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Volumn 86, Issue 19, 2012, Pages 10661-10674

HIV controllers maintain a population of highly efficient Th1 effector cells in contrast to patients treated in the long term

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; GAG PROTEIN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 21; INTERLEUKIN 4; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PERFORIN;

EID: 84869050052     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00056-12     Document Type: Article
Times cited : (54)

References (85)
  • 1
    • 79955470991 scopus 로고    scopus 로고
    • Antigen sensitivity and T-cell receptor avidity as critical determinants of HIV control
    • Appay V, Iglesias MC. 2011. Antigen sensitivity and T-cell receptor avidity as critical determinants of HIV control. Curr. Opin. HIV AIDS 6:157-162.
    • (2011) Curr. Opin. HIV AIDS , vol.6 , pp. 157-162
    • Appay, V.1    Iglesias, M.C.2
  • 2
    • 0036604438 scopus 로고    scopus 로고
    • +) CTLs ex vivo
    • +) CTLs ex vivo. J. Immunol. 168:5954-5958.
    • (2002) J. Immunol , vol.168 , pp. 5954-5958
    • Appay, V.1
  • 3
    • 73549099347 scopus 로고    scopus 로고
    • Effector mechanisms in HIV-1 infected elite controllers: highly active immune responses?
    • Blankson JN. 2010. Effector mechanisms in HIV-1 infected elite controllers: highly active immune responses? Antiviral Res. 85:295-302.
    • (2010) Antiviral Res , vol.85 , pp. 295-302
    • Blankson, J.N.1
  • 4
    • 79955420643 scopus 로고    scopus 로고
    • CD4 dynamics over a 15 year-period among HIV controllers enrolled in the ANRS French observatory
    • doi:10.1371/journal.pone.0018726
    • Boufassa F, et al. 2011. CD4 dynamics over a 15 year-period among HIV controllers enrolled in the ANRS French observatory. PLoS One. 6:e18726. doi:10.1371/journal.pone.0018726.
    • (2011) PLoS One. , vol.6
    • Boufassa, F.1
  • 5
    • 53449093632 scopus 로고    scopus 로고
    • Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections
    • Brenchley JM, et al. 2008. Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections. Blood 112:2826-2835.
    • (2008) Blood , vol.112 , pp. 2826-2835
    • Brenchley, J.M.1
  • 6
    • 33845532053 scopus 로고    scopus 로고
    • Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    • Brenchley JM, et al. 2006. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat. Med. 12:1365-1371
    • (2006) Nat. Med. , vol.12 , pp. 1365-1371
    • Brenchley, J.M.1
  • 7
    • 67651087322 scopus 로고    scopus 로고
    • IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells
    • Brockman MA, et al. 2009. IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells. Blood. 114:346-356.
    • (2009) Blood , vol.114 , pp. 346-356
    • Brockman, M.A.1
  • 8
    • 33845875194 scopus 로고    scopus 로고
    • + T lymphocytes with cellular maturation
    • + T lymphocytes with cellular maturation. J. Exp. Med. 203:2865-2877.
    • (2006) J. Exp. Med , vol.203 , pp. 2865-2877
    • Casazza, J.P.1
  • 11
    • 78649516786 scopus 로고    scopus 로고
    • + T cell function
    • + T cell function. J. Virol. 85:733-741.
    • (2011) J. Virol , vol.85 , pp. 733-741
    • Chevalier, M.F.1
  • 12
    • 79957917187 scopus 로고    scopus 로고
    • +T cells, including Th17 and cycling subsets, are intact in the gut mucosa of HIV-1-infected long-term nonprogressors
    • +T cells, including Th17 and cycling subsets, are intact in the gut mucosa of HIV-1-infected long-term nonprogressors. J. Virol. 85:5880-5888.
    • (2011) J. Virol. , vol.85 , pp. 5880-5888
    • Ciccone, E.J.1
  • 13
    • 79960835109 scopus 로고    scopus 로고
    • Interrogating the repertoire: broadening the scope of peptide-MHC multimer analysis
    • Davis MM, Altman JD, Newell EW. 2011. Interrogating the repertoire: broadening the scope of peptide-MHC multimer analysis. Nat. Rev. Immunol. 11:551-558.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 551-558
    • Davis, M.M.1    Altman, J.D.2    Newell, E.W.3
  • 14
    • 79551614790 scopus 로고    scopus 로고
    • HIV infection, inflammation, immunosenescence, and aging
    • Deeks SG. 2011. HIV infection, inflammation, immunosenescence, and aging. Annu. Rev. Med. 62:141-155.
