus infection in HIV-infected patients
    • (doi:10.1056/NEJMoa040842)
    • Torriani FJ et al. 2004 Peginterferon Alfa-2a plus ribavirin for chronic hepatitis C virus infection in HIV-infected patients. N. Engl. J. Med. 351, 438-450. (doi:10.1056/NEJMoa040842)
    • (2004) N. Engl. J. Med. , vol.351 , pp. 438-450
    • Torriani, F.J.1
  • 77
    • 0022573263 scopus 로고
    • Human alpha-and betainterferon but not gamma suppress the in vitro replication of LAV, HTLV-III, and ARV-2
    • (doi:10.1089/jir.1986.6.143)
    • Yamamoto JK, Barre-Sinoussi F, Bolton V, Pedersen NC, Gardner MB. 1986 Human alpha-and betainterferon but not gamma suppress the in vitro replication of LAV, HTLV-III, and ARV-2. J. Interferon Res. 6, 143-152. (doi:10.1089/jir.1986.6.143)
    • (1986) J. Interferon Res. , vol.6 , pp. 143-152
    • Yamamoto, J.K.1    Barre-Sinoussi, F.2    Bolton, V.3    Pedersen, N.C.4    Gardner, M.B.5
  • 78
    • 84855272511 scopus 로고    scopus 로고
    • + cells from individuals with Aicardi-Goutieres syndrome are highly susceptible to HIV-1 infection
    • (doi:10.1371/journal.ppat. 1002425)
    • + cells from individuals with Aicardi-Goutieres syndrome are highly susceptible to HIV-1 infection. PLoS Pathog. 7, e1002425. (doi:10.1371/journal.ppat. 1002425)
    • (2011) PLoS Pathog. , vol.7
    • Berger, A.1
  • 79
    • 62849103646 scopus 로고    scopus 로고
    • Human TRIM gene expression in response to interferons
    • (doi:10.1371/journal.pone.0004894)
    • Carthagena L et al. 2009 Human TRIM gene expression in response to interferons. PLoS ONE 4, e4894. (doi:10.1371/journal.pone.0004894)
    • (2009) PLoS ONE , vol.4
    • Carthagena, L.1
  • 80
    • 84886953102 scopus 로고    scopus 로고
    • Human MX2 is an interferoninduced post-entry inhibitor of HIV-1 infection
    • (doi:10.1038/nature12542)
    • Goujon C et al. 2013 Human MX2 is an interferoninduced post-entry inhibitor of HIV-1 infection. Nature 502, 559-562. (doi:10.1038/nature12542)
    • (2013) Nature , vol.502 , pp. 559-562
    • Goujon, C.1
  • 81
    • 84886949134 scopus 로고    scopus 로고
    • MX2 is an interferon-induced inhibitor of HIV-1 infection
    • (doi:10.1038/nature12653)
    • Kane M et al. 2013 MX2 is an interferon-induced inhibitor of HIV-1 infection. Nature 502, 563-566. (doi:10.1038/nature12653)
    • (2013) Nature , vol.502 , pp. 563-566
    • Kane, M.1
  • 82
    • 44649102135 scopus 로고    scopus 로고
    • Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection
    • (doi:10.1073/ pnas.0802203105)
    • Keele BF et al. 2008 Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection. Proc. Natl Acad. Sci. USA 105, 7552-7557. (doi:10.1073/ pnas.0802203105)
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 7552-7557
    • Keele, B.F.1
  • 83
    • 84888776867 scopus 로고    scopus 로고
    • Relative resistance of HIV-1 founder viruses to control by interferonalpha
    • (doi:10.1186/1742-4690-10-146)
    • Fenton-May AE et al. 2013 Relative resistance of HIV-1 founder viruses to control by interferonalpha. Retrovirology 10, 146. (doi:10.1186/1742-4690-10-146)
    • (2013) Retrovirology , vol.10 , pp. 146
    • Fenton-May, A.E.1
  • 84
    • 84876867850 scopus 로고    scopus 로고
    • Phenotypic properties of transmitted founder HIV-1
    • (doi:10.1073/pnas.1304288110)
    • Parrish NF et al. 2013 Phenotypic properties of transmitted founder HIV-1. Proc. Natl Acad. Sci. USA 110, 6626-6633. (doi:10.1073/pnas.1304288110)
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 6626-6633
    • Parrish, N.F.1
  • 85
    • 77956113383 scopus 로고    scopus 로고
    • Type I interferon modulates the battle of host immune system against viruses
    • (doi:10.1016/ S0065-2164(10)73004-5)
    • Seo YJ, Hahm B. 2010 Type I interferon modulates the battle of host immune system against viruses. Adv. Appl. Microbiol. 73, 83-101. (doi:10.1016/ S0065-2164(10)73004-5)
    • (2010) Adv. Appl. Microbiol. , vol.73 , pp. 83-101
    • Seo, Y.J.1    Hahm, B.2
  • 86
    • 77949409948 scopus 로고    scopus 로고
    • Targeting early infection to prevent HIV-1 mucosal transmission
    • (doi:10.1038/nature08757)
    • Haase AT. 2010 Targeting early infection to prevent HIV-1 mucosal transmission. Nature 464, 217-223. (doi:10.1038/nature08757)
    • (2010) Nature , vol.464 , pp. 217-223
    • Haase, A.T.1
  • 87
    • 77952977625 scopus 로고    scopus 로고
    • Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease
    • (doi:10.1126/scitranslmed.3000632)
    • Favre D et al. 2010 Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease. Sci. Transl. Med. 2, 32ra36. (doi:10.1126/scitranslmed.3000632)
    • (2010) Sci. Transl. Med. , vol.2
    • Favre, D.1
  • 88
    • 33646468496 scopus 로고    scopus 로고
    • Differential expression of IFN-alpha and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients
    • (doi:10.1073/pnas.0600363103)
    • Herbeuval JP et al. 2006 Differential expression of IFN-alpha and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients. Proc. Natl Acad. Sci. USA 103, 7000-7005. (doi:10.1073/pnas.0600363103)
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 7000-7005
    • Herbeuval, J.P.1
  • 89
    • 58149380860 scopus 로고    scopus 로고
    • Primary infection with simian immunodeficiency virus: Plasmacytoid dendritic cell homing to lymph nodes, type I interferon, and immune suppression
    • (doi:10.1182/blood-2008-06-162651)
    • Malleret B et al. 2008 Primary infection with simian immunodeficiency virus: plasmacytoid dendritic cell homing to lymph nodes, type I interferon, and immune suppression. Blood 112, 4598-4608. (doi:10.1182/blood-2008-06-162651)
    • (2008) Blood , vol.112 , pp. 4598-4608
    • Malleret, B.1
  • 90
    • 84864936397 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells (pDCs) from HIV controllers produce interferonalpha and differentiate into functional killer pDCs under HIV activation
    • (doi:10.1093/infdis/jis384)
    • Barblu L, Machmach K, Gras C, Delfraissy JF, Boufassa F, Leal M, Ruiz-Mateos E, Lambotte O, Herbeuval JP. 2012 Plasmacytoid dendritic cells (pDCs) from HIV controllers produce interferonalpha and differentiate into functional killer pDCs under HIV activation. J. Infect. Dis. 206, 790-801. (doi:10.1093/infdis/jis384)
    • (2012) J. Infect. Dis. , vol.206 , pp. 790-801
    • Barblu, L.1    McHmach, K.2    Gras, C.3    Delfraissy, J.F.4    Boufassa, F.5    Leal, M.6    Ruiz-Mateos, E.7    Lambotte, O.8    Herbeuval, J.P.9
  • 91
    • 84861384888 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells reduce HIV production in elite controllers
    • (doi:10.1128/JVI.07114-11)
    • Machmach K et al. 2012 Plasmacytoid dendritic cells reduce HIV production in elite controllers. J. Virol. 86, 4245-4252. (doi:10.1128/JVI.07114-11)
    • (2012) J. Virol. , vol.86 , pp. 4245-4252
    • McHmach, K.1
  • 92
    • 70450193060 scopus 로고    scopus 로고
    • The CDK inhibitor p21Cip1/WAF1 is induced by FcgR activation and restricts the replication of human immunodeficiency virus type 1 and related primate lentiviruses in human macrophages
    • (doi:10.1128/JVI.01395-09)
    • Bergamaschi A, David A, Le Rouzic E, Nisole S, Barre-Sinoussi F, Pancino G. 2009 The CDK inhibitor p21Cip1/WAF1 is induced by FcgR activation and restricts the replication of human immunodeficiency virus type 1 and related primate lentiviruses in human macrophages. J. Virol. 83, 12 253-12 265. (doi:10.1128/JVI.01395-09)
    • (2009) J. Virol. , vol.83 , pp. 12253-12265
    • Bergamaschi, A.1    David, A.2    Le Rouzic, E.3    Nisole, S.4    Barre-Sinoussi, F.5    Pancino, G.6
  • 93
    • 84887279415 scopus 로고    scopus 로고
    • APOBEC3G polymorphism as a selective barrier to cross-species transmission and emergence of pathogenic SIV and AIDS in a primate host
    • (doi:10.1371/journal.ppat.1003641)
    • Krupp A, McCarthy KR, Ooms M, Letko M, Morgan JS, Simon V, Johnson WE. 2013 APOBEC3G polymorphism as a selective barrier to cross-species transmission and emergence of pathogenic SIV and AIDS in a primate host. PLoS Pathog. 9, e1003641. (doi:10.1371/journal.ppat.1003641)
    • (2013) PLoS Pathog. , vol.9
    • Krupp, A.1    McCarthy, K.R.2    Ooms, M.3    Letko, M.4    Morgan, J.S.5    Simon, V.6    Johnson, W.E.7
  • 94
    • 84878956988 scopus 로고    scopus 로고
    • HIV restriction factors and mechanisms of evasion
    • (doi:10.1101/ cshperspect.a006940)
    • Malim MH, Bieniasz PD. 2012 HIV restriction factors and mechanisms of evasion. Cold Spring Harb. Perspect. Med. 2, a006940. (doi:10.1101/ cshperspect.a006940)
    • (2012) Cold Spring Harb. Perspect. Med. , vol.2
    • Malim, M.H.1    Bieniasz, P.D.2
  • 95
  • 97
    • 19944426225 scopus 로고    scopus 로고
    • Exhaustive genotyping of the CEM15 (APOBEC3G) gene and absence of association with AIDS progression in a French cohort
    • (doi:10.1086/426826)
    • Do H et al. 2005 Exhaustive genotyping of the CEM15 (APOBEC3G) gene and absence of association with AIDS progression in a French cohort. J. Infect. Dis. 191, 159-163. (doi:10.1086/426826)
