Corrigendum to Sensory nerves in lung and airways [Compr Physiol, 4, (2014), 287-324] DOI:10.1002/cphy.c130020;Sensory nerves in lung and airways

Comprehensive Physiology

Volumn 4, Issue 1, 2014, Pages 287-324

  Lee, Lu Yuan ^a   Yu, Jerry ^b,c,d  

^a UNIVERSITY OF KENTUCKY   (United States)

^b University of Louisville School of Medicine   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOVASCULAR FUNCTION; CYTOLOGY; DYSPNEA; HUMAN; IMMUNE SYSTEM; INNERVATION; LUNG; MECHANOTRANSDUCTION; PATHOPHYSIOLOGY; PHYSIOLOGY; REFLEX; RESPIRATORY SYSTEM; RESPIRATORY TRACT DISEASE; SENSORY NERVE; SENSORY NERVE CELL;

CARDIOVASCULAR PHYSIOLOGICAL PHENOMENA; DYSPNEA; HUMANS; IMMUNE SYSTEM; LUNG; MECHANOTRANSDUCTION, CELLULAR; REFLEX; RESPIRATORY SYSTEM; RESPIRATORY TRACT DISEASES; SENSORY RECEPTOR CELLS; VISCERAL AFFERENTS;

EID: 84899860722     PISSN: None     EISSN: 20404603     Source Type: Journal    
DOI: 10.1002/cphy.cv05i04corr     Document Type: Erratum

References (420)

1. Adriaensen D, Brouns I, Pintelon I, De Proost I, Timmermans JP. Evidence for a role of neuroepithelial bodies as complex airway sensors: Comparison with smooth muscle-associated airway receptors. J Appl Physiol 101: 960-970, 2006.
2. Adriaensen D, Timmermans JP, Brouns I, Berthoud HR, Neuhuber WL, Scheuermann DW. Pulmonary intraepithelial vagal nodose afferent nerve terminals are confined to neuroepithelial bodies: An anterograde tracing and confocal microscopy study in adult rats. Cell Tissue Res 293: 395-405, 1998.
3. Adrian ED. Afferent impulses in the vagus and their effect on respiration. J Physiol 79: 332-358, 1933.
4. Agostoni E, Chinnock JE, De Daly MB, Murray JG. Functional and histological studies of the vagus nerve and its branches to the heart, lungs and abdominal viscera in the cat. J Physiol 135: 182-205, 1957.
5. Ainsworth DM, Smith CA, Johnson BD, Eicker SW, Henderson KS, Dempsey JA. Vagal contributions to respiratory muscle activity during eupnea in the awake dog. J Appl Physiol 72: 1355-1361, 1992.
6. Aitken ML, Marini JJ. Effect of heat delivery and extraction on airway conductance in normal and in asthmatic subjects. Am Rev Respir Dis 131: 357-361, 1985.
7. Akopian AN. Regulation of nociceptive transmission at the periphery via TRPA1-TRPV1 interactions. Curr Pharm Biotechnol 12: 89-94, 2011.
8. Alessandri-Haber N, Dina OA, Joseph EK, Reichling D, Levine JD. A transient receptor potential vanilloid 4-dependent mechanism of hyperalgesia is engaged by concerted action of inflammatory mediators. J Neurosci 26: 3864-3874, 2006.
9. Alessandri-Haber N, Joseph E, DinaOA, Liedtke W, Levine JD.TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator. Pain 118: 70-79, 2005.
10. Allen DA, Schertel ER, Weisbrode SE, Myerowitz PD. Acute lung injury isolated to an in situ lung preparation causes sustained reflex cardiovascular depression in dogs. J Appl Physiol 77: 1850-1857, 1994.
11. Anderson JW, Sant'Ambrogio FB, Mathew OP, Sant'ambrogio G. Water-responsive laryngeal receptors in the dog are not specialized endings. Respir Physiol 79: 33-43, 1990.
12. Andre E, Campi B, Materazzi S, Trevisani M, Amadesi S, Massi D, Creminon C, Vaksman N, Nassini R, Civelli M, Baraldi PG, Poole DP, Bunnett NW, Geppetti P, Patacchini R. Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J Clin Invest 118: 2574-2582, 2008.
13. Andre E, Gatti R, Trevisani M, Preti D, Baraldi PG, Patacchini R, Geppetti P. Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents. Br J Pharmacol 158: 1621-1628, 2009.
14. Auais A, Adkins B, Napchan G, Piedimonte G. Immunomodulatory effects of sensory nerves during respiratory syncytial virus infection in rats. Am J Physiol Lung Cell Mol Physiol 285: L105-L113, 2003.
15. Bailey EF, Fregosi RF. Modulation of upper airway muscle activities by bronchopulmonary afferents. J Appl Physiol 101: 609-617, 2006.
16. Baluk P, Gabella G. Afferent nerve endings in the tracheal muscle of guinea-pigs and rats. Anat Embryol (Berl) 183: 81-87, 1991.
17. Baluk P, Nadel JA, Mcdonald DM. Substance P-immunoreactive sensory axons in the rat respiratory-tract-a quantitative study of their distribution and role in neurogenic inflammation. J Comp Neurolo 319: 586-598, 1992.
18. Banzett RB, Coleridge HM, Coleridge JC, Kidd C. Proceedings: Multiterminal afferent fibres from the thoracic viscera in sympathetic rami communicantes of cats and dogs. J Physiol 254: 57P-58P, 1976.
19. Banzett RB, Lansing RW, Reid MB, Adams L, Brown R. 'Air hunger' arising from increased PCO2 in mechanically ventilated quadriplegics. Respir Physiol 76: 53-67, 1989.
20. Benini L, Ferrari M, Sembenini C, Olivieri M, Micciolo R, Zuccali V, Bulighin GM, Fiorino F, Ederle A, Cascio VL, Vantini I. Cough threshold in reflux oesophagitis: Influence of acid and of laryngeal and oesophageal damage. Gut 46: 762-767, 2000.
21. Bennett FM, Tallman RD, Jr., Grodins FS. Role of VCO2 in control of breathing of awake exercising dogs. J Appl Physiol 56: 1335-1339, 1984.
22. Bergren DR. Sensory receptor activation by mediators of defense reflexes in guinea-pig lungs. Respir Physiol 108: 195-204, 1997.
23. Bergren DR, Peterson DF. Identification of vagal sensory receptors in the rat lung: Are there subtypes of slowly adapting receptors? J Physiol 464: 681-698, 1993.
24. Berthoud HR, Lynn PA, Blackshaw LA. Vagal and spinal mechanosensors in the rat stomach and colon have multiple receptive fields. Am J Physiol-Reg I 280: R1371-R1381, 2001.
25. Bessac BF, Jordt SE. Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. Physiology (Bethesda) 23: 360-370, 2008.
26. Bessac BF, Sivula M, von Hehn CA, Escalera J, Cohn L, Jordt SE. TRPA1 is a major oxidant sensor in murine airway sensory neurons. J Clin Invest 118: 1899-1910, 2008.
27. Birrell MA, Belvisi MG, Grace M, Sadofsky L, Faruqi S, Hele DJ, Maher SA, Freund-Michel V, Morice AH. TRPA1 agonists evoke coughing in guinea pig and human volunteers. Am J Respir Crit Care Med 180: 1042-1047, 2009.
28. Bonini S, Lambiase A, Bonini S, Angelucci F, Magrini L, Manni L, Aloe L. Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma. Proc Natl Acad Sci U S A 93: 10955-10960, 1996.
29. Bouchama A, Parhar RS, el-Yazigi A, Sheth K, al-Sedairy S. Endotoxemia and release of tumor necrosis factor and interleukin 1 alpha in acute heatstroke. J Appl Physiol 70: 2640-2644, 1991.
30. Boushey HA, Richardson PS, Widdicombe JG, Wise JC. The response of laryngeal afferent fibres to mechanical and chemical stimuli. J Physiol 240: 153-175, 1974.
31. Breder CD, Dinarello CA, Saper CB. Interleukin-1 immunoreactive innervation of the human hypothalamus. Science 240: 321-324, 1988.
32. Brooks GA, Hittelman KJ, Faulkner JA, Beyer RE. Tissue temperatures and whole-animal oxygen consumption after exercise. Am J Physiol 221: 427-431, 1971.
33. Brouns I, De Proost I, Pintelon I, Timmermans JP, Adriaensen D. Sensory receptors in the airways: Neurochemical coding of smooth muscleassociated airway receptors and pulmonary neuroepithelial body innervation. Auton Neurosci 126-127: 307-319, 2006.
34. Brouns I, Pintelon I, Van GJ, De P, I, Timmermans JP, Adriaensen D. Vesicular glutamate transporter 2 is expressed in different nerve fibre populations that selectively contact pulmonary neuroepithelial bodies. Histochem Cell Biol 121: 1-12, 2004.
35. Brouns I, Van Genechten J, Hayashi H, Gajda M, Gomi T, Burnstock G, Timmermans JP, Adriaensen D. Dual sensory innervation of pulmonary neuroepithelial bodies. Am J Respir Cell Mol Biol 28: 275-285, 2003.
36. Buckner CK, Songsiridej V, Dick EC, Busse WW. In vivo and in vitro studies on the use of the guinea pig as a model for virus-provoked airway hyperreactivity. Am Rev Respir Dis 132: 305-310, 1985.
37. Burki NK, Lee LY. Mechanisms of dyspnea. Chest 138: 1196-1201, 2010.
38. Caceres AI, Brackmann M, Elia MD, Bessac BF, del Camino D, D'Amours M, Witek JS, Fanger CM, Chong JA, Hayward NJ, Homer RJ, Cohn L, Huang X, Moran MM, Jordt SE. A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proc Natl Acad Sci U S A 106: 9099-9104, 2009.
39. Calderwood SK, Bornstein B, Farnum EK, Stevenson MA. Heat shock stimulates the release of arachidonic acid and the synthesis of prostaglandins and leukotriene B4 in mammalian cells. J Cell Physiol 141: 325-333, 1989.
40. Canning BJ. Reflex regulation of airway smooth muscle tone. J Appl Physiol 101: 971-985, 2006.
41. Canning BJ. Functional implications of the multiple afferent pathways regulating cough. Pulm Pharmacol Ther 24: 295-299, 2011.
42. Canning BJ, Farmer DG, Mori N. Mechanistic studies of acid-evoked coughing in anesthetized guinea pigs. Am J Physiol Regul Integr Comp Physiol 291: R454-R463, 2006.
43. Canning BJ, Mazzone SB, Meeker SN, Mori N, Reynolds SM, Undem BJ. Identification of the tracheal and laryngeal afferent neurones mediating cough in anaesthetized guinea-pigs. J Physiol 557: 543-558, 2004.
44. Canning BJ, Mori N, Mazzone SB. Vagal afferent nerves regulating the cough reflex. Respir Physiol Neurobiol 152: 223-242, 2006.
45. Canning BJ, Reynolds SM, Mazzone SB. Multiple mechanisms of reflex bronchospasm in guinea pigs. J Appl Physiol 91: 2642-2653, 2001.