    • (2011) Annu. Rev. Med. , vol.62 , pp. 141-155
    • Deeks, S.G.1
  • 15
    • 34548689151 scopus 로고    scopus 로고
    • Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy
    • Deeks SG, Walker BD. 2007. Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy. Immunity. 27:406-416.
    • (2007) Immunity. , vol.27 , pp. 406-416
    • Deeks, S.G.1    Walker, B.D.2
  • 16
    • 63449124466 scopus 로고    scopus 로고
    • Emerging concepts in the immunopathogenesis of AIDS
    • Douek DC, Roederer M, Koup RA. 2009. Emerging concepts in the immunopathogenesis of AIDS. Annu. Rev. Med. 60:471-484.
    • (2009) Annu. Rev. Med. , vol.60 , pp. 471-484
    • Douek, D.C.1    Roederer, M.2    Koup, R.A.3
  • 17
    • 3042842613 scopus 로고    scopus 로고
    • Predictors of immunological failure after initial response to highly active antiretroviral therapy in HIV-1-infected adults: a EuroSIDA study
    • Dragsted UB, et al. 2004. Predictors of immunological failure after initial response to highly active antiretroviral therapy in HIV-1-infected adults: a EuroSIDA study. J. Infect. Dis. 190:148-155.
    • (2004) J. Infect. Dis. , vol.190 , pp. 148-155
    • Dragsted, U.B.1
  • 18
    • 67649217469 scopus 로고    scopus 로고
    • IL-21 is required to control chronic viral infection
    • Elsaesser H, Sauer K, Brooks DG. 2009. IL-21 is required to control chronic viral infection. Science. 324:1569-1572.
    • (2009) Science. , vol.324 , pp. 1569-1572
    • Elsaesser, H.1    Sauer, K.2    Brooks, D.G.3
  • 19
    • 27644489746 scopus 로고    scopus 로고
    • Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment
    • Emu B, et al. 2005. Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment. J.Virol. 79:14169-14178.
    • (2005) J.Virol. , vol.79 , pp. 14169-14178
    • Emu, B.1
  • 20
    • 77957944425 scopus 로고    scopus 로고
    • + T-cell responses
    • + T-cell responses. J. Virol. 84:11020-11029.
    • (2010) J. Virol. , vol.84 , pp. 11020-11029
    • Ferre, A.L.1
  • 21
    • 68149100383 scopus 로고    scopus 로고
    • Negative feedback control of the autoimmune response through antigen-induced differentiation of IL-10-secreting Th1 cells
    • Gabrysova L, et al. 2009. Negative feedback control of the autoimmune response through antigen-induced differentiation of IL-10-secreting Th1 cells. J. Exp. Med. 206:1755-1767.
    • (2009) J. Exp. Med. , vol.206 , pp. 1755-1767
    • Gabrysova, L.1
  • 23
    • 67651087476 scopus 로고    scopus 로고
    • Prevalence and comparative characteristics of longterm nonprogressors and HIV controller patients in the French Hospital Database on HIV
    • Grabar S, et al. 2009. Prevalence and comparative characteristics of longterm nonprogressors and HIV controller patients in the French Hospital Database on HIV. AIDS. 23:1163-1169.
    • (2009) AIDS. , vol.23 , pp. 1163-1169
    • Grabar, S.1
  • 24
    • 77649243563 scopus 로고    scopus 로고
    • Immune and virological benefits of 10 years of permanent viral control with antiretroviral therapy
    • Guihot A, et al. 2010. Immune and virological benefits of 10 years of permanent viral control with antiretroviral therapy. AIDS 24:614-617.
    • (2010) AIDS , vol.24 , pp. 614-617
    • Guihot, A.1
  • 25
    • 33745091465 scopus 로고    scopus 로고
    • Functional signatures of protective antiviral T-cell immunity in human virus infections
    • Harari A, et al. 2006. Functional signatures of protective antiviral T-cell immunity in human virus infections. Immunol. Rev. 211:236-254.
