Extending the understanding of sensory neuropeptides

European Journal of Pharmacology

Volumn 533, Issue 1-3, 2006, Pages 171-181

  De Swert, Katelijne O ^a   Joos, Guy F ^a,b  

^a GHENT UNIVERSITY   (Belgium)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Airway inflammation; Asthma; Chronic obstructive pulmonary disease; Neurokinin A; Substance P; Tachykinin

Indexed keywords

2 BENZHYDRYL 3 (2 METHOXYBENZYLAMINO) 1 AZABICYCLO[2.2.2]OCTANE; 3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; ALLERGEN; CAPSAICIN; CIGARETTE SMOKE; CS 003; DNK 333A; FK 224; N BENZYL N2 [4 HYDROXY 1 [(1 METHYL 1H INDOL 3 YL)CARBONYL]PROLYL] N METHYL 3 (2 NAPHTHYL)ALANINAMIDE; NEPADUTANT; NEUROKININ A; NEUROKININ B; NEUROPEPTIDE; OSANETANT; OZONE; SAREDUTANT; SUBSTANCE P; TACHYKININ; TACHYKININ RECEPTOR; TACHYKININ RECEPTOR ANTAGONIST; THIORPHAN; UNCLASSIFIED DRUG;

AIRWAY; ASTHMA; BLOOD VESSEL PERMEABILITY; BRONCHOSPASM; CELL GROWTH; CELL PROLIFERATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL TRIAL; COUGHING; DRUG ANTAGONISM; EXTRAVASATION; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; LUNG ALVEOLUS EPITHELIUM; MESENCHYME CELL; MUCUS SECRETION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SENSORY NERVE;

ANIMALS; ASTHMA; BRONCHOCONSTRICTION; CLINICAL TRIALS; DISEASE MODELS, ANIMAL; HUMANS; NEUROKININ A; NEURONS, AFFERENT; NEUROTRANSMITTER AGENTS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RECEPTORS, TACHYKININ; RESPIRATORY SYSTEM; RESPIRATORY SYSTEM AGENTS; SUBSTANCE P;

EID: 33644800014     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.12.066     Document Type: Review

References (150)

