Role for plasmacytoid dendritic cells in anti-HIV innate immunity

Immunology and Cell Biology

Volumn 83, Issue 5, 2005, Pages 578-585

  Müller Trutwin, Michaela ^a   Hosmalin, Anne ^b  

^a INSTITUT PASTEUR   (France)

^b INSTITUT COCHIN   (France)

Author keywords

Adaptive immunity; HIV; Innate immunity; Interferon; Plasmacytoid dendritic cell

Indexed keywords

ALPHA1 INTERFERON; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; OLIGODEOXYNUCLEOTIDE DERIVATIVE;

CYTOKINE PRODUCTION; DENDRITIC CELL; DISEASE COURSE; DRUG MECHANISM; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGICAL TOLERANCE; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; NONHUMAN; PROTEIN FUNCTION; REVIEW; T LYMPHOCYTE; VIRUS LOAD; VIRUS REPLICATION;

ANIMALS; DENDRITIC CELLS; HIV INFECTIONS; HIV-1; HUMANS; IMMUNITY, NATURAL;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 29144467887     PISSN: 08189641     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1711.2005.01394.x     Document Type: Review

References (108)

1. Shortman K, Heath WR. Immunity or tolerance? That is the question for dendritic cells. Nat. Immunol 2001; 2: 988-9. CrossRef MEDLINE ISI Abstract CSA Abstract
2. Colonna M, Trinchieri G, Liu YJ. Plasmacytoid dendritic cells in immunity. Nat. Immunol. 2004; 5: 1219-26. CrossRef MEDLINE ISI Abstract
3. Siegal F, Kadowaki N, Shodell M et al. The nature of the principal type 1 interferon-producing cells in human blood. Science 1999; 284: 1835-7. CrossRef MEDLINE ISI Abstract CSA Abstract
4. Grouard G, Rissoan M-C, Filgueira L, Durand I, Banchereau J, Liu Y-J. The enigmatic plasmacytoid T cells develop into dendritic cells with Interleukin 3 and CD40-ligand. J. Exp. Med 1997; 185: 1101-111. CrossRef MEDLINE ISI Abstract CSA Abstract
5. Rissoan MC, Soumelis V, Kadowaki N et al. Reciprocal control of T helper cell and dendritic cell differentiation. Science 1999; 283: 1183-6. CrossRef MEDLINE ISI Abstract CSA Abstract
6. Cella M, Jarrossay D, Facchetti F et al. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat. Med. 1999; 5: 919-24. CrossRef MEDLINE ISI Abstract CSA Abstract
7. Dzionek A, Sohma Y, Nagafune J et al. BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction. J. Exp. Med. 2001; 194: 1823-34. CrossRef MEDLINE ISI Abstract CSA Abstract
8. Steinman RM, Granelli-Piperno A, Pope M et al. The interaction of immunodeficiency viruses with dendritic cells. Curr. Top. Microbiol. Immunol 2003; 276: 1-30. MEDLINE ISI Abstract CSA Abstract
9. Patterson S, Robinson SP, English NR, Knight SC. Subpopulations of peripheral blood dendritic cells show differential susceptibility to infection with a lymphotropic strain of HIV-1. Immunol. Lett. 1999; 66: 111-116. CrossRef MEDLINE ISI Abstract CSA Abstract
10. Patterson S, Rae A, Hockey N, Gilmour J, Gotch F. Plasmacytoid dendritic cells are highly susceptible to human immunodeficiency virus type 1 infection and release infectious virus. J. Virol. 2001; 75: 6710-713. CrossRef MEDLINE ISI Abstract CSA Abstract
11. Turville SG, Cameron PU, Handley A et al. Diversity of receptors binding HIV on dendritic cell subsets. Nat. Immunol. 2002; 3: 975-83. CrossRef MEDLINE ISI Abstract CSA Abstract
12. Fong L, Mengozzi M, Abbey NW, Herndier BG, Engleman EG. Productive infection of plasmacytoid dendritic cells with human immunodeficiency virus type 1 is triggered by CD40 ligation. J. Virol. 2002; 76: 11 033-41. CrossRef
13. Schmidt B, Scott I, Whitmore RG et al. Low-level HIV infection of plasmacytoid dendritic cells: onset of cytopathic effects and cell death after PDC maturation. Virology 2004; 329: 280-88. MEDLINE ISI Abstract