    • (2006) Immunol. Rev. , vol.211 , pp. 236-254
    • Harari, A.1
  • 26
    • 1642500367 scopus 로고    scopus 로고
    • Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1-infected subjects with progressive disease: changes after antiretroviral therapy
    • Harari A, Petitpierre S, Vallelian F, Pantaleo G. 2004. Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1-infected subjects with progressive disease: changes after antiretroviral therapy. Blood 103:966-972.
    • (2004) Blood , vol.103 , pp. 966-972
    • Harari, A.1    Petitpierre, S.2    Vallelian, F.3    Pantaleo, G.4
  • 27
    • 79953815120 scopus 로고    scopus 로고
    • + T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression
    • + T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression. Blood 117:3799-3808.
    • (2011) Blood , vol.117 , pp. 3799-3808
    • Hersperger, A.R.1
  • 29
    • 77954080011 scopus 로고    scopus 로고
    • Perforin expression directly ex vivo by HIVspecific CD8 T-cells is a correlate of HIV elite control
    • doi:10.1371/journal.ppat.1000917
    • Hersperger AR, et al. 2010. Perforin expression directly ex vivo by HIVspecific CD8 T-cells is a correlate of HIV elite control. PLoS Pathog. 6:e1000917. doi:10.1371/journal.ppat.1000917.
    • (2010) PLoS Pathog. , vol.6
    • Hersperger, A.R.1
  • 30
    • 39349088126 scopus 로고    scopus 로고
    • + T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy
    • + T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy. J. Infect. Dis. 197:126-133.
    • (2008) J. Infect. Dis. , vol.197 , pp. 126-133
    • Hunt, P.W.1
  • 31
    • 79951837963 scopus 로고    scopus 로고
    • + T cells may contribute to viral persistence in HIV controllers
    • + T cells may contribute to viral persistence in HIV controllers. Clin. Infect. Dis. 52:681-687.
    • (2011) Clin. Infect. Dis. , vol.52 , pp. 681-687
    • Hunt, P.W.1
  • 32
    • 79551649723 scopus 로고    scopus 로고
    • A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers
    • doi:10.1371/journal.pone.0015924
    • Hunt PW, et al. 2011. A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers. PLoS One 6:e15924. doi:10.1371/journal.pone.0015924.
    • (2011) PLoS One , vol.6
    • Hunt, P.W.1
  • 33
    • 73949110184 scopus 로고    scopus 로고
    • Dynamics and consequences of IL-21 production in HIV-infected individuals: a longitudinal and cross-sectional study
    • Iannello A, et al. 2010. Dynamics and consequences of IL-21 production in HIV-infected individuals: a longitudinal and cross-sectional study. J. Immunol. 184:114-126.
    • (2010) J. Immunol. , vol.184 , pp. 114-126
    • Iannello, A.1
  • 35
    • 69249208673 scopus 로고    scopus 로고
    • + T cell responses without high-frequency fixation of mutations
    • + T cell responses without high-frequency fixation of mutations. J. Virol. 83: 8722-8732.
    • (2009) J. Virol. , vol.83 , pp. 8722-8732
    • Jones, R.B.1
  • 36
    • 35448968969 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 controllers but not noncontrollers maintain CD4 T cells coexpressing three cytokines
    • Kannanganat S, et al. 2007. Human immunodeficiency virus type 1 controllers but not noncontrollers maintain CD4 T cells coexpressing three cytokines. J. Virol. 81:12071-12076.
    • (2007) J. Virol. , vol.81 , pp. 12071-12076
    • Kannanganat, S.1
  • 37
    • 78049401660 scopus 로고    scopus 로고
    • +T cell function by multiple costimulatory receptors during chronic HIV infection
    • +T cell function by multiple costimulatory receptors during chronic HIV infection. J. Immunol. 185:3007-3018.
    • (2010) J. Immunol. , vol.185 , pp. 3007-3018
    • Kassu, A.1
  • 38
    • 4043176043 scopus 로고    scopus 로고
    • Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides
    • Kaufmann DE, et al. 2004. Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides.J. Virol. 78:4463-4477.
    • (2004) J. Virol. , vol.78 , pp. 4463-4477
    • Kaufmann, D.E.1
  • 39
    • 34548680261 scopus 로고    scopus 로고
    • + T cells correlates with disease progression and defines a reversible immune dysfunction
    • + T cells correlates with disease progression and defines a reversible immune dysfunction. Nat. Immunol. 8:1246-1254.