1. C. Advenier, E. Naline, G. Drapeau, and D. Regoli Relative potencies of neurokinins in guinea-pig trachea and human bronchus Eur. J. Pharmacol. 139 1987 133 137
2. C. Advenier, E. Naline, L. Toty, H. Bakdach, X. Edmonds-Alt, P. Vilain, J.-C. Breliere, and G. Le Fur Effects on the isolated human bronchus of SR 48968, a potent and selective nonpeptide antagonist of the neurokinin A (NK2) receptors Am. Rev. Respir. Dis. 146 1992 1177 1181
3. C. Advenier, V. Lagente, and E. Boichot The role of tachykinin receptor antagonists in the prevention of bronchial hyperresponsiveness, airway inflammation and cough Eur. Respir. J. 10 1997 1892 1906
4. C. Advenier, G. Joos, M. Molimard, V. Lagente, and R. Pauwels Role of tachykinins as contractile agonists of human airways in asthma Clin. Exp. Allergy 29 1999 579 584
5. J. Aliakbar, S.P. Sreedharan, C.W. Turck, and E.J. Goetzl Selective localization of vasoactive intestinal peptide and substance P in human eosinophils Biochem. Biophys. Res. Commun. 148 1987 1440 1445
6. T.A. Almeida, J. Rojo, P.M. Nieto, F.M. Pinto, M. Hernandez, J.D. Martin, and M.L. Candenas Tachykinins and tachykinin receptors: structure and activity relationships Curr. Med. Chem. 11 2004 2045 2081
7. S. Amadesi, J. Moreau, M. Tognetto, J. Springer, M. Trevisani, E. Naline, C. Advenier, A. Fischer, D. Vinci, C.E. Mapp, D. Miotto, and P. Geppetti NK1 receptor stimulation causes contraction and inositol phosphate increase in medium-size human isolated bronchi Am. J. Respir. Crit. Care Med. 163 2001 1206 1211
8. J.C. Anthes, R.W. Chapman, C. Richard, S. Eckel, M. Corboz, J.A. Hey, X. Fernandez, S. Greenfeder, R. McLeod, S. Sehring, C. Rizzo, Y. Crawley, N.Y. Shih, J. Piwinski, G. Reichard, P. Ting, N. Carruthers, F.M. Cuss, M. Billah, W. Kreutner, and R.W. Egan SCH 206272: a potent, orally active tachykinin NK(1), NK(2), and NK(3) receptor antagonist Eur. J. Pharmacol. 450 2002 191 202
9. P. Baluk, C. Bertrand, P. Geppetti, D.M. McDonald, and J.A. Nadel NK1 receptor antagonist CP-99,994 inhibits cigarette smoke-induced neutrophil and eosinophil adhesion in rat tracheal venules Exp. Lung Res. 22 1996 409 418
10. P.J. Barnes Asthma as an axon reflex Lancet 1 1986 242 245
11. P.J. Barnes Neurogenic inflammation in the airways Respir. Physiol. 125 2001 145 154
12. C. Bertrand, P. Geppetti, J. Baker, I. Yamawaki, and J.A. Nadel Role of neurogenic inflammation in antigen-induced vascular extravasation in guinea pig trachea J. Immunol. 150 1993 1479 1485
13. C. Bertrand, P. Geppetti, P.D. Graf, A. Foresi, and J.A. Nadel Involvement of neurogenic inflammation in antigen-induced bronchoconstriction in guinea pigs Am. J. Physiol. 265 1993 L507 L511
14. J.L. Black, P.R.A. Johnson, L. Alouan, and C.L. Armour Neurokinin A with K+ channel blockade potentiates contraction to electrical stimulation in human bronchus Eur. J. Pharmacol. 180 1990 311 317
15. D.C. Bolser, F.C. DeGennaro, S. O'Reilly, R.L. McLeod, and J.A. Hey Central antitussive activity of the NK1 and NK2 tachykinin receptor antagonists, CP-99,994 and SR 48968, in the guinea-pig and cat Br. J. Pharmacol. 121 1997 165 170
16. P. Boni, L. Ballati, and S. Evangelista Tachykinin NK1 and NK2 receptors mediate the non-cholinergic bronchospastic response to capsaicin and vagal stimulation in guinea-pigs J. Auton. Pharmacol. 15 1995 49 54
17. P. Boschetto, D. Miotto, I. Bononi, D. Faggian, M. Plebani, A. Papi, C. Creminon, E. De Rosa, L.M. Fabbri, and C.E. Mapp Sputum substance P and neurokinin A are reduced during exacerbations of chronic obstructive pulmonary disease Pulm. Pharmacol. Ther. 18 2005 199 205
18. J. Bousquet Global initiative for asthma (GINA) and its objectives Clin. Exp. Allergy 30 2000 2 5
19. J.J. Bowden, A.M. Garland, P. Baluk, P. Lefevre, E.F. Grady, S.R. Vigna, N.W. Bunnett, and D.M. McDonald Direct observation of substance P-induced internalization of neurokinin 1 (NK1) receptors at sites of inflammation Proc. Natl. Acad. Sci. U. S. A. 91 1994 8964 8968
20. M.J. Carr, D.D. Hunter, D.B. Jacoby, and B.J. Undem Expression of tachykinins in nonnociceptive vagal afferent neurons during respiratory viral infection in guinea pigs Am. J. Respir. Crit. Care Med. 165 2002 1071 1075
