메뉴 건너뛰기




Volumn 8, Issue 4, 2011, Pages S12-S19

Validating transcripts with probes and imaging technology

Author keywords

[No Author keywords available]

Indexed keywords

FLUORESCENT DYE; MESSENGER RNA;

EID: 79953273690     PISSN: 15487091     EISSN: 15487105     Source Type: Journal    
DOI: 10.1038/nmeth.1573     Document Type: Article
Times cited : (179)

References (78)
  • 2
    • 0030992159 scopus 로고    scopus 로고
    • Discovery and analysis of inflammatory disease-related genes using cDNA microarrays
    • Heller, R.A. et al. Discovery and analysis of inflammatory disease-related genes using cDNA microarrays. Proc. Natl. Acad. Sci. USA 94, 2150-2155 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 2150-2155
    • Heller, R.A.1
  • 3
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • Sorlie, T. et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl. Acad. Sci. USA 98, 10869-10874 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 10869-10874
    • Sorlie, T.1
  • 4
    • 18244409687 scopus 로고    scopus 로고
    • Gene expression profiling predicts clinical outcome of breast cancer
    • van’t Veer, L.J. et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 415, 530-536 (2002).
    • (2002) Nature , vol.415 , pp. 530-536
    • Van’t Veer, L.J.1
  • 5
    • 0037213715 scopus 로고    scopus 로고
    • Gene expression and the myth of the average cell
    • Levsky, J.M. & Singer, R.H. Gene expression and the myth of the average cell. Trends Cell Biol. 13, 4-6 (2003).
    • (2003) Trends Cell Biol , vol.13 , pp. 4-6
    • Levsky, J.M.1    Singer, R.H.2
  • 6
    • 53549123008 scopus 로고    scopus 로고
    • Nature, nurture or chance: Stochastic gene expression and its consequences
    • Raj, A. & van Oudenaarden, A. Nature, nurture or chance: Stochastic gene expression and its consequences. Cell 135, 216-226 (2008).
    • (2008) Cell , vol.135 , pp. 216-226
    • Raj, A.1    Van Oudenaarden, A.2
  • 7
    • 0031004175 scopus 로고    scopus 로고
    • Genetic instability in colorectal cancers
    • Lengauer, C., Kinzler, K.W. & Vogelstein, B. Genetic instability in colorectal cancers. Nature 386, 623-627 (1997).
    • (1997) Nature , vol.386 , pp. 623-627
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 8
    • 76649128993 scopus 로고    scopus 로고
    • Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype
    • Park, S.Y., Gonen, M., Kim, H.J., Michor, F. & Polyak, K. Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype. J. Clin. Invest. 120, 636-644 (2010).
    • (2010) J. Clin. Invest , vol.120 , pp. 636-644
    • Park, S.Y.1    Gonen, M.2    Kim, H.J.3    Michor, F.4    Polyak, K.5
  • 9
    • 74949101897 scopus 로고    scopus 로고
    • Inferring tumor progression from genomic heterogeneity
    • Navin, N. et al. Inferring tumor progression from genomic heterogeneity. Genome Res. 20, 68-80 (2010).
    • (2010) Genome Res , vol.20 , pp. 68-80
    • Navin, N.1
  • 11
    • 0030575911 scopus 로고    scopus 로고
    • Laser capture microdissection
    • Emmert-Buck, M.R. et al. Laser capture microdissection. Science 274, 998-1001 (1996).
    • (1996) Science , vol.274 , pp. 998-1001
    • Emmert-Buck, M.R.1
  • 12
    • 0032894224 scopus 로고    scopus 로고
    • Quantitative RT-PCR: Pitfalls and potential
    • Freeman, W.M., Walker, S.J. & Vrana, K.E. Quantitative RT-PCR: Pitfalls and potential. Biotechniques 26, 112-125 (1999).
    • (1999) Biotechniques , vol.26 , pp. 112-125
    • Freeman, W.M.1    Walker, S.J.2    Vrana, K.E.3
  • 13
    • 33845218548 scopus 로고    scopus 로고
    • Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR
    • Warren, L., Bryder, D., Weissman, I.L. & Quake, S.R. Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR. Proc. Natl. Acad. Sci. USA 103, 17807-17812 (2006).
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 17807-17812
    • Warren, L.1    Bryder, D.2    Weissman, I.L.3    Quake, S.R.4
  • 14
    • 61349150537 scopus 로고    scopus 로고
    • Transcription factor achaete scute-like 2 controls intestinal stem cell fate
    • van der Flier, L.G. et al. Transcription factor achaete scute-like 2 controls intestinal stem cell fate. Cell 136, 903-912 (2009).
    • (2009) Cell , vol.136 , pp. 903-912
    • Van Der Flier, L.G.1
  • 15
    • 0042671348 scopus 로고    scopus 로고
    • Fluorescence in situ hybridization: Past, present and future
    • Levsky, J.M. & Singer, R.H. Fluorescence in situ hybridization: Past, present and future. J. Cell Sci. 116, 2833-2838 (2003).
    • (2003) J. Cell Sci , vol.116 , pp. 2833-2838
    • Levsky, J.M.1    Singer, R.H.2
  • 16
    • 0034024980 scopus 로고    scopus 로고
    • Cytochemical nucleic acid research during the twentieth century
    • van der Ploeg, M. Cytochemical nucleic acid research during the twentieth century. Eur. J. Histochem. 44, 7-42 (2000).
    • (2000) Eur. J. Histochem , vol.44 , pp. 7-42
    • Van Der Ploeg, M.1
  • 17
    • 75949124381 scopus 로고    scopus 로고
    • In situ hybridization to identify gut stem cells
    • chapter 11, unit 2F.1
    • Gregorieff, A. & Clevers, H. In situ hybridization to identify gut stem cells. Curr. Protoc. Stem. Cell. Biol. chapter 11, unit 2F.1 (2010).
    • (2010) Curr. Protoc. Stem. Cell. Biol
    • Gregorieff, A.1    Clevers, H.2
  • 18
    • 71649113974 scopus 로고    scopus 로고
    • Visualization of individual Scr mRNAs during Drosophila embryogenesis yields evidence for transcriptional bursting
    • Pare, A. et al. Visualization of individual Scr mRNAs during Drosophila embryogenesis yields evidence for transcriptional bursting. Curr. Biol. 19, 2037-2042 (2009).
    • (2009) Curr. Biol , vol.19 , pp. 2037-2042
    • Pare, A.1
  • 19
    • 0030820621 scopus 로고    scopus 로고
    • Stability, specificity and fluorescence brightness of multiply-labeled fluorescent DNA probes
    • Randolph, J.B. & Waggoner, A.S. Stability, specificity and fluorescence brightness of multiply-labeled fluorescent DNA probes. Nucleic Acids Res. 25, 2923-2929 (1997).
    • (1997) Nucleic Acids Res , vol.25 , pp. 2923-2929
    • Randolph, J.B.1    Waggoner, A.S.2
  • 21
    • 0032562720 scopus 로고    scopus 로고
    • Visualization of single RNA transcripts in situ
    • This pioneering work demonstrated single-molecule transcript imaging in fixed cells using multiply-labeled fluorescent probes
    • Femino, A.M., Fay, F.S., Fogarty, K. & Singer, R.H. Visualization of single RNA transcripts in situ. Science 280, 585-590 (1998).This pioneering work demonstrated single-molecule transcript imaging in fixed cells using multiply-labeled fluorescent probes.
    • (1998) Science , vol.280 , pp. 585-590
    • Femino, A.M.1    Fay, F.S.2    Fogarty, K.3    Singer, R.H.4
  • 23
    • 34547604468 scopus 로고    scopus 로고
    • Noise in gene expression determines cell fate in Bacillus subtilis
    • Maamar, H., Raj, A. & Dubnau, D. Noise in gene expression determines cell fate in Bacillus subtilis. Science 317, 526-529 (2007).
    • (2007) Science , vol.317 , pp. 526-529
    • Maamar, H.1    Raj, A.2    Dubnau, D.3
  • 24
    • 57149101122 scopus 로고    scopus 로고
    • Single-RNA counting reveals alternative modes of gene expression in yeast
    • Zenklusen, D., Larson, D.R. & Singer, R.H. Single-RNA counting reveals alternative modes of gene expression in yeast. Nat. Struct. Mol. Biol. 15, 1263-1271 (2008).
