An in vitro method for detecting chemical sensitization using human reconstructed skin models and its applicability to cosmetic, pharmaceutical, and medical device safety testing

Cutaneous and Ocular Toxicology

Volumn 31, Issue 4, 2012, Pages 292-305

  McKim, James M ^a   Keller III, Donald J ^a   Gorski, Joel R ^b  

^a CeeTox Inc ^*  (United States)

^b NAMSA   (United States)

Author keywords

Allergic contact; Antioxidant response element; Dermatitis; in vitro skin sensitization; Medical devices; Nrf2; Reconstructed human skin

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; 1,4 BENZOQUINONE; 2 AMINOPHENOL; 2 MERCAPTOBENZOTHIAZOLE; 2,3 BUTANEDIONE; 4 VINYLPYRIDINE; BENZOIC ACID; COSMETIC; EUGENOL; GLYCEROL; ISOEUGENOL; METOLACHLOR; TRANSCRIPTION FACTOR NRF1; TRANSCRIPTION FACTOR NRF2;

ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DEVICE SAFETY; DRUG INDUSTRY; DRUG SAFETY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYGIENE PRODUCT; IN VITRO STUDY; KERATINOCYTE; MEDICAL DEVICE; MODEL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIZATION; SKIN ALLERGY; SOLUBILITY; TOXICITY TESTING;

EID: 84868623562     PISSN: 15569527     EISSN: 15569535     Source Type: Journal    
DOI: 10.3109/15569527.2012.667031     Document Type: Article

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