    • (2007) Nat. Immunol. , vol.8 , pp. 1246-1254
    • Kaufmann, D.E.1
  • 40
    • 15744361847 scopus 로고    scopus 로고
    • Limited durability of viral control following treated acute HIV infection
    • doi:10.1371/ journal.pmed.0010036
    • Kaufmann DE, et al. 2004. Limited durability of viral control following treated acute HIV infection. PLoS Med. 1:e36. doi:10.1371/ journal.pmed.0010036.
    • (2004) PLoS Med. , vol.1
    • Kaufmann, D.E.1
  • 41
    • 22544453346 scopus 로고    scopus 로고
    • Characteristics, determinants, and clinical relevance of CD4 T cell recovery to =500 cells/microL in HIV type 1-in-fected individuals receiving potent antiretroviral therapy
    • Kaufmann GR, et al. 2005. Characteristics, determinants, and clinical relevance of CD4 T cell recovery to =500 cells/microL in HIV type 1-in-fected individuals receiving potent antiretroviral therapy. Clin. Infect. Dis.41:361-372.
    • (2005) Clin. Infect. Dis. , vol.41 , pp. 361-372
    • Kaufmann, G.R.1
  • 43
    • 0037289484 scopus 로고    scopus 로고
    • Challenges in staining T cells using HLA class II tetramers
    • Kwok WW. 2003. Challenges in staining T cells using HLA class II tetramers. Clin. Immunol. 106:23-28.
    • (2003) Clin. Immunol. , vol.106 , pp. 23-28
    • Kwok, W.W.1
  • 44
    • 7244248655 scopus 로고    scopus 로고
    • +) T cells using MHC class II multimer bead sorting and immunoscope analysis
    • +) T cells using MHC class II multimer bead sorting and immunoscope analysis. Eur. J. Immunol. 34:2941-2949.
    • (2004) Eur. J. Immunol. , vol.34 , pp. 2941-2949
    • Lemaitre, F.1
  • 45
    • 23044435922 scopus 로고    scopus 로고
    • Loss of HIV-1-specific T cell proliferation in chronic HIV-1 infection: cause or consequence of viral replication?
    • Lichterfeld M, Pantaleo G, Altfeld M. 2005. Loss of HIV-1-specific T cell proliferation in chronic HIV-1 infection: cause or consequence of viral replication? AIDS 19:1225-1227.
    • (2005) AIDS , vol.19 , pp. 1225-1227
    • Lichterfeld, M.1    Pantaleo, G.2    Altfeld, M.3
  • 46
    • 54449084622 scopus 로고    scopus 로고
    • + T-cell restoration in gut-associated lymphoid tissue of HIV-infected patients is associated with enhanced Th17 cells and polyfunctional HIV-specific T-cell responses
    • + T-cell restoration in gut-associated lymphoid tissue of HIV-infected patients is associated with enhanced Th17 cells and polyfunctional HIV-specific T-cell responses. Mucosal Immunol.1:475-488.
    • (2008) Mucosal Immunol. , vol.1 , pp. 475-488
    • Macal, M.1
  • 47
    • 1642504308 scopus 로고    scopus 로고
    • MHC class II tetramers and the pursuit of antigen-specific T cells: define, deviate, delete
    • Mallone R, Nepom GT. 2004. MHC class II tetramers and the pursuit of antigen-specific T cells: define, deviate, delete. Clin. Immunol. 110:232-242.
    • (2004) Clin. Immunol. , vol.110 , pp. 232-242
    • Mallone, R.1    Nepom, G.T.2
  • 48
    • 57449109484 scopus 로고    scopus 로고
    • +T cells is required for HIV-infected cell elimination associated with immune control
    • +T cells is required for HIV-infected cell elimination associated with immune control. Immunity 29:1009-1021.
    • (2008) Immunity , vol.29 , pp. 1009-1021
    • Migueles, S.A.1
  • 49
    • 43249093908 scopus 로고    scopus 로고
    • Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection
    • Ndhlovu LC, et al. 2008. Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection. AIDS. 22: 990-992.
    • (2008) AIDS. , vol.22 , pp. 990-992
    • Ndhlovu, L.C.1
  • 50
    • 77950952763 scopus 로고    scopus 로고
    • +T-cell response in different phases of HIV infection
    • +T-cell response in different phases of HIV infection. AIDS 24:947-957.
    • (2010) AIDS , vol.24 , pp. 947-957
    • Nemes, E.1
  • 52
    • 77951877224 scopus 로고    scopus 로고
    • +elite controllers have low HIV-specific T-cell activation yet maintain strong, polyfunctional T-cell responses
    • +elite controllers have low HIV-specific T-cell activation yet maintain strong, polyfunctional T-cell responses. AIDS. 24: 1095-1105.
    • (2010) AIDS. , vol.24 , pp. 1095-1105
    • Owen, R.E.1
  • 53
    • 41649083599 scopus 로고    scopus 로고
    • Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy
    • U.S.A.
    • Palmer S, et al. 2008. Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy. Proc. Natl. Acad. Sci. U. S. A. 105:3879-3884.
    • (2008) Proc. Natl. Acad. Sci. , vol.105 , pp. 3879-3884
    • Palmer, S.1
  • 54
    • 70349434887 scopus 로고    scopus 로고
    • Persistent low-level viremia in HIV-1 elite controllers and relationship to immunologic parameters
    • Pereyra F, et al. 2009. Persistent low-level viremia in HIV-1 elite controllers and relationship to immunologic parameters. J. Infect. Dis. 200:984-990.
    • (2009) J. Infect. Dis. , vol.200 , pp. 984-990
    • Pereyra, F.1
  • 55
    • 0032941595 scopus 로고    scopus 로고
    • + T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression
    • + T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression. Nat. Med. 5:518-525.
    • (1999) Nat. Med. , vol.5 , pp. 518-525
    • Pitcher, C.J.1
  • 56
    • 79955476141 scopus 로고    scopus 로고
    • HIV-specific CD4 T cells and immune control of viral replication
    • Porichis F, Kaufmann DE. 2011. HIV-specific CD4 T cells and immune control of viral replication. Curr. Opin. HIV AIDS. 6:174-180.
    • (2011) Curr. Opin. HIV AIDS. , vol.6 , pp. 174-180
    • Porichis, F.1    Kaufmann, D.E.2
  • 57
    • 79961006794 scopus 로고    scopus 로고
    • Responsiveness of HIV-specific CD4 T cells to PD-1 blockade
    • Porichis F, et al. 2011. Responsiveness of HIV-specific CD4 T cells to PD-1 blockade. Blood. 118:965-974.
    • (2011) Blood. , vol.118 , pp. 965-974
    • Porichis, F.1
  • 58
    • 37049027525 scopus 로고    scopus 로고
    • +T-cell subsets in human immunodeficiency virus controllers: an ANRS EP36 study
    • +T-cell subsets in human immunodeficiency virus controllers: an ANRS EP36 study. J. Virol. 81:13904-13915.
    • (2007) J. Virol. , vol.81 , pp. 13904-13915
    • Potter, S.J.1
  • 59
    • 77649250683 scopus 로고    scopus 로고
    • +Th17 cells and gradual decline in regulatory T cells
    • +Th17 cells and gradual decline in regulatory T cells. AIDS. 24:491-502.
    • (2010) AIDS. , vol.24 , pp. 491-502
    • Prendergast, A.1
  • 60
    • 84855927062 scopus 로고    scopus 로고
    • HIV-specific CD4 T cell responses to different viral proteins have discordant associations with viral load and clinical outcome
    • Ranasinghe S, et al. 2012. HIV-specific CD4 T cell responses to different viral proteins have discordant associations with viral load and clinical outcome. J. Virol. 86:277-283.
    • (2012) J. Virol. , vol.86 , pp. 277-283
    • Ranasinghe, S.1
  • 61
    • 79251515158 scopus 로고    scopus 로고
    • SPICE:exploration and analysis of post-cytometric complex multivariate datasets
    • Roederer M, Nozzi JL, Nason MC. 2011. SPICE: exploration and analysis of post-cytometric complex multivariate datasets. Cytometry A 79:167-174.
    • (2011) Cytometry A , vol.79 , pp. 167-174
    • Roederer, M.1    Nozzi, J.L.2    Nason, M.C.3
  • 62
    • 0030665257 scopus 로고    scopus 로고
    • + T cell responses associated with control of viremia
    • + T cell responses associated with control of viremia. Science. 278:1447-1450.