14. Yonezawa A, Morita R, Takaori-Kondo A et al. Natural alpha interferon-producing cells respond to human immunodeficiency virus type 1 with alpha interferon production and maturation into dendritic cells. J. Virol. 2003; 77: 3777-84. CrossRef MEDLINE ISI Abstract CSA Abstract
15. Smed-Sorensen A, Lore K, Vasudevan J et al. Differential susceptibility to human immunodeficiency virus type 1 infection of myeloid and plasmacytoid dendritic cells. J. Virol 2005; 79: 8861-9. CrossRef MEDLINE ISI Abstract
16. Donaghy H, Gazzard B, Gotch F, Patterson S. Dysfunction and infection of freshly isolated blood myeloid and plasmacytoid dendritic cells in patients infected with HIV-1. Blood 2003; 101: 4505-511. CrossRef MEDLINE ISI Abstract
17. Keir ME, Stoddart CA, Linquist-Stepps V, Moreno ME, McCune JM. IFN-alpha secretion by type 2 predendritic cells up-regulates MHC class I in the HIV-1-infected thymus. J. Immunol. 2002; 168: 325-31. MEDLINE ISI Abstract CSA Abstract
18. Lore K, Smed-Sorensen A, Vasudevan J, Mascola JR, Koup RA. Myeloid and plasmacytoid dendritic cells transfer HIV-1 preferentially to antigen-specific CD4+ T cells. J. Exp. Med. 2005; 201: 2023-33. CrossRef MEDLINE ISI Abstract
19. Cameron PU, Freudenthal PS, Barker JM, Gezelter S, Inaba K, Steinman RM. Dendritic cells exposed to human immunodeficiency virus type 1 transmit a vigorous cytopathic infection to CD4+ T cells. Science 1992; 257: 383-7. MEDLINE ISI Abstract CSA Abstract
20. Fonteneau JF, Larsson M, Beignon AS et al. Human immunodeficiency virus type 1 activates plasmacytoid dendritic cells and concomitantly induces the bystander maturation of myeloid dendritic cells. J. Virol. 2004; 78: 5223-32. CrossRef MEDLINE ISI Abstract CSA Abstract
21. Granelli-Piperno A, Golebiowska A, Trumpfheller C, Siegal FP, Steinman RM. HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation. Proc. Natl Acad. Sci. USA 2004; 101: 7669-74. CrossRef MEDLINE ISI Abstract CSA Abstract
22. Santini SM, Lapenta C, Logozzi M et al. Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice. J. Exp. Med. 2000; 191: 1777-88. CrossRef MEDLINE ISI Abstract CSA Abstract
23. Carbonneil C, Aouba A, Burgard M et al. Dendritic cells generated in the presence of granulocyte-macrophage colony-stimulating factor and IFN-alpha are potent inducers of HIV-specific CD8 T cells. AIDS 2003; 17: 1731-40. CrossRef MEDLINE ISI Abstract CSA Abstract
24. Khatissian E, Tovey MC, Cumont MC et al. The relationship between the interferon alpha response and viral burden in primary SIV infection. AIDS Res. Hum. Retroviruses 1996; 12: 1273-8. MEDLINE ISI Abstract CSA Abstract
25. Kamga I, Develioglu L, Lichtner M et al. Type I interferon production is profoundly impaired in primary HIV-1 infection. J. Infect. Dis. 2005; 192: 303-310 CrossRef MEDLINE ISI Abstract
26. Grassi FR, Hosmalin A, McIlroy D, Calvez V, Debrè P, Autran B. CD11c-positive dendritic cells are depleted in the blood of HIV-infected patients. AIDS 1999; 13: 759-66. [CrossRef MEDLINE ISI Abstract CSA Abstract
27. Servet C, Zitvogel L, Hosmalin A. Dendritic cells in innate immune responses against HIV. Curr. Mol. Med. 2002; 2: 739-56. CrossRef MEDLINE CSA Abstract
28. Soumelis V, Scott I, Gheyas F et al. Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients. Blood 2001; 98: 906-912. CrossRef MEDLINE ISI Abstract
29. Donaghy H, Pozniak A, Gazzard B et al. Loss of blood CD11c(+) myeloid and CD11c(-) plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load. Blood 2001; 98: 2574-6. CrossRef MEDLINE ISI Abstract