    • (2005) J. Infect. Dis. , vol.191 , pp. 159-163
    • Do, H.1
  • 98
    • 67650675663 scopus 로고    scopus 로고
    • Human TRIM5alpha expression levels and reduced susceptibility to HIV-1 infection
    • (doi:10. 1086/598861)
    • Sewram S, Singh R, Kormuth E, Werner L, Mlisana K, Karim SS, Ndung'u T. 2009 Human TRIM5alpha expression levels and reduced susceptibility to HIV-1 infection. J. Infect. Dis. 199, 1657-1663. (doi:10. 1086/598861)
    • (2009) J. Infect. Dis. , vol.199 , pp. 1657-1663
    • Sewram, S.1    Singh, R.2    Kormuth, E.3    Werner, L.4    Mlisana, K.5    Karim, S.S.6    Ndung'U, T.7
  • 99
    • 77649269022 scopus 로고    scopus 로고
    • + T-cells from HIV-1-infected individuals
    • (doi:10.1371/journal.ppat.1000781)
    • + T-cells from HIV-1-infected individuals. PLoS Pathog. 6, e1000781. (doi:10.1371/journal.ppat.1000781)
    • (2010) PLoS Pathog. , vol.6
    • Rotger, M.1
  • 100
    • 12644274812 scopus 로고    scopus 로고
    • Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposure
    • (doi:10.1038/ nm0496-412)
    • Paxton WA et al. 1996 Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposure. Nat. Med. 2, 412-417. (doi:10.1038/ nm0496-412)
    • (1996) Nat. Med. , vol.2 , pp. 412-417
    • Paxton, W.A.1
  • 101
    • 33751185929 scopus 로고    scopus 로고
    • Persistent resistance to HIV-1 infection in CD4 T cells from exposed uninfected Vietnamese individuals is mediated by entry and post-entry blocks
    • (doi:10.1186/ 1742-4690-3-81)
    • Saez-Cirion A, Versmisse P, Truong LX, Chakrabarti LA, Carpentier W, Barre-Sinoussi F, Scott-Algara D, Pancino G. 2006 Persistent resistance to HIV-1 infection in CD4 T cells from exposed uninfected Vietnamese individuals is mediated by entry and post-entry blocks. Retrovirology 3, 81. (doi:10.1186/ 1742-4690-3-81)
    • (2006) Retrovirology , vol.3 , pp. 81
    • Saez-Cirion, A.1    Versmisse, P.2    Truong, L.X.3    Chakrabarti, L.A.4    Carpentier, W.5    Barre-Sinoussi, F.6    Scott-Algara, D.7    Pancino, G.8
  • 102
    • 79953305839 scopus 로고    scopus 로고
    • + T cells from elite controllers resist HIV-1 infection by selective upregulation of p21
    • (doi:10.1172/JCI44539)
    • + T cells from elite controllers resist HIV-1 infection by selective upregulation of p21. J. Clin. Invest. 121, 1549-1560. (doi:10.1172/JCI44539)
    • (2011) J. Clin. Invest. , vol.121 , pp. 1549-1560
    • Chen, H.1
  • 103
    • 79961008229 scopus 로고    scopus 로고
    • + T cells from HIV controllers
    • (doi:10.1182/ blood-2010-12-327106)
    • + T cells from HIV controllers. Blood 118, 955-964. (doi:10.1182/ blood-2010-12-327106)
    • (2011) Blood , vol.118 , pp. 955-964
    • Saez-Cirion, A.1
  • 104
    • 0028337166 scopus 로고
    • Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
    • Koup RA, Safrit JT, Cao Y, Andrews CA, McLeod G, Borkowsky W, Farthing C, Ho DD. 1994 Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 68, 4650-4655.
    • (1994) J. Virol. , vol.68 , pp. 4650-4655
    • Koup, R.A.1    Safrit, J.T.2    Cao, Y.3    Andrews, C.A.4    McLeod, G.5    Borkowsky, W.6    Farthing, C.7    Ho, D.D.8
  • 105
    • 16944365445 scopus 로고    scopus 로고
    • Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus
    • (doi:10. 1038/nm0297-205)
    • Borrow P et al. 1997 Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus. Nat. Med. 3, 205-211. (doi:10. 1038/nm0297-205)
    • (1997) Nat. Med. , vol.3 , pp. 205-211
    • Borrow, P.1
  • 106
    • 33846101731 scopus 로고    scopus 로고
    • + T-cell responses to different HIV proteins have discordant associations with viral load
    • (doi:10.1038/ nm1520)
    • + T-cell responses to different HIV proteins have discordant associations with viral load. Nat. Med. 13, 46-53. (doi:10.1038/ nm1520)
    • (2007) Nat. Med. , vol.13 , pp. 46-53
    • Kiepiela, P.1
  • 107
    • 0028978720 scopus 로고
    • Gag-specific cytotoxic responses to HIV type 1 are associated with a decreased risk of progression to AIDS-related complex or AIDS
    • (doi:10.1089/ aid.1995.11.903)
    • Riviere Y et al. 1995 Gag-specific cytotoxic responses to HIV type 1 are associated with a decreased risk of progression to AIDS-related complex or AIDS. AIDS Res. Hum. Retroviruses 11, 903-907. (doi:10.1089/ aid.1995.11.903)
    • (1995) AIDS Res. Hum. Retroviruses , vol.11 , pp. 903-907
    • Riviere, Y.1
  • 108
    • 33645240933 scopus 로고    scopus 로고
    • Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1
    • (doi:10.1128/JVI.80.7.3617-3623.2006)
    • Martinez-Picado J et al. 2006 Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1. J. Virol. 80, 3617-3623. (doi:10.1128/JVI.80.7.3617-3623.2006)
    • (2006) J. Virol. , vol.80 , pp. 3617-3623
    • Martinez-Picado, J.1
  • 109
    • 0031985775 scopus 로고    scopus 로고
    • Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaques
    • Matano T, Shibata R, Siemon C, Connors M, Lane HC, Martin MA. 1998 Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaques. J. Virol. 72, 164-169.
    • (1998) J. Virol , vol.72 , pp. 164-169
    • Matano, T.1    Shibata, R.2    Siemon, C.3    Connors, M.4    Lane, H.C.5    Martin, M.A.6
  • 110
    • 67650457719 scopus 로고    scopus 로고
    • + lymphocyte depletion but does not account for accelerated SIV pathogenesis
    • (doi:10.1084/jem.20090356)
    • + lymphocyte depletion but does not account for accelerated SIV pathogenesis. J. Exp. Med. 206, 1575-1588. (doi:10.1084/jem.20090356)
    • (2009) J. Exp. Med. , vol.206 , pp. 1575-1588
    • Okoye, A.1
  • 111
    • 0033559648 scopus 로고    scopus 로고
    • + T cell depletion in simian immunodeficiency virus-infected macaques
    • (doi:10.1084/jem.189.6.991)
    • + T cell depletion in simian immunodeficiency virus-infected macaques. J. Exp. Med. 189, 991-998. (doi:10.1084/jem.189.6.991)
    • (1999) J. Exp. Med. , vol.189 , pp. 991-998
    • Jin, X.1
  • 112
    • 0032986421 scopus 로고    scopus 로고
    • + lymphocytes using a mouse-human chimeric monoclonal antibody
    • (doi:10. 1016/S0002-9440(10)65450-8)
    • + lymphocytes using a mouse-human chimeric monoclonal antibody. Am. J. Pathol. 154, 1923-1932. (doi:10. 1016/S0002-9440(10)65450-8)
    • (1999) Am. J. Pathol. , vol.154 , pp. 1923-1932
    • Schmitz, J.E.1
  • 114
    • 0022967777 scopus 로고
    • + lymphocytes can control HIV infection in vitro by suppressing virus replication
    • (doi:10.1126/science.2431484)
    • + lymphocytes can control HIV infection in vitro by suppressing virus replication. Science 234, 1563-1566. (doi:10.1126/science.2431484)
    • (1986) Science , vol.234 , pp. 1563-1566
    • Walker, C.M.1    Moody, D.J.2    Stites, D.P.3    Levy, J.A.4
  • 115
    • 0028608085 scopus 로고
    • + T cell-mediated protection against an intracellular bacterium by perforin-dependent cytotoxicity
    • (doi:10.1002/eji.1830241223)
    • + T cell-mediated protection against an intracellular bacterium by perforin-dependent cytotoxicity. Eur. J. Immunol. 24, 3068-3072. (doi:10.1002/eji.1830241223)
    • (1994) Eur. J. Immunol. , vol.24 , pp. 3068-3072
    • Kagi, D.1    Ledermann, B.2    Burki, K.3    Hengartner, H.4    Zinkernagel, R.M.5
  • 116
    • 0027937745 scopus 로고
    • Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways
    • (doi:10.1038/370650a0)
    • Lowin B, Hahne M, Mattmann C, Tschopp J. 1994 Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature 370, 650-652. (doi:10.1038/370650a0)
    • (1994) Nature , vol.370 , pp. 650-652
    • Lowin, B.1    Hahne, M.2    Mattmann, C.3    Tschopp, J.4
  • 117
    • 84857059757 scopus 로고    scopus 로고
    • Acquired transcriptional programming in functional and exhausted virus-specific CD8 T cells
    • (doi:10.1097/COH.0b013e328 34ddcf2)
    • Youngblood B, Wherry EJ, Ahmed R. 2012 Acquired transcriptional programming in functional and exhausted virus-specific CD8 T cells. Curr. Opin. HIV AIDS 7, 50-57. (doi:10.1097/COH.0b013e328 34ddcf2)
    • (2012) Curr. Opin. HIV AIDS , vol.7 , pp. 50-57
    • Youngblood, B.1    Wherry, E.J.2    Ahmed, R.3
  • 118
    • 0035282444 scopus 로고    scopus 로고
    • Skewed maturation of memory HIV-specific CD8 T lymphocytes
    • (doi:10.1038/35065118)
    • Champagne P et al. 2001 Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature 410, 106-111. (doi:10.1038/35065118)
    • (2001) Nature , vol.410 , pp. 106-111
    • Champagne, P.1
  • 119
    • 19344370239 scopus 로고    scopus 로고
    • + T-cell differentiation towards senescence in HIV-1 infection
    • (doi:10.1371/journal. pbio.0020020)
    • + T-cell differentiation towards senescence in HIV-1 infection. PLoS Biol. 2, E20. (doi:10.1371/journal. pbio.0020020)
    • (2004) PLoS Biol. , vol.2
    • Papagno, L.1
  • 120
    • 0034661671 scopus 로고    scopus 로고
    • + T cells in HIVinfected progressors and long-term nonprogressors
    • + T cells in HIVinfected progressors and long-term nonprogressors. J. Immunol. 165, 1082-1092.