21. R.-M. Catalioto, M. Criscuoli, P. Cucchi, A. Giachetti, D. Giannotti, S. Giuliani, A. Lecci, A. Lippi, R. Patacchini, L. Quartara, A.R. Renzetti, M. Tramontana, F. Arcamone, and C.A. Maggi MEN 11420 (Nepadutant), a novel glycosylated bicyclic peptide tachykinin NK2 receptor antagonist Br. J. Pharmacol. 123 1998 81 91
22. D. Cheung, E.H. Bel, J. Den Hartigh, J.H. Dijkman, and P.J. Sterk The effect of an inhaled neutral endopeptidase inhibitor, thiorphan, on airway responses to neurokinin A in normal humans in vivo Am. Rev. Respir. Dis. 145 1992 1275 1280
23. H.W. Chu, M. Kraft, J.E. Krause, M.D. Rex, and R.J. Martin Substance P and its receptor neurokinin 1 expression in asthmatic airways J. Allergy Clin. Immunol. 106 2000 713 722
24. G.N. Colasurdo, J.E. Loader, J.P. Graves, and G.L. Larsen Modulation of acetylcholine release in rabbit airways in vitro Am. J. Physiol., Lung Cell. Mol. Physiol. 268 1995 L432 L437
25. H.J. Cooke, P. Fox, L. Alferes, C.C. Fox, and S.A. Wolfe Presence of NK1 receptors on a mucosal-like mast cell line, RBL-2H3 cells Can. J. Physiol. Pharmacol. 76 1998 188 193
26. L.J.M. Cross, L.G. Heaney, and M. Ennis Further characterisation of substance P induced histamine release from human bronchoalveolar lavage mast cells Inflamm. Res. 45 1996 S11 S12
27. G. D'Agostino, D. Erbelding, and H. Kilbinger Tachykinin NK(2) receptors facilitate acetylcholine release from guinea-pig isolated trachea Eur. J. Pharmacol. 396 2000 29 32
28. S. Daoui, C. Cognon, E. Naline, and X. Edmonds-Alt Involvement of tachykinin NK3 receptors in citric acid-induced cough and bronchial responses in guinea pigs Am. J. Respir. Crit. Care Med. 158 1998 42 48
29. K.O. De Swert, A. D'Hulst, G.F. Joos, and R.A. Pauwels Role of the tachykinin NK1 receptor on smoke-induced airway inflammation in mice Am. J. Respir. Crit. Care Med. 167 2003 A146
30. K.O. De Swert, K.G. Tournoy, G.F. Joos, and R.A. Pauwels The role of the tachykinin NK1 receptor in airway changes in a mouse model of allergic asthma J. Allergy. Clin. Immunol. 113 2004 1093 1099
31. A. De Vries, M.C. Dessing, F. Engels, P.A.J. Henricks, and F.P. Nijkamp Nerve growth factor induces a neurokinin-1 receptor-mediated airway hyperresponsiveness in guinea pigs Am. J. Respir. Crit. Care Med. 159 1999 1541 1544
32. A. Delaunois, P. Gustin, and M. Ansay Role of neuropeptides in acetylcholine-induced edema in isolated and perfused rabbit lungs J. Pharmacol. Exp. Ther. 266 1993 483 491
33. P. Diemunsch, and L. Grelot Potential of substance P antagonists as antiemetics Drugs 60 2000 533 546
34. R.A. Duffy, J.A. Hedrick, G. Randolph, C.A. Morgan, M.E. Cohen-Williams, G. Vassileva, J.E. Lachowicz, M. Laverty, M. Maguire, L.S. Shan, E. Gustafson, and G.B. Varty Centrally administered hemokinin-1 (HK-1), a neurokinin NK1 receptor agonist, produces substance P-like behavioral effects in mice and gerbils Neuropharmacology 45 2003 242 250
35. J.L. Ellis, J.S.K. Sham, and B.J. Undem Tachykinin-independent effects of capsaicin on smooth muscle in human isolated bronchi Am. J. Respir. Crit. Care Med. 155 1997 751 755
36. X. Emonds-Alt, P. Vilain, P. Goulaouic, V. Proietto, D. Van Broeck, C. Advenier, E. Naline, G. Neliat, G. Le Fur, and J.C. Breliere A potent and selective non-peptide antagonist of the neurokinin A (NK2) receptor Life Sci. 50 1992 L101 L106
37. T.W. Evans, C.M. Dixon, B. Clarke, T.-B. Conradson, and P.J. Barnes Comparison of neurokinin A and substance P on cardiovascular and airway function in man Br. J. Clin. Pharmacol. 25 1988 273 275
38. J.V. Fahy, H.H. Wong, P. Geppetti, J.M. Reis, S.C. Harris, D.B. Maclean, J.A. Nadel, and H.A. Boushey Effect of an NK1 receptor antagonist (CP-99,994) on hypertonic saline-induced bronchoconstriction and cough in male asthmatic subjects Am. J. Respir. Crit. Care Med. 152 1995 879 884
39. M.J.B. Finney, J.A. Karlsson, and C.G.A. Persson Effects of bronchoconstrictors and bronchodilators on a novel human small airway preparation Br. J. Pharmacol. 85 1985 29 36
40. N. Frossard, and P.J. Barnes Effect of tachykinins in small human airways Neuropeptides 19 1991 157 161
41. R.W. Fuller, C.M.S. Dixon, and P.J. Barnes Bronchoconstrictor response to inhaled capsaicin in man J. Appl. Physiol. 58 1985 1080 1084
42. R.W. Fuller, D.L. Maxwