Increased presence of monounsaturated fatty acids in the stratum corneum of human skin equivalents

Journal of Investigative Dermatology

Volumn 133, Issue 1, 2013, Pages 59-67

  Thakoersing, Varsha S ^a   Van Smeden, Jeroen ^a   Mulder, Aat A ^a   Vreeken, Rob J ^a   El Ghalbzouri, Abdoelwaheb ^b   Bouwstra, Joke A ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE; ACYL COENZYME A DESATURASE 1; CERAMIDE; CHOLESTEROL; MONOUNSATURATED FATTY ACID; SATURATED FATTY ACID;

ARTICLE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FATTY ACID DESATURATION; FATTY ACID SYNTHESIS; FIBROBLAST; HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; LIPID ANALYSIS; LIPID COMPOSITION; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN; STRATUM CORNEUM;

EID: 84872186168     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2012.262     Document Type: Article

References (40)

1. Ackermann K, Borgia SL, Korting HC et al. (2010) The Phenion full-thickness skin model for percutaneous absorption testing. Skin Pharmacol Physiol 23:105-122
2. Alepee N, Tornier C, Robert C et al. (2009) A catch-up validation study on reconstructed human epidermis (SkinEthic RHE) for full replacement of the Draize skin irritation test. Toxicol In Vitro 24:257-666
3. Asbill C, Kim N, El-Kattan A et al. (2000) Evaluation of a human bioengineered skin equivalent for drug permeation studies. Pharm Res 17:1092-77
4. Batheja P, Song Y, Wertz P et al. (2009) Effects of growth conditions on the barrier properties of a human skin equivalent. Pharm Res 26:1689-7000
5. Bligh EG, Dyer WJ (1959) A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37:911-77
6. Bouwstra J, Pilgram G, Gooris G et al. (2001) New aspects of the skin barrier organization. Skin Pharmacol Appl Skin Physiol 14(Suppl 1):52-622
7. Bouwstra JA, Gooris GS, van der Spek JA et al. (1991) Structural investigations of human stratum corneum by small-angle X-ray scattering. J Invest Dermatol 97:1005-122
8. Bouwstra JA, Groenink HW, Kempenaar JA et al. (2008) Water distribution and natural moisturizer factor content in human skin equivalents are regulated by environmental relative humidity. J Invest Dermatol 128:378-888
9. Bouwstra JA, Ponec M (2006) The skin barrier in healthy and diseased state. Biochim Biophys Acta 1758:2080-955
10. Damien F, Boncheva M (2010) The extent of orthorhombic lipid phases in the stratum corneum determines the barrier efficiency of human skin in vivo. J Invest Dermatol 130:611-44
11. De Jager M, Gooris G, Ponec M et al. (2004) Acylceramide head group architecture affects lipid organization in synthetic ceramide mixtures. J Invest Dermatol 123:911-66
12. El Ghalbzouri A, Commandeur S, Rietveld MH et al. (2009) Replacement of animal-derived collagen matrix by human fibroblast-derived dermal matrix for human skin equivalent products. Biomaterials 30:71-88
13. El Ghalbzouri A, Siamari R, Willemze R et al. (2008) Leiden reconstructed human epidermal model as a tool for the evaluation of the skin corrosion and irritation potential according to the ECVAM guidelines. Toxicol In Vitro 22:1311-200
14. Feingold KR (2009) The outer frontier: The importance of lipid metabolism in the skin. J Lipid Res 50(Suppl):S417-222
15. Gault CR, Obeid LM, Hannun YA (2010) An overview of sphingolipid metabolism: From synthesis to breakdown. Adv Exp Med Biol 688:1-233
16. Gibbs S (2009) In vitro irritation models and immune reactions. Skin Pharmacol Physiol 22:103-133
17. Jennemann R, Rabionet M, Gorgas K et al. (2012) Loss of ceramide synthase 33 causes lethal skin barrier disruption. Hum Mol Genet 21:586-6088
18. Liu G (2009) Stearoyl-CoA desaturase inhibitors: Update on patented compounds. Expert Opin Ther Pat 19:1169-911