    • (2000) J. Immunol. , vol.165 , pp. 1082-1092
    • Gea-Banacloche, J.C.1
  • 121
    • 33646686040 scopus 로고    scopus 로고
    • + T cells
    • (doi:10.1182/blood-2005-12-4818)
    • + T cells. Blood 107, 4781-4789. (doi:10.1182/blood-2005-12-4818)
    • (2006) Blood , vol.107 , pp. 4781-4789
    • Betts, M.R.1
  • 122
    • 0036852179 scopus 로고    scopus 로고
    • + T cell proliferation is coupled to perforin expression and is maintained in nonprogressors
    • (doi:10.1038/ni845)
    • + T cell proliferation is coupled to perforin expression and is maintained in nonprogressors. Nat. Immunol. 3, 1061-1068. (doi:10.1038/ni845)
    • (2002) Nat. Immunol. , vol.3 , pp. 1061-1068
    • Migueles, S.A.1
  • 123
    • 55949118498 scopus 로고    scopus 로고
    • Flow cytometric detection of perforin upregulation in human CD8 T cells
    • (doi:10.1002/cyto.a.20596)
    • Hersperger AR, Makedonas G, Betts MR. 2008 Flow cytometric detection of perforin upregulation in human CD8 T cells. Cytometry A 73, 1050-1057. (doi:10.1002/cyto.a.20596)
    • (2008) Cytometry A , vol.73 , pp. 1050-1057
    • Hersperger, A.R.1    Makedonas, G.2    Betts, M.R.3
  • 124
    • 57449109484 scopus 로고    scopus 로고
    • + T cells is required for HIV-infected cell elimination associated with immune control
    • (doi:10.1016/j.immuni. 2008.10.010)
    • + T cells is required for HIV-infected cell elimination associated with immune control. Immunity 29, 1009-1021. (doi:10.1016/j.immuni. 2008.10.010)
    • (2008) Immunity , vol.29 , pp. 1009-1021
    • Migueles, S.A.1
  • 125
    • 67649213034 scopus 로고    scopus 로고
    • Heterogeneity in HIV suppression by CD8 T cells from HIV controllers: Association with Gag-specific CD8 T cell responses
    • (doi:10.4049/ jimmunol.0803928)
    • Saez-Cirion A et al. 2009 Heterogeneity in HIV suppression by CD8 T cells from HIV controllers: association with Gag-specific CD8 T cell responses. J. Immunol. 182, 7828-7837. (doi:10.4049/ jimmunol.0803928)
    • (2009) J. Immunol. , vol.182 , pp. 7828-7837
    • Saez-Cirion, A.1
  • 126
    • 33847388794 scopus 로고    scopus 로고
    • + T lymphocytes recognize infected cells before AIDSvirus integration and viral protein expression
    • + T lymphocytes recognize infected cells before AIDSvirus integration and viral protein expression. J. Immunol. 178, 2746-2754.
    • (2007) J. Immunol. , vol.178 , pp. 2746-2754
    • Sacha, J.B.1
  • 127
    • 84875529857 scopus 로고    scopus 로고
    • CD8 T-cells from most HIVinfected patients lack ex vivo HIV-suppressive capacity during acute and early infection
    • (doi:10.1371/journal.pone.0059767)
    • Lecuroux C et al. 2013 CD8 T-cells from most HIVinfected patients lack ex vivo HIV-suppressive capacity during acute and early infection. PLoS ONE 8, e59767. (doi:10.1371/journal.pone.0059767)
    • (2013) PLoS ONE , vol.8
    • Lecuroux, C.1
  • 128
    • 84868534523 scopus 로고    scopus 로고
    • Profound metabolic, functional, and cytolytic differences characterize HIV-specific CD8 T cells in primary and chronic HIV infection
    • (doi:10.1182/ blood-2012-04-422550)
    • Trautmann L et al. 2012 Profound metabolic, functional, and cytolytic differences characterize HIV-specific CD8 T cells in primary and chronic HIV infection. Blood 120, 3466-3477. (doi:10.1182/ blood-2012-04-422550)
    • (2012) Blood , vol.120 , pp. 3466-3477
    • Trautmann, L.1
  • 129
    • 84875520974 scopus 로고    scopus 로고
    • + T cells
    • (doi:10.1016/j.immuni.2012.11.021)
    • + T cells. Immunity 38, 425-436. (doi:10.1016/j.immuni.2012.11.021)
    • (2013) Immunity , vol.38 , pp. 425-436
    • Ladell, K.1
  • 130
    • 84862621390 scopus 로고    scopus 로고
    • TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection
    • (doi:10. 1038/ni.2342)
    • Chen H et al. 2012 TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection. Nat. Immunol. 13, 691-700. (doi:10. 1038/ni.2342)
    • (2012) Nat. Immunol. , vol.13 , pp. 691-700
    • Chen, H.1
  • 131
    • 80054721608 scopus 로고    scopus 로고
    • Dendritic cell dysfunction during primary HIV-1 infection
    • (doi:10.1093/infdis/jir616)
    • Huang J et al. 2011 Dendritic cell dysfunction during primary HIV-1 infection. J. Infect. Dis. 204, 1557-1562. (doi:10.1093/infdis/jir616)
    • (2011) J. Infect. Dis. , vol.204 , pp. 1557-1562
    • Huang, J.1
  • 132
    • 77956033397 scopus 로고    scopus 로고
    • Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers
    • (doi:10.1128/ JVI.01009-10)
    • Huang J, Burke PS, Cung TD, Pereyra F, Toth I, Walker BD, Borges L, Lichterfeld M, Yu XG. 2010 Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers. J. Virol. 84, 9463-9471. (doi:10.1128/ JVI.01009-10)
    • (2010) J. Virol. , vol.84 , pp. 9463-9471
    • Huang, J.1    Burke, P.S.2    Cung, T.D.3    Pereyra, F.4    Toth, I.5    Walker, B.D.6    Borges, L.7    Lichterfeld, M.8    Yu, X.G.9
  • 133
    • 43949124825 scopus 로고    scopus 로고
    • HLA class Irestricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus control
    • (doi:10.1128/JVI.02176-07)
    • Emu B, Sinclair E, Hatano H, Ferre A, Shacklett B, Martin JN, McCune JM, Deeks SG. 2008 HLA class Irestricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus control. J. Virol. 82, 5398-5407. (doi:10.1128/JVI.02176-07)
    • (2008) J. Virol. , vol.82 , pp. 5398-5407
    • Emu, B.1    Sinclair, E.2    Hatano, H.3    Ferre, A.4    Shacklett, B.5    Martin, J.N.6    McCune, J.M.7    Deeks, S.G.8
  • 134
    • 40049094957 scopus 로고    scopus 로고
    • Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy
    • (doi:10.1086/526786)
    • Pereyra F et al. 2008 Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy. J. Infect. Dis. 197, 563-571. (doi:10.1086/526786)
    • (2008) J. Infect. Dis. , vol.197 , pp. 563-571
    • Pereyra, F.1
  • 135
    • 84864020166 scopus 로고    scopus 로고
    • + T cell responses maintain highly functional, broadly directed central memory responses
    • (doi:10.1128/ JVI.00531-12)
    • + T cell responses maintain highly functional, broadly directed central memory responses. J. Virol. 86, 6959-6969. (doi:10.1128/ JVI.00531-12)
    • (2012) J. Virol. , vol.86 , pp. 6959-6969
    • Ndhlovu, Z.M.1
  • 136
    • 84863337769 scopus 로고    scopus 로고
    • Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation
    • (doi:10.1016/j.immuni. 2012.01.014)
    • Shan L et al. 2012 Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation. Immunity 36, 491-501. (doi:10.1016/j.immuni. 2012.01.014)
    • (2012) Immunity , vol.36 , pp. 491-501
    • Shan, L.1
  • 137
    • 0037007670 scopus 로고    scopus 로고
    • + T cells
    • (doi:10. 1038/417095a)
    • + T cells. Nature 417, 95-98. (doi:10. 1038/417095a)
    • (2002) Nature , vol.417 , pp. 95-98
    • Douek, D.C.1
  • 138
    • 73949119632 scopus 로고    scopus 로고
    • Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1
    • (doi:10.1073/pnas. 0907898106)
    • Benlahrech A et al. 2009 Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1. Proc. Natl Acad. Sci. USA 106, 19 940-19 945. (doi:10.1073/pnas. 0907898106)
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 19940-19945
    • Benlahrech, A.1
  • 139
    • 78650311033 scopus 로고    scopus 로고
    • Comprehensive analysis of virus-specific T-cells provides clues for the failure of therapeutic immunization with ALVAC-HIV vaccine
    • (doi:10.1097/QAD.0b013e328 340fe55)
    • Papagno L et al. 2011 Comprehensive analysis of virus-specific T-cells provides clues for the failure of therapeutic immunization with ALVAC-HIV vaccine. AIDS 25, 27-36. (doi:10.1097/QAD.0b013e328 340fe55)
    • (2011) AIDS , vol.25 , pp. 27-36
    • Papagno, L.1
  • 140
    • 84861173075 scopus 로고    scopus 로고
    • The Thai phase III trial (RV144) vaccine regimen induces T cell responses that preferentially target epitopes within the V2 region of HIV-1 envelope
    • (doi:10.4049/jimmunol.1102756)
    • de Souza MS et al. 2012 The Thai phase III trial (RV144) vaccine regimen induces T cell responses that preferentially target epitopes within the V2 region of HIV-1 envelope. J. Immunol. 188, 5166-5176. (doi:10.4049/jimmunol.1102756)
    • (2012) J. Immunol. , vol.188 , pp. 5166-5176
    • de Souza, M.S.1
  • 141
    • 84898726122 scopus 로고    scopus 로고
    • HIV-1 specific CD4 responses in primary HIV-1 infection predict disease progression in the SPARTAC trial
    • (doi:10. 1097/QAD.0000000000000130)
    • Frater J et al. 2014 HIV-1 specific CD4 responses in primary HIV-1 infection predict disease progression in the SPARTAC trial. AIDS 28, 699-708. (doi:10. 1097/QAD.0000000000000130)
    • (2014) AIDS , vol.28 , pp. 699-708
    • Frater, J.1
  • 143
    • 4644234449 scopus 로고    scopus 로고
    • + T-cells: The holy grail?