46. Carr MJ, Hunter DD, Jacoby DB, Undem BJ. Expression of tachykinins in nonnociceptive vagal afferent neurons during respiratory viral infection in guinea pigs. Am J Respir Crit Care Med 165: 1071-1075, 2002.
47. Carr RW, Gregory JE, Proske U. Summation of responses of cat muscle spindles to combined static and dynamic fusimotor stimulation. Brain Res 800: 97-104, 1998.
48. Carr RW, Morgan DL, Proske U. Impulse initiation in the mammalian muscle spindle during combined fusimotor stimulation and succinyl choline infusion. J Neurophysiol 75: 1703-1713, 1996.
49. Cassidy SS, Ashton JH, Wead WB, Kaufman MP, Monsereenusorn Y, Whiteside JA. Reflex cardiovascular responses caused by stimulation of pulmonary C-fibers with capsaicin in dogs. J Appl Physiol 60: 949-958, 1986.
50. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature 389: 816-824, 1997.
51. Chapleau MW, Li Z, Meyrelles SS, Ma X, Abboud FM. Mechanisms determining sensitivity of baroreceptor afferents in health and disease. Ann N Y Acad Sci 940: 1-19, 2001.
52. Charan NB, Albert RK, Lakshminarayan S, Kirk W, Butler J. Factors affecting bronchial blood flowthrough bronchopulmonary anastomoses in dogs. Am Rev Respir Dis 134: 85-88, 1986.
53. Chen HF, Lee BP, Kou YR. Mechanisms underlying stimulation of rapidly adapting receptors during pulmonary air embolism in dogs. Respir Physiol 109: 1-13, 1997.
54. Chen Y, Plenderleith MB, Hills BA. Influence of surfactant on the activity of slowly adapting stretch receptors in the lung. Respir Physiol 112: 135-143, 1998.
55. Cheng SE, Luo SF, Jou MJ, Lin CC, Kou YR, Lee IT, Hsieh HL, Yang CM. Cigarette smoke extract induces cytosolic phospholipase A2 expression via NADPH oxidase, MAPKs, AP-1, and NF-kappaB in human tracheal smooth muscle cells. Free Radic Biol Med 46: 948-960, 2009.
56. Choudry NB, Fuller RW, Pride NB. Sensitivity of the human cough reflex: Effect of inflammatory mediators prostaglandin E2, bradykinin, and histamine. Am Rev Respir Dis 140: 137-141, 1989.
57. Chuang HH, Prescott ED, Kong H, Shields S, Jordt SE, Basbaum AI, Chao MV, Julius D. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature 411: 957-962, 2001.
58. Clifford PS, Litzow JT, von Colditz JH, Coon RL. Effect of chronic pulmonary denervation on ventilatory responses to exercise. J Appl Physiol 61: 603-610, 1986.
59. Coleridge HM. Afferent vagal C-fibers in the dog lung: Their discharge during spontaneous breathing and their stimulation by alloxan and pulmonary congestion. In: Paintal AS, editor. Krogh Centenary Symposium on Respiratory Adaptations, Capillary Exchange and Reflex Mechanisms. Delhi: Vallabhbhai Patel Chest Institute, 1977, pp. 393-406.
60. Coleridge HM, Coleridge JC, Baker DG, Ginzel KH, Morrison MA. Comparison of the effects of histamine and prostaglandin on afferent C-fiber endings and irritant receptors in the intrapulmonary airways. Adv Exp Med Biol 99: 291-305, 1978.
61. Coleridge HM, Coleridge JC, Green JF, Parsons GH. Pulmonary C-fiber stimulation by capsaicin evokes reflex cholinergic bronchial vasodilation in sheep. J Appl Physiol 72: 770-778, 1992.
62. Coleridge HM, Coleridge JC, Roberts AM. Rapid shallow breathing evoked by selective stimulation of airway C fibres in dogs. J Physiol 340: 415-433, 1983.
63. Coleridge HM, Coleridge JC, Schultz HD. Afferent pathways involved in reflex regulation of airway smooth muscle. Pharmacol Ther 42: 1-63, 1989.
64. Coleridge HM, Coleridge JCG. Impulse activity in afferent vagal Cfibres with endings in the intrapulmonary airways of dogs. Respir Physiol 29: 125-142, 1977.
65. Coleridge HM, Coleridge JCG. Reflexes evoked from tracheobronchial tree and lungs. In: Cherniack NS, Widdicombe JG, editors. Handbook of Physiology. Bethsda: American Physiological Society, 1986, p. 395-430.
66. Coleridge JC, Coleridge HM, Schelegle ES, Green JF. Acute inhalation of ozone stimulates bronchial C-fibers and rapidly adapting receptors in dogs. J Appl Physiol 74: 2345-2352, 1993.
67. Coleridge JCG, Coleridge HM. Afferent vagal C fibre innervation of the lungs and airways and its functional significance. Rev Physiol Biochem Pharmacol 99: 1-110, 1984.
68. Coon RL, Clifford PS, Hopp FA, Zuperku EJ. Reflex ventilatory effects of KCl stimulation of lung receptors with sympathetic afferents. Respir Physiol 82: 349-358, 1990.
69. Coyle AJ, Ackerman SJ, Irvin CG. Cationic proteins induce airway hyperresponsiveness dependent on charge interactions. Am Rev Respir Dis 147: 896-900, 1993.
70. Cutz E, Jackson A. Neuroepithelial bodies as airway oxygen sensors. Respir Physiol 115: 201-214, 1999.
71. Cutz E, Yeger H, Pan J. Pulmonary neuroendocrine cell system in pediatric lung disease-recent advances. Pediatr Dev Pathol 10: 419-435, 2007.
72. Daly MB. Interactions between respiration and circulation In: Cherniack NS, Widdicombe JG, editors. Handbook of Physiology. Bethesda: American Physiological Society, 1986, pp. 529-594.
73. Daly MD, Kirkman E. Cardiovascular responses to stimulation of pulmonary C fibres in the cat: Their modulation by changes in respiration. J Physiol 402: 43-63, 1988.
74. Daly MD, Ward J, Wood LM. Modification by lung inflation of the vascular responses from the carotid body chemoreceptors and other receptors in dogs. J Physiol 378: 13-30, 1986.
75. Daniel EE, Kannan M, Davis C, Posey-Daniel V. Ultrastructural studies on the neuromuscular control of human tracheal and bronchial muscle. Respir Physiol 63: 109-128, 1986.
76. Davenport PW, Sant'Ambrogio FB, Sant'ambrogio G. Adaptation of tracheal stretch receptors. Respir Physiol 44: 339-349, 1981.
77. Davies A, Pirie L, Eyre-Todd RA. Adaptation of pulmonary receptors in the spontaneously breathing anaesthetized rat. Eur Respir J 9: 1637-1642, 1996.
78. Davies SF, McQuaid KR, Iber C, McArthur CD, Path MJ, Beebe DS, Helseth HK. Extreme dyspnea from unilateral pulmonary venous obstruction. Demonstration of a vagal mechanism and relief by right vagotomy. Am Rev Respir Dis 136: 184-188, 1987.
79. Davis B, Roberts AM, Coleridge HM, Coleridge JC. Reflex tracheal gland secretion evoked by stimulation of bronchial C-fibers in dogs. J Appl Physiol 53: 985-991, 1982.
80. De Swert KO, Joos GF. Extending the understanding of sensory neuropeptides. Eur J Pharmacol 533: 171-181, 2006.
81. Devillier P, Acker GM, Advenier C, Marsac J, Regoli D, Frossard N. Activation of an epithelial neurokinin NK-1 receptor induces relaxation of rat trachea through release of prostaglandin E2. J Pharmacol Exp Ther 263: 767-772, 1992.
82. Dhaka A, Viswanath V, Patapoutian A. TRP Ion Channels and Temperature Sensation. Annu Rev Neurosci 29: 135-161, 2006.
83. DiCarlo SE, Collins HL, Chen CY. Vagal afferents reflexly inhibit exercise in conscious rats. Med Sci Sports Exerc 26: 459-462, 1994.
84. Dickerson C, Undem B, Bullock B,Winchurch RA. Neuropeptide regulation of proinflammatory cytokine responses. J Leukoc Biol 63: 602-605, 1998.
85. Dicpinigaitis PV. Experimentally induced cough. Pulm Pharmacol Ther 20: 319-324, 2007.
86. Dinh QT, Groneberg DA, Peiser C, Mingomataj E, Joachim RA, Witt C, Arck PC, Klapp BF, Fischer A. Substance P expression in TRPV1 and trkA-positive dorsal root ganglion neurons innervating the mouse lung. Respir Physiol Neurobiol 144: 15-24, 2004.
87. Dmitrieva N, Shelton D, Rice AS, McMahon SB. The role of nerve growth factor in a model of visceral inflammation. Neuroscience 78: 449-459, 1997.
88. Doherty MJ, Mister R, Pearson MG, Calverley PM. Capsaicin responsiveness and cough in asthma and chronic obstructive pulmonary disease. Thorax 55: 643-649, 2000.
89. Donoghue S, Garcia M, Jordan D, Spyer KM. The brain-stem projections of pulmonary stretch afferent neurones in cats and rabbits. J Physiol 322: 353-363, 1982.
90. Drummond HA,Welsh MJ, Abboud FM. ENaC subunits are molecular components of the arterial baroreceptor complex. Ann N Y Acad Sci 940: 42-47, 2001.
91. Düring MV, Andres KH, Iravani J. The fine structure of the pulmonary stretch receptor in the rat. Z Anat Entwicklungsgesch 143: 215-222, 1974.
92. Eagles JP, Purple RL. Afferent fibers with multiple encoding sites. Brain Res 77: 187-193, 1974.
93. Eckert DJ, Saboisky JP, Jordan AS, White DP, Malhotra A.Asecondary reflex suppression phase is present in genioglossus but not tensor palatini in response to negative upper airway pressure. J Appl Physiol 108: 1619-1624, 2010.
94. Ek M,Kurosawa M, Lundeberg T, Ericsson A. Activation of vagal afferents after intravenous injection of interleukin-1beta: Role of endogenous prostaglandins. J Neurosci 18: 9471-9479, 1998.
95. Eljamal M, Wong LB, Yeates DB. Capsaicin-activated bronchial-and alveolar-initiated pathways regulating tracheal ciliary beat frequency. J Appl Physiol 77: 1239-1245, 1994.
96. Eschenbacher WL, Boushey HA, Sheppard D. Alteration in osmolarity of inhaled aerosols cause bronchoconstriction and cough, but absence of a permeant anion causes cough alone. Am Rev Respir Dis 129: 211-215, 1984.
97. Fahy JV, Wong HH, Geppetti P, Reis JM, Harris SC, Maclean DB, Nadel JA, Boushey HA. Effect of an NK1 receptor antagonist (CP-99,994) on hypertonic saline-induced bronchoconstriction and cough in male asthmatic subjects. Am J Respir Crit Care Med 152: 879-884, 1995.
