Cross-sectional detection of acute HIV infection: Timing of transmission, inflammation and antiretroviral therapy

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Gay, Cynthia ^a   Dibben, Oliver ^b   Anderson, Jeffrey A ^a   Stacey, Andrea ^b   Mayo, Ashley J ^a   Norris, Philip J ^c,d   Kuruc, JoAnn D ^a   Salazar Gonzalez, Jesus F ^e   Li, Hui ^e   Keele, Brandon F ^e   Hicks, Charles ^f   Margolis, David ^a   Ferrari, Guido ^f   Haynes, Barton ^f   Swanstrom, Ronald ^a   Shaw, George M ^e   Hahn, Beatrice H ^e   Eron, Joseph J ^a   Borrow, Persephone ^b   Cohen, Myron S ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c BLOOD SYSTEMS RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e University of Alabama at Birmingham   (United States)

^f DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 15; INTERLEUKIN 18; INTERLEUKIN 1BETA; CHEMOKINE;

ADOLESCENT; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DISEASE DURATION; DISEASE MARKER; DNA SEQUENCE; FEMALE; GENE SEQUENCE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; MALE HOMOSEXUAL; MOLECULAR CLOCK; NUCLEOTIDE SEQUENCE; PREDICTION; PROTEIN DETERMINATION; PUBLIC HEALTH SERVICE; SCREENING TEST; SERODIAGNOSIS; UNINDEXED SEQUENCE; VIREMIA; VIRUS DETECTION; VIRUS LOAD; VIRUS TRANSMISSION; ACUTE DISEASE; BAYES THEOREM; BLOOD; CASE CONTROL STUDY; CROSS-SECTIONAL STUDY; DEMOGRAPHY; DISEASE TRANSMISSION; GENETICS; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN IMMUNODEFICIENCY VIRUS 1; INFLAMMATION; MIDDLE AGED; TIME;

ACUTE DISEASE; ADOLESCENT; ADULT; AGED; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; BASE SEQUENCE; BAYES THEOREM; CASE-CONTROL STUDIES; CHEMOKINES; CROSS-SECTIONAL STUDIES; DEMOGRAPHY; FEMALE; HIV INFECTIONS; HIV SERONEGATIVITY; HIV-1; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; TIME FACTORS; VIRAL LOAD; YOUNG ADULT;

EID: 79955918570     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019617     Document Type: Article

References (44)