    • (doi:10.1111/j.1365-2249.2004.02605.x)
    • + T-cells: the holy grail? Clin. Exp. Immunol. 138, 10-13. (doi:10.1111/j.1365-2249.2004.02605.x)
    • (2004) Clin. Exp. Immunol. , vol.138 , pp. 10-13
    • Appay, V.1
  • 144
    • 84857751302 scopus 로고    scopus 로고
    • HIV-specific cytolytic CD4 T cell responses during acute HIV infection predict disease outcome
    • (doi:10.1126/scitranslmed.3003165)
    • Soghoian DZ et al. 2012 HIV-specific cytolytic CD4 T cell responses during acute HIV infection predict disease outcome. Sci. Transl. Med. 4, 123ra125. (doi:10.1126/scitranslmed.3003165)
    • (2012) Sci. Transl. Med. , vol.4
    • Soghoian, D.Z.1
  • 146
    • 27644489746 scopus 로고    scopus 로고
    • Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment
    • (doi:10.1128/JVI.79.22.14169-14178.2005)
    • Emu B et al. 2005 Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment. J. Virol. 79, 14 169-14 178. (doi:10.1128/JVI.79.22.14169-14178.2005)
    • (2005) J. Virol. , vol.79 , pp. 14169-14178
    • Emu, B.1
  • 147
    • 37049027525 scopus 로고    scopus 로고
    • + T-cell subsets in human immunodeficiency virus controllers: An ANRS EP36 study
    • (doi:10. 1128/JVI.01401-07)
    • + T-cell subsets in human immunodeficiency virus controllers: an ANRS EP36 study. J. Virol. 81, 13 904-13 915. (doi:10. 1128/JVI.01401-07)
    • (2007) J. Virol. , vol.81 , pp. 13904-13915
    • Potter, S.J.1
  • 148
    • 84869050052 scopus 로고    scopus 로고
    • HIV controllers maintain a population of highly efficient Th1 effector cells in contrast to patients treated in the long term
    • (doi:10.1128/JVI. 00056-12)
    • Vingert B et al. 2012 HIV controllers maintain a population of highly efficient Th1 effector cells in contrast to patients treated in the long term. J. Virol. 86, 10 661-10 674. (doi:10.1128/JVI. 00056-12)
    • (2012) J. Virol. , vol.86 , pp. 10661-10674
    • Vingert, B.1
  • 149
    • 34548680261 scopus 로고    scopus 로고
    • + T cells correlates with disease progression and defines a reversible immune dysfunction
    • (doi:10. 1038/ni1515)
    • + T cells correlates with disease progression and defines a reversible immune dysfunction. Nat. Immunol. 8, 1246-1254. (doi:10. 1038/ni1515)
    • (2007) Nat. Immunol. , vol.8 , pp. 1246-1254
    • Kaufmann, D.E.1
  • 150
    • 40449085117 scopus 로고    scopus 로고
    • +) T cells during HIV infection
    • (doi:10.1038/nm1728)
    • +) T cells during HIV infection. Nat. Med. 14, 266-274. (doi:10.1038/nm1728)
    • (2008) Nat. Med. , vol.14 , pp. 266-274
    • van Grevenynghe, J.1
  • 151
    • 77649245149 scopus 로고    scopus 로고
    • + T cells respond to minimal amounts of Gag antigen due to high TCR avidity
    • (doi:10. 1371/journal.ppat.1000780)
    • + T cells respond to minimal amounts of Gag antigen due to high TCR avidity. PLoS Pathog. 6, e1000780. (doi:10. 1371/journal.ppat.1000780)
    • (2010) PLoS Pathog. , vol.6
    • Vingert, B.1
  • 152
    • 77957944425 scopus 로고    scopus 로고
    • + T-cell responses
    • (doi:10.1128/JVI.00980-10)
    • + T-cell responses. J. Virol. 84, 11 020-11 029. (doi:10.1128/JVI.00980-10)
    • (2010) J. Virol. , vol.84 , pp. 11020-11029
    • Ferre, A.L.1
  • 153
  • 154
    • 84875539507 scopus 로고    scopus 로고
    • Simian immunodeficiency virus infects follicular helper CD4 T cells in lymphoid tissues during pathogenic infection of pigtail macaques
    • (doi:10.1128/ JVI.02497-12)
    • Xu Y et al. 2013 Simian immunodeficiency virus infects follicular helper CD4 T cells in lymphoid tissues during pathogenic infection of pigtail macaques. J. Virol. 87, 3760-3773. (doi:10.1128/ JVI.02497-12)
    • (2013) J. Virol. , vol.87 , pp. 3760-3773
    • Xu, Y.1
  • 156
    • 84859415408 scopus 로고    scopus 로고
    • + T cells during simian immunodeficiency virus infection: T/B cell homeostasis, activation, and potential mechanism for viral escape
    • (doi:10.4049/jimmunol.1103138)
    • + T cells during simian immunodeficiency virus infection: T/B cell homeostasis, activation, and potential mechanism for viral escape. J. Immunol. 188, 3247-3256. (doi:10.4049/jimmunol.1103138)
    • (2012) J. Immunol. , vol.188 , pp. 3247-3256
    • Hong, J.J.1    Amancha, P.K.2    Rogers, K.3    Ansari, A.A.4    Villinger, F.5
  • 157
    • 84865997747 scopus 로고    scopus 로고
    • Expansion of HIV-specific T follicular helper cells in chronic HIV infection
    • (doi:10.1172/JCI64314)
    • Lindqvist M et al. 2012 Expansion of HIV-specific T follicular helper cells in chronic HIV infection. J. Clin. Invest. 122, 3271-3280. (doi:10.1172/JCI64314)
    • (2012) J. Clin. Invest. , vol.122 , pp. 3271-3280
    • Lindqvist, M.1
  • 158
    • 84865395104 scopus 로고    scopus 로고
    • CD4 T follicular helper cell dynamics during SIV infection
    • (doi:10.1172/JCI63039)
    • Petrovas C et al. 2012 CD4 T follicular helper cell dynamics during SIV infection. J. Clin. Invest. 122, 3281-3294. (doi:10.1172/JCI63039)
    • (2012) J. Clin. Invest. , vol.122 , pp. 3281-3294
    • Petrovas, C.1
  • 159
    • 84872093577 scopus 로고    scopus 로고
    • The split personality of regulatory T cells in HIV infection
    • (doi:10.1182/blood-2012-07-409755)
    • Chevalier MF, Weiss L. 2012 The split personality of regulatory T cells in HIV infection. Blood 121, 29-37. (doi:10.1182/blood-2012-07-409755)
    • (2012) Blood , vol.121 , pp. 29-37
    • Chevalier, M.F.1    Weiss, L.2
  • 160
    • 33750320502 scopus 로고    scopus 로고
    • + regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART
    • (doi:10.1182/blood-2006-04-016923)
    • + regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART. Blood 108, 3072-3078. (doi:10.1182/blood-2006-04-016923)
    • (2006) Blood , vol.108 , pp. 3072-3078
    • Epple Jr., H.1
  • 161
    • 76949087872 scopus 로고    scopus 로고
    • Th17 cells, HIV and the gut mucosal barrier
    • (doi:10.1097/COH. 0b013e328335eda3)
    • Dandekar S, George MD, Baumler AJ. 2010 Th17 cells, HIV and the gut mucosal barrier. Curr. Opin. HIV AIDS 5, 173-178. (doi:10.1097/COH. 0b013e328335eda3)
    • (2010) Curr. Opin. HIV AIDS , vol.5 , pp. 173-178
    • Dandekar, S.1    George, M.D.2    Baumler, A.J.3
  • 162
    • 84860359331 scopus 로고    scopus 로고
    • Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue
    • (doi:10.1093/infdis/jis236)
    • Angin M et al. 2012 Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue. J. Infect. Dis. 205, 1495-1500. (doi:10.1093/infdis/jis236)
    • (2012) J. Infect. Dis. , vol.205 , pp. 1495-1500
    • Angin, M.1
  • 163
    • 79551649723 scopus 로고    scopus 로고
    • A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers
    • (doi:10.1371/journal.pone. 0015924)
    • Hunt PW et al. 2011 A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers. PLoS ONE 6, e15924. (doi:10.1371/journal.pone. 0015924)
    • (2011) PLoS ONE , vol.6
    • Hunt, P.W.1
  • 165
    • 84860372550 scopus 로고    scopus 로고
    • Early and long-lasting alteration of effector CD45RA-Foxp3high regulatory T-cell homeostasis during HIV infection
    • (doi:10.1093/infdis/jis235)
    • Simonetta F, Lecuroux C, Girault I, Goujard C, Sinet M, Lambotte O, Venet A, Bourgeois C. 2012 Early and long-lasting alteration of effector CD45RA-Foxp3high regulatory T-cell homeostasis during HIV infection. J. Infect. Dis. 205, 1510-1519. (doi:10.1093/infdis/jis235)
    • (2012) J. Infect. Dis. , vol.205 , pp. 1510-1519
    • Simonetta, F.1    Lecuroux, C.2    Girault, I.3    Goujard, C.4    Sinet, M.5    Lambotte, O.6    Venet, A.7    Bourgeois, C.8
  • 167
    • 84860153884 scopus 로고    scopus 로고
    • The antibody response against HIV-1
    • (doi:10.1101/cshperspect.a007039)
    • Overbaugh J, Morris L. 2012 The antibody response against HIV-1. Cold Spring Harb. Perspect. Med. 2, a007039. (doi:10.1101/cshperspect.a007039)
    • (2012) Cold Spring Harb. Perspect. Med. , vol.2
    • Overbaugh, J.1    Morris, L.2
  • 168
    • 67650453747 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 elite neutralizers: Individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm
    • (doi:10.1128/JVI.00110-09)
    • Simek MD et al. 2009 Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm. J. Virol. 83, 7337-7348. (doi:10.1128/JVI.00110-09)
    • (2009) J. Virol. , vol.83 , pp. 7337-7348
    • Simek, M.D.1
  • 169
    • 84887626950 scopus 로고    scopus 로고
    • Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys
    • (doi:10.1038/nature12744)
    • Barouch DH et al. 2013 Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature 503, 224-228. (doi:10.1038/nature12744)
    • (2013) Nature , vol.503 , pp. 224-228
    • Barouch, D.H.1
  • 170
    • 34347206841 scopus 로고    scopus 로고
    • Mucosal immune responses in the genital tract of HIV-1-exposed uninfected women
    • (doi:10.1111/j.1365-2796.2007.01822.x)
    • Hirbod T, Broliden K. 2007 Mucosal immune responses in the genital tract of HIV-1-exposed uninfected women. J. Intern. Med. 262, 44-58. (doi:10.1111/j.1365-2796.2007.01822.x).