    • (2008) Nat. Struct. Mol. Biol , vol.15 , pp. 1263-1271
    • Zenklusen, D.1    Larson, D.R.2    Singer, R.H.3
  • 25
    • 77951101695 scopus 로고    scopus 로고
    • Transcript counting in single cells reveals dynamics of rDNA transcription
    • Tan, R.Z. & van Oudenaarden, A. Transcript counting in single cells reveals dynamics of rDNA transcription. Mol. Syst. Biol. 6, 358 (2010).
    • (2010) Mol. Syst. Biol , vol.6 , pp. 358
    • Tan, R.Z.1    Van Oudenaarden, A.2
  • 27
    • 24044542944 scopus 로고    scopus 로고
    • Gene expression profiling in single cells within tissue
    • Capodieci, P. et al. Gene expression profiling in single cells within tissue. Nat. Methods 2, 663-665 (2005).
    • (2005) Nat. Methods , vol.2 , pp. 663-665
    • Capodieci, P.1
  • 28
    • 53349161901 scopus 로고    scopus 로고
    • Imaging individual mRNA molecules using multiple singly labeled probes
    • Single-molecule transcript imaging in cells and in fixed tissues was achieved using multiple singly labeled probes
    • Raj, A., van den Bogaard, P., Rifkin, S.A., van Oudenaarden, A. & Tyagi, S. Imaging individual mRNA molecules using multiple singly labeled probes. Nat. Methods 5, 877-879 (2008).Single-molecule transcript imaging in cells and in fixed tissues was achieved using multiple singly labeled probes.
    • (2008) Nat. Methods , vol.5 , pp. 877-879
    • Raj, A.1    Van Den Bogaard, P.2    Rifkin, S.A.3    Van Oudenaarden, A.4    Tyagi, S.5
  • 29
    • 77649220197 scopus 로고    scopus 로고
    • Noise can induce bimodality in positive transcriptional feedback loops without bistability
    • To, T.L. & Maheshri, N. Noise can induce bimodality in positive transcriptional feedback loops without bistability. Science 327, 1142-1145 (2010).
    • (2010) Science , vol.327 , pp. 1142-1145
    • To, T.L.1    Maheshri, N.2
  • 30
    • 67650921949 scopus 로고    scopus 로고
    • Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression
    • Khalil, A.M. et al. Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc. Natl. Acad. Sci. USA 106, 11667-11672 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 11667-11672
    • Khalil, A.M.1
  • 31
    • 77249114260 scopus 로고    scopus 로고
    • Variability in gene expression underlies incomplete penetrance
    • Raj, A., Rifkin, S.A., Andersen, E. & van Oudenaarden, A. Variability in gene expression underlies incomplete penetrance. Nature 463, 913-918 (2010).
    • (2010) Nature , vol.463 , pp. 913-918
    • Raj, A.1    Rifkin, S.A.2    Ersen, E.3    Van Oudenaarden, A.4
  • 32
    • 77955102352 scopus 로고    scopus 로고
    • Quantifying E. Coli proteome and transcriptome with single-molecule sensitivity in single cells
    • Taniguchi, Y. et al. Quantifying E. coli proteome and transcriptome with single-molecule sensitivity in single cells. Science 329, 533-538 (2010).
    • (2010) Science , vol.329 , pp. 533-538
    • Taniguchi, Y.1
  • 33
    • 69049086730 scopus 로고    scopus 로고
    • Imaging individual microRNAs in single mammalian cells in situ
    • Lu, J. & Tsourkas, A. Imaging individual microRNAs in single mammalian cells in situ. Nucleic Acids Res. 37, e100 (2009).
    • (2009) Nucleic Acids Res , vol.37 , pp. e100
    • Lu, J.1    Tsourkas, A.2
  • 34
    • 77952243279 scopus 로고    scopus 로고
    • In situ detection and genotyping of individual mRNA molecules
    • This work introduced a sensitive single-molecule transcript-imaging technique that uses padlock probes and in situ target-primed rolling-circle amplification in cells and tissues to specifically detect targets with a single nucleotide difference
    • Larsson, C., Grundberg, I., Soderberg, O. & Nilsson, M. In situ detection and genotyping of individual mRNA molecules. Nat. Methods 7, 395-397 (2010). This work introduced a sensitive single-molecule transcript-imaging technique that uses padlock probes and in situ target-primed rolling-circle amplification in cells and tissues to specifically detect targets with a single nucleotide difference.
