Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection

Nature

Volumn 434, Issue 7037, 2005, Pages 1093-1097

  Mattapallil, Joseph J ^a   Douek, Daniel C ^b   Hill, Brenna ^b   Nishimura, Yoshiaki ^a   Martin, Malcolm ^a   Roederer, Mario ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; IMMUNOLOGY; TISSUE; VIRUSES;

HUMAN IMMUNODEFICIENCY VIRUS (HIV); PATHOGENS; POLYMERASE CHAIN REACTION; SIMIAN IMMUNODEFICIENCY VIRUS (SIV);

CELLS;

CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; MESSENGER RNA;

MEDICINE;

ACUTE PHASE RESPONSE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LOSS; CELL SELECTION; CONTROLLED STUDY; HELPER CELL; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE DEFICIENCY; MEMORY CELL; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE POLYMERASE CHAIN REACTION; RHESUS MONKEY; SIMIAN IMMUNODEFICIENCY VIRUS; VACCINATION; VIRUS INFECTION; VIRUS LOAD; ACUTE DISEASE; ANIMAL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DEATH; GENETICS; HUMAN; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; ISOLATION AND PURIFICATION; MACACA; METABOLISM; MONKEY DISEASE; PATHOLOGY; PHYSIOLOGY; VIROLOGY;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; MACACA; MACACA MULATTA; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS;

ACUTE DISEASE; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DEATH; HUMANS; IMMUNOLOGIC MEMORY; MACACA MULATTA; RECEPTORS, CCR5; RNA, MESSENGER; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; VIRAL LOAD;

EID: 17844374605     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03501     Document Type: Article

References (25)

1. + T cell depletion and viral replication in SIV infection. Science 280, 427-431 (1998).
2. + T-cell depletion in primary simian immunodeficiency virus infection. J. Virol. 72, 6421-6429 (1998).
3. + T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J. Exp. Med. 200, 749-759 (2004).
4. + T cells in lymphoid tissues during simian immunodeficiency virus infection. J. Virol. 74, 11001-11007 (2000).
5. + T cells are rapidly eliminated in early SIV infection in vivo. J. Virol. 74, 57-64 (2000).
6. Mattapallil, J. J., Letvin, N. L. & Roederer, M. T-cell dynamics during acute SIV infection. AIDS 18, 13-23 (2004).
7. + T cells. Nature 417, 95-98 (2002).
8. Haase, A. T. et al. Quantitative image analysis of HIV-1 infection in lymphoid tissue. Science 274, 985-989 (1996).
9. + T cell demographics and dynamics in lymphatic tissues. Annu. Rev. Immunol 17, 625-656 (1999).
10. Lassen, K., Han, Y., Zhou, Y., Siliciano, J. & Siliciano, R. F. The multifactorial nature of HIV-1 latency. Trends Mol. Med. 10, 525-531 (2004).
11. Chen, Z., Zhou, P. Ho, D. D., Landau, N. R. & Marx, P. A. Genetically divergent strains of simian immunodeficiency virus use CCR5 as a coreceptor for entry. J. Virol. 71, 2705-2714 (1997).
12. Marcon, L. et al. Utilization of C-C chemokine receptor 5 by the envelope glycoproteins of a pathogenic simian immunodeficiency virus, S1Vmac239. J. Virol. 71, 2522-2527 (1997).
13. Jung, A. et al. Multiply infected spleen cells in HIV patients. Nature 418, 144 (2002).
14. Gratton, S., Cheynier, R., Dumaurier, M. J., Oksenhendler, E. & Wain-Hobson, S. Highly restricted spread of HIV-1 and multiply infected cells within splenic germinal centers. Proc. Natl Acad. Sci. USA 97, 14566-14571 (2000).
15. + T cell subsets in rhesus monkeys, explaining their divergent clinical courses. Proc. Natl Acad. Sci. USA 101, 12324-12329 (2004).
16. Mengozzi, M. et al. Naive CD4 T cells inhibit CD28-costimulated R5-tropic HIV replication in memory CD4 T cells. Proc. Natl Acad. Sci. USA 98, 11644-11649 (2001).
17. + T cells. Science 286, 1353-1357 (1999).
18. + T cells in transmission and acute simian immunodeficiency virus infection. Proc. Natl Acad. Sci. USA 101, 5640-5645 (2004).
19. Endo, Y. et al. Short- and long-term clinical outcomes in rhesus monkeys inoculated with a highly pathogenic chimeric simian/human immunodeficiency virus. J. Virol. 74, 6935-6945 (2000).
20. Pitcher, C. J. et al. Development and homeostasis of T cell memory in rhesus macaque. J. Immunol. 168, 29-43 (2002).
21. + lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatment. J. Virol. 75, 10187-10199 (2001).
22. Livak, K. J. & Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the ΔΔCT Method. Methods 25, 402-408 (2001).
23. Mori, K., Ringler, D. J., Kodama, T. & Desrosiers, R. C. Complex determinants of macrophage tropism in env of simian immunodeficiency virus. J. Virol. 66, 2067-2075 (1992).
24. Folks, T. M. et al. Biological and biochemical characterization of a cloned Leu-3-cell surviving infection with the acquired immune deficiency syndrome retrovirus. J. Exp. Med. 164, 280-290 (1986).
25. Folks, T. et al. Characterization of a continuous T-cell line susceptible to the cytopathic effects of the acquired immunodeficiency syndrome (AIDS)-associated retrovirus. Proc. Natl Acad. Sci. USA 82, 4539-4543 (1985).