Blocking of α4β7 gut-homing integrin during acute infection leads to decreased plasma and gastrointestinal tissue viral loads in simian immunodeficiency virus-infected rhesus macaques

Journal of Immunology

Volumn 186, Issue 2, 2011, Pages 1044-1059

  Ansari, Aftab A ^a   Reimann, Keith A ^b   Mayne, Ann E ^a   Takahashi, Yoshiaki ^a   Stephenson, Susan T ^a   Wang, Rijian ^b   Wang, Xinyue ^b   Li, Jichu ^b   Price, Andrew A ^b   Little, Dawn M ^a   Zaidi, Mohammad ^a   Lyles, Robert ^c   Villinger, Francois ^a,d  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c EMORY UNIVERSITY   (United States)

^d EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4BETA7 INTEGRIN; INTEGRIN; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MONOCLONAL ANTIBODY; RECOMBINANT RHESUS MONOCLONAL ANTIBODY ALPHA4BETA7 INTEGRIN; UNCLASSIFIED DRUG; VIRUS DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; CD4+ T LYMPHOCYTE; CELL LINEAGE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GASTROINTESTINAL INFECTION; IMMUNOMODULATION; INNATE IMMUNITY; LENTIVIRUS INFECTION; MEMORY T LYMPHOCYTE; NATURAL KILLER CELL; NONHUMAN; PHARMACOLOGICAL BLOCKING; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; RHESUS MONKEY; SIMIAN IMMUNODEFICIENCY VIRUS; SINGLE DRUG DOSE; VIRUS LOAD;

ACUTE DISEASE; ANIMALS; ANTIBODIES, BLOCKING; DNA, VIRAL; GASTRIC MUCOSA; INJECTIONS, INTRAVENOUS; INTEGRIN ALPHA4; INTEGRIN BETA CHAINS; INTEGRINS; INTESTINAL MUCOSA; MACACA MULATTA; PROTEIN TRANSPORT; PROVIRUSES; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; VACCINES, SYNTHETIC; VIRAL LOAD;

EID: 79251555316     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1003052     Document Type: Article

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