    • (2010) Nat. Methods , vol.7 , pp. 395-397
    • Larsson, C.1    Grundberg, I.2    Soderberg, O.3    Nilsson, M.4
  • 35
  • 36
    • 0029939848 scopus 로고    scopus 로고
    • Heterogeneity in telomere length of human chromosomes
    • Lansdorp, P.M. et al. Heterogeneity in telomere length of human chromosomes. Hum. Mol. Genet. 5, 685-691 (1996).
    • (1996) Hum. Mol. Genet , vol.5 , pp. 685-691
    • Lansdorp, P.M.1
  • 37
    • 31344454565 scopus 로고    scopus 로고
    • In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes
    • Kloosterman, W.P., Wienholds, E., de Bruijn, E., Kauppinen, S. & Plasterk, R.H. In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes. Nat. Methods 3, 27-29 (2006).
    • (2006) Nat. Methods , vol.3 , pp. 27-29
    • Kloosterman, W.P.1    Wienholds, E.2    de Bruijn, E.3    Kauppinen, S.4    Plasterk, R.H.5
  • 39
    • 0037008488 scopus 로고    scopus 로고
    • Single-cell gene-expression profiling
    • This work substantially increased the number of targets that can be simultaneously imaged by using combination of probes labeled with spectrally distinct fluorophores
    • Levsky, J.M., Shenoy, S.M., Pezo, R.C. & Singer, R.H. Single-cell gene-expression profiling. Science 297, 836-840 (2002).This work substantially increased the number of targets that can be simultaneously imaged by using combination of probes labeled with spectrally distinct fluorophores.
    • (2002) Science , vol.297 , pp. 836-840
    • Levsky, J.M.1    Shenoy, S.M.2    Pezo, R.C.3    Singer, R.H.4
  • 40
    • 0026475032 scopus 로고
    • Fluorescence ratio measurements of double-labeled probes for multiple in situ hybridization by digital imaging microscopy
    • Nederlof, P.M., van der Flier, S., Vrolijk, J., Tanke, H.J. & Raap, A.K. Fluorescence ratio measurements of double-labeled probes for multiple in situ hybridization by digital imaging microscopy. Cytometry 13, 839-845 (1992).
    • (1992) Cytometry , vol.13 , pp. 839-845
    • Nederlof, P.M.1    Van Der Flier, S.2    Vrolijk, J.3    Tanke, H.J.4    Raap, A.K.5
  • 41
    • 0025092180 scopus 로고
    • Multiple fluorescence in situ hybridization
    • Nederlof, P.M. et al. Multiple fluorescence in situ hybridization. Cytometry 11, 126-131 (1990).
    • (1990) Cytometry , vol.11 , pp. 126-131
    • Nederlof, P.M.1
  • 43
    • 28944434119 scopus 로고    scopus 로고
    • Real-time kinetics of gene activity in individual bacteria
    • Golding, I., Paulsson, J., Zawilski, S.M. & Cox, E.C. Real-time kinetics of gene activity in individual bacteria. Cell 123, 1025-1036 (2005).
    • (2005) Cell , vol.123 , pp. 1025-1036
    • Golding, I.1    Paulsson, J.2    Zawilski, S.M.3    Cox, E.C.4
  • 44
    • 0032185810 scopus 로고    scopus 로고
    • Localization of ASH1 mRNA particles in living yeast. Mol
    • This work introduced the MS2 method for single mRNA detection in live cells
    • Bertrand, E. et al. Localization of ASH1 mRNA particles in living yeast. Mol. Cell 2, 437-445 (1998).This work introduced the MS2 method for single mRNA detection in live cells.
    • (1998) Cell , vol.2 , pp. 437-445
    • Bertrand, E.1
  • 45
    • 0347156907 scopus 로고    scopus 로고
    • Single mRNA molecules demonstrate probabilistic movement in living mammalian cells
    • Fusco, D. et al. Single mRNA molecules demonstrate probabilistic movement in living mammalian cells. Curr. Biol. 13, 161-167 (2003).
    • (2003) Curr. Biol , vol.13 , pp. 161-167
    • Fusco, D.1
  • 46
    • 2942733310 scopus 로고    scopus 로고
    • Dynamics of single mRNPs in nuclei of living cells
    • Shav-Tal, Y. et al. Dynamics of single mRNPs in nuclei of living cells. Science 304, 1797-1800 (2004).