98. Favier R,Kepenekian G, Desplanches D, Flandrois R. Effects of chronic lung denervation on breathing pattern and respiratory gas exchanges during hypoxia, hypercapnia and exercise. Respir Physiol 47: 107-119, 1982.
99. Ferrari M, Olivieri M, Sembenini C, Benini L, Zuccali V, Bardelli E, Bovo P, Cavallini G, Vantini I, Lo Cascio V. Tussive effect of capsaicin in patients with gastroesophageal reflux without cough. Am J Respir Crit Care Med 151: 557-561, 1995.
100. Fischer A, McGregor GP, Saria A, Philippin B, Kummer W. Induction of tachykinin gene and peptide expression in guinea pig nodose primary afferent neurons by allergic airway inflammation. J Clin Invest 98: 2284-2291, 1996.
101. Fisher JT, Sant'ambrogio G. Location and discharge properties of respiratory vagal afferents in the newborn dog. Respir Physiol 50: 209-220, 1982.
102. Flavahan NA, Slifman NR, Gleich GJ, Vanhoutte PM. Human eosinophil major basic protein causes hyperreactivity of respiratory smooth muscle. Role of the epithelium. Am Rev Respir Dis 138: 685-688, 1988.
103. Flume PA, Eldridge FL, Edwards LJ, Mattison LE. Relief of the 'air hunger' of breathholding.Arole for pulmonary stretch receptors. Respir Physiol 103: 221-232, 1996.
104. Flynn C, Forster HV, Pan LG, Bisgard GE. Role of hilar nerve afferents in hyperpnea of exercise. J Appl Physiol 59: 798-806, 1985.
105. Foreman RD, Blair RW. Central organization of sympathetic cardiovascular response to pain. Annu Rev Physiol 50: 607-622, 1988.
106. Forster HV, Haouzi P, Dempsey JA. Control of breathing during exercise. Compr Physiol 2: 743-777, 2012.
107. Fowler WS. Breaking point of breath-holding. J Appl Physiol 6: 539-545, 1954.
108. Fox AJ, Barnes PJ, Dray A. Stimulation of guinea-pig tracheal afferent fibres by non-isosmotic and low-chloride stimuli and the effect of frusemide. J Physiol 482: 179-187, 1995.
109. Fox AJ, Lalloo UG, Belvisi MG, Bernareggi M, Chung KF, Barnes PJ. Bradykinin-evoked sensitization of airway sensory nerves: A mechanism for ACE-inhibitor cough. Nat Med 2: 814-817, 1996.
110. Fox AJ, Patel HJ, Barnes PJ, Belvisi MG. Release of nerve growth factor by human pulmonary epithelial cells: Role in airway inflammatory diseases. Eur J Pharmacol 424: 159-162, 2001.
111. Fox AJ, Urban L, Barnes PJ, Dray A. Effects of capsazepine against capsaicin-evoked and proton-evoked excitation of single airway cfibers and vagus nerve from the guinea-pig. Neuroscience 67: 741-752, 1995.
112. Frigas E, Loegering DA, Gleich GJ. Cytotoxic effects of the guinea pig eosinophil major basic protein on tracheal epithelium. Lab Invest 42: 35-43, 1980.
113. Fu LW, Longhurst JC. Interleukin-1beta sensitizes abdominal visceral afferents of cats to ischaemia and histamine. J Physiol 521: 249-260, 1999.
114. Fukami Y. Interaction of impulse activities originating from individual Golgi tendon organs innervated by branches of a single axon. J Physiol 298: 483-499, 1980.
115. Gagnon P, Bussieres JS, Ribeiro F, Gagnon SL, Saey D, Gagne N, Provencher S, Maltais F. Influences of spinal anesthesia on exercise tolerance in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 186: 606-615, 2012.
116. Galoyan SM, Petruska JC, Mendell LM. Mechanisms of sensitization of the response of single dorsal root ganglion cells from adult rat to noxious heat. Eur J Neurosci 18: 535-541, 2003.
117. Gandevia SC. Spinal and supraspinal factors in human muscle fatigue. Physiol Rev 81: 1725-1789, 2001.
118. Gandevia SC, Butler JE, Taylor JL, Crawford MR. Absence of viscerosomatic inhibition with injections of lobeline designed to activate human pulmonary C fibres. J Physiol 511: 289-300, 1998.
119. Gandevia SC, Taylor JL, Butler JE. Stopping exercise: Role of pulmonary C fibers and inhibition of motoneurons. News Physiol Sci 15: 241-245, 2000.
120. Garrity ER, Stimler NP, Munoz NM, Tallet J, David AC, Leff AR. Sympathetic modulation of biochemical and physiological response to immune degranulation in canine bronchial airways in vivo. J Clin Invest 75: 2038-2046, 1985.
121. Geppetti P, Materazzi S, Nicoletti P. The transient receptor potential vanilloid 1: Role in airway inflammation and disease. Eur J Pharmacol 533: 207-214, 2006.
122. Geppetti P, Patacchini R, Nassini R, Materazzi S. Cough: The emerging role of the TRPA1 channel. Lung 188: S63-S68, 2010.
123. Gern JE. Viral respiratory infection and the link to asthma. Pediatr Infect Dis J 23: S78-S86, 2004.
124. Ginzel KH, Eldred E. Reflex of depression of somatic motor activity from heart, lungs and carotid sinus. In: Paintal AS, Gill-Kumar P, editors. Krogh Centenary Symposium on Respiratory Adaptations, Capillary Exchange and Reflex Mechanisms. Delhi: Vallabhbhai Patel Chest Institute, 1977, pp. 358-394.
125. Gleich GJ. The eosinophil and bronchial asthma: Current understanding. J Allergy Clin Immunol 85: 422-436, 1990.
126. Gleich GJ, Flavahan NA, Fujisawa T, Vanhoutte PM. The eosinophil as a mediator of damage to respiratory epithelium: A model for bronchial hyperreactivity. J Allergy Clin Immunol 81: 776-781, 1988.
127. Goehler LE, Gaykema RP, Hansen MK, Anderson K, Maier SF, Watkins LR. Vagal immune-to-brain communication: A visceral chemosensory pathway. Auton Neurosci 85: 49-59, 2000.
128. Gordon T, Sheppard D, McDonald DM, Distefano S, Scypinski L. Airway hyperresponsiveness and inflammation induced by toluene diisocyanate in guinea pigs. Am Rev Respir Dis 132: 1106-1112, 1985.
129. Gourine AV, Rudolph K, Korsak AS, Kubatko J, Tesfaigzi J, Kozak W, Kluger MJ. Role of capsaicin-sensitive afferents in fever and cytokine responses during systemic and local inflammation in rats. Neuroimmunomodulation 9: 13-22, 2001.
130. Greco EC, Fordyce WE, Gonzalez F, Reischl P, Grodins FS. Respiratory responses to intravenous and intrapulmonary CO2 in awake dogs. J Appl Physiol 45: 109-114, 1978.
131. Gregory RJ, Cheng SH, Rich DP, Marshall J, Paul S, Hehir K, Ostedgaard L, Klinger KW,Welsh MJ, Smith AE. Expression and characterization of the cystic fibrosis transmembrane conductance regulator. Nature 347: 382-386, 1990.
132. Grigg P. Biophysical studies of mechanoreceptors. J Appl Physiol 60: 1107-1115, 1986.
133. Groneberg DA, Niimi A, Dinh QT, Cosio B, Hew M, Fischer A, Chung KF. Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough. Am J Respir Crit Care Med 170: 1276-1280, 2004.
134. Gu Q, Kwong K, Lee LY. Ca2+ transient evoked by chemical stimulation is enhanced by PGE2 in vagal sensory neurons:Role of cAMP/PKA signaling pathway. J Neurophysiol 89: 1985-1993, 2003.
135. Gu Q, Lee LY. Hypersensitivity of pulmonary C fibre afferents induced by cationic proteins in the rat. J Physiol 537: 887-897, 2001.
136. Gu Q, Lee LY. Characterization of acid signaling in rat vagal pulmonary sensory neurons. Am J Physiol Lung Cell Mol Physiol 291: L58-L65, 2006.
137. Gu Q, Ni D, Lee LY. Expression of neuronal nicotinic acetylcholine receptors in rat vagal pulmonary sensory neurons. Respir Physiol Neurobiol 161: 87-91, 2008.
138. Gu Q, Wiggers ME, Gleich GJ, Lee LY. Sensitization of isolated rat vagal pulmonary sensory neurons by eosinophil-derived cationic proteins. Am J Physiol Lung Cell Mol Physiol 294: L544-L552, 2008.
139. Gu QH, Lim ME, Gleich GJ, Lee LY. Mechanisms of eosinophil major basic protein-induced hyperexcitability of vagal pulmonary chemosensitive neurons. Am J Physiol Lung Cell Mol Physiol 296: L453-L461, 2009.
140. Guardiola J, Proctor M, Li H, Punnakkattu R, Lin S, Yu J. Airway mechanoreceptor deactivation. J Appl Physiol 103: 600-607, 2007.
141. Guler AD, Lee H, Iida T, Shimizu I, Tominaga M, Caterina M. Heatevoked activation of the ion channel, TRPV4.JNeurosci 22: 6408-6414, 2002.
142. Gunawardena S, Bravo E, Kappagoda CT. Effect of chronic mitral valve damage on activity of pulmonary rapidly adapting receptors in the rabbit. J Physiol 511: 79-88, 1998.
143. GuzA. Experimental results of vagal block in cardiopulmonary disease. In: Porter R, editor. Breathing: Hering-Breuer Centenary Symposium. London: Churchill, 1970, pp. 315-329.
144. Guz A. Brain, breathing and breathlessness. Respir Physiol 109: 197-204, 1997.
145. Habler HJ, Janig W, Koltzenburg M. Activation of unmyelinated afferent fibres by mechanical stimuli and inflammation of the urinary bladder in the cat. J Physiol 425: 545-562, 1990.
146. Hajj AM, Burki NK, Lee LY. Role of tachykinins in sulfur dioxideinduced bronchoconstriction in anesthetized guinea pigs. J Appl Physiol 80: 2044-2050, 1996.
147. Hamamoto T, Takumida M, Hirakawa K, Takeno S, Tatsukawa T. Localization of transient receptor potential channel vanilloid subfamilies in the mouse larynx. Acta Otolaryngol 128: 685-693, 2008.
148. Hamamoto T, Takumida M, Hirakawa K, Tatsukawa T, Ishibashi T. Localization of transient receptor potential vanilloid (TRPV) in the human larynx. Acta Otolaryngol 129: 560-568, 2009.
149. Hamann K, Gleich G, Gunde LR, White A. Interaction between respiratory epithelium and eosinophil granule proteins in asthma: The eosinophil hypothesis. Chap. 9. In: Farmer SG, Hay DWP, editor. The Airway Epithelium: Physiology, Pathophysiology, and Pharmacology. New York: Dekker, 1991.
150. Hargreaves M, Ravi K, Kappagoda CT. Responses of slowly and rapidly adapting receptors in the airways of rabbits to changes in the Starling forces. J Physiol 432: 81-97, 1991.
