The use of skin models in drug development

Advanced Drug Delivery Reviews

Volumn 69-70, Issue , 2014, Pages 81-102

  Mathes, Stephanie H ^a   Ruffner, Heinz ^b   Graf Hausner, Ursula ^a  

^a ZURICH UNIVERSITY OF APPLIED SCIENCES   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Disease; Drugs; Equivalents; Skin

Indexed keywords

DISEASES; SKIN; TISSUE;

ANALYTICAL METHOD; DATA CORRELATIONS; DRUGS; EQUIVALENTS; PHARMACEUTICAL RESEARCH AND DEVELOPMENT; PROCESS AUTOMATION; PRODUCTION PROCEDURE; TECHNICAL DEMANDS;

THREE DIMENSIONAL;

NEW DRUG; DERMATOLOGICAL AGENT;

ANALYSIS; ANALYTIC METHOD; AUTOMATION; BIOLOGICAL ACTIVITY; BIOLOGICAL MODEL; COMPARATIVE STUDY; CORRELATION ANALYSIS; DISEASE MODEL; DRUG ADMINISTRATION; DRUG DEVELOPMENT; DRUG FORMULATION; DRUG METABOLISM; ENDOTHELIUM CELL; EPIDERMIS; EXPLANT; HAIR FOLLICLE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LANGERHANS CELL; MOLECULAR ANALYSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; SKIN; SKIN DISEASE; SKIN MODEL; SKIN PIGMENTATION; STANDARD; STEM CELL; STRUCTURAL ANALYSIS; SUBCUTANEOUS TISSUE; TISSUE ENGINEERING; ANIMAL; CULTURE TECHNIQUE; DRUG EFFECTS; FUNCTIONS OF THE SKIN AND ITS APPENDAGES; ORGAN CULTURE TECHNIQUE; PATHOLOGY; PROCEDURES; SKIN DISEASES; TRENDS;

ANIMALS; CELL CULTURE TECHNIQUES; DERMATOLOGIC AGENTS; DRUG DISCOVERY; HUMANS; MODELS, BIOLOGICAL; ORGAN CULTURE TECHNIQUES; SKIN DISEASES; SKIN PHYSIOLOGICAL PHENOMENA;

EID: 84899994174     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2013.12.006     Document Type: Review

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