Mechanisms of wound reepithelialization: Hints from a tissue-engineered reconstructed skin to long-standing questions

FASEB Journal

Volumn 15, Issue 13, 2001, Pages 2377-2389

  Laplante, Alain F ^a   Germain, Lucie ^a   Auger, François A ^a   Moulin, Véronique ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

Drug screening; Epithelia; Keratinocyte; Wound healing

Indexed keywords

COLLAGEN TYPE 4; FIBRIN; FILAGGRIN; KALININ; KERATIN; LORICRIN;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; EPITHELIZATION; GENETIC ENGINEERING; HUMAN; HUMAN TISSUE; KERATINOCYTE; PRIORITY JOURNAL; REGENERATION; SKIN EPITHELIUM; SKIN FIBROBLAST; SPATIAL ORIENTATION; WOUND CLOSURE; WOUND HEALING;

CELL ADHESION MOLECULES; CELLS, CULTURED; COLLAGEN TYPE IV; EPIDERMIS; EPITHELIUM; FEMALE; FIBROBLASTS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; KERATINOCYTES; MALE; MICROSCOPY, ELECTRON; SKIN; WOUND HEALING;

EID: 0035163082     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.01-0250com     Document Type: Article

References (63)

1. Detection of basement membrane zone antigens during epidermal wound healing in pigs
2. Healing of full-thickness cutaneous wounds in the pig. I. Immunohistochemical study of epidermodermal junction regeneration
3. Wound healing of human skin transplanted onto the nude mouse. II. An immunohistological and ultrastructural study of the epidermal basement membrane zone reconstruction and connective tissue reorganization
4. Wound healing of human skin transplanted onto the nude mouse. I. An immunohistological study of the reepithelialization process
5. Human wound repair. I. Epidermal regeneration
6. Wound care and wound healing
7. Epidermal regeneration studied in domestic pig
8. Expression of heat shock proteins in mouse skin during wound healing
9. Epithelialization
10. Keratinocyte migratic and the extracellular matrix
11. Movements of epithelial cell sheets in vitro
12. The spreading of epithelial cells during wound closure in Xenopus larvae
13. Cell migration in repair of mouse corneal epithelium
14. The biological foundations of wound repair
15. A pattern of epidermal cell migration during wound healing
16. Epithelial migration in organ culture. Morphological and time lapse cinematographic analysis of migrating stratified squamous epithelium
17. Immunomorphological and ultrastructural aspects of keratinocyte migration in epidermal wound healing
18. Studies in the healing of cutaneous wounds. I. The healing of incisions through the skin of pigs
19. Epithelialization of small wounds
20. Fate of human keratinocytes during reepithelialization in an organotypic culture model
21. Characterization of a new in vitro model for studies of reepithelialization in human partial thickness wounds
22. Epidermal migration during the healing of suction blisters in rat skin: A scanning and transmission electron microscopic study
23. Active epidermal movement in human skin in vitro
24. Characterization of a new tissue-engineered human skin equivalent with hair
25. Tissue engineered biomaterials: Biological and mechanical characteristics
26. Improvement of human keratinocyte isolation and culture using thermolysin
27. A completely biological tissue-engineered human blood vessel
28. Early basement membrane formation following the grafting of cultured epidermal sheets detached with thermolysin or dispase
29. The time-dependent localization of Ki67 antigen-positive cells in human skin wounds
30. Ultrastructural morphometry of normal human dermal-epidermal junction. The influence of age, sex, and body region on laminar and nonlaminar components
31. Fibronectin and fibrin provide a provisional matrix for epidermal cell migration during wound reepithelialization
32. Distinctive integrin expression in the newly forming epidermis during wound healing in humans
33. The structure and development of skin
34. Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies
35. Epidermal differentiation and keratin gene expression
36. Keratohyalin granule proteins
37. Characterization of a class of cationic proteins that specifically interact with intermediate filaments
38. Identification, of a major keratinocyte cell envelope protein, loricrin
39. The 'ins' and 'outs' of intermediate filament organization
40. Regeneration of the basal lamina complex during epithelial wound healing
41. Kalinin: An epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments
42. Localization of the collagenous component in skin basement membrane
43. Cellular origin of the dermal-epidermal basement membrane
44. Dynamics of basement membrane formation by keratinocyte-fibroblast interactions in organotypic skin culture
45. Laminin-5 expression is independent of the injury and the microenvironment during reepithelialization of wounds
46. Expression of integrins and basement membrane components by wound keratinocytes
47. Cultured epidermal sheet grafting with Hemaseel HMN fibrin sealant on nude mice
48. Role and innocuity of Tisseel, a tissue glue, in the grafting process and in vivo evolution of human cultured epidermis
49. Mechanism of human keratinocyte migration on fibronectin: Unique roles of RGD site and integrins
50. Mesenchymal-epithelial interactions regulate gene expression of type VII collagen and kalinin in keratinocytes and dermal-epidermal junction formation in a skin equivalent model
51. Examination of the epidermis by the strip method of removing horny layers. I. Observations on thickness of the horny layer, and on mitotic activity after stripping
52. Effect of local wound environment on epidermal healing
53. Keratinization
54. The α3 laminin subunit. α 6β4 and α3β1 integrin coordinately regulate wound healing in cultured epithelial cells and in the skin
55. Laminin 5 deposition promotes keratinocyte motility
56. Urokinase- and tissue-type plasminogen activators in keratinocytes during wound reepithelialization in vivo
57. Processing of laminin-5 and its functional consequences: Role of plasmin and tissue-type plasminogen activator
58. Laminin-5 inhibits human keratinocyte migration
59. In vitro engineering of human skin-like tissue
60. Immunochemistry of a keratinocyte-fibroblast co-culture model for reconstruction of human skin
61. Living tissue formed in vitro and accepted as skin-equivalent tissue of full thickness
62. In vitro reconstruction of a human capillary-like network in a tissue-engineered skin equivalent
63. A human tissue-engineered vascular media: A new model for pharmacological studies of contractile responses