    • (1997) Science. , vol.278 , pp. 1447-1450
    • Rosenberg, E.S.1
  • 63
    • 67649849924 scopus 로고    scopus 로고
    • + T cells recognize and inhibit SIV replication in infected macrophages early after infection
    • U. S. A.
    • + T cells recognize and inhibit SIV replication in infected macrophages early after infection. Proc. Natl. Acad. Sci. U. S. A. 106:9791-9796.
    • (2009) Proc. Natl. Acad. Sci. , vol.106 , pp. 9791-9796
    • Sacha, J.B.1
  • 64
    • 34249852256 scopus 로고    scopus 로고
    • HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar CTL activation phenotype
    • U. S. A.
    • Saez-Cirion A, et al. 2007. HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar CTL activation phenotype. Proc. Natl. Acad. Sci. U. S. A. 104:6776-6781.
    • (2007) Proc. Natl. Acad. Sci. , vol.104 , pp. 6776-6781
    • Saez-Cirion, A.1
  • 65
    • 77950525439 scopus 로고    scopus 로고
    • + T cell activation during HIV infection
    • + T cell activation during HIV infection. Nat. Med. 16:452-459.
    • (2010) Nat. Med. , vol.16 , pp. 452-459
    • Said, E.A.1
  • 66
    • 77954348400 scopus 로고    scopus 로고
    • Hepatitis C infection in HIV-1 natural viral suppressors
    • Sajadi MM, Shakeri N, Talwani R, Redfield RR. 2010. Hepatitis C infection in HIV-1 natural viral suppressors. AIDS 24:1689-1695.
    • (2010) AIDS , vol.24 , pp. 1689-1695
    • Sajadi, M.M.1    Shakeri, N.2    Talwani, R.3    Redfield, R.R.4
  • 67
    • 79954568221 scopus 로고    scopus 로고
    • Long-term non-progressors display a greater number of Th17 cells than HIV-infected typical progressors
    • Salgado M, et al. 2011. Long-term non-progressors display a greater number of Th17 cells than HIV-infected typical progressors. Clin. Immunol. 139:110-114.
    • (2011) Clin. Immunol. , vol.139 , pp. 110-114
    • Salgado, M.1
  • 68
    • 20144364902 scopus 로고    scopus 로고
    • + T lymphocyte turnover and activation increase upon viral rebound
    • + T lymphocyte turnover and activation increase upon viral rebound. J. Clin. Invest. 115:443-450.
    • (2005) J. Clin. Invest. , vol.115 , pp. 443-450
    • Scriba, T.J.1
  • 69
    • 27744561661 scopus 로고    scopus 로고
    • Expansion and contraction of HIV-specific CD4 T cells with short bursts of viremia, but physical loss of the majority of these cells with sustained viral replication
    • Seth N, Kaufmann D, Lahey T, Rosenberg ES, Wucherpfennig KW. 2005. Expansion and contraction of HIV-specific CD4 T cells with short bursts of viremia, but physical loss of the majority of these cells with sustained viral replication. J. Immunol. 175:6948-6958.
    • (2005) J. Immunol. , vol.175 , pp. 6948-6958
    • Seth, N.1    Kaufmann, D.2    Lahey, T.3    Rosenberg, E.S.4    Wucherpfennig, K.W.5
  • 70
    • 84857751302 scopus 로고    scopus 로고
    • HIV-specific cytolytic CD4 T cell responses during acute HIV infection predict disease outcome
    • Soghoian DZ, et al. 2012. HIV-specific cytolytic CD4 T cell responses during acute HIV infection predict disease outcome. Sci. Transl. Med. 4:123ra125.
    • (2012) Sci. Transl. Med. , vol.4
    • Soghoian, D.Z.1
  • 71
    • 33947386685 scopus 로고    scopus 로고
    • + T cells are a consequence of antigen load
    • + T cells are a consequence of antigen load.J. Virol. 81:2713-2725.
    • (2007) J. Virol. , vol.81 , pp. 2713-2725
    • Tilton, J.C.1
  • 72
    • 67649991445 scopus 로고    scopus 로고
    • Interleukin-10-secreting T cells define a suppressive subset within the HIV-1-specific T-cell population
    • Torheim EA, et al. 2009. Interleukin-10-secreting T cells define a suppressive subset within the HIV-1-specific T-cell population. Eur. J. Immunol. 39:1280-1287.
