Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies

Journal of Experimental Medicine

Volumn 210, Issue 4, 2013, Pages 655-663

  McGuire, Andrew T ^a   Hoot, Sam ^a   Dreyer, Anita M ^a   Lippy, Adriana ^a   Stuart, Andrew ^a   Cohen, Kristen W ^a,b   Jardine, Joseph ^c   Menis, Sergey ^c   Scheid, Johannes F ^d   West, Anthony P ^e   Schief, William R ^c   Stamatatos, Leonidas ^a,b  

^a SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d ROCKEFELLER UNIVERSITY   (United States)

^e CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CD4 ANTIBODY; VIRUS ENVELOPE PROTEIN; CD4 ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; NEUTRALIZING ANTIBODY;

ANTIBODY AFFINITY; ANTIBODY COMBINING SITE; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE ACTIVATION; CALCIUM TRANSPORT; CONTROLLED STUDY; HUMAN; HUMAN CELL; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN GLYCOSYLATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; GENETICS; GLYCOSYLATION; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; PROTEIN SECONDARY STRUCTURE; TUMOR CELL LINE;

AIDS VACCINES; ANTIBODIES, NEUTRALIZING; ANTIGENS, CD4; CELL LINE, TUMOR; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; GLYCOSYLATION; HIV ANTIBODIES; HIV-1; HUMANS; PROTEIN ENGINEERING; PROTEIN STRUCTURE, SECONDARY;

MLCS; MLOWN;

EID: 84878626061     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20122824     Document Type: Article

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