30. Chehimi J, Campbell DE, Azzoni L et al. Persistent decreases in blood plasmacytoid dendritic cell number and function despite effective highly active antiretroviral therapy and increased blood myeloid dendritic cells in HIV-infected individuals. J. Immunol 2002; 168: 4796-801. MEDLINE ISI Abstract CSA Abstract
31. Barron MA, Blyveis N, Palmer BE, MaWhinney S, Wilson CC. Influence of plasma viremia on defects in number and immunophenotype of blood dendritic cell subsets in human immunodeficiency virus 1-infected individuals. J. Infect. Dis. 2003; 187: 26-37. CrossRef MEDLINE ISI Abstract CSA Abstract
32. Anthony DD, Yonkers NL, Post AB et al. Selective impairments in dendritic cell-associated function distinguish hepatitis C virus and HIV infection. J. Immunol 2004; 172: 4907-916. MEDLINE ISI Abstract CSA Abstract
33. Finke JS, Shodell M, Shah K, Siegal FP, Steinman RM. Dendritic cell numbers in the blood of HIV-1 infected patients before and after changes in antiretroviral therapy. J. Clin. Immunol. 2004; 24: 647-52. CrossRef MEDLINE ISI Abstract
34. Azzoni L, Rutstein RM, Chehimi J, Farabaugh MA, Nowmos A, Montaner LJ. Dendritic and natural killer cell subsets associated with stable or declining CD4+ cell counts in treated HIV-1-infected children. J. Infect. Dis. 2005; 191: 1451-9. CrossRef MEDLINE ISI Abstract
35. Pacanowski J, Kahi S, Baillet M et al. Reduced blood CD123+ and CD11c+ dendritic cell numbers in primary HIV-1 infection. Blood 2001; 9: 3016-21. CrossRef MEDLINE
36. Pacanowski J, Develioglu L, Kamga I et al. Early plasmacytoid dendritic cell changes predict plasma HIV rebound in primary infection. J. Infect. Dis. 2004; 190: 1889-92.
37. Thiebot H, Louache F, Vaslin B et al. Early and persistent bone marrow hematopoiesis defect in simian/human immunodeficiency virus-infected macaques despite efficient reduction of viremia by highly active antiretroviral therapy during primary infection. J. Virol. 2001; 75: 11 594-602. CrossRef MEDLINE CSA Abstract
38. Thiebot H, Vaslin B, Derdouch S et al. Impact of bone marrow hematopoiesis failure on T-cell generation during pathogenic simian immunodeficiency virus infection in macaques. Blood 2005; 105: 2403-409. CrossRef MEDLINE ISI Abstract
39. Feldman S, Stein D, Amrute S et al. Decreased interferon-alpha production in HIV-infected patients correlates with numerical and functional deficiencies in circulating type 2 dendritic cell precursors. Clin. Immunol. 2001; 101: 201-210. CrossRef MEDLINE ISI Abstract CSA Abstract
40. Foussat A, Bouchet-Delbos L, Berrebi D et al. Deregulation of the expression of the fractalkine/fractalkine receptor complex in HIV-1-infected patients. Blood 2001; 98: 1678-86. CrossRef MEDLINE ISI Abstract
41. Lore K, Sonnerborg A, Brostrom C et al. Accumulation of DC-SIGN+CD40 + dendritic cells with reduced CD80 and CD86 expression in lymphoid tissue during acute HIV-1 infection. AIDS 2002; 16: 683-92. CrossRef MEDLINE ISI Abstract CSA Abstract
42. Zimmer MI, Larregina AT, Castillo CM et al. Disrupted homeostasis of Langerhans cells and interdigitating dendritic cells in monkeys with AIDS. Blood 2002; 99: 2859-68. CrossRef MEDLINE ISI Abstract
43. McIlroy D, Autran B, Clauvel J-P, Oksenhendler E, Debrè P, Hosmalin A. Low CD83, but normal MHC class II and costimulatory molecule expression, on spleen dendritic cells from HIV+ patients. AIDS Res. Hum. Retroviruses 1998; 14: 505-513. MEDLINE ISI Abstract CSA Abstract
44. Lopez C, Fitzgerald PA, Siegal FP. Severe acquired immune deficiency syndrome in male homosexuals: diminished capacity to make interferon-alpha in vitro associated with severe opportunistic infections. J. Infect. Dis. 1983; 148: 962-6. MEDLINE ISI Abstract CSA Abstract