1. Abel K, Rocke DM, Chohan B, Fritts L, Miller CJ, (2005) Temporal and anatomic relationship between virus replication and cytokine gene expression after vaginal simian immunodeficiency virus infection. J Virol 79: 12164-12172.
2. Piatak M Jr, Saag MS, Yang LC, Clark SJ, Kappes JC, et al. (1993) High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science 259: 1749-1754.
3. Goonetilleke N, Liu MK, Salazar-Gonzalez JF, Ferrari G, Giorgi E, et al. (2009) The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection. J Exp Med 206: 1253-1272.
4. Koup RA, Safrit JT, Cao Y, Andrews CA, McLeod G, et al. (1994) Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J Virol 68: 4650-4655.
5. Borrow P, Lewicki H, Hahn BH, Shaw GM, Oldstone MB, (1994) Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J Virol 68: 6103-6110.
6. Deeks SG, Kitchen CM, Liu L, Guo H, Gascon R, et al. (2004) Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load. Blood 104: 942-947.
7. Mehandru S, Poles MA, Tenner-Racz K, Jean-Pierre P, Manuelli V, et al. (2006) Lack of mucosal immune reconstitution during prolonged treatment of acute and early HIV-1 infection. PLoS Med 3: e484.
8. Mellors JW, Kingsley LA, Rinaldo CR Jr, Todd JA, Hoo BS, et al. (1995) Quantitation of HIV-1 RNA in plasma predicts outcome after seroconversion. Ann Intern Med 122: 573-579.
9. McMichael AJ, Borrow P, Tomaras GD, Goonetilleke N, Haynes BF, (2010) The immune response during acute HIV-1 infection: clues for vaccine development. Nat Rev Immunol 10: 11-23.
10. Pilcher CD, Tien HC, Eron JJ Jr, Vernazza PL, Leu SY, et al. (2004) Brief but efficient: acute HIV infection and the sexual transmission of HIV. J Infect Dis 189: 1785-1792.
11. Brenner BG, Roger M, Routy JP, Moisi D, Ntemgwa M, et al. (2007) High rates of forward transmission events after acute/early HIV-1 infection. J Infect Dis 195: 951-959.
12. Wawer MJ, Gray RH, Sewankambo NK, Serwadda D, Li X, et al. (2005) Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda. J Infect Dis 191: 1403-1409.
13. Pilcher CD, Fiscus SA, Nguyen TQ, Foust E, Wolf L, et al. (2005) Detection of acute infections during HIV testing in North Carolina. N Engl J Med 352: 1873-1883.
14. Tomaras GD, Yates NL, Liu P, Qin L, Fouda GG, et al. (2008) Initial B-cell responses to transmitted human immunodeficiency virus type 1: virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremia. J Virol 82: 12449-12463.
15. Keele BF, Giorgi EE, Salazar-Gonzalez JF, Decker JM, Pham KT, et al. (2008) Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection. Proc Natl Acad Sci U S A 105: 7552-7557.
16. Gay C, Johnson A, McCoy S, Kuruc J, McGee K, et al. Efficacy of NNRTI-based antiretroviral therapy initiated during acute HIV infection; 2008 Mexico City, Mexico.
17. Simmonds P, Balfe P, Ludlam CA, Bishop JO, Brown AJ, (1990) Analysis of sequence diversity in hypervariable regions of the external glycoprotein of human immunodeficiency virus type 1. J Virol 64: 5840-5850.
18. Edmonson PF, Mullins JI, (1992) Efficient amplification of HIV half-genomes from tissue DNA. Nucleic Acids Res 20: 4933.
19. Palmer S, Kearney M, Maldarelli F, Halvas EK, Bixby CJ, et al. (2005) Multiple, linked human immunodeficiency virus type 1 drug resistance mutations in treatment-experienced patients are missed by standard genotype analysis. J Clin Microbiol 43: 406-413.
20. Salazar-Gonzalez JF, Bailes E, Pham KT, Salazar MG, Guffey MB, et al. (2008) Deciphering human immunodeficiency virus type 1 transmission and early envelope diversification by single-genome amplification and sequencing. J Virol 82: 3952-3970.
21. Higgins DG, Thompson JD, Gibson TJ, (1996) Using CLUSTAL for multiple sequence alignments. Methods Enzymol 266: 383-402.
22. Kumar S, Tamura K, Nei M, (1994) MEGA: Molecular Evolutionary Genetics Analysis software for microcomputers. Comput Appl Biosci 10: 189-191.
23. Drummond AJ, Rambaut A, (2007) BEAST: Bayesian evolutionary analysis by sampling trees. BMC Evol Biol 7: 214.
24. Anderson JA, Ping LH, Dibben O, Jabara CB, Arney L, et al. (2010) HIV-1 Populations in Semen Arise through Multiple Mechanisms. PLoS Pathog 6.
25. Stacey AR, Norris PJ, Qin L, Haygreen EA, Taylor E, et al. (2009) Induction of a striking systemic cytokine cascade prior to peak viremia in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infections. J Virol 83: 3719-3733.
26. Lee HY, Giorgi EE, Keele BF, Gaschen B, Athreya GS, et al. (2009) Modeling sequence evolution in acute HIV-1 infection. J Theor Biol 261: 341-360.
27. de Oliveira T, Pillay D, Gifford RJ, (2010) The HIV-1 subtype C epidemic in South America is linked to the United Kingdom. PLoS One 5: e9311.
28. Abecasis AB, Vandamme AM, Lemey P, (2009) Quantifying differences in the tempo of human immunodeficiency virus type 1 subtype evolution. J Virol 83: 12917-12924.
29. Mattapallil JJ, Douek DC, Hill B, Nishimura Y, Martin M, et al. (2005) Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection. Nature 434: 1093-1097.
30. Li Q, Duan L, Estes JD, Ma ZM, Rourke T, et al. (2005) Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells. Nature 434: 1148-1152.
31. Schacker T, Collier AC, Hughes J, Shea T, Corey L, (1996) Clinical and epidemiologic features of primary HIV infection. Ann Intern Med 125: 257-264.
32. Lindback S, Thorstensson R, Karlsson AC, von Sydow M, Flamholc L, et al. (2000) Diagnosis of primary HIV-1 infection and duration of follow-up after HIV exposure. Karolinska Institute Primary HIV Infection Study Group. AIDS 14: 2333-2339.
33. Roberts L, Passmore JS, Williamson C, Little F, Bebell L, et al. (2010) Plasma cytokine levels during acute HIV-1 infection predict HIV disease progression. AIDS 24: 819-831.
34. Fidler S, Fox J, Porter K, Weber J, (2008) Primary HIV infection: to treat or not to treat? Curr Opin Infect Dis 21: 4-10.
35. Fidler S, Ewings F, Porter K, Cooper D, Tambussi G, et al. (2010) A comparison of HIV viral rebound following ART cessation in primary and chronic HIV infection San Francisco, CA.
36. Gianella S, von Wyl V, Fischer M, Niederost B, Joos B, et al. (2010) Impact of early ART on proviral HIV-1 DNA and plasma viremia in acutely infected patients San Francisco, CA.
37. Bowman MC, Archin NM, Margolis DM, (2009) Pharmaceutical approaches to eradication of persistent HIV infection. Expert Rev Mol Med 11: e6.
38. Rieder P, Joos B, von Wyl V, Boni J, Yerly S, et al. (2010) Strong effect of early ART during primary HIV-1 infection in preventing further spread of HIV in sexually active men having sex with men San Francisco, CA.
39. Haissman JM, Vestergaard LS, Sembuche S, Erikstrup C, Mmbando B, et al. (2009) Plasma cytokine levels in Tanzanian HIV-1-infected adults and the effect of antiretroviral treatment. J Acquir Immune Defic Syndr 52: 493-497.
40. Sachdeva RK, Wanchu A, Bagga R, Malla N, Sharma M, (2010) Effect of non-nucleoside reverse transcriptase inhibitors on cytokine, chemokine, and immunoglobulin profiles in serum and genital secretions of HIV-infected women. J Interferon Cytokine Res 30: 299-310.
41. Neuhaus J, Jacobs DR Jr, Baker JV, Calmy A, Duprez D, et al. (2010) Markers of inflammation, coagulation, and renal function are elevated in adults with HIV infection. J Infect Dis 201: 1788-1795.
42. Regidor DL, Detels R, Breen EC, Widney DP, Jacobson LP, et al. (2011) Effect of highly active antiretroviral therapy on biomarkers of B-lymphocyte activation and inflammation. AIDS 25: 303-314.
43. Miller WC, Rosenberg NE, Rutstein SE, Powers KA, (2010) Role of acute and early HIV infection in the sexual transmission of HIV. Curr Opin HIV AIDS 5: 277-282.
44. Lee HH, Dineva MA, Chua YL, Ritchie AV, Ushiro-Lumb I, et al. (2010) Simple amplification-based assay: a nucleic acid-based point-of-care platform for HIV-1 testing. J Infect Dis 201 (Suppl 1): S65-72.