19. Masukawa Y, Narita H, Sato H et al. (2009) Comprehensive quantification of ceramide species in human stratum corneum. J Lipid Res 50:1708-199
20. Masukawa Y, Narita H, Shimizu E et al. (2008) Characterization of overall ceramide species in human stratum corneum. J Lipid Res 49:1466-766
21. Mauvoisin D, Mounier C (2011) Hormonal and nutritional regulation of SCD11 gene expression. Biochimie 93:78-866
22. Miyazaki M, Dobrzyn A, Elias PM et al. (2005) Stearoyl-CoA desaturase-22 gene expression is required for lipid synthesis during early skin and liver development. Proc Natl Acad Sci USA 102:12501-66
23. Mizutani Y, Mitsutake S, Tsuji K et al. (2009) Ceramide biosynthesis in keratinocyte and its role in skin function. Biochimie 91:784-900
24. Motta S, Monti M, Sesana S et al. (1993) Ceramide composition of the psoriatic scale. Biochim Biophys Acta 1182:147-511
25. Netzlaff F, Kaca M, Bock U et al. (2007) Permeability of the reconstructed human epidermis model Episkin in comparison to various human skin preparations. Eur J Pharm Biopharm 66:127-344
26. Netzlaff F, Lehr CM, Wertz PW et al. (2005) The human epidermis models EpiSkin, SkinEthic and EpiDerm: An evaluation of morphology and their suitability for testing phototoxicity, irritancy, corrosivity, and substance transport. Eur J Pharm Biopharm 60:167-788
27. Ntambi JM, Miyazaki M, Dobrzyn A (2004) Regulation of stearoyl-CoA desaturase expression. Lipids 39:1061-55
28. Ponec M, Boelsma E, Gibbs S et al. (2002) Characterization of reconstructed skin models. Skin Pharmacol Appl Skin Physiol 155 (Suppl 1):4-177
29. Ponec M, Weerheim A, Kempenaar J et al. (1997) The formation of competent barrier lipids in reconstructed human epidermis requires the presence of vitamin C. J Invest Dermatol 109:348-555
30. Ponec M, Weerheim A, Lankhorst P et al. (2003) New acylceramide in native and reconstructed epidermis. J Invest Dermatol 120:581-88
31. Rissmann R, Groenink HW, Weerheim AM et al. (2006) New insights into ultrastructure, lipid composition and organization of vernix caseosa. J Invest Dermatol 126:1823-333
32. Schafer-Korting M, Bock U, Diembeck W et al. (2008) The use of reconstructed human epidermis for skin absorption testing: Results of the validation study. Altern Lab Anim 36:161-877
33. Schmook FP, Meingassner JG, Billich A (2001) Comparison of human skin or epidermis models with human and animal skin in in-vitro percutaneous absorption. Int J Pharm 215:51-66
34. Suhonen TM, Pasonen-Seppanen S, Kirjavainen M et al. (2003) Epidermal cell culture model derived from rat keratinocytes with permeability characteristics comparable to human cadaver skin. Eur J Pharm Sci 20:107-133
35. Thakoersing VS, Gooris G, Mulder AA et al. (2012) Unravelling barrier properties of three different in-house human skin equivalents. Tissue Eng Part C Methods 18:1-111
36. Thakoersing VS, Ponec M, Bouwstra JA (2010) Generation of human skin equivalents under submerged conditions-mimicking the in utero environment. Tissue Eng Part A 16:1433-411
37. Van Smeden J, Hoppel L, van der Heijden R et al. (2011) LC/MS analysis of stratum corneum lipids: Ceramide profiling and discovery. J Lipid Res 52: 1211-211
38. Wertz PW (2000) Lipids and barrier function of the skin. Acta Derm Venereol Suppl (Stockh) 208:7-111
39. Zghoul N, Fuchs R, Lehr CM et al. (2001) Reconstructed skin equivalents for assessing percutaneous drug absorption from pharmaceutical formulations. Altex 18:103-66
40. Zhang L, Ge L, Parimoo S et al. (1999) Human stearoyl-CoA desaturase: Alternative transcripts generated from a single gene by usage of tandem polyadenylation sites. Biochem J 340(Pt 1):255-644