    • (2004) Science , vol.304 , pp. 1797-1800
    • Shav-Tal, Y.1
  • 47
    • 34250219568 scopus 로고    scopus 로고
    • A genomic integration method to visualize localization of endogenous mRNAs in living yeast
    • Haim, L., Zipor, G., Aronov, S. & Gerst, J.E. A genomic integration method to visualize localization of endogenous mRNAs in living yeast. Nat. Methods 4, 409-412 (2007).
    • (2007) Nat. Methods , vol.4 , pp. 409-412
    • Haim, L.1    Zipor, G.2    Aronov, S.3    Gerst, J.E.4
  • 48
    • 4444285375 scopus 로고    scopus 로고
    • Visualization of RNA-protein interactions in living cells: FMRP and IMP1 interact on mRNAs
    • Rackham, O. & Brown, C.M. Visualization of RNA-protein interactions in living cells: FMRP and IMP1 interact on mRNAs. EMBO J. 23, 3346-3355 (2004).
    • (2004) EMBO J , vol.23 , pp. 3346-3355
    • Rackham, O.1    Brown, C.M.2
  • 49
    • 65449131152 scopus 로고    scopus 로고
    • Imaging intracellular RNA distribution and dynamics in living cells
    • Tyagi, S. Imaging intracellular RNA distribution and dynamics in living cells. Nat. Methods 6, 331-338 (2009).
    • (2009) Nat. Methods , vol.6 , pp. 331-338
    • Tyagi, S.1
  • 50
    • 34250191761 scopus 로고    scopus 로고
    • RNA visualization in live bacterial cells using fluorescent protein complementation
    • Valencia-Burton, M., McCullough, R.M., Cantor, C.R. & Broude, N.E. RNA visualization in live bacterial cells using fluorescent protein complementation. Nat. Methods 4, 421-427 (2007).
    • (2007) Nat. Methods , vol.4 , pp. 421-427
    • Valencia-Burton, M.1    McCullough, R.M.2    Cantor, C.R.3    Broude, N.E.4
  • 51
    • 34250210525 scopus 로고    scopus 로고
    • Imaging dynamics of endogenous mitochondrial RNA in single living cells
    • Ozawa, T., Natori, Y., Sato, M. & Umezawa, Y. Imaging dynamics of endogenous mitochondrial RNA in single living cells. Nat. Methods 4, 413-419 (2007).
    • (2007) Nat. Methods , vol.4 , pp. 413-419
    • Ozawa, T.1    Natori, Y.2    Sato, M.3    Umezawa, Y.4
  • 52
    • 0029670262 scopus 로고    scopus 로고
    • Molecular beacons: Probes that fluoresce upon hybridization
    • Molecular beacons were introduced for the detection of single mRNAs in live cells
    • Tyagi, S. & Kramer, F.R. Molecular beacons: Probes that fluoresce upon hybridization. Nat. Biotechnol. 14, 303-308 (1996). Molecular beacons were introduced for the detection of single mRNAs in live cells.
    • (1996) Nat. Biotechnol , vol.14 , pp. 303-308
    • Tyagi, S.1    Kramer, F.R.2
  • 55
    • 77949838467 scopus 로고    scopus 로고
    • Single molecule densitive multivalent polyethylene glycol probes for RNA imaging
    • Lifland, A.W., Zurla, C. & Santangelo, P.J. Single molecule densitive multivalent polyethylene glycol probes for RNA imaging. Bioconjug. Chem. 21, 483-488 (2010).
    • (2010) Bioconjug. Chem , vol.21 , pp. 483-488
    • Lifland, A.W.1    Zurla, C.2    Santangelo, P.J.3
  • 56
    • 67349101852 scopus 로고    scopus 로고
    • Single molecule-sensitive probes for imaging RNA in live cells
    • Santangelo, P.J. et al. Single molecule-sensitive probes for imaging RNA in live cells. Nat. Methods 6, 347-349 (2009).
    • (2009) Nat. Methods , vol.6 , pp. 347-349
    • Santangelo, P.J.1
  • 57
    • 0036231415 scopus 로고    scopus 로고
    • Precise nanometer localization analysis for individual fluorescent probes
    • Thompson, R.E., Larson, D.R. & Webb, W.W. Precise nanometer localization analysis for individual fluorescent probes. Biophys. J. 82, 2775-2783 (2002).