151. Hargreaves M, Ravi K, Kappagoda CT. Effect of bradykinin on respiratory rate in anaesthetized rabbits: Role of rapidly adapting receptors. J Physiol 468: 501-513, 1993.
152. Harms CA, Zeng YJ, Smith CA, Vidruk EH, Dempsey JA. Negative pressure-induced deformation of the upper airway causes central apnea in awake and sleeping dogs. J Appl Physiol 80: 1528-1539, 1996.
153. Harty HR, Mummery CJ, Adams L, Banzett RB, Wright IG, Banner NR, Yacoub MH, Guz A. Ventilatory relief of the sensation of the urge to breathe in humans: Are pulmonary receptors important? J Physiol 490: 805-815, 1996.
154. Haxhiu MA, Cherniack NS, Strohl KP. Reflex responses of laryngeal and pharyngeal submucosal glands in dogs. J Appl Physiol 71: 1669-1673, 1991.
155. Hayes D, Jr., Collins PB, Khosravi M, Lin RL, Lee LY. Bronchoconstriction triggered by breathing hot humid air in patients with asthma: Role of cholinergic reflex. Am J Respir Crit Care Med 185: 1190-1196, 2012.
156. Higenbottam T. Chronic cough and the cough reflex in common lung diseases. Pulm Pharmacol Ther 15: 241-247, 2002.
157. Hille B. Ion Channels of Excitable Membraines (3rd ed). Sunderland, Massachusetts: Sinauer Associates, Inc., 2001.
158. Ho CY, Gu Q, Lin YS, Lee LY. Sensitivity of vagal afferent endings to chemical irritants in the rat lung. Respir Physiol 127: 113-124, 2001.
159. Ho CY, Lee LY. Ozone enhances excitabilities of pulmonary C fibers to chemical and mechanical stimuli in anesthetized rats. J Appl Physiol 85: 1509-1515, 1998.
160. Holmes R. Afferent fibers of the stellate ganglion. Quart J Exp Physiol 4427: 1-28, 1959.
161. Holtzman MJ, Cunningham JH, Sheller JR, Irsigler GB, Nadel JA, Boushey HA. Effect of ozone on bronchial reactivity in atopic and nonatopic subjects. Am Rev Respir Dis 120: 1059-1067, 1979.
162. Holtzman MJ, Fabbri LM, O'Byrne PM, Gold BD, Aizawa H, Walters EH, Alpert SE, Nadel JA. Importance of airway inflammation for hyperresponsiveness induced by ozone. Am Rev Respir Dis 127: 686-690, 1983.
163. Hong JL, Kwong K, Lee LY. Stimulation of pulmonary C fibres by lactic acid in rats: Contributions of H+ and lactate ions. J Physiol 500: 319-329, 1997.
164. Hong JL, Lee LY. Cigarette smoke-induced bronchoconstriction: Causative agents and role of thromboxane receptors. J Appl Physiol 81: 2053-2059, 1996.
165. Horch KW, Whitehorn D, Burgess PR. Impulse generation in type I cutaneous mechanoreceptors. J Neurophysiol 37: 267-281, 1974.
166. Horner RL. Neural control of the upper airway: Integrative physiological mechanisms and relevance for sleep disordered breathing. Compr Physiol 2: 479-535, 2012.
167. Hoyle GW, Graham RM, Finkelstein JB, Nguyen KP, Gozal D, Friedman M. Hyperinnervation of the airways in transgenic mice overexpressing nerve growth factor. Am J Respir Cell Mol Biol 18: 149-157, 1998.
168. Hsu CC, Lin RL, Lin YS, Lee LY. Bronchoconstriction induced by increasing airway temperature in ovalbumin-sensitized rats: Role of tachykinins. J Appl Physiol: (In press, 2013), 2013.
169. Hsu JY, Stone RA, Logan-Sinclair RB,Worsdell M, Busst CM, Chung KF. Coughing frequency in patients with persistent cough: Assessment using a 24 hour ambulatory recorder. Eur Respir J 7: 1246-1253, 1994.
170. Hu C, Wedde-Beer K, Auais A, Rodriguez MM, Piedimonte G. Nerve growth factor and nerve growth factor receptors in respiratory syncytial virus-infected lungs. Am J Physiol Lung Cell Mol Physiol 283: L494-L502, 2002.
171. Hu YM, Gu QH, Lin RL, Kryscio R, Lee LY. Calcium transient evoked by TRPV1 activators is enhanced by tumor necrosis factor-alpha in rat pulmonary sensory neurons. Am J Physiol Lung Cell Mol Physiol 299: L483-L492, 2010.
172. Huang EJ, Reichardt LF. Neurotrophins: Roles in neuronal development and function. Annu Rev Neurosci 24: 677-736, 2001.
173. Hummel T, Sengupta JN, Meller ST, Gebhart GF. Responses of T2-4 spinal cord neurons to irritation of the lower airways in the rat. Am J Physiol 273: R1147-R1157, 1997.
174. Hunt CC. Mammalian muscle spindle: Peripheral mechanisms. Physiol Rev 70: 643-663, 1990.
175. Hunt JF, Fang K, Malik R, Snyder A, Malhotra N, Platts-Mills TA, Gaston B. Endogenous airway acidification. Implications for asthma pathophysiology. Am J Respir Crit Care Med 161: 694-699, 2000.
176. Hunter DD, Myers AC, Undem BJ. Nerve growth factor-induced phenotypic switch in guinea pig airway sensory neurons. Am J Respir Crit Care Med 161: 1985-1990, 2000.
177. Iber C, Simon P, Skatrud JB, Mahowald MW, Dempsey JA. The Breuer-Hering reflex in humans. Effects of pulmonary denervation and hypocapnia. Am J Respir Crit Care Med 152: 217-224, 1995.
178. Jacoby DB, Costello RM, Fryer AD. Eosinophil recruitment to the airway nerves. J Allergy Clin Immunol 107: 211-218, 2001.
179. Jammes Y, Fornaris E, Mei N, Barrat E. Afferent and efferent components of the bronchial vagal branches in cats. J Auton Nerv Syst 5: 165-176, 1982.
180. Jia Y, Lee LY. Role of TRPV receptors in respiratory diseases. Biochim Biophys Acta 1772: 915-927, 2007.
181. Jiang Q, DeTolla L, van Rooijen N, Singh IS, Fitzgerald B, Lipsky MM, Kane AS, Cross AS, Hasday JD. Febrile-range temperature modifies early systemic tumor necrosis factor alpha expression in mice challenged with bacterial endotoxin. Infect Immun 67: 1539-1546, 1999.
182. Joad JP, Kott KS, Bonham AC. Nitric oxide contributes to substance P-induced increases in lung rapidly adapting receptor activity in guineapigs. J Physiol 503: 635-643, 1997.
183. Jonzon A, Pisarri TE, Coleridge JC, Coleridge HM. Rapidly adapting receptor activity in dogs is inversely related to lung compliance. J Appl Physiol 61: 1980-1987, 1986.
184. Joos GF, Kips JC, Peleman RA, Pauwels RA. Tachykinin antagonists and the airways. Arch Int Pharmacodyn Ther 329: 205-219, 1995.
185. Joris L, Dab I, Quinton PM. Elemental composition of human airway surface fluid in healthy and diseased airways. Am Rev Respir Dis 148: 1633-1637, 1993.
186. Kappagoda CT, Man GC, Teo KK. Behaviour of canine pulmonary vagal afferent receptors during sustained acute pulmonary venous pressure elevation. J Physiol 394: 249-265, 1987.
187. Kappagoda CT, Ravi K. The rapidly adapting receptors in mammalian airways and their responses to changes in extravascular fluid volume. Exp Physiol 91: 647-654, 2006.
188. Karlsson JA, Fuller RW. Pharmacological regulation of the cough reflex-from experimental models to antitussive effects in Man. Pulm Pharmacol Ther 12: 215-228, 1999.
189. Kaufman MP, Iwamoto GA, Ashton JH, Cassidy SS. Responses to inflation of vagal afferents with endings in the lung of dogs. Circ Res 51: 525-531, 1982.
190. Kaufman MP, Ordway GA, Waldrop TG. Effect of PEEP on discharge of pulmonary C-fibers in dogs. J Appl Physiol 59: 1085-1089, 1985.
191. Knowlton GC, Larrabee MG. A unitary analysis of pulmonary volume receptors. Am J Physiol 147: 100-114, 1946.
192. Koepchen HP, Kalia M, Sommer D, Klussendorf D. Action of type J afferents on the discharge pattern of medullary respiratory neurons. In: Paintal AS, Gill-Kumar P, editors. Krogh Centenary Symposium on Respiratory Adaptations, Capillary Exchange and Reflex Mechanisms. Delhi: Vallabhbhai Patel Chest Institute, 1977, pp. 407-425.
193. Kollarik M, Ru F, Undem BJ. Acid-sensitive vagal sensory pathways and cough. Pulm Pharmacol Ther 20: 402-411, 2007.
194. Kollarik M, Undem BJ. Mechanisms of acid-induced activation of airway afferent nerve fibres in guinea-pig. J Physiol 543: 591-600, 2002.
195. Komatsu T, Yamamoto M, Shimokata K, Nagura H. Distribution of substance P-immunoreactive and calcitonin gene-related peptideimmunoreactive nerves in normal human lungs. Int Arch Allergy Appl Immunol 95: 23-28, 1991.
196. Kostikas K, Papatheodorou G, Ganas K, Psathakis K, Panagou P, Loukides S. pH in expired breath condensate of patients with inflammatory airway diseases. Am J Respir Crit Care Med 165: 1364-1370, 2002.
197. Kostreva DR, Hopp FA, Zuperku EJ, Igler FO, Coon RL, Kampine JP. Respiratory inhibition with sympathetic afferent stimulation in the canine and primate. J Appl Physiol 44: 718-724, 1978.
198. Kostreva DR, Zuperku EJ, Hess GL, Coon RL, Kampine JP. Pulmonary afferent activity recorded from sympathetic nerves. J Appl Physiol 39: 37-40, 1975.
199. Kou YR, Kwong K, Lee LY. Airway inflammation and hypersensitivity induced by chronic smoking. Respir Physiol Neurobiol 178: 395-405, 2011.
200. Kou YR, Lee LY. Stimulation of rapidly adapting receptors in canine lungs by a single breath of cigarette smoke. J Appl Physiol 68: 1203-1210, 1990.
201. Kou YR, Lee LY. Mechanisms of cigarette smoke-induced stimulation of rapidly adapting receptors in canine lungs. Respir Physiol 83: 61-75, 1991.
202. Krauhs JM. Morphology of presumptive slowly adapting receptors in dog trachea. Anat Rec 210: 73-85, 1984.
203. Krstew E, Jarrott B, Lawrence AJ. Bradykinin B2 receptors in nodose ganglia of rat and human. Eur J Pharmacol 348: 175-180, 1998.