    • (2009) Eur. J. Immunol. , vol.39 , pp. 1280-1287
    • Torheim, E.A.1
  • 73
    • 40449085117 scopus 로고    scopus 로고
    • +) T cells during HIV infection
    • +) T cells during HIV infection. Nat. Med. 14:266-274.
    • (2008) Nat. Med. , vol.14 , pp. 266-274
    • van Grevenynghe, J.1
  • 74
    • 77649245149 scopus 로고    scopus 로고
    • + T cells respond to minimal amounts of Gag antigen due to high TCR avidity
    • doi:10.1371/journal.ppat.1000780
    • + T cells respond to minimal amounts of Gag antigen due to high TCR avidity. PLoS Pathog. 6:e1000780. doi:10.1371/journal.ppat.1000780.
    • (2010) PLoS Pathog. , vol.6
    • Vingert, B.1
  • 75
    • 46749115446 scopus 로고    scopus 로고
    • A fundamental role for interleukin-21 in the generation of T follicular helper cells
    • Vogelzang A, et al. 2008. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity. 29:127-137.
    • (2008) Immunity. , vol.29 , pp. 127-137
    • Vogelzang, A.1
  • 76
    • 36849036211 scopus 로고    scopus 로고
    • IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner
    • Wei L, Laurence A, Elias KM, O'Shea JJ. 2007. IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J. Biol. Chem. 282:34605-34610.
    • (2007) J. Biol. Chem. , vol.282 , pp. 34605-34610
    • Wei, L.1    Laurence, A.2    Elias, K.M.3    O'shea, J.J.4
  • 77
    • 79551690940 scopus 로고    scopus 로고
    • Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllers
    • Williams LD, et al. 2011. Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllers. J. Virol. 85:2316-2324..
    • (2011) J. Virol. , vol.85 , pp. 2316-2324
    • Williams, L.D.1
  • 78
    • 77949357362 scopus 로고    scopus 로고
    • T-cell exhaustion: characteristics, causes and conversion
    • Yi JS, Cox MA, Zajac AJ. 2010. T-cell exhaustion: characteristics, causes and conversion. Immunology. 129:474-481.
    • (2010) Immunology. , vol.129 , pp. 474-481
    • Yi, J.S.1    Cox, M.A.2    Zajac, A.J.3
  • 79
    • 67649203681 scopus 로고    scopus 로고
    • A vital role for interleukin-21 in the control of a chronic viral infection
    • Yi JS, Du M, Zajac AJ. 2009. A vital role for interleukin-21 in the control of a chronic viral infection. Science 324:1572-1576.
    • (2009) Science , vol.324 , pp. 1572-1576
    • Yi, J.S.1    Du, M.2    Zajac, A.J.3
  • 81
    • 0347911962 scopus 로고    scopus 로고
    • + T cells endowed with proliferative capacity
    • + T cells endowed with proliferative capacity. J. Exp. Med. 198:1909-1922.
    • (2003) J. Exp. Med. , vol.198 , pp. 1909-1922
    • Younes, S.A.1
  • 82
    • 77957256910 scopus 로고    scopus 로고
    • The elusive identity of T follicular helper cells
    • Yu D, Vinuesa CG. 2010. The elusive identity of T follicular helper cells. Trends Immunol. 31:377-383.
    • (2010) Trends Immunol. , vol.31 , pp. 377-383
    • Yu, D.1    Vinuesa, C.G.2
  • 83
    • 77956198865 scopus 로고    scopus 로고
    • + T cells are induced in acute and chronic progressive HIV infection and are associated with relative viral control
    • + T cells are induced in acute and chronic progressive HIV infection and are associated with relative viral control. J. Immunol. 185:498-506.
    • (2010) J. Immunol. , vol.185 , pp. 498-506
    • Yue, F.Y.1
  • 84
    • 45749136793 scopus 로고    scopus 로고
    • + T cells are detectable in early human immunodeficiency virus type 1 infection
    • + T cells are detectable in early human immunodeficiency virus type 1 infection. J. Virol. 82:6767-6771.
    • (2008) J. Virol , vol.82 , pp. 6767-6771
    • Yue, F.Y.1


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