    • (2007) J. Intern. Med. , vol.262 , pp. 44-58
    • Hirbod, T.1    Broliden, K.2
  • 171
    • 0032989686 scopus 로고    scopus 로고
    • HIV-1-specific mucosal IgA in a cohort of HIV-1-resistant Kenyan sex workers
    • (doi:10.1097/00002030-199901140-00004)
    • Kaul R et al. 1999 HIV-1-specific mucosal IgA in a cohort of HIV-1-resistant Kenyan sex workers. AIDS 13, 23-29. (doi:10.1097/00002030-199901140-00004)
    • (1999) AIDS , vol.13 , pp. 23-29
    • Kaul, R.1
  • 172
    • 0034766611 scopus 로고    scopus 로고
    • HIV type 1-specific IgG2 antibodies: Markers of helper T cell type 1 response and prognostic marker of long-term nonprogression
    • (doi:10.1089/088922201753197105)
    • Ngo-Giang-Huong N et al. 2001 HIV type 1-specific IgG2 antibodies: markers of helper T cell type 1 response and prognostic marker of long-term nonprogression. AIDS Res. Hum. Retroviruses 17, 1435-1446. (doi:10.1089/088922201753197105)
    • (2001) AIDS Res. Hum. Retroviruses , vol.17 , pp. 1435-1446
    • Ngo-Giang-Huong, N.1
  • 173
    • 84873395169 scopus 로고    scopus 로고
    • Isotype-switched immunoglobulin G antibodies to HIV Gag proteins may provide alternative or additional immune responses to 'protective' human leukocyte antigen-B alleles in HIV controllers
    • (doi:10.1097/QAD.0b013e32835cb720)
    • French MA et al. 2013 Isotype-switched immunoglobulin G antibodies to HIV Gag proteins may provide alternative or additional immune responses to 'protective' human leukocyte antigen-B alleles in HIV controllers. AIDS 27, 519-528. (doi:10.1097/QAD.0b013e32835cb720)
    • (2013) AIDS , vol.27 , pp. 519-528
    • French, M.A.1
  • 174
    • 84896730604 scopus 로고    scopus 로고
    • Divergent antibody subclass and specificity profiles but not protective HLA-B alleles are associated with variable antibody effector function among HIV-1 controllers
    • (doi:10.1128/ JVI.03130-13)
    • Lai JI, Licht AF, Dugast AS, Suscovich T, Choi I, Bailey-Kellogg C, Alter G, Ackerman ME. 2013 Divergent antibody subclass and specificity profiles but not protective HLA-B alleles are associated with variable antibody effector function among HIV-1 controllers. J. Virol. 88, 2799-2809. (doi:10.1128/ JVI.03130-13)
    • (2013) J. Virol. , vol.88 , pp. 2799-2809
    • Lai, J.I.1    Licht, A.F.2    Dugast, A.S.3    Suscovich, T.4    Choi, I.5    Bailey-Kellogg, C.6    Alter, G.7    Ackerman, M.E.8
  • 175
    • 67149120819 scopus 로고    scopus 로고
    • Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllers
    • (doi:10.1097/QAD.0b013e328329f97d)
    • Lambotte O et al. 2009 Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllers. AIDS 23, 897-906. (doi:10.1097/QAD.0b013e328329f97d)
    • (2009) AIDS , vol.23 , pp. 897-906
    • Lambotte, O.1
  • 176
    • 84862798995 scopus 로고    scopus 로고
    • Epistatic interactions between Fc (GM) and FcgR genes and the host control of human immunodeficiency virus replication
    • (doi:10.1016/j.humimm. 2011.12.008)
    • Deepe RN, Kistner-Griffin E, Martin JN, Deeks SG, Pandey JP. 2012 Epistatic interactions between Fc (GM) and FcgR genes and the host control of human immunodeficiency virus replication. Hum. Immunol. 73, 263-266. (doi:10.1016/j.humimm. 2011.12.008)
    • (2012) Hum. Immunol. , vol.73 , pp. 263-266
    • Deepe, R.N.1    Kistner-Griffin, E.2    Martin, J.N.3    Deeks, S.G.4    Pandey, J.P.5
  • 177
    • 69249213610 scopus 로고    scopus 로고
    • Matrix metalloprotease inhibitors restore impaired NK cellmediated antibody-dependent cellular cytotoxicity in human immunodeficiency virus type 1 infection
    • (doi:10.1128/JVI.02666-08)
    • Liu Q, Sun Y, Rihn S, Nolting A, Tsoukas PN, Jost S, Cohen K, Walker B, Alter G. 2009 Matrix metalloprotease inhibitors restore impaired NK cellmediated antibody-dependent cellular cytotoxicity in human immunodeficiency virus type 1 infection. J. Virol. 83, 8705-8712. (doi:10.1128/JVI.02666-08)
    • (2009) J. Virol. , vol.83 , pp. 8705-8712
    • Liu, Q.1    Sun, Y.2    Rihn, S.3    Nolting, A.4    Tsoukas, P.N.5    Jost, S.6    Cohen, K.7    Walker, B.8    Alter, G.9
  • 178
    • 84867902474 scopus 로고    scopus 로고
    • Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family
    • (doi:10.1128/JVI.01023-12)
    • Bonsignori M et al. 2012 Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family. J. Virol. 86, 11 521-11 532. (doi:10.1128/JVI.01023-12)
    • (2012) J. Virol. , vol.86 , pp. 11521-11532
    • Bonsignori, M.1
  • 179
    • 73349094086 scopus 로고    scopus 로고
    • Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand
    • (doi:10.1056/ NEJMoa0908492)
    • Rerks-Ngarm S et al. 2009 Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. N. Engl. J. Med. 361, 2209-2220. (doi:10.1056/ NEJMoa0908492)
    • (2009) N. Engl. J. Med. , vol.361 , pp. 2209-2220
    • Rerks-Ngarm, S.1
  • 180
    • 84885761187 scopus 로고    scopus 로고
    • p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway
    • (doi:10.1073/ pnas.1306719110)
    • Allouch A et al. 2013 p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway. Proc. Natl Acad. Sci. USA 110, E3997-E4006. (doi:10.1073/ pnas.1306719110)
    • (2013) Proc. Natl Acad. Sci. USA , vol.110
    • Allouch, A.1
  • 181
    • 44649140372 scopus 로고    scopus 로고
    • Complement-HIV interactions during all steps of viral pathogenesis
    • (doi:10.1016/j.vaccine.2007.12.003)
    • Stoiber H, Banki Z, Wilflingseder D, Dierich MP. 2008 Complement-HIV interactions during all steps of viral pathogenesis. Vaccine 26, 3046-3054. (doi:10.1016/j.vaccine.2007.12.003)
    • (2008) Vaccine , vol.26 , pp. 3046-3054
    • Stoiber, H.1    Banki, Z.2    Wilflingseder, D.3    Dierich, M.P.4
  • 182
    • 77954082267 scopus 로고    scopus 로고
    • Complement as an endogenous adjuvant for dendritic cell-mediated induction of retrovirus-specific CTLs
    • (doi:10.1371/journal.ppat.1000891)
    • Banki Z et al. 2010 Complement as an endogenous adjuvant for dendritic cell-mediated induction of retrovirus-specific CTLs. PLoS Pathog. 6, e1000891. (doi:10.1371/journal.ppat.1000891)
    • (2010) PLoS Pathog. , vol.6
    • Banki, Z.1
  • 183
    • 84870291347 scopus 로고    scopus 로고
    • Antibodies attenuate the capacity of dendritic cells to stimulate HIVspecific cytotoxic T lymphocytes
    • (doi:10.1016/j.jaci. 2012.08.025)
    • Posch W et al. 2012 Antibodies attenuate the capacity of dendritic cells to stimulate HIVspecific cytotoxic T lymphocytes. J. Allergy Clin. Immunol. 130, 1368-1374. (doi:10.1016/j.jaci. 2012.08.025)
    • (2012) J. Allergy Clin. Immunol. , vol.130 , pp. 1368-1374
    • Posch, W.1
  • 184
    • 84865171842 scopus 로고    scopus 로고
    • Coagulation biomarkers predict disease progression in SIV-infected nonhuman primates
    • (doi:10.1182/ blood-2012-03-414706)
    • Pandrea I et al. 2012 Coagulation biomarkers predict disease progression in SIV-infected nonhuman primates. Blood 120, 1357-1366. (doi:10.1182/ blood-2012-03-414706)
    • (2012) Blood , vol.120 , pp. 1357-1366
    • Pandrea, I.1
  • 185