45. Siegal FP, Lopez C, Fitzgerald PA et al. Opportunistic infections in acquired immune deficiency syndrome result from synergistic defects of both the natural and adaptive components of cellular immunity. J. Clin. Invest. 1986; 78: 115-23. MEDLINE ISI Abstract
46. Howell DM, Feldman SB, Kloser P, Fitzgerald-Bocarsly P. Decreased frequency of functional natural interferon-producing cells in peripheral blood of patients with the acquired immune deficiency syndrome. Clin. Immunol. Immunopathol. 1994; 71: 223-30. CrossRef MEDLINE CSA Abstract
47. Ferbas JJ, Toso JF, Logar AJ, Navratil JS, Rinaldo CR. CD4+ blood dendritic cells are potent producers of IFN-α in response to in vitro HIV infection. J. Immunol. 1994; 152: 4649-62. MEDLINE ISI Abstract CSA Abstract
48. Ferbas J, Navratil J, Logar A, Rinaldo C. Selective decrease in HIV-1-induced alpha interferon production by peripheral blood mononuclear cells during HIV-1 infection. Clin. Diagn. Lab. Immunol. 1995; 2: 138-42. MEDLINE ISI Abstract CSA Abstract
49. Feldman SB, Milone MC, Kloser P, Fitzgerald-Bocarsly P. Functional deficiencies in two distinct interferon alpha-producing cell populations in peripheral blood mononuclear cells from human immunodeficiency virus seropositive patients. J. Leukoc. Biol. 1995; 57: 214-220. MEDLINE ISI Abstract CSA Abstract
50. Smith DE, Walker BD, Cooper DA, Rosenberg ES, Kaldor JM. Is antiretroviral treatment of primary HIV infection clinically justified on the basis of current evidence? AIDS 2004; 18: 709-718. CrossRef MEDLINE ISI Abstract CSA Abstract
51. Lacabaratz-Porret C, Urrutia A, Doisne JM et al. Impact of antiretroviral therapy and changes in virus load on human immunodeficiency virus (HIV)-specific T cell responses in primary HIV infection. J. Infect. Dis. 2003; 187: 748-57. CrossRef MEDLINE ISI Abstract CSA Abstract
52. Shearer GM, Clerici M. Cytokine profiles in HIV type 1 disease and protection. AIDS Res. Hum. Retroviruses 1998; 14: S149-52. MEDLINE ISI Abstract
53. Letvin NL, Walker BD. Immunopathogenesis and immunotherapy in AIDS virus infections. Nat. Med. 2003; 9: 861-6. CrossRef MEDLINE ISI Abstract CSA Abstract
54. Pantaleo G, Koup RA. Correlates of immune protection in HIV-1 infection: what we know, what we don't know, what we should know. Nat. Med. 2004; 10: 806-810. CrossRef MEDLINE ISI Abstract CSA Abstract
55. Siegal FP, Fitzgerald-Bocarsly P, Holland BK, Shodell M. Interferon-alpha generation and immune reconstitution during antiretroviral therapy for human immunodeficiency virus infection. AIDS 2001; 15: 1603-612. CrossRef MEDLINE ISI Abstract CSA Abstract
56. Poli G, Orenstein JM, Kinter A, Folks TM, Fauci AS. Interferon-alpha but not AZT suppresses HIV expression in chronically infected cell lines. Science 1989; 244: 575-7. MEDLINE ISI Abstract CSA Abstract
57. Bednarik DP, Mosca JD, Raj NB, Pitha PM. Inhibition of human immunodeficiency virus (HIV) replication by HIV-trans-activated alpha 2-interferon. Proc Natl Acad. Sci. USA 1989; 86: 4958-62. MEDLINE ISI Abstract CSA Abstract
58. Gendelman HE, Baca LM, Turpin J et al. Regulation of HIV replication in infected monocytes by IFN-alpha. Mechanisms for viral restriction. J. Immunol. 1990; 145: 2669-76. MEDLINE ISI Abstract CSA Abstract
59. Shirazi Y, Pitha PM. Alpha Interferon inhibits early stages of the human immunodeficiency virus type 1 replication cycle. J. Virol. 1992; 66: 1321-8. MEDLINE ISI Abstract CSA Abstract