204. Kummer W, Fischer A, Kurkowski R, Heym C. The sensory and sympathetic innervation of guinea-pig lung and trachea as studied by retrograde neuronal tracing and double-labelling immunohistochemistry. Neuroscience 49: 715-737, 1992.
205. Kuo YL, Lai CJ. Ovalbumin sensitizes vagal pulmonary C-fiber afferents in Brown Norway rats. J Appl Physiol 105: 611-620, 2008.
206. Kwong K,Kollarik M, Nassenstein C, Ru F, Undem BJ. P2X2 receptors differentiate placodal vs. neural crest C-fiber phenotypes innervating guinea pig lungs and esophagus. Am J Physiol Lung Cell Mol Physiol 295: L858-L865, 2008.
207. Kwong K, Lee LY. PGE(2) sensitizes cultured pulmonary vagal sensory neurons to chemical and electrical stimuli. J Appl Physiol 93: 1419-1428, 2002.
208. Lai CJ, Ruan T, Kou YR. The involvement of hydroxyl radical and cyclooxygenase metabolites in the activation of lung vagal sensory receptors by circulatory endotoxin in rats. J Appl Physiol 98: 620-628, 2005.
209. Lai JP, Douglas SD, Ho WZ. Human lymphocytes express substance P and its receptor. J Neuroimmunol 86: 80-86, 1998.
210. Lamb JP, Sparrow MP. Three-dimensional mapping of sensory innervation with substance p in porcine bronchial mucosa: Comparison with human airways. Am J Respir Crit Care Med 166: 1269-1281, 2002.
211. Lansing RW, Gracely RH, Banzett RB. The multiple dimensions of dyspnea: Review and hypotheses. Respir Physiol Neurobiol 167: 53-60, 2009.
212. Larsell O. The ganglia, plexuses, and nerve-terminations of the mammalian lung and pleura pulmonalis. J Comp Neurol 35: 97-132, 1922.
213. Lee KF, Li E, Huber LJ, Landis SC, Sharpe AH, Chao MV, Jaenisch R. Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell 69: 737-749, 1992.
214. Lee LY. Inhibitory effect of gas phase cigarette smoke on breathing: Role of hydroxyl radical. Respir Physiol 82: 227-238, 1990.
215. Lee LY. Respiratory sensations evoked by activation of bronchopulmonary C-fibers. Respir Physiol Neurobiol 167: 26-35, 2009.
216. Lee LY, Beck ER, Morton RF, Kou YR, Frazier DT. Role of bronchopulmonary C-fiber afferents in the apneic response to cigarette smoke. J Appl Physiol 63: 1366-1373, 1987.
217. Lee LY, Bleecker ER, Nadel JA. Effect of ozone on bronchomotor response to inhaled histamine aerosol in dogs. J Appl Physiol 43: 626-631, 1977.
218. Lee LY, Gerhardstein DC,Wang AL, Burki NK. Nicotine is responsible for airway irritation evoked by cigarette smoke inhalation in men. J Appl Physiol 75: 1955-1961, 1993.
219. Lee LY, Gu Q. Cough sensors. IV. Nicotinic membrane receptors on cough sensors. Handb Exp Pharmacol 187: 77-98, 2009a.
220. Lee LY, Gu Q. Role of TRPV1 in inflammation-induced airway hypersensitivity. Curr Opin Pharmacol 9: 243-249, 2009b.
221. Lee LY, Gu Q, Gleich GJ. Effects of human eosinophil granule-derived cationic proteins on C-fiber afferents in the rat lung. J Appl Physiol 91: 1318-1326, 2001.
222. Lee LY, Kou YR, Frazier DT, Beck ER, Pisarri TE, Coleridge HM, Coleridge JC. Stimulation of vagal pulmonary C-fibers by a single breath of cigarette smoke in dogs. J Appl Physiol 66: 2032-2038, 1989.
223. Lee LY, Morton RF, Kou YR. Acute effects of cigarette smoke on breathing in rats: Vagal and nonvagal mechanisms. J Appl Physiol 68: 955-961, 1990.
224. Lee LY, Morton RF, Lundberg JM. Pulmonary chemoreflexes elicited by intravenous injection of lactic acid in anesthetized rats. J Appl Physiol 81: 2349-2357, 1996.
225. Lee LY, Pisarri TE. Afferent properties and reflex functions of bronchopulmonary C-fibers. Respir Physiol 125: 47-65, 2001.
226. Lee LY, Undem BJ. Brochopulmonary vagal sensory nerves. Chapter 11. In: Undem BJ, Weinreich D, editors. Advances in Vagal Afferent Neurobiology. CRC Press, 2005, p. 279-313.
227. Leff AR, Stimler NP, Munoz NM, Shioya T, Tallet J, Dame C. Augmentation of respiratory mast cell secretion of histamine caused by vagus nerve stimulation during antigen challenge. J Immunol 136: 1066-1073, 1986.
228. Leon A, Buriani A, Dal Toso R, Fabris M, Romanello S, Aloe L, Levi-Montalcini R. Mast cells synthesize, store, and release nerve growth factor. Proc Natl Acad Sci U S A 91: 3739-3743, 1994.
229. Li H, Du L, Otmishi P, He Y, Guardiola J, Yu J. Opposite responses to lidocaine between intrapulmonary mechanical and chemical sensors. Am J Physiol Regul Integr Comp Physiol 297: R853-R858, 2009.
230. Li HF, Yu J. Airway chemosensitive receptors in vagus nerve perform neuro-immune interaction for lung-brain communication. Adv Exp Med Biol 648: 421-426, 2009.
231. Li PC, Shaw CF, Kuo TF, Chien CT. Inducible nitric oxide synthase evoked nitric oxide counteracts capsaicin-induced airway smooth muscle contraction, but exacerbates plasma extravasation. Neurosci Lett 378: 117-122, 2005.
232. Liedtke W, Choe Y, Marti-Renom MA, Bell AM, Denis CS, Sali A, Hudspeth AJ, Friedman JM, Heller S. Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 103: 525-535, 2000.
233. Lieu T, Kollarik M, Myers AC, Undem BJ. Neurotrophin and GDNF family ligand receptor expression in vagal sensory nerve subtypes innervating the adult guinea pig respiratory tract. Am J Physiol Lung Cell Mol Physiol 300: L790-L798, 2011.
234. Lin RL, Gu Q, Lin YS, Lee LY. Stimulatory effect ofCO2 on vagal bronchopulmonary C-fiber afferents during airway inflammation. J Appl Physiol 99: 1704-1711, 2005.
235. Lin RL, Hayes D, Jr., Lee LY. Bronchoconstriction induced by hyperventilation with humidified hot air: Role of TRPV1-expressing airway afferents. J Appl Physiol 106: 1917-1924, 2009.
236. Lin S, Li H, Xu L, Moldoveanu B, Guardiola J, Yu J. Arachidonic acid products in airway nociceptor activation during acute lung injury. Exp Physiol 96: 966-976, 2011.
237. Lin S, Walker J, Xu L, Gozal D, Yu J. Respiratory: Behaviours of pulmonary sensory receptors during development of acute lung injury in the rabbit. Exp Physiol 92: 749-755, 2007.
238. Lin YS, Hsu CC, Bien MY, Hsu HC,Weng HT, Kou YR. Activations of TRPA1 and P2X receptors are important in ROS-mediated stimulation of capsaicin-sensitive lung vagal afferents by cigarette smoke in rats. J Appl Physiol 108: 1293-1303, 2010.
239. Lommatzsch M, Schloetcke K, Klotz J, Schuhbaeck K, Zingler D, Zingler C, Schulte-Herbruggen O, Gill H, Schuff-Werner P, Virchow JC. Brain-derived neurotrophic factor in platelets and airflow limitation in asthma. Am J Respir Crit Care Med 171: 115-120, 2005.
240. Lou YP, Lundberg JM. Inhibition of lowpH evoked activation of airway sensory nerves by capsazepine, a novel capsaicin-receptor antagonist. Biochem Biophys Res Commun 189: 537-544, 1992.
241. Lowry R, Higenbottam T, Johnson T, Godden D. Inhibition of artificially induced cough in man by bronchodilators. Br J Clin Pharmacol 24: 503-510, 1987.
242. Lowry RH,Wood AM, Higenbottam TW. Effects of pH and osmolarity on aerosol-induced cough in normal volunteers. Clin Sci (Lond) 74: 373-376, 1988.
243. Lundberg JM. New aspects on airway innervation. Pharmacol Toxicol 72: 21-27, 1993.
244. Lundberg JM, Saria A. Polypeptide-containing neurons in airway smooth muscle. Annu Rev Physiol 49: 557-572, 1987.
245. Mak JC, Barnes PJ. Autoradiographic visualization of bradykinin receptors in human and guinea pig lung. Eur J Pharmacol 194: 37-43, 1991.
246. Manning HL, Shea SA, Schwartzstein RM, Lansing RW, Brown R, Banzett RB. Reduced tidal volume increases 'air hunger' at fixed PCO2 in ventilated quadriplegics. Respir Physiol 90: 19-30, 1992.
247. Marek W, Muckenhoff K, Prabhakar NR. Significance of pulmonary vagal afferents for respiratory muscle activity in the cat. J Physiol Pharmacol 59: 407-420, 2008.
248. Maron MB,Wagner JA, Horvath SM. Thermoregulatory responses during competitive marathon running. J Appl Physiol 42: 909-914, 1977.
249. Marshall JM, Metcalfe JD. Cardiovascular changes associated with augmented breaths in normoxia and hypoxia in the rat. J Physiol 400: 15-27, 1988.
250. MathewOP, Abu-Osba YK, Thach BT. Genioglossus muscle responses to upper airway pressure changes: Afferent pathways. J Appl Physiol 52: 445-450, 1982.
251. Matsumoto S, Ikeda M, Nishikawa T, Yoshida S, Tanimoto T, Ito M, Saiki C, Takeda M. Excitatory mechanism of deflationary slowly adapting pulmonary stretch receptors in the rat lung. J Pharmacol Exp Ther 300: 597-604, 2002.
252. Matsumoto S, Ikeda M, Yoshida S, Tanimoto T, Takeda M, Nasu M. Prostaglandin E2-induced modification of tetrodotoxin-resistant Na+ currents involves activation of both EP2 and EP4 receptors in neonatal rat nodose ganglion neurones. Br J Pharmacol 145: 503-513, 2005.
253. Matsumoto S, Takahashi T, Tanimoto T, Saiki C, Takeda M, Ojima K. Excitatory mechanism of veratridine on slowly adapting pulmonary stretch receptors in anesthetized rabbits. Life Sci 63: 1431-1437, 1998.
254. Matsumoto S, Yamasaki M, Nagayama T, Kanno T, Shimizu T. Effects of atropine on the responses of rapidly adapting pulmonary stretch receptors and dynamic lung compliance to sodium cyanide-induced hyperpnea. J Auton Nerv Syst 44: 53-59, 1993.
255. Mazzone SB, Mori N, Burman M, Palovich M, Belmonte KE, Canning BJ. Fluorescent styryl dyes FM1-43 and FM2-10 are muscarinic receptor antagonists: Intravital visualization of receptor occupancy. J Physiol 575: 23-35, 2006.