    • (2002) Biophys. J , vol.82 , pp. 2775-2783
    • Thompson, R.E.1    Larson, D.R.2    Webb, W.W.3
  • 59
    • 0033384861 scopus 로고    scopus 로고
    • Three-dimensional imaging by deconvolution microscopy
    • McNally, J.G., Karpova, T., Cooper, J. & Conchello, J.A. Three-dimensional imaging by deconvolution microscopy. Methods 19, 373-385 (1999).
    • (1999) Methods , vol.19 , pp. 373-385
    • McNally, J.G.1    Karpova, T.2    Cooper, J.3    Conchello, J.A.4
  • 60
    • 77952216273 scopus 로고    scopus 로고
    • Fast, single-molecule localization that achieves theoretically minimum uncertainty
    • Smith, C.S., Joseph, N., Rieger, B. & Lidke, K.A. Fast, single-molecule localization that achieves theoretically minimum uncertainty. Nat. Methods 7, 373-375 (2010).
    • (2010) Nat. Methods , vol.7 , pp. 373-375
    • Smith, C.S.1    Joseph, N.2    Rieger, B.3    Lidke, K.A.4
  • 61
    • 67651159312 scopus 로고    scopus 로고
    • Stem cells, self-renewal, and differentiation in the intestinal epithelium
    • van der Flier, L.G. & Clevers, H. Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu. Rev. Physiol. 71, 241-260 (2009).
    • (2009) Annu. Rev. Physiol , vol.71 , pp. 241-260
    • Van Der Flier, L.G.1    Clevers, H.2
  • 62
    • 34249079154 scopus 로고    scopus 로고
    • Network motifs: Theory and experimental approaches
    • Alon, U. Network motifs: Theory and experimental approaches. Nat. Rev. Genet. 8, 450-461 (2007).
    • (2007) Nat. Rev. Genet , vol.8 , pp. 450-461
    • Alon, U.1
  • 64
    • 0034682512 scopus 로고    scopus 로고
    • Fluorescence microscopy with diffraction resolution barrier broken by stimulated emission
    • Klar, T.A., Jakobs, S., Dyba, M., Egner, A. & Hell, S.W. Fluorescence microscopy with diffraction resolution barrier broken by stimulated emission. Proc. Natl. Acad. Sci. USA 97, 8206-8210 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 8206-8210
    • Klar, T.A.1    Jakobs, S.2    Dyba, M.3    Egner, A.4    Hell, S.W.5
  • 65
    • 33749026335 scopus 로고    scopus 로고
    • Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM)
    • Rust, M.J., Bates, M. & Zhuang, X. Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). Nat. Methods 3, 793-795 (2006).
    • (2006) Nat. Methods , vol.3 , pp. 793-795
    • Rust, M.J.1    Bates, M.2    Zhuang, X.3
  • 66
    • 33747179417 scopus 로고    scopus 로고
    • Imaging intracellular fluorescent proteins at nanometer resolution
    • Betzig, E. et al. Imaging intracellular fluorescent proteins at nanometer resolution. Science 313, 1642-1645 (2006).
    • (2006) Science , vol.313 , pp. 1642-1645
    • Betzig, E.1
  • 67
    • 34249945258 scopus 로고    scopus 로고
    • Far-field optical nanoscopy
    • Hell, S.W. Far-field optical nanoscopy. Science 316, 1153-1158 (2007).
    • (2007) Science , vol.316 , pp. 1153-1158
    • Hell, S.W.1
  • 68
    • 42949083695 scopus 로고    scopus 로고
    • Live-cell photoactivated localization microscopy of nanoscale adhesion dynamics
    • Shroff, H., Galbraith, C.G., Galbraith, J.A. & Betzig, E. Live-cell photoactivated localization microscopy of nanoscale adhesion dynamics. Nat. Methods 5, 417-423 (2008).
    • (2008) Nat. Methods , vol.5 , pp. 417-423
    • Shroff, H.1    Galbraith, C.G.2    Galbraith, J.A.3    Betzig, E.4
  • 69
    • 0031964360 scopus 로고    scopus 로고
    • Sorting of beta-actin mRNA and protein to neurites and growth cones in culture
    • Bassell, G.J. et al. Sorting of beta-actin mRNA and protein to neurites and growth cones in culture. J. Neurosci. 18, 251-265 (1998).