60. Sanhadji K, Leissner P, Firouzi R et al. Experimental gene therapy: the transfer of Tat-inducible interferon genes protects human cells against HIV-1 challenge in vitro and in vivo in severe combined immunodeficient mice. AIDS 1997; 11: 977-86. CrossRef MEDLINE ISI Abstract CSA Abstract
61. Lapenta C, Santini SM, Proietti E et al. Type I interferon is a powerful inhibitor of in vivo HIV-1 infection and preserves human CD4(+) T cells from virus-induced depletion in SCID mice transplanted with human cells. Virology 1999; 263: 78-88. CrossRef MEDLINE ISI Abstract CSA Abstract
62. Vieillard V, Jouveshomme S, Leflour N et al. Transfer of human CD4 (+) T lymphocytes producing beta interferon in Hu-PBL-SCID mice controls human immunodeficiency virus infection. J. Virol. 1999; 73: 10 281-8.
63. Tough DF. Type I interferon as a link between innate and adaptive immunity through dendritic cell stimulation. Leuk. Lymphoma 2004; 45: 257-64. CrossRef MEDLINE ISI Abstract CSA Abstract
64. Cella M, Facchetti F, Lanzavecchia A, Colonna M. Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization. Nat. Immunol. 2000; 1: 305-310. CrossRef MEDLINE ISI Abstract CSA Abstract
65. Kadowaki N, Antonenko S, Lau J, Liu Y. Natural interferon a/b-producing cells link innate and adaptive immunity. J. Exp. Med. 2000; 192: 219-25. CrossRef MEDLINE ISI Abstract CSA Abstract
66. Biron CA. Interferons alpha and beta as immune regulators - a new look. Immunity 2001; 14: 661-4. CrossRef MEDLINE ISI Abstract CSA Abstract
67. Lum JJ, Pilon AA, Sanchez-Dardon J et al. Induction of cell death in HIV-infected macrophages and resting memory CD4 T cells by TRAIL-Apo2L. J. Virol. 2001; 75: 11 128-36. CrossRef MEDLINE CSA Abstract
68. Lichtner M, Maranon C, Vidalain PO et al. HIV-1 infected dendritic cells induce apoptotic death in infected and uninfected primary CD4+ T lymphocytes. AIDS Res. Hum. Retroviruses 2004; 20: 175-82. CrossRef MEDLINE ISI Abstract CSA Abstract
69. Herbeuval JP, Boasso A, Grivel JC et al. TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected patients and its in vitro production by antigen-presenting cells. Blood 2005; 105: 2458-64. CrossRef MEDLINE ISI Abstract
70. Miura Y, Misawa N, Maeda N et al. Critical contribution of TNF-related apoptosis-inducing ligand (TRAIL) to apoptosis of human CD4+ T cells in HIV-1 infected hu-PBL-NOD-SCID mice. J. Exp. Med. 2001; 193: 651-9. CrossRef MEDLINE ISI Abstract CSA Abstract
71. Estaquier J, Idziorek T, De Bels F et al. Programmed cell death and AIDS: significance of T-cell apoptosis in pathogenic and nonpathogenic primate lentiviral infections. Proc. Natl Acad. Sci. USA 1994; 91: 9431-5. MEDLINE ISI Abstract CSA Abstract
72. Le Bon A, Etchart N, Rossmann C et al. Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon. Nat. Immunol. 2003; 4: 1009-1015. CrossRef MEDLINE ISI Abstract CSA Abstract
73. Lizee G, Basha G, Tiong J et al. Control of dendritic cell cross-presentation by the major histocompatibility complex class I cytoplasmic domain. Nat. Immunol. 2003; 4: 1065-73. CrossRef MEDLINE ISI Abstract
74. Marañón C, Desoutter JF, Hoeffel G, Cohen W, Hanau D, Hosmalin A. Dendritic cells cross-present HIV antigens from live as well as apoptotic infected CD4+ T lymphocytes. Proc. Natl Acad. Sci. USA 2004; 101: 6092-7. CrossRef MEDLINE ISI Abstract CSA Abstract
75. Schwartz O, Marechal V, Le Gall S, Lemonnier F, Heard JM. Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein. Nat. Med. 1996; 2: 338-42. CrossRef MEDLINE ISI Abstract CSA Abstract