256. Mazzone SB, Reynolds SM, Mori N, Kollarik M, Farmer DG, Myers AC, Canning BJ. Selective expression of a sodium pump isozyme by cough receptors and evidence for its essential role in regulating cough. J Neurosci 29: 13662-13671, 2009.
257. McAlexander MA, Undem BJ. Potassium channel blockade induces action potential generation in guinea-pig airway vagal afferent neurones. J Auton Nerv Syst 78: 158-164, 2000.
258. McCormick KM, Bravo EM, Kappagoda CT. Role of adrenergic receptors in the reflex diuresis in rabbits during pulmonary lymphatic obstruction. Exp Physiol 90: 341-347, 2005.
259. McCormick KM, Gunawardena S, Ravi K, Bravo EM, Kappagoda CT. Role of nitric oxide in the reflex diuresis in rabbits during pulmonary lymphatic obstruction. Exp Physiol 89: 487-496, 2004.
260. Mellen NM, Feldman JL. Phasic lung inflation shortens inspiration and respiratory period in the lung-attached neonate rat brain stem spinal cord. J Neurophysiol 83: 3165-3168, 2000.
261. Miserocchi G, Sant'ambrogio G. Responses of pulmonary stretch receptors to static pressure inflations. Respir Physiol 21: 77-85, 1974.
262. Mitchell JE, Campbell AP, New NE, Sadofsky LR, Kastelik JA, Mulrennan SA, Compton SJ, Morice AH. Expression and characterization of the intracellular vanilloid receptor (TRPV1) in bronchi from patients with chronic cough. Exp Lung Res 31: 295-306, 2005.
263. Morrow J, Jackson RL. Lipid-derived autacoids:Eicosanoids and platelet-activating factor. In: Hardman J, Limbird L, editors. The Pharmacologocal Basis of Therapeutics. New York: McGraw-Hill, 2001, pp. 669-685.
264. Myers AC, Kajekar R, Undem BJ. Allergic inflammation-induced neuropeptide production in rapidly adapting afferent nerves in guinea pig airways. Am J Physiol Lung Cell Mol Physiol 282: L775-L781, 2002.
265. Nassenstein C, Kwong K, Taylor-Clark T, Kollarik M, Macglashan DM, Braun A, Undem BJ. Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs. J Physiol 586: 1595-1604, 2008.
266. Nassenstein C, Taylor-Clark TE, Myers AC, Ru F, Nandigama R, Bettner W, Undem BJ. Phenotypic distinctions between neural crest and placodal derived vagal C-fibres in mouse lungs. J Physiol 588: 4769-4783, 2010.
267. Neuhuber WL. Lung sensors: Complex functions require complex structures. Am J Respir Cell Mol Biol 28: 265-266, 2003.
268. Ni D, Gu Q, Hu HZ, Gao N, Zhu MX, Lee LY. Thermal sensitivity of isolated vagal pulmonary sensory neurons: Role of transient receptor potential vanilloid receptors. Am J Physiol Regul Integr Comp Physiol 291: R541-R550, 2006.
269. Ni D, Lee LY. Effect of increasing temperature on TRPV1-mediated responses in isolated rat pulmonary sensory neurons. Am J Physiol Lung Cell Mol Physiol 294: L563-L571, 2008a.
270. Ni D, Lee LY. Lack of potentiating effect of increasing temperature on responses to chemical activators in vagal sensory neurons isolated from TRPV1-null mice. Am J Physiol Lung Cell Mol Physiol 295: L897-L904, 2008b.
271. Niijima A. The afferent discharges from sensors for interleukin 1 beta in the hepatoportal system in the anesthetized rat. J Auton Nerv Syst 61: 287-291, 1996.
272. Nilius B, Owsianik G, Voets T, Peters JA. Transient receptor potential cation channels in disease. Physiol Rev 87: 165-217, 2007.
273. Nilius B, Talavera K, Owsianik G, Prenen J, Droogmans G, Voets T. Gating of TRP channels: A voltage connection? J Physiol 567: 35-44, 2005.
274. Nishino T, Hiraga K, Mizuguchi T, Honda Y. Respiratory reflex responses to stimulation of tracheal mucosa in enflurane-anesthetized humans. J Appl Physiol 65: 1069-1074, 1988.
275. Nishino T, Tagaito Y, Isono S. Cough and other reflexes on irritation of airway mucosa in man. Pulm Pharmacol 9: 285-292, 1996.
276. O'Connell F, Thomas VE, Studham JM, Pride NB, Fuller RW. Capsaicin cough sensitivity increases during upper respiratory infection. Respir Med 90: 279-286, 1996.
277. Ogilvie MD, Bogen DK, Galante RJ, Pack AI. Response of stretch receptors to static inflations and deflations in an isolated tracheal segment. Respir Physiol 75: 289-307, 1989.
278. Oh EJ, Mazzone SB, Canning BJ, Weinreich D. Reflex regulation of airway sympathetic nerves in guinea-pigs. J Physiol 573: 549-564, 2006.
279. Olgart C, Frossard N. Human lung fibroblasts secrete nerve growth factor: Effect of inflammatory cytokines and glucocorticoids. Eur Respir J 18: 115-121, 2001.
280. Opie LH, SmithAC, Spalding JM. Conscious appreciation of the effects produced by independent changes of ventilation volume and of end-tidal PCO2 in paralysed patients. J Physiol 149: 494-499, 1959.
281. Ordway GA, Pitetti KH. Stimulation of pulmonary C fibres decreases coronary arterial resistance in dogs. J Physiol 371: 277-288, 1986.
282. Paintal AS. The mechanism of excitation of type J receptors, and the J reflex. In: Porter R, editor. Breathing: Hering-Breuer centenary symposium. London: Churchill, 1970, pp. 59-71.
283. Paintal AS. Vagal sensory receptors and their reflex effects. Physiol Rev 53: 159-227, 1973.
284. Paintal AS. Sensations from J-receptors. News Physiol Sci 10: 238-243, 1995.
285. Paintal AS. Some recent advances in studies on J receptors. Adv Exp Med Biol 381: 15-25, 1995.
286. Paintal AS. The nature and effects of sensory inputs into the respiratory centers. Fed Proc 36: 2428-2432, 1977.
287. Paredi P, Kharitonov SA, Barnes PJ. Faster rise of exhaled breath temperature in asthma: A novel marker of airway inflammation? Am J Respir Crit Care Med 165: 181-184, 2002.
288. Pepys J, Pickering CA, Breslin AB, Terry DJ. Asthma due to inhaled chemical agents, tolylene di-isocyanate. Clin Allergy 2: 225-236, 1972.
289. Phillipson EA, Duffin J, Cooper JD. Critical dependence of respiratory rhythmicity on metabolic CO2 load. J Appl Physiol 50: 45-54, 1981.
290. Phillipson EA, Fishman NH, Hickey RF, Nadel JA. Effect of differential vagal blockade on ventilatory response to CO2 in awake dogs. J Appl Physiol 34: 759-763, 1973.
291. Piacentini GL, Peroni D, Crestani E, Zardini F, Bodini A, Costella S, Boner AL. Exhaled air temperature in asthma: Methods and relationship with markers of disease. Clin Exp Allergy 37: 415-419, 2007.
292. Pickar JG, Hill JM, Kaufman MP. Stimulation of vagal afferents inhibits locomotion in mesencephalic cats. J Appl Physiol 74: 103-110, 1993.
293. Piedimonte G. Contribution of neuroimmune mechanisms to airway inflammation and remodeling during and after respiratory syncytial virus infection. Pediatr Infect Dis J 22: S66-S74, 2003.
294. Piedimonte G, Rodriguez MM, King KA, McLean S, Jiang X. Respiratory syncytial virus upregulates expression of the substance P receptor in rat lungs. Am J Physiol 277: L831-L840, 1999.
295. Pisarri TE, Coleridge JC, Coleridge HM. Capsaicin-induced bronchial vasodilation in dogs: Central and peripheral neural mechanisms. J Appl Physiol 74: 259-266, 1993.
296. Pisarri TE, Jonzon A, Coleridge HM, Coleridge JC. Intravenous injection of hypertonic NaCl solution stimulates pulmonary C-fibers in dogs. Am J Physiol 260: H1522-H1530, 1991.
297. Pisarri TE, Jonzon A, Coleridge HM, Coleridge JC. Vagal afferent and reflex responses to changes in surface osmolarity in lower airways of dogs. J Appl Physiol 73: 2305-2313, 1992.
298. Pisarri TE, Jonzon A, Coleridge JC, Coleridge HM. Rapidly adapting receptors monitor lung compliance in spontaneously breathing dogs. J Appl Physiol 68: 1997-2005, 1990.
299. Pisarri TE, Yu J, Coleridge HM, Coleridge JCG. Background activity in pulmonary vagal C-fibers and its effects on breathing. Respir Physiol 64: 29-43, 1986.
300. Planas ME, Rodriguez L, Sanchez S, Pol O, Puig MM. Pharmacological evidence for the involvement of the endogenous opioid system in the response to local inflammation in the rat paw. Pain 60: 67-71, 1995.
301. Plato M, Kummer W, Haberberger RV. Structural and neurochemical comparison of vagal and spinal afferent neurons projecting to the rat lung. Neurosci Lett 395: 215-219, 2006.
302. Prudon B, Birring SS, Vara DD, Hall AP, Thompson JP, Pavord ID. Cough and glottic-stop reflex sensitivity in health and disease. Chest 127: 550-557, 2005.
303. Pugh LG, Corbett JL, Johnson RH. Rectal temperatures, weight losses, and sweat rates in marathon running. J Appl Physiol 23: 347-352, 1967.
304. Qin C, Foreman RD, Farber JP. Afferent pathway and neuromodulation of superficial and deeper thoracic spinal neurons receiving noxious pulmonary inputs in rats. Auton Neurosci 131: 77-86, 2007.
305. Qin C, Foreman RD, Farber JP. Characterization of thoracic spinal neurons with noxious convergent inputs from heart and lower airways in rats. Brain Res 1141: 84-91, 2007.
306. Qin C, Foreman RD, Farber JP. Inhalation of a pulmonary irritant modulates activity of lumbosacral spinal neurons receiving colonic input in rats. Am J Physiol Regul Integr Comp Physiol 293: R2052-R2058, 2007c.
307. Quigg M, Elfvin LG, Aldskogius H. Anterograde transsynaptic transport of WGA-HRP from spinal afferents to postganglionic sympathetic cells of the stellate ganglion of the guinea pig. Brain Res 518: 173-178, 1990.
308. Rahman I, Adcock IM. Oxidative stress and redox regulation of lung inflammation in COPD. Eur Respir J 28: 219-242, 2006.
309. Ramer MS, Bradbury EJ, McMahon SB. Nerve growth factor induces P2X(3) expression in sensory neurons. J Neurochem 77: 864-875, 2001.
310. Ravi K. Distribution and location of slowly adapting pulmonary stretch receptors in the airways of cats. J Auton Nerv Syst 15: 205-216, 1986.