    • 43949088825 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cell dynamics and alpha interferon production during simian immunodeficiency virus infection with a nonpathogenic outcome
    • (doi:10.1128/JVI.02433-07)
    • Diop OM et al. 2008 Plasmacytoid dendritic cell dynamics and alpha interferon production during simian immunodeficiency virus infection with a nonpathogenic outcome. J. Virol. 82, 5145-5152. (doi:10.1128/JVI.02433-07)
    • (2008) J. Virol. , vol.82 , pp. 5145-5152
    • Diop, O.M.1
  • 186
    • 84887309874 scopus 로고    scopus 로고
    • Kinetics of myeloid dendritic cell trafficking and activation: Impact on progressive, nonprogressive and controlled SIV infections
    • (doi:10.1371/ journal.ppat.1003600)
    • Wijewardana V et al. 2013 Kinetics of myeloid dendritic cell trafficking and activation: impact on progressive, nonprogressive and controlled SIV infections. PLoS Pathog. 9, e1003600. (doi:10.1371/ journal.ppat.1003600)
    • (2013) PLoS Pathog. , vol.9
    • Wijewardana, V.1
  • 187
    • 55049083095 scopus 로고    scopus 로고
    • Sooty mangabeys and rhesus macaques exhibit significant divergent natural killer cell responses during both acute and chronic phases of SIV infection
    • (doi:10.1016/j.cellimm.2008.06.006)
    • Pereira LE, Johnson RP, Ansari AA. 2008 Sooty mangabeys and rhesus macaques exhibit significant divergent natural killer cell responses during both acute and chronic phases of SIV infection. Cell. Immunol. 254, 10-19. (doi:10.1016/j.cellimm.2008.06.006)
    • (2008) Cell. Immunol. , vol.254 , pp. 10-19
    • Pereira, L.E.1    Johnson, R.P.2    Ansari, A.A.3
  • 188
    • 84883365277 scopus 로고    scopus 로고
    • Intact type i interferon production and IRF7 function in sooty mangabeys
    • (doi:10.1371/journal. ppat.1003597)
    • Bosinger SE et al. 2013 Intact type i interferon production and IRF7 function in sooty mangabeys. PLoS Pathog. 9, e1003597. (doi:10.1371/journal. ppat.1003597)
    • (2013) PLoS Pathog. , vol.9
    • Bosinger, S.E.1
  • 189
    • 72849136282 scopus 로고    scopus 로고
    • Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response
    • (doi:10.1172/JCI40093)
    • Jacquelin B et al. 2009 Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response. J. Clin. Invest. 119, 3544-3555. (doi:10.1172/JCI40093)
    • (2009) J. Clin. Invest. , vol.119 , pp. 3544-3555
    • Jacquelin, B.1
  • 191
    • 84860255621 scopus 로고    scopus 로고
    • Immune responses driven by protective human leukocyte antigen alleles from long-term nonprogressors are associated with low HIV reservoir in central memory CD4 T cells
    • (doi:10.1093/cid/cis188)
    • Descours B et al. 2012 Immune responses driven by protective human leukocyte antigen alleles from long-term nonprogressors are associated with low HIV reservoir in central memory CD4 T cells. Clin. Infect. Dis. 54, 1495-1503. (doi:10.1093/cid/cis188)
    • (2012) Clin. Infect. Dis. , vol.54 , pp. 1495-1503
    • Descours, B.1
  • 192
    • 34547752932 scopus 로고    scopus 로고
    • Low immune activation despite high levels of pathogenic human immunodeficiency virus type 1 results in long-term asymptomatic disease
    • (doi:10.1128/JVI.02663-06)
    • Choudhary SK, Vrisekoop N, Jansen CA, Otto SA, Schuitemaker H, Miedema F, Camerini D. 2007 Low immune activation despite high levels of pathogenic human immunodeficiency virus type 1 results in long-term asymptomatic disease. J. Virol. 81, 8838-8842. (doi:10.1128/JVI.02663-06)
    • (2007) J. Virol. , vol.81 , pp. 8838-8842
    • Choudhary, S.K.1    Vrisekoop, N.2    Jansen, C.A.3    Otto, S.A.4    Schuitemaker, H.5    Miedema, F.6    Camerini, D.7
  • 193
    • 39349088126 scopus 로고    scopus 로고
    • + T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy
    • (doi:10.1086/524143)
    • + T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy. J. Infect. Dis. 197, 126-133. (doi:10.1086/524143)
    • (2008) J. Infect. Dis. , vol.197 , pp. 126-133
    • Hunt, P.W.1
  • 194
    • 67651125105 scopus 로고    scopus 로고
    • Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV-associated atherosclerosis
    • (doi:10.1097/QAD. 0b013e32832b514b)
    • Hsue PY, Hunt PW, Schnell A, Kalapus SC, Hoh R, Ganz P, Martin JN, Deeks SG. 2009 Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV-associated atherosclerosis. AIDS 23, 1059-1067. (doi:10.1097/QAD. 0b013e32832b514b)
    • (2009) AIDS , vol.23 , pp. 1059-1067
    • Hsue, P.Y.1    Hunt, P.W.2    Schnell, A.3    Kalapus, S.C.4    Hoh, R.5    Ganz, P.6    Martin, J.N.7    Deeks, S.G.8
  • 195
    • 84870251319 scopus 로고    scopus 로고
    • Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers
    • (doi:10.1097/ QAD.0b013e32835a9950)
    • Pereyra F et al. 2012 Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers. AIDS 26, 2409-2412. (doi:10.1097/ QAD.0b013e32835a9950)
    • (2012) AIDS , vol.26 , pp. 2409-2412
    • Pereyra, F.1
  • 197
    • 84895070040 scopus 로고    scopus 로고
    • + T-cell counts in HIV controller patients
    • (doi:10.1097/QAD.0000000000000174)
    • + T-cell counts in HIV controller patients. AIDS 28, 467-476. (doi:10.1097/QAD.0000000000000174)
    • (2013) AIDS , vol.28 , pp. 467-476
    • Noel, N.1
  • 198
    • 58149382617 scopus 로고    scopus 로고
    • Evidence for persistent lowlevel viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapy
    • (doi:10.1128/JVI.01763-08)
    • Hatano H et al. 2009 Evidence for persistent lowlevel viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapy. J. Virol. 83, 329-335. (doi:10.1128/JVI.01763-08)
    • (2009) J. Virol. , vol.83 , pp. 329-335
    • Hatano, H.1
  • 199
    • 79955420643 scopus 로고    scopus 로고
    • CD4 dynamics over a 15 yearperiod among HIV controllers enrolled in the ANRS French observatory
    • (doi:10. 1371/journal.pone.0018726)
    • Boufassa F et al. 2011 CD4 dynamics over a 15 yearperiod among HIV controllers enrolled in the ANRS French observatory. PLoS ONE 6, e18726. (doi:10. 1371/journal.pone.0018726)
    • (2011) PLoS ONE , vol.6
    • Boufassa, F.1
  • 200
    • 79952408305 scopus 로고    scopus 로고
    • Transcriptional profiling of CD4 T cells identifies distinct subgroups of HIV-1 elite controllers
    • (doi:10. 1128/JVI.01846-10)
    • Vigneault F et al. 2011 Transcriptional profiling of CD4 T cells identifies distinct subgroups of HIV-1 elite controllers. J. Virol. 85, 3015-3019. (doi:10. 1128/JVI.01846-10)
    • (2011) J. Virol. , vol.85 , pp. 3015-3019
    • Vigneault, F.1
  • 201
    • 85020718320 scopus 로고    scopus 로고
    • + T cell responses restrict SIV replication to follicular helper T cells
    • Atlanta, GA, USA, 3-6 November 2013
    • + T cell responses restrict SIV replication to follicular helper T cells. In 31st Annual Symp. on Nonhuman Primate Models for AIDS. Atlanta, GA, USA, 3-6 November 2013.
    • (2013) 31st Annual Symp. on Nonhuman Primate Models for AIDS
    • Fukazawa, Y.1
  • 203
    • 58149177783 scopus 로고    scopus 로고
    • + T cell depletion
    • + T cell depletion. J. Immunol. 181, 6687-6691.