76. Andrieu M, Chassin D, Desoutter JF et al. HIV-1 Nef protein induces a down-regulation of the dendritic cell surface expression of MHC class I and impairs antigen presentation to CTL. AIDS Res. Hum. Retroviruses 2001; 17: 1365-70. CrossRef MEDLINE ISI Abstract CSA Abstract
77. Thiebaut R, Pellegrin I, Chene G et al. Immunological markers after long-term treatment interruption in chronically HIV-1 infected patients with CD4 cell count above 400 x 1 0(6) cells/1. AIDS 2005;19: 53-61. MEDLINE ISI Abstract
78. Tebas P, Henry K, Mondy K et al. Effect of prolonged discontinuation of successful antiretroviral therapy on CD4+ T cell decline in human immunodeficiency virus-infected patients: implications for intermittent therapeutic strategies. J. Infect. Dis. 2002; 186: 851-4. CrossRef MEDLINE ISI Abstract CSA Abstract
79. Lafeuillade A, Poggi C, Hittinger G, Counillon E, Emilie D. Predictors of plasma human immunodeficiency virus type 1 RNA control after discontinuation of highly active antiretroviral therapy initiated at acute infection combined with structured treatment interruptions and immune-based therapies. J. Infect. Dis. 2003; 188: 1426-32. CrossRef MEDLINE ISI Abstract CSA Abstract
80. Maggiolo F, Ripamonti D, Gregis G, Quinzan G, Callegaro A, Suter F. Effect of prolonged discontinuation of successful antiretroviral therapy on CD4 T cells: a controlled, prospective trial. AIDS 2004; 18: 439-46. CrossRef MEDLINE ISI Abstract CSA Abstract
81. Kanto T, Inoue M, Miyatake H et al. Reduced numbers and impaired ability of myeloid and plasmacytoid dendritic cells to polarize T helper cells in chronic hepatitis C virus infection. J. Infect. Dis. 2004; 190: 1919-26. CrossRef MEDLINE ISI Abstract
82. Longman RS, Talal AH, Jacobson IM, Rice CM, Albert ML. Normal functional capacity in circulating myeloid and plasmacytoid dendritic cells in patients with chronic hepatitis C. J. Infect. Dis. 2005; 192: 497-503. CrossRef MEDLINE ISI Abstract
83. Pichyangkul S, Endy TP, Kalayanarooj S et al. A blunted blood plasmacytoid dendritic cell response to an acute systemic viral infection is associated with increased disease severity. J. Immunol. 2003; 171: 5571-8. MEDLINE ISI Abstract CSA Abstract
84. Weiss L, Donkova-Petrini V, Caccavelli L, Balbo M, Carbonneil C, Levy Y. Human immunodeficiency virus-driven expansion of CD4+CD25+ regulatory T cells which suppress HIV-specific CD4 T-cell responses in HIV-infected patients. Blood 2004; 104: 3249-56. CrossRef MEDLINE ISI Abstract
85. Carbonneil C, Donkova-Petrini V, Aouba A, Weiss L. Defective dendritic cell function in HIV-infected patients receiving effective highly active antiretroviral therapy: neutralization of IL-10 production and depletion of CD4+CD25+ T cells restore high levels of HIV-specific CD4+ T cell responses induced by dendritic cells generated in the presence of IFN-alpha. J. Immunol. 2004; 172: 7832-40. MEDLINE ISI Abstract CSA Abstract
86. Kinter AL, Hennessey M, Bell A et al. CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status. J. Exp. Med. 2004; 200: 331-43. CrossRef MEDLINE ISI Abstract CSA Abstract
87. Andersson J, Boasso A, Nilsson J et al. The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients. J. Immunol. 2005; 174: 3143-7. MEDLINE ISI Abstract
88. Gilliet M, Liu YJ. Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells. J. Exp. Med. 2002; 195: 695-704. CrossRef MEDLINE ISI Abstract CSA Abstract
89. Moseman EA, Liang X, Dawson AJ et al. Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4 +CD25+ regulatory T cells. J. Immunol. 2004; 173: 4433-42. MEDLINE ISI Abstract
90. Steinman RM, Hawiger D, Nussenzweig MC. Tolerogenic dendritic cells. Annu. Rev. Immunol. 2003; 21: 685-711. CrossRef MEDLINE ISI Abstract CSA Abstract