311. Ravi K, Bravo M, Kappagoda CT. Effect of pulmonary lymphatic obstruction on rabbit urine flow. J Physiol 505: 833-840, 1997.
312. Ravi K, Kappagoda T. Rapidly adapting receptors in acute heart failure and their impact on dyspnea. Respir Physiol Neurobiol 167: 107-115, 2009.
313. Ravi K, Singh M, Julka DB. Properties of rapidly adapting receptors of the airways in monkeys (Macaca mulatta). Respir Physiol 99: 51-62, 1995.
314. Ricco MM, Kummer W, Biglari B, Myers AC, Undem BJ. Interganglionic segregation of distinct vagal afferent fibre phenotypes in guineapig airways. J Physiol 496: 521-530, 1996.
315. Robertson DP, Simpson RK, Rose JE, Garza JS. Video-assisted endoscopic thoracic ganglionectomy. J Neurosurg 79: 238-240, 1993.
316. Romanovsky AA, Simons CT, Kulchitsky VA, Sugimoto N, Szekely M. Vagus nerve in fever. Recent developments. Ann N Y Acad Sci 856: 298-299, 1998.
317. Ruan T, Gu Q, Kou YR, Lee LY. Hyperthermia increases sensitivity of pulmonary C-fibre afferents in rats. J Physiol 565: 295-308, 2005.
318. Ruan T, Ho CY, Kou YR. Afferent vagal pathways mediating respiratory reflexes evoked by ROS in the lungs of anesthetized rats. J Appl Physiol 94: 1987-1998, 2003.
319. Ruan T, Lin YS, Lin KS, Kou YR. Sensory transduction of pulmonary reactive oxygen species by capsaicin-sensitive vagal lung afferent fibres in rats. J Physiol 565: 563-578, 2005.
320. Ruan T, Lin YS, Lin KS, Kou YR. Mediator mechanisms involved in TRPV1 and P2X receptor-mediated, ROS-evoked bradypneic reflex in anesthetized rats. J Appl Physiol 101: 644-654, 2006.
321. Russell NJ, Raybould HE, Trenchard D. Role of vagal C-fiber afferents in respiratory response to hypercapnia. J Appl Physiol 56: 1550-1558, 1984.
322. Sahin G, Webber SE, Widdicombe JG. Lung and cardiac reflex actions on the tracheal vasculature in anaesthetized dogs. J Physiol 387: 47-57, 1987.
323. Sanico AM, Stanisz AM, Gleeson TD, Bora S, Proud D, Bienenstock J, Koliatsos VE, Togias A. Nerve growth factor expression and release in allergic inflammatory disease of the upper airways. Am J Respir Crit Care Med 161: 1631-1635, 2000.
324. Sant'Ambrogio G. Information arising from the tracheobronchial tree of mammals. Physiol Rev 62: 531-569, 1982.
325. Sant'ambrogio G. Nervous receptors of the tracheobronchial tree. Annu Rev Physiol 49: 611-627, 1987.
326. Sant'ambrogio G, Anderson JW, Sant'Ambrogio FB, Mathew OP. Response of laryngeal receptors to water solutions of different osmolality and ionic composition. Respir Med 85: 57-60, 1991.
327. Sant'ambrogio G, Mathew OP, Fisher JT, Sant'Ambrogio FB. Laryngeal receptors responding to transmural pressure, airflow and local muscle activity. Respir Physiol 54: 317-330, 1983.
328. Sant'ambrogio G, Remmers JE, de Groot WJ, Callas G, Mortola JP. Localization of rapidly adapting receptors in the trachea and main stem bronchus of the dog. Respir Physiol 33: 359-366, 1978.
329. Sant'ambrogio G, Tsubone H, Sant'Ambrogio FB. Sensory information from the upper airway: Role in the control of breathing. Respir Physiol 102: 1-16, 1995.
330. Sant'ambrogio G, Widdicombe J. Reflexes from airway rapidly adapting receptors. Respir Physiol 125: 33-45, 2001.
331. Sato E, Koyama S, Okubo Y, Kubo K, Sekiguchi M. Acetylcholine stimulates alveolar macrophages to release inflammatory cell chemotactic activity. Am J Physiol 274: L970-L979, 1998.
332. Schelegle ES, Green JF. An overview of the anatomy and physiology of slowly adapting pulmonary stretch receptors. Respir Physiol 125: 17-31, 2001.
333. Schleputz M, Rieg AD, Seehase S, Spillner J, Perez-Bouza A, Braunschweig T, Schroeder T, Bernau M, Lambermont V, Schlumbohm C, Sewald K, Autschbach R, Braun A, Kramer BW, Uhlig S, Martin C. Neurally mediated airway constriction in human and other species: A comparative study using precision-cut lung slices (PCLS). PLoS One 7: e47344, 2012.
334. Schultz HD, Roberts AM, Bratcher C, Coleridge HM, Coleridge JC, Davis B. Pulmonary C-fibers reflexly increase secretion by tracheal submucosal glands in dogs. J Appl Physiol 58: 907-910, 1985.
335. Schwartz LB, Lewis RA, Seldin D, Austen KF. Acid hydrolases and tryptase from secretory granules of dispersed human lung mast cells. J Immunol 126: 1290-1294, 1981.
336. Seals DR, Suwarno NO, Joyner MJ, Iber C, Copeland JG, Dempsey JA. Respiratory modulation of muscle sympathetic nerve activity in intact and lung denervated humans. Circ Res 72: 440-454, 1993.
337. Sevoz C, Nosjean A, Callera JC, Machado B, Hamon M, Laguzzi R. Stimulation of 5-HT3 receptors in the NTS inhibits the cardiac Bezold-Jarisch reflex response. Am J Physiol 271: H80-H87, 1996.
338. Shanahan F, Denburg JA, Fox J, Bienenstock J, Befus D. Mast cell heterogeneity: Effects of neuroenteric peptides on histamine release. J Immunol 135: 1331-1337, 1985.
339. Sheppard D, Rizk NW, Boushey HA, Bethel RA. Mechanism of cough and bronchoconstriction induced by distilled water aerosol. Am Rev Respir Dis 127: 691-694, 1983.
340. Sheppard D, Scypinski L. A tachykinin receptor antagonist inhibits and an inhibitor of tachykinin metabolism potentiates toluene diisocyanateinduced airway hyperresponsiveness in guinea pigs. Am Rev Respir Dis 138: 547-551, 1988.
341. Shu X, Mendell LM. Acute sensitization by NGF of the response of small-diameter sensory neurons to capsaicin. J Neurophysiol 86: 2931-2938, 2001.
342. Simon PM, Zurob AS,WiesWM,Leiter JC, Hubmayr RD. Entrainment of respiration in humans by periodic lung inflations. Effect of state and CO2. Am J Respir Crit Care Med 160: 950-960, 1999.
343. Solway J, Leff AR. Sensory neuropeptides and airway function. J Appl Physiol 71: 2077-2087, 1991.
344. Sorokin SP, Hoyt RF. On the supposed function of neuroepithelial bodies in adult mammalian lungs. News Physiol Sci 5: 89-95, 1990.
345. Soukhova-O'Hare GK, Zhang JW, Gozal D,Yu J. Bradykinin B2 receptors mediate pulmonary sympathetic afferents induced reflexes in rabbits. Life Sci 78: 1990-1997, 2006.
346. Soukhova G,Wang Y, Ahmed M,Walker J, Yu J. Bradykinin stimulates respiratory drive by activating pulmonary sympathetic afferents in the rabbit. J Appl Physiol 95: 241-249, 2003.
347. Strotmann R, Harteneck C, Nunnenmacher K, Schultz G, Plant TD. OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol 2: 695-702, 2000.
348. Szallasi A. The vanilloid (capsaicin) receptor: Receptor types and species differences. Gen Pharmacol 25: 223-243, 1994.
349. Szarek JL, Spurlock B. Antagonism of cholinergic nerve-mediated contractions by the sensory nerve inhibitory system in rat bronchi. J Appl Physiol 81: 260-265, 1996.
350. Szarek JL, Spurlock B, Gruetter CA, Lemke S. Substance P and capsaicin release prostaglandin E2 from rat intrapulmonary bronchi. Am J Physiol 275: L1006-L1012, 1998.
351. Taha BH, Simon PM, Dempsey JA, Skatrud JB, Iber C. Respiratory sinus arrhythmia in humans: An obligatory role for vagal feedback from the lungs. J Appl Physiol 78: 638-645, 1995.
352. Talavera K, Gees M, Karashima Y, Meseguer VM, Vanoirbeek JA, Damann N, Everaerts W, Benoit M, Janssens A, Vennekens R, Viana F, Nemery B, Nilius B, Voets T. Nicotine activates the chemosensory cation channel TRPA1. Nat Neurosci 12: 1293-1299, 2009.
353. Taylor-Clark TE, McAlexander MA, Nassenstein C, Sheardown SA, Wilson S, Thornton J, Carr MJ, Undem BJ. Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autacoid 4-oxononenal. J Physiol 586: 3447-3459, 2008.
354. Taylor-Clark TE, Undem BJ. Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels. J Physiol 588: 423-433, 2010.
355. Taylor-Clark TE, Undem BJ. Sensing pulmonary oxidative stress by lung vagal afferents. Respir Physiol Neurobiol 178: 406-413, 2011.
356. Taylor RF, Lee LY, Jewell LA, Frazier DT. Effect of nicotine aerosol on slowly adapting receptors in the airways of the dog. J Neurosci Res 15: 583-593, 1986.
357. Therien AG, Blostein R. Mechanisms of sodium pump regulation. Am J Physiol Cell Physiol 279: C541-C566, 2000.
358. Thompson JE, Scypinski LA, Gordon T, Sheppard D. Tachykinins mediate the acute increase in airway responsiveness caused by toluene diisocyanate in guinea pigs. Am Rev Respir Dis 136: 43-49, 1987.
359. Tiberio IF, Leick-Maldonado EA, Miyahara L, Kasahara DI, Spilborghs GM, Martins MA, Saldiva PH. Effects of neurokinins on airway and alveolar eosinophil recruitment. Exp Lung Res 29: 165-177, 2003.
360. Tracey KJ. The inflammatory reflex. Nature 420: 853-859, 2002.
361. Trenchard D. CO2/H+ receptors in the lungs of anaesthetized rabbits. Respir Physiol 63: 227-240, 1986.
362. Uchida K, Shiraishi M, Naito Y, Torii Y, Nakamura Y, Osawa T. Activation of stress signaling pathways by the end product of lipid peroxidation. 4-hydroxy-2-nonenal is a potential inducer of intracellular peroxide production. J Biol Chem 274: 2234-2242, 1999.
363. Undem BJ, Carr MJ. Pharmacology of airway afferent nerve activity. Respir Res 2: 234-244, 2001.
364. Undem BJ, Chuaychoo B, Lee MG, Weinreich D, Myers AC, Kollarik M. Subtypes of vagal afferent C-fibres in guinea-pig lungs. J Physiol 556: 905-917, 2004.