    • (2008) J. Immunol. , vol.181 , pp. 6687-6691
    • Pandrea, I.1
  • 204
    • 84897965706 scopus 로고    scopus 로고
    • HIV cure research: Advances and prospects
    • In press, (doi:10. 1016/j.virol.2014.02.021)
    • Passaes CP, Saez-Cirion A. In press. HIV cure research: advances and prospects. Virology. (doi:10. 1016/j.virol.2014.02.021)
    • Virology
    • Passaes, C.P.1    Saez-Cirion, A.2
  • 206
    • 0035853422 scopus 로고    scopus 로고
    • Proviral HIV-1 DNA in subjects followed since primary HIV-1 infection who suppress plasma viral load after one year of highly active antiretroviral therapy
    • (doi:10.1097/00002030-200104130-00001)
    • Ngo-Giang-Huong N et al. 2001 Proviral HIV-1 DNA in subjects followed since primary HIV-1 infection who suppress plasma viral load after one year of highly active antiretroviral therapy. AIDS 15, 665-673. (doi:10.1097/00002030-200104130-00001)
    • (2001) AIDS , vol.15 , pp. 665-673
    • Ngo-Giang-Huong, N.1
  • 207
    • 0037169213 scopus 로고    scopus 로고
    • Homogeneous quasispecies in 16 out of 17 individuals during very early HIV-1 primary infection
    • (doi:10.1097/ 00002030-200201250-00007)
    • Delwart E, Magierowska M, Royz M, Foley B, Peddada L, Smith R, Heldebrant C, Conrad A, Busch M. 2002 Homogeneous quasispecies in 16 out of 17 individuals during very early HIV-1 primary infection. AIDS 16, 189-195. (doi:10.1097/ 00002030-200201250-00007)
    • (2002) AIDS , vol.16 , pp. 189-195
    • Delwart, E.1    Magierowska, M.2    Royz, M.3    Foley, B.4    Peddada, L.5    Smith, R.6    Heldebrant, C.7    Conrad, A.8    Busch, M.9
  • 208
    • 78650440267 scopus 로고    scopus 로고
    • B cells in early and chronic HIV infection: Evidence for preservation of immune function associated with early initiation of antiretroviral therapy
    • (doi:10.1182/blood-2010-05-285528)
    • Moir S et al. 2010 B cells in early and chronic HIV infection: evidence for preservation of immune function associated with early initiation of antiretroviral therapy. Blood 116, 5571-5579. (doi:10.1182/blood-2010-05-285528)
    • (2010) Blood , vol.116 , pp. 5571-5579
    • Moir, S.1
  • 209
    • 59649116097 scopus 로고    scopus 로고
    • IL-2, IL-7 and IL-15 as immuno-modulators during SIV/HIV vaccination and treatment
    • (doi:10.2174/157016209787048519)
    • Leone A, Picker LJ, Sodora DL. 2009 IL-2, IL-7 and IL-15 as immuno-modulators during SIV/HIV vaccination and treatment. Curr. HIV Res. 7, 83-90. (doi:10.2174/157016209787048519)
    • (2009) Curr. HIV Res. , vol.7 , pp. 83-90
    • Leone, A.1    Picker, L.J.2    Sodora, D.L.3
  • 210
    • 65249105408 scopus 로고    scopus 로고
    • Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment
    • (doi:10.1172/JCI38052)
    • Levy Y et al. 2009 Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment. J. Clin. Invest. 119, 997-1007. (doi:10.1172/JCI38052)
    • (2009) J. Clin. Invest. , vol.119 , pp. 997-1007
    • Levy, Y.1
  • 211
    • 84864125153 scopus 로고    scopus 로고
    • Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: Results of a phase I/IIa randomized, placebo-controlled, multicenter study
    • (doi:10.1093/cid/cis383)
    • Levy Y et al. 2012 Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: results of a phase I/IIa randomized, placebo-controlled, multicenter study. Clin. Infect. Dis. 55, 291-300. (doi:10.1093/cid/cis383)
    • (2012) Clin. Infect. Dis. , vol.55 , pp. 291-300
    • Levy, Y.1
  • 212
    • 84879302206 scopus 로고    scopus 로고
    • Interleukin-7 promotes HIV persistence during antiretroviral therapy
    • (doi:10.1182/blood-2012-11-465625)
    • Vandergeeten C et al. 2013 Interleukin-7 promotes HIV persistence during antiretroviral therapy. Blood 121, 4321-4329. (doi:10.1182/blood-2012-11-465625)
    • (2013) Blood , vol.121 , pp. 4321-4329
    • Vandergeeten, C.1
  • 213
    • 77951889263 scopus 로고    scopus 로고
    • Safety, tolerability, and mechanisms of antiretroviral activity of pegylated interferon Alfa-2a in HIV-1-monoinfected participants: A phase II clinical trial
    • (doi:10.1086/652420)
    • Asmuth DM et al. 2010 Safety, tolerability, and mechanisms of antiretroviral activity of pegylated interferon Alfa-2a in HIV-1-monoinfected participants: a phase II clinical trial. J. Infect. Dis. 201, 1686-1696. (doi:10.1086/652420)
    • (2010) J. Infect. Dis. , vol.201 , pp. 1686-1696
    • Asmuth, D.M.1
  • 214
    • 84871797372 scopus 로고    scopus 로고
    • Pegylated Interferon alfa-2a monotherapy results in suppression of HIV type 1 replication and decreased cell-associated HIV DNA integration
    • (doi:10. 1093/infdis/jis663)
    • Azzoni L et al. 2013 Pegylated Interferon alfa-2a monotherapy results in suppression of HIV type 1 replication and decreased cell-associated HIV DNA integration. J. Infect. Dis. 207, 213-222. (doi:10. 1093/infdis/jis663)
    • (2013) J. Infect. Dis. , vol.207 , pp. 213-222
    • Azzoni, L.1
  • 215
    • 78650307734 scopus 로고    scopus 로고
    • Alpha interferon administration during structured interruptions of combination antiretroviral therapy in patients with chronic HIV-1 infection: INTERVAC ANRS 105 trial
    • (doi:10.1097/ QAD.0b013e328340a1e7)
    • Boue F, Reynes J, Rouzioux C, Emilie D, Souala F, Tubiana R, Goujard C, Lancar R, Costagliola D. 2011 Alpha interferon administration during structured interruptions of combination antiretroviral therapy in patients with chronic HIV-1 infection: INTERVAC ANRS 105 trial. AIDS 25, 115-118. (doi:10.1097/ QAD.0b013e328340a1e7)
    • (2011) AIDS , vol.25 , pp. 115-118
    • Boue, F.1    Reynes, J.2    Rouzioux, C.3    Emilie, D.4    Souala, F.5    Tubiana, R.6    Goujard, C.7    Lancar, R.8    Costagliola, D.9
  • 216
    • 84858986741 scopus 로고    scopus 로고
    • Role of PD-1 in HIV pathogenesis and as target for therapy
    • (doi:10.1007/s11904-011-0106-4)
    • Porichis F, Kaufmann DE. 2012 Role of PD-1 in HIV pathogenesis and as target for therapy. Curr. HIV/ AIDS Rep. 9, 81-90. (doi:10.1007/s11904-011-0106-4)
    • (2012) Curr. HIV/ AIDS Rep. , vol.9 , pp. 81-90
    • Porichis, F.1    Kaufmann, D.E.2
  • 217
    • 62249172189 scopus 로고    scopus 로고
    • Enhancing SIV-specific immunity in vivo by PD-1 blockade
    • (doi:10.1038/nature07662)
    • Velu V et al. 2009 Enhancing SIV-specific immunity in vivo by PD-1 blockade. Nature 458, 206-210. (doi:10.1038/nature07662)
    • (2009) Nature , vol.458 , pp. 206-210
    • Velu, V.1
  • 218
    • 85020692119 scopus 로고    scopus 로고
    • PD-1 blockade as an adjunct therapy for ART: Improves anti-SIV immunity, virologic response to ART and gut CD4 T cell restoration
    • Atlanta, GA, USA, 3-6 November 2013
    • Velu V, Mylvaganam G, Freeman G, Ahmed R, Amara R. 2013 PD-1 blockade as an adjunct therapy for ART: improves anti-SIV immunity, virologic response to ART and gut CD4 T cell restoration. In 31st Annual Symp. on Nonhuman Primate Models for AIDS, Atlanta, GA, USA, 3-6 November 2013.
    • (2013) 31st Annual Symp. on Nonhuman Primate Models for AIDS
    • Velu, V.1    Mylvaganam, G.2    Freeman, G.3    Ahmed, R.4    Amara, R.5
  • 219
    • 68349139711 scopus 로고    scopus 로고
    • HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
    • (doi:10.1038/nm.1972)
    • Chomont N et al. 2009 HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nat. Med. 15, 893-900. (doi:10.1038/nm.1972)
    • (2009) Nat. Med. , vol.15 , pp. 893-900
    • Chomont, N.1
  • 220
    • 84860584561 scopus 로고    scopus 로고
    • PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques
    • (doi:10.1172/JCI60612)
    • Dyavar Shetty R, Velu V, Titanji K, Bosinger SE, Freeman GJ, Silvestri G, Amara RR. 2012 PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques. J. Clin. Invest. 122, 1712-1716. (doi:10.1172/JCI60612)
    • (2012) J. Clin. Invest. , vol.122 , pp. 1712-1716
    • Dyavar Shetty, R.1    Velu, V.2    Titanji, K.3    Bosinger, S.E.4    Freeman, G.J.5    Silvestri, G.6    Amara, R.R.7
  • 221
    • 84876420618 scopus 로고    scopus 로고
    • Immune activation and HIV persistence: Considerations for novel therapeutic interventions
    • (doi:10.1097/COH.0b013e32835f9788)
    • Hatano H. 2013 Immune activation and HIV persistence: considerations for novel therapeutic interventions. Curr. Opin. HIV AIDS 8, 211-216. (doi:10.1097/COH.0b013e32835f9788)
    • (2013) Curr. Opin. HIV AIDS , vol.8 , pp. 211-216
    • Hatano, H.1
  • 222
    • 0030663246 scopus 로고    scopus 로고
    • Comparison of hydroxychloroquine with zidovudine in asymptomatic patients infected with human immunodeficiency virus type 1
    • (doi:10.1016/S0149-2918(97)80045-8)
    • Sperber K, Chiang G, Chen H, Ross W, Chusid E, Gonchar M, Chow R, Liriano O. 1997 Comparison of hydroxychloroquine with zidovudine in asymptomatic patients infected with human immunodeficiency virus type 1. Clin. Ther. 19, 913-923. (doi:10.1016/S0149-2918(97)80045-8)
    • (1997) Clin. Ther. , vol.19 , pp. 913-923
    • Sperber, K.1    Chiang, G.2    Chen, H.3    Ross, W.4    Chusid, E.5    Gonchar, M.6    Chow, R.7    Liriano, O.8
  • 223
    • 0029121276 scopus 로고
    • Hydroxychloroquine treatment of patients with human immunodeficiency virus type 1
    • (doi:10.1016/ 0149-2918(95)80039-5)
    • Sperber K, Louie M, Kraus T, Proner J, Sapira E, Lin S, Stecher V, Mayer L. 1995 Hydroxychloroquine treatment of patients with human immunodeficiency virus type 1. Clin. Ther. 17, 622-636. (doi:10.1016/ 0149-2918(95)80039-5)
    • (1995) Clin. Ther. , vol.17 , pp. 622-636
    • Sperber, K.1    Louie, M.2    Kraus, T.3    Proner, J.4    Sapira, E.5    Lin, S.6    Stecher, V.7    Mayer, L.8
  • 224
    • 75749126515 scopus 로고    scopus 로고
    • Chloroquine modulates HIV-1-induced plasmacytoid dendritic cell alpha interferon: Implication for T-cell activation
    • (doi:10.1128/AAC.01246-09)
    • Martinson JA, Montoya CJ, Usuga X, Ronquillo R, Landay AL, Desai SN. 2010 Chloroquine modulates HIV-1-induced plasmacytoid dendritic cell alpha interferon: implication for T-cell activation. Antimicrob. Agents Chemother. 54, 871-881. (doi:10.1128/AAC.01246-09)
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 871-881
    • Martinson, J.A.1    Montoya, C.J.2    Usuga, X.3    Ronquillo, R.4    Landay, A.L.5    Desai, S.N.6
  • 226
    • 84864149976 scopus 로고    scopus 로고
    • Effects of hydroxychloroquine on immune activation and disease progression among HIV-infected patients not receiving antiretroviral therapy: A randomized controlled trial
    • (doi:10.1001/jama.2012.6936)
    • Paton NI et al. 2012 Effects of hydroxychloroquine on immune activation and disease progression among HIV-infected patients not receiving antiretroviral therapy: a randomized controlled trial. JAMA 308, 353-361. (doi:10.1001/jama.2012.6936)
    • (2012) JAMA , vol.308 , pp. 353-361
    • Paton, N.I.1
  • 228
    • 84877252239 scopus 로고    scopus 로고
    • Effect of statin therapy in reducing the risk of serious non-AIDS-defining events and nonaccidental death
    • (doi:10.1093/cid/cit053)
    • Overton ET, Kitch D, Benson CA, Hunt PW, Stein JH, Smurzynski M, Ribaudo HJ, Tebas P. 2013 Effect of statin therapy in reducing the risk of serious non-AIDS-defining events and nonaccidental death. Clin. Infect. Dis 56, 1471-1479. (doi:10.1093/cid/cit053)
    • (2013) Clin. Infect. Dis , vol.56 , pp. 1471-1479
    • Overton, E.T.1    Kitch, D.2    Benson, C.A.3    Hunt, P.W.4    Stein, J.H.5    Smurzynski, M.6    Ribaudo, H.J.7    Tebas, P.8
  • 229
    • 84874739728 scopus 로고    scopus 로고
    • Statin therapy and mortality in HIV-infected individuals; a Danish nationwide population-based cohort study
    • (doi:10.1371/journal.pone.0052828)
    • Rasmussen LD, Kronborg G, Larsen CS, Pedersen C, Gerstoft J, Obel N. 2013 Statin therapy and mortality in HIV-infected individuals; a Danish nationwide population-based cohort study. PLoS ONE 8, e52828. (doi:10.1371/journal.pone.0052828)
    • (2013) PLoS ONE , vol.8
    • Rasmussen, L.D.1    Kronborg, G.2    Larsen, C.S.3    Pedersen, C.4    Gerstoft, J.5    Obel, N.6
  • 230
    • 84922462830 scopus 로고    scopus 로고
    • Statin use is associated with incident diabetes mellitus among patients in the HIV outpatient study
    • Atlanta, GA, USA, 3-6 March 2013. Abstract no. 767
    • Lichtenstein K et al. 2013 Statin use is associated with incident diabetes mellitus among patients in the HIV outpatient study. In 20th CROI, Atlanta, GA, USA, 3-6 March 2013. Abstract no. 767.
