Organotypic cell cultures and two-photon imaging: Tools for in vitro and in vivo assessment of percutaneous drug delivery and skin toxicity

Journal of Controlled Release

Volumn 161, Issue 2, 2012, Pages 656-667

  Pappinen, Sari ^a   Pryazhnikov, Evgeny ^b,c   Khiroug, Leonard ^b,c   Ericson, Marica B ^d   Yliperttula, Marjo ^b   Urtti, Arto ^b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c Neurotar Ltd   (Finland)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Cell culture; Imaging; Permeability; Skin irritation; Transdermal drug delivery; Two photon microscopy

Indexed keywords

BARRIER PROPERTIES; DRUG ABSORPTION; DRUG PERMEATION; EMERGING TECHNOLOGIES; HARMFUL CHEMICALS; HUMAN SKIN; IN-VITRO; IN-VIVO; MICROSCOPIC IMAGING; PERMEANTS; PERMEATION PROCESS; PROTECTIVE LAYERS; RAPID DEVELOPMENT; SKIN EQUIVALENTS; SKIN IRRITATION; SKIN STRUCTURE; SKIN TOXICITY; STRATUM CORNEUM; TRANSDERMAL DRUG DELIVERY; TWO PHOTON; TWO PHOTON IMAGING; TWO PHOTON MICROSCOPY;

CELL CULTURE; DRUG DELIVERY; IMAGING TECHNIQUES; MECHANICAL PERMEABILITY; MICROSCOPIC EXAMINATION; PERMEATION; PHOTONS; TOXICITY; VISUALIZATION;

SKIN;

PENETRATION ENHANCING AGENT; SKIN LIPID;

CELL CULTURE; CYTOTOXICITY TEST; DISEASE MODEL; DRUG DELIVERY SYSTEM; DRUG PENETRATION; EXPERIMENTAL RAT; HUMAN; MELANOMA; MOLECULAR IMAGING; NONHUMAN; ORGANOTYPIC CELL CULTURE; PERCUTANEOUS DRUG DELIVERY; PRIORITY JOURNAL; PSORIASIS; REVIEW; SKIN IRRITATION; SKIN PERMEABILITY; SKIN STRUCTURE; SKIN TOXICITY; TOXICITY TESTING; TRANSDERMAL DRUG ADMINISTRATION; TWO PHOTON MICROSCOPIC IMAGING;

ADMINISTRATION, CUTANEOUS; ANIMALS; CELL CULTURE TECHNIQUES; HUMANS; IRRITANTS; MICROSCOPY, FLUORESCENCE, MULTIPHOTON; PERMEABILITY; SKIN; SKIN ABSORPTION;

EID: 84862638855     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.03.005     Document Type: Review

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