91. Giorgi JV, Hultin LE, McKeating IA et al. Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J. Infect. Dis. 1999; 179: 859-70. CrossRef MEDLINE ISI Abstract CSA Abstract
92. + T-cell changes independent of viral load. Blood 2004; 104: 942-7. CrossRef MEDLINE ISI Abstract
93. Almeida M, Cordero M, Almeida J, Orfao A. Different subsets of peripheral blood dendritic cells show distinct phenotypic and functional abnormalities in HIV-1 infection. AIDS 2005; 19: 261-71. MEDLINE ISI Abstract
94. Kornfeld C, Ploquin MJ, Pandrea I et al. Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS. J. Clin. Invest. 2005; 115: 1082-91. CrossRef MEDLINE ISI Abstract
95. Emilie D, Burgard M, Lascoux-Combe C et al. Early control of HIV replication in primary HIV-1 infection treated with antiretroviral drugs and pegylated IFN alpha: results from the Primoferon A (ANRS 086) Study. AIDS 2001; 15: 1435-7. CrossRef MEDLINE ISI Abstract CSA Abstract
96. Wille-Reece U, Wu CY, Flynn BJ, Kedl RM, Seder RA. Immunization with HIV-1 Gag protein conjugated to a TLR7/8 agonist results in the generation of HIV-1 Gag-specific Th1 and CD8+ T cell responses. J. Immunol. 2005; 174:7676-83. MEDLINE ISI Abstract
97. Jiang JQ, Patrick A, Moss RB, Rosenthal KL. CD8+ T-cell-mediated cross-clade protection in the genital tract following intranasal immunization with inactivated human immunodeficiency virus antigen plus CpG oligodeoxynucleotides. J. Virol. 2005; 79: 393-400. CrossRef MEDLINE ISI Abstract
98. Gurney KB, Colantonio AD, Blom B, Spits H, Uittenbogaart CH. Endogenous IFN-alpha production by plasmacytoid dendritic cells exerts an antiviral effect on thymic HIV-1 infection. J. Immunol. 2004; 173: 7269-76. MEDLINE ISI Abstract
99. Ashkar AA, Yao XD, Gill N, Sajic D, Patrick AJ, Rosenthal KL. Toll-like receptor (TLR)-3, but not TLR4, agonist protects against genital herpes infection in the absence of inflammation seen with CpG DNA. J. Infect. Dis. 2004; 190: 1841-9. CrossRef MEDLINE ISI Abstract
100. Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 2004; 303: 1529-31. CrossRef MEDLINE ISI Abstract CSA Abstract
101. Levy JA. The importance of the innate immune system in controlling HIV infection and disease. Trends Immunol. 2001; 22: 312-316. CrossRef MEDLINE ISI Abstract CSA Abstract
102. Chougnet C, Shearer GM, Landay AL. The role of antigen-presenting cells in HIV pathogenesis. Curr. Infect. Dis. Rep. 2002; 4: 266-71. MEDLINE
103. Kavanagh DG, Bhardwaj N. A division of labor: DC subsets and HIV receptor diversity. Nat. Immunol. 2002; 3: 891-3. CrossRef MEDLINE ISI Abstract CSA Abstract
104. Stebbing J, Patterson S, Gotch F. New insights into the immunology and evolution of HIV. Cell Res. 2003; 13: 1-7. MEDLINE ISI Abstract
105. Donaghy H, Stebbing J, Patterson S. Antigen presentation and the role of dendritic cells in HIV. Curr. Opin. Infect. Dis. 2004; 17: 1-6. CrossRef MEDLINE ISI Abstract
106. McKenna K, Beignon AS, Bhardwaj N. Plasmacytoid dendritic cells: linking innate and adaptive immunity. J. Virol. 2005; 79: 17-27. CrossRef MEDLINE ISI Abstract
107. Tasca S, Tambussi G, Nozza S et al. Escape of monocyte-derived dendritic cells of HIV-1 infected individuals from natural killer cell-mediated lysis. AIDS 2003; 17: 2291-8. CrossRef MEDLINE ISI Abstract CSA Abstract
108. Dalod M, Salazar-Mather TP, Malmgaard L et al. Interferon alpha/beta and interleukin 12 responses to viral infections: Pathways regulating dendritic cell cytokine expression in vivo. J. Exp. Med. 2002; 195: 517-28. CrossRef MEDLINE ISI Abstract CSA Abstract