365. Undem BJ, Hunter DD, Liu M, Haak-Frendscho M, Oakragly A, Fischer A. Allergen-induced sensory neuroplasticity in airways. Int Arch Allergy Immunol 118: 150-153, 1999.
366. Undem BJ, Potenzieri C. Autonomic neural control of intrathoracic airways. Compr Physiol 2: 1241-1267, 2012.
367. Van LA. Pulmonary neuroendocrine cells (PNEC) and neuroepithelial bodies (NEB): chemoreceptors and regulators of lung development. Paediatr Respir Rev 2: 171-176, 2001.
368. van Lommel A, Lauweryns JM, Berthoud HR. Pulmonary neuroepithelial bodies are innervated by vagal afferent nerves: An investigation with in vivo anterograde DiI tracing and confocal microscopy. Anat Embryol (Berl) 197: 325-330, 1998.
369. Veelken R, Leonard M, Stetter A, Hilgers KF, Mann JF, Reeh PW, Geiger H, Luft FC. Pulmonary serotonin 5-HT3-sensitive afferent fibers modulate renal sympathetic nerve activity in rats. Am J Physiol 272: H979-H986, 1997.
370. Veres TZ, Rochlitzer S, Shevchenko M, Fuchs B, Prenzler F, Nassenstein C, Fischer A, Welker L, Holz O, Muller M, Krug N, Braun A. Spatial interactions between dendritic cells and sensory nerves in allergic airway inflammation. Am J Respir Cell Mol Biol 37: 553-561, 2007.
371. Veres TZ, Shevchenko M, Krasteva G, Spies E, Prenzler F, Rochlitzer S, Tschernig T, Krug N, Kummer W, Braun A. Dendritic cell-nerve clusters are sites of T cell proliferation in allergic airway inflammation. Am J Pathol 174: 808-817, 2009.
372. Voets T, Droogmans G,Wissenbach U, Janssens A, Flockerzi V, Nilius B. The principle of temperature-dependent gating in cold-and heatsensitive TRP channels. Nature 430: 748-754, 2004.
373. Waldmann R, Bassilana F, de Weille J, Champigny G, Heurteaux C, Lazdunski M. Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons. J Biol Chem 272: 20975-20978, 1997.
374. Waldmann R, Champigny G, Bassilana F, Heurteaux C, Lazdunski M. A proton-gated cation channel involved in acid-sensing. Nature 386: 173-177, 1997.
375. Wang AL, Blackford TL, Lee LY. Vagal bronchopulmonary C-fibers and acute ventilatory response to inhaled irritants. Respir Physiol 104: 231-239, 1996.
376. Wang Y, Soukhova G, Proctor M, Walker J, Yu J. Bradykinin causes hypotension by activating pulmonary sympathetic afferents in the rabbit. J Appl Physiol 95: 233-240, 2003.
377. Wang YF, Yu J. Na+/K+-ATPase as a marker for detecting pulmonary sensory receptors. Acta Physiologica Sinica 54: 390-394, 2002.
378. Wang YF, Yu J. Structural survey of airway sensory receptors in the rabbit using confocal microscopy. Acta Physiologica Sinica 56: 119-129, 2004.
379. Wasserman K, Whipp BJ, Casaburi R, Beaver WL. Carbon dioxide flow and exercise hyperpnea. Cause and effect. Am Rev Respir Dis 115: 225-237, 1977.
380. Wasserman K, Whipp BJ, Casaburi R, Huntsman DJ, Castagna J, Lugliani R. Regulation of arterial PCO2 during intravenousCO2 loading. J Appl Physiol 38: 651-656, 1975.
381. Watanabe N, Horie S, Michael GJ, Keir S, Spina D, Page CP, Priestley JV. Immunohistochemical co-localization of transient receptor potential vanilloid (TRPV)1 and sensory neuropeptides in the guinea-pig respiratory system. Neuroscience 141: 1533-1543, 2006.
382. Webber SE,Widdicombe JG. Reflex control of the tracheal vasculature of sheep. J Appl Physiol 75: 2173-2179, 1993.
383. Widdicombe JG. Airway receptors. Respir Physiol 125: 3-15, 2001.
384. Widdicombe JG. Receptors in the trachea and bronchi of the cat.JPhysiol 123: 71-104, 1954.
385. Widdicombe JG. Nervous receptors in the respiratory tree and lungs. Chapter 6. In: Hornbein T, editor. Lung Biology in Health and Disease Regulation of Breathing. New York: Dekker, 1981.
386. Widdicombe JG. Overview of neural pathways in allergy and asthma. Pulm Pharmacol Ther 16: 23-30, 2003.
387. Widdicombe JG, Sant'ambrogio G, Mathew OP. Nerve receptors of the upper airway. Chap. 6. In: Mathew OP, Sant'ambrogio G, editors. Respiratory Function of the Upper Airway. New York: Dekker, 1988.
388. Wilfong ER, Dey RD. Nerve growth factor and substance P regulation in nasal sensory neurons after toluene diisocyanate exposure. Am J Respir Cell Mol Biol 30: 793-800, 2004.
389. Winner E, Zhang JW, Proctor M, Yu J. Ouabain stimulates slowly adapting pulmonary stretch receptors. Acta Physiologica Sinica 57: 689-695, 2005.
390. Winning AJ, Hamilton RD, Shea SA, Guz A. Respiratory and cardiovascular effects of central and peripheral intravenous injections of capsaicin in man: Evidence for pulmonary chemosensitivity. Clin Sci (Lond) 71: 519-526, 1986.
391. Winston J, Toma H, Shenoy M, Pasricha PJ. Nerve growth factor regulates VR-1 mRNA levels in cultures of adult dorsal root ganglion neurons. Pain 89: 181-186, 2001.
392. Winter J. Brain derived neurotrophic factor, but not nerve growth factor, regulates capsaicin sensitivity of rat vagal ganglion neurones. Neurosci Lett 241: 21-24, 1998.
393. Winter J, Forbes CA, Sternberg J, Lindsay RM. Nerve growth factor (NGF) regulates adult rat cultured dorsal root ganglion neuron responses to the excitotoxin capsaicin. Neuron 1: 973-981, 1988.
394. Wolff AP, May M, Nuelle D. The tympanic membrane. A source of the cough reflex. JAMA 223: 1269, 1973.
395. Wong CH, Matai R, Morice AH. Cough induced by low pH. Respir Med 93: 58-61, 1999.
396. Wood LG, Gibson PG, Garg ML. Biomarkers of lipid peroxidation, airway inflammation and asthma. Eur Respir J 21: 177-186, 2003.
397. Xu J, Yang W, Zhang G, Gu Q, Lee LY. Calcium transient evoked by nicotine in isolated rat vagal pulmonary sensory neurons. Am J Physiol Lung Cell Mol Physiol 292: L54-L61, 2007.
398. Yamamoto Y, Atoji Y, Suzuki Y. Nerve endings in bronchi of the dog that react with antibodies against neurofilament protein. J Anat 187: 59-65, 1995.
399. Yamamoto Y, Atoji Y, Suzuki Y. Calretinin immunoreactive nerve endings in the trachea and bronchi of the rat. J Vet Med Sci 61: 267-269, 1999.
400. Yamamoto Y, Hayashi M, Atoji Y, Suzuki Y. Vagal afferent nerve endings in the trachealis muscle of the dog. Arch Histol Cytol 57: 473-480, 1994.
401. Young JD, Peterson CG, Venge P, Cohn ZA. Mechanism of membrane damage mediated by human eosinophil cationic protein. Nature 321: 613-616, 1986.
402. Yu J. An overview of vagal airway receptors. Acta Physiologica Sinica 54: 451-459, 2002.
403. Yu J. Airway mechanosensors. Respir Physiol Neurobiol 148: 217-243, 2005.
404. Yu J. Pulmonary rapidly adapting receptors and airway constriction. Adv Exp Med Biol 450: 159-166, 1998.
405. Yu J. Spectrum of myelinated pulmonary afferents. Am J Physiol Regul Integr Comp Physiol 279: R2142-R2148, 2000.
406. Yu J, Coleridge JCG, Coleridge HM. Influence of lung stiffness on rapidly adapting receptors in rabbits and cats. Respir Physiol 68: 161-176, 1987.
407. Yu J, Lin S, Zhang J, Otmishi P, Guardiola JJ. Airway nociceptors activated by pro-inflammatory cytokines. Respir Physiol Neurobiol 156: 116-119, 2007.
408. Yu J, Lin SX, Zhang JW,Walker JF. Pulmonary nociceptors are potentially connected with neuroepithelial bodies. Adv Exp Med Biol 580: 301-306, 2006.
409. Yu J, Roberts AM. Indirect effects of histamine on pulmonary rapidly adapting receptors in cats. Respir Physiol 79: 101-110, 1990.
410. Yu J, Roberts AM, Joshua IG. Lung inflation evokes reflex dilation of microvessels in rat skeletal muscle. Am J Physiol 258: H939-H945, 1990.
411. Yu J, Schultz HD, Goodman J, Coleridge JCG, Coleridge HM, Davis B. Pulmonary rapidly adapting receptors reflexly increase airway secretion in dogs. J Appl Physiol 67: 682-687, 1989.
412. Yu J, Wang Y, Soukhova G, Collins LC, Falcone JC. Excitatory lung reflex may stress inspiratory muscle by suppressing expiratory muscle activity. J Appl Physiol 90: 857-864, 2001.
413. Yu J, Wang YF, Zhang JW. Structure of slowly adapting pulmonary stretch receptors in the lung periphery. J Appl Physiol 95: 385-393, 2003.
414. Yu J, Zhang J. A single pulmonary mechano-sensory unit possesses multiple encoders in rabbits. Neurosci Lett 362: 171-175, 2004.
415. Yu J, Zhang J, Wang Y, Fan F, Yu A. Neuroepithelial bodies not connected to pulmonary slowly adapting stretch receptors. Respir Physiol Neurobiol 144: 1-14, 2004.
416. Yu J, Zhang JF, Roberts AM, Collins LC, Fletcher EC. Pulmonary rapidly adapting receptor stimulation does not increase airway resistance in anesthetized rabbits. Am J Respir Crit Care Med 160: 906-12, 1999.
417. Zagorodnyuk VP, Brookes SJ. Transduction sites of vagal mechanoreceptors in the guinea pig esophagus. J Neurosci 20: 6249-6255, 2000.
418. Zhang G, Lin RL,Wiggers M, SnowDM, Lee LY. Altered expression of TRPV1 and sensitivity to capsaicin in pulmonary myelinated afferents following chronic airway inflammation in the rat. J Physiol 586: 5771-5786, 2008.
419. Zhang J, Walker JF, Guardiola J, Yu J. Pulmonary sensory and reflex responses in the mouse. J Appl Physiol 110: 986-992, 2006.
420. Zou AP, Cowley AW, Jr. alpha(2)-adrenergic receptor-mediated increase in NO production buffers renal medullary vasoconstriction. Am J Physiol Regul Integr Comp Physiol 279: R769-R777, 2000.