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Volumn 272, Issue 5265, 1996, Pages 1167-1170

Prognosis in HIV-1 infection predicted by the quantity of virus in plasma

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; VIRUS RNA;

EID: 0030070991     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.272.5265.1167     Document Type: Article
Times cited : (2356)

References (31)
  • 7
    • 0028909872 scopus 로고
    • J. W. Mellors et al., Ann. Intern. Med. 122, 573 (1995); S. Jurrians et al., Virology 204, 223 (1994); D. R. Henrard et al., JAMA 274, 554 (1995).
    • (1995) Ann. Intern. Med. , vol.122 , pp. 573
    • Mellors, J.W.1
  • 8
    • 0028024718 scopus 로고
    • J. W. Mellors et al., Ann. Intern. Med. 122, 573 (1995); S. Jurrians et al., Virology 204, 223 (1994); D. R. Henrard et al., JAMA 274, 554 (1995).
    • (1994) Virology , vol.204 , pp. 223
    • Jurrians, S.1
  • 9
    • 0029081506 scopus 로고
    • J. W. Mellors et al., Ann. Intern. Med. 122, 573 (1995); S. Jurrians et al., Virology 204, 223 (1994); D. R. Henrard et al., JAMA 274, 554 (1995).
    • (1995) JAMA , vol.274 , pp. 554
    • Henrard, D.R.1
  • 10
    • 13344256443 scopus 로고    scopus 로고
    • note
    • Details of the recruitment and characteristics of the MACS cohort have been described elsewhere (9). The MACS protocol was approved by the Biomedical Institutional Review Board of the University of Pittsburgh. All subjects gave written informed consent after the potential consequences of study participation were explained.
  • 12
    • 13344266754 scopus 로고    scopus 로고
    • note
    • + T cells by the total lymphocyte count.
  • 14
    • 13344253978 scopus 로고    scopus 로고
    • note
    • For subjects developing AIDS, the samples tested were from study entry, the first follow-up visit (6 months), the most recent visit before AIDS diagnosis, and equally spaced visits in between. For AIDS-free subjects, the samples tested were from study entry, the 6-month follow-up visit, the last available visit, and equally spaced visits in between.
  • 15
    • 13344264882 scopus 로고    scopus 로고
    • note
    • Developed by Chiron, the assay measures HIV-1 RNA associated with viral particles that are separated from 1.0-ml plasma samples by centrifugation at 23,500g for 1 hour at 4°C. Performance characteristics of the assay have been described elsewhere (14). For our study, the interassay coefficient of variation for the positive control samples tested with each batch of experimental samples was 18%. All samples were coded and the assay operators were blinded to clinical outcomes.
  • 17
    • 33845382806 scopus 로고
    • E. L. Kaplan and P. Meier, J. Am. Stat Assoc. 53, 457 (1958). Kaplan-Meier analyses were performed with Statistica version 4.5 (StatSoft, Tulsa, OK).
    • (1958) J. Am. Stat Assoc. , vol.53 , pp. 457
    • Kaplan, E.L.1    Meier, P.2
  • 18
    • 0003667275 scopus 로고
    • Chapman & Hall, London
    • D. R. Cox and D. Oakes, Analysis of Survival Data (Chapman & Hall, London, 1984). Cox proportional hazards analyses were performed with Splus version 3.3 (StatSci Division of Mathsoft, Seattle, WA).
    • (1984) Analysis of Survival Data
    • Cox, D.R.1    Oakes, D.2
  • 19
    • 0022211651 scopus 로고
    • B. J. Kennedy et al., Cancer 56, 2547 (1985).
    • (1985) Cancer , vol.56 , pp. 2547
    • Kennedy, B.J.1
  • 21
    • 0024805742 scopus 로고    scopus 로고
    • D. D. Ho, T. Moudgil, M. Alam, N. Engl. J. Med. 321, 1621 (1989); R. W. Coombs et al., ibid., p. 1626; P. Gupta et al., Virology 196, 586 (1993).
    • (1989) N. Engl. J. Med. , vol.321 , pp. 1621
    • Ho, D.D.1    Moudgil, T.2    Alam, M.3
  • 22
    • 0024805742 scopus 로고    scopus 로고
    • D. D. Ho, T. Moudgil, M. Alam, N. Engl. J. Med. 321, 1621 (1989); R. W. Coombs et al., ibid., p. 1626; P. Gupta et al., Virology 196, 586 (1993).
    • N. Engl. J. Med. , pp. 1626
    • Coombs, R.W.1
  • 23
    • 0027430660 scopus 로고
    • D. D. Ho, T. Moudgil, M. Alam, N. Engl. J. Med. 321, 1621 (1989); R. W. Coombs et al., ibid., p. 1626; P. Gupta et al., Virology 196, 586 (1993).
    • (1993) Virology , vol.196 , pp. 586
    • Gupta, P.1
  • 24
    • 0028811974 scopus 로고
    • X. Wei et al., Nature 373, 117 (1995).
    • (1995) Nature , vol.373 , pp. 117
    • Wei, X.1
  • 28
    • 13344257224 scopus 로고    scopus 로고
    • paper presented (Infectious Disease Society of America), Washington, DC, 28 February to 1 March
    • W. Freimulh et al., paper presented at the Third Conference on Retroviruses and Opportunistic Infections (Infectious Disease Society of America), Washington, DC, 28 February to 1 March 1996;
    • (1996) Third Conference on Retroviruses and Opportunistic Infections
    • Freimulh, W.1
  • 30
    • 0010645911 scopus 로고
    • D. Finkelstein and D. A. Shoenfeld, Eds. Wiley, New York
    • V. DeGruttola, R. Gelman, S. Lagakos, in AIDS Clinical Trials, D. Finkelstein and D. A. Shoenfeld, Eds. (Wiley, New York, 1995), pp. 129-142.
    • (1995) AIDS Clinical Trials , pp. 129-142
    • DeGruttola, V.1    Gelman, R.2    Lagakos, S.3
  • 31
    • 13344251151 scopus 로고    scopus 로고
    • note
    • We thank the participants and staff of the Pitt Men's Study for their dedication and support. Supported by Public Health Service contract N01-Al-72632 and cooperative agreement U01-Al-35041 and by grant support from the National Institutes of Health (R01 Al34301-01 and Al34294-01A2), the Medical Research Service of the Department of Veterans Affairs, and the Pathology Education and Research Foundation of the University of Pittsburgh.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.