    • (1998) J. Neurosci , vol.18 , pp. 251-265
    • Bassell, G.J.1
  • 70
    • 70349440771 scopus 로고    scopus 로고
    • In situ visualization of gene expression using polymer- coated quantum-dot-DNA conjugates
    • Choi, Y. et al. In situ visualization of gene expression using polymer- coated quantum-dot-DNA conjugates. Small 5, 2085-2091 (2009).
    • (2009) Small , vol.5 , pp. 2085-2091
    • Choi, Y.1
  • 71
    • 28544438826 scopus 로고    scopus 로고
    • Method for multiplex cellular detection of mRNAs using quantum dot fluorescent in situ hybridization
    • Chan, P., Yuen, T., Ruf, F., Gonzalez-Maeso, J. & Sealfon, S.C. Method for multiplex cellular detection of mRNAs using quantum dot fluorescent in situ hybridization. Nucleic Acids Res. 33, e161 (2005).
    • (2005) Nucleic Acids Res , vol.33 , pp. e161
    • Chan, P.1    Yuen, T.2    Ruf, F.3    Gonzalez-Maeso, J.4    Sealfon, S.C.5
  • 72
    • 40449139964 scopus 로고    scopus 로고
    • Identification of a serotonin/glutamate receptor complex implicated in psychosis
    • Gonzalez-Maeso, J. et al. Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature 452, 93-97 (2008).
    • (2008) Nature , vol.452 , pp. 93-97
    • Gonzalez-Maeso, J.1
  • 73
    • 46749091612 scopus 로고    scopus 로고
    • Bioconjugated quantum dots for in vivo molecular and cellular imaging
    • Smith, A.M., Duan, H., Mohs, A.M. & Nie, S. Bioconjugated quantum dots for in vivo molecular and cellular imaging. Adv. Drug Deliv. Rev. 60, 1226-1240 (2008).
    • (2008) Adv. Drug Deliv. Rev , vol.60 , pp. 1226-1240
    • Smith, A.M.1    Duan, H.2    Mohs, A.M.3    Nie, S.4
  • 74
    • 33746885087 scopus 로고    scopus 로고
    • Imaging of multiple mRNA targets using quantum dot based in situ hybridization and spectral deconvolution in clinical biopsies
    • Tholouli, E. et al. Imaging of multiple mRNA targets using quantum dot based in situ hybridization and spectral deconvolution in clinical biopsies. Biochem. Biophys. Res. Commun. 348, 628-636 (2006).
    • (2006) Biochem. Biophys. Res. Commun , vol.348 , pp. 628-636
    • Tholouli, E.1
  • 75
    • 61649121490 scopus 로고    scopus 로고
    • Single molecule tracking of quantum dot-labeled mRNAs in a cell nucleus
    • Ishihama, Y. & Funatsu, T. Single molecule tracking of quantum dot-labeled mRNAs in a cell nucleus. Biochem. Biophys. Res. Commun. 381, 33-38 (2009).
    • (2009) Biochem. Biophys. Res. Commun , vol.381 , pp. 33-38
    • Ishihama, Y.1    Funatsu, T.2
  • 76
    • 77955953680 scopus 로고    scopus 로고
    • Making the message clear: Visualizing mRNA localization
    • Weil, T.T., Parton, R.M. & Davis, I. Making the message clear: Visualizing mRNA localization. Trends Cell Biol. 20, 380-390 (2010).
    • (2010) Trends Cell Biol , vol.20 , pp. 380-390
    • Weil, T.T.1    Parton, R.M.2    Davis, I.3
  • 77
    • 0024319520 scopus 로고
    • A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback
    • Tautz, D. & Pfeifle, C. A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. Chromosoma 98, 81-85 (1989).
    • (1989) Chromosoma , vol.98 , pp. 81-85
    • Tautz, D.1    Pfeifle, C.2
  • 78
    • 0032614932 scopus 로고    scopus 로고
    • Using green fluorescent protein fusion proteins to quantitate microtubule and spindle dynamics in budding yeast
    • Bloom, K.S. et al. Using green fluorescent protein fusion proteins to quantitate microtubule and spindle dynamics in budding yeast. Methods Cell Biol. 61, 369-383 (1999).
    • (1999) Methods Cell Biol , vol.61 , pp. 369-383
    • Bloom, K.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.