    • (2013) 20th CROI
    • Lichtenstein, K.1
  • 231
    • 84897416431 scopus 로고    scopus 로고
    • In vivo administration of a JAK3 inhibitor during acute SIV infection leads to significant increases in viral load during chronic infection
    • (doi:10.1371/ journal.ppat.1003929)
    • Takahashi Y et al. 2014 In vivo administration of a JAK3 inhibitor during acute SIV infection leads to significant increases in viral load during chronic infection. PLoS Pathog. 10, e1003929. (doi:10.1371/ journal.ppat.1003929)
    • (2014) PLoS Pathog. , vol.10
    • Takahashi, Y.1
  • 233
    • 84859250847 scopus 로고    scopus 로고
    • Impact of multitargeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection
    • (doi:10.1371/ journal.pone.0033948)
    • Ananworanich J et al. 2012 Impact of multitargeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection. PLoS ONE 7, e33948. (doi:10.1371/ journal.pone.0033948)
    • (2012) PLoS ONE , vol.7
    • Ananworanich, J.1
  • 234
    • 79955918570 scopus 로고    scopus 로고
    • Cross-sectional detection of acute HIV infection: Timing of transmission, inflammation and antiretroviral therapy
    • (doi:10.1371/journal.pone.0019617)
    • Gay C et al. 2011 Cross-sectional detection of acute HIV infection: timing of transmission, inflammation and antiretroviral therapy. PLoS ONE 6, e19617. (doi:10.1371/journal.pone.0019617)
    • (2011) PLoS ONE , vol.6
    • Gay, C.1
  • 235
    • 79954988179 scopus 로고    scopus 로고
    • Single and multiple dose pharmacokinetics of maraviroc in saliva, semen, and rectal tissue of healthy HIV-negative men
    • (doi:10.1093/infdis/jir059)
    • Brown KC et al. 2011 Single and multiple dose pharmacokinetics of maraviroc in saliva, semen, and rectal tissue of healthy HIV-negative men. J. Infect. Dis. 203, 1484-1490. (doi:10.1093/infdis/jir059)
    • (2011) J. Infect. Dis. , vol.203 , pp. 1484-1490
    • Brown, K.C.1
  • 236
    • 84894046809 scopus 로고    scopus 로고
    • Intensification of a raltegravir-based regimen with maraviroc in early HIV-1 infection
    • (doi:10.1097/ QAD.0000000000000066)
    • Puertas MC et al. 2013 Intensification of a raltegravir-based regimen with maraviroc in early HIV-1 infection. AIDS 28, 325-334. (doi:10.1097/ QAD.0000000000000066)
    • (2013) AIDS , vol.28 , pp. 325-334
    • Puertas, M.C.1
  • 237
    • 84887375924 scopus 로고    scopus 로고
    • Response: Maraviroc intensification and microbial translocation
    • (doi:10.1182/blood-2013-08-516930)
    • Hunt PW, Lederman MM, Deeks SG. 2013 Response: maraviroc intensification and microbial translocation. Blood 122, 2283-2284. (doi:10.1182/blood-2013-08-516930)
    • (2013) Blood , vol.122 , pp. 2283-2284
    • Hunt, P.W.1    Lederman, M.M.2    Deeks, S.G.3
  • 238
    • 84887375643 scopus 로고    scopus 로고
    • Maraviroc-induced decrease in circulating bacterial products is not linked to an increase in immune activation in HIV-infected individuals
    • (doi:10.1182/ blood-2013-06-507012)
    • Psomas C et al. 2013 Maraviroc-induced decrease in circulating bacterial products is not linked to an increase in immune activation in HIV-infected individuals. Blood 122, 2282-2283. (doi:10.1182/ blood-2013-06-507012)
    • (2013) Blood , vol.122 , pp. 2282-2283
    • Psomas, C.1
  • 239
    • 84887290531 scopus 로고    scopus 로고
    • Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers
    • (doi:10.1371/ journal.ppat.1003691)
    • Hatano H et al. 2013 Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers. PLoS Pathog. 9, e1003691. (doi:10.1371/ journal.ppat.1003691)
    • (2013) PLoS Pathog. , vol.9
    • Hatano, H.1
  • 240
    • 84872037286 scopus 로고    scopus 로고
    • A dendritic cell-based vaccine elicits T cell responses associated with control of HIV-1 replication
    • (doi:10.1126/scitranslmed.3004682)
    • Garcia F et al. 2013 A dendritic cell-based vaccine elicits T cell responses associated with control of HIV-1 replication. Sci. Transl. Med. 5, 166ra162. (doi:10.1126/scitranslmed.3004682)
    • (2013) Sci. Transl. Med. , vol.5
    • Garcia, F.1
  • 242
    • 84878552360 scopus 로고    scopus 로고
    • + T cells in mice
    • (doi:10.1172/JCI64704)
    • + T cells in mice. J. Clin. Invest. 123, 2629-2642. (doi:10.1172/JCI64704)
    • (2013) J. Clin. Invest. , vol.123 , pp. 2629-2642
    • Zhou, J.1
  • 243
    • 79957618772 scopus 로고    scopus 로고
    • Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine
    • (doi:10.1038/nature10003)
    • Hansen SG et al. 2011 Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine. Nature 473, 523-527. (doi:10.1038/nature10003)
    • (2011) Nature , vol.473 , pp. 523-527
    • Hansen, S.G.1
  • 244
    • 84877957880 scopus 로고    scopus 로고
    • + T cell epitope recognition paradigms
    • (doi:10.1126/science.1237874)
    • + T cell epitope recognition paradigms. Science 340, 1237874. (doi:10.1126/science.1237874)
    • (2013) Science , vol.340 , pp. 1237874
    • Hansen, S.G.1
  • 245
    • 20944446452 scopus 로고    scopus 로고
    • Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies
    • (doi:10.1038/nm1244)
    • Trkola A et al. 2005 Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies. Nat. Med. 11, 615-622. (doi:10.1038/nm1244)
    • (2005) Nat. Med. , vol.11 , pp. 615-622
    • Trkola, A.1
  • 246
    • 84869155712 scopus 로고    scopus 로고
    • Evolution of an HIV glycandependent broadly neutralizing antibody epitope through immune escape
    • (doi:10.1038/nm.2985)
    • Moore PL et al. 2012 Evolution of an HIV glycandependent broadly neutralizing antibody epitope through immune escape. Nat. Med. 18, 1688-1692. (doi:10.1038/nm.2985)
    • (2012) Nat. Med. , vol.18 , pp. 1688-1692
    • Moore, P.L.1
  • 247
    • 84866495323 scopus 로고    scopus 로고
    • Human antibodies that neutralize HIV-1: Identification, structures, and B cell ontogenies
    • (doi:10. 1016/j.immuni.2012.08.012)
    • Kwong PD, Mascola JR. 2012 Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies. Immunity 37, 412-425. (doi:10. 1016/j.immuni.2012.08.012)
    • (2012) Immunity , vol.37 , pp. 412-425
    • Kwong, P.D.1    Mascola, J.R.2
  • 248
    • 84876797103 scopus 로고    scopus 로고
    • Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
    • (doi:10.1038/nature 12053)
    • Liao HX et al. 2013 Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. Nature 496, 469-476. (doi:10.1038/nature 12053)
    • (2013) Nature , vol.496 , pp. 469-476
    • Liao, H.X.1
  • 249
    • 84877609579 scopus 로고    scopus 로고
    • Rational HIV immunogen design to target specific germline B cell receptors
    • (doi:10.1126/science.1234150)
    • Jardine J et al. 2013 Rational HIV immunogen design to target specific germline B cell receptors. Science 340, 711-716. (doi:10.1126/science.1234150)
    • (2013) Science , vol.340 , pp. 711-716
    • Jardine, J.1
  • 250
    • 84878626061 scopus 로고    scopus 로고
    • Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies
    • (doi:10. 1084/jem.20122824)
    • McGuire AT et al. 2013 Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies. J. Exp. Med. 210, 655-663. (doi:10. 1084/jem.20122824)
    • (2013) J. Exp. Med. , vol.210 , pp. 655-663
    • McGuire, A.T.1
  • 251
    • 84886778874 scopus 로고    scopus 로고
    • Protective efficacy of a global HIV-1 mosaic vaccine against heterologous SHIV challenges in rhesus monkeys
    • (doi:10.1016/j.cell.2013.09.061)
    • Barouch DH et al. 2013 Protective efficacy of a global HIV-1 mosaic vaccine against heterologous SHIV challenges in rhesus monkeys. Cell 155, 531-539. (doi:10.1016/j.cell.2013.09.061)
    • (2013) Cell , vol.155 , pp. 531-539
    • Barouch, D.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.