An epidermal equivalent assay for identification and ranking potency of contact sensitizers

Toxicology and Applied Pharmacology

Volumn 272, Issue 2, 2013, Pages 529-541

  Gibbs, Susan ^a   Corsini, Emanuela ^b   Spiekstra, Sander W ^a   Galbiati, Valentina ^b   Fuchs, Horst W ^c   DeGeorge, George ^d   Troese, Matthew ^d   Hayden, Patrick ^e   Deng, Wei ^e   Roggen, Erwin ^f  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF MILAN   (Italy)

^c CellSystems GmbH   (Germany)

^d MB Research Laboratories   (United States)

^e MATTEK CORPORATION   (United States)

^f 3Rs Management and Consultancy ^*  (Denmark)

Author keywords

Epidermal equivalent; IL 18; In vitro; Irritant; Potency; Sensitizer

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; 2 MERCAPTOBENZOTHIAZOLE; ACETALDEHYDE; ACETONE; ACID; ALCOHOL; BENZOCAINE; CHLORIDE; CHLOROBENZENE; CINNAMALDEHYDE; CINNAMALDEHYDE DERIVATIVE; CINNAMYL ALCOHOL; CITRAL; COBALT; CONTACT ALLERGEN; DIMETHYL SULFOXIDE; EUGENOL; FORMALDEHYDE; GLYOXAL; INTERLEUKIN 18; ISOEUGENOL; NITROBENZENE DERIVATIVE; OLIVE OIL; OXAZOLONE; PHENOL; PHENYLENEDIAMINE; RESORCINOL; SALICYLIC ACID METHYL ESTER; WATER;

ARTICLE; ASSAY; CONCENTRATION (PARAMETERS); CONTACT SENSITIZATION; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; ENVIRONMENTAL EXPOSURE; EPIDERMAL EQUIVALENT ASSAY; EXPERIMENTAL MODEL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MOLECULAR STABILITY; NONHUMAN; NORMAL HUMAN; SKIN SENSITIZATION; SOLUBILITY; SUPERNATANT;

2-MERCAPTOBENZOTHIAZOLE; 4-NITROBENZYL BROMIDE; C-OH; CA; CINNAMALDEHYDE; CINNAMIC ALCOHOL; DIMETHYLFORMAMIDE; DIMETHYLSULFOXIDE; DINITROCHLOROBENZENE; DIPARTIMENTO DI SCIENZE FARMACOLOGICHE E BIOMOLECOLARI; DISFEB; DMF; DMSO; DNCB; DSA(05) (ΜG/CM(2)); EE; EPIDERMAL EQUIVALENT; EUG; EUGENOL; GLC; GLYCEROL; GLYOXAL; GXL; HBA; HYDROXYBENZOIC ACID; IL-18; IN VITRO; INDUCTION DOSE PER SKIN AREA (DSA) THAT PRODUCES A POSITIVE RESPONSE IN 5% OF THE TESTED POPULATION; INTERLEUKIN-18; IRRITANT; LAC; LACTIC ACID; MBT; NBB; P-PHENYLENDIAMINE; PHENOL; PHL; POTENCY; PPD; RES; RESORCINOL; SDS; SENSITIZER; SODIUM DODECYL SULPHATE; VU UNIVERSITY MEDICAL CENTRE; VUMC;

ALLERGENS; BIOLOGICAL ASSAY; DERMATITIS, ALLERGIC CONTACT; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPIDERMIS; HUMANS; INTERLEUKIN-18; MODELS, IMMUNOLOGICAL; PREDICTIVE VALUE OF TESTS; SKIN IRRITANCY TESTS;

EID: 84884154403     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.07.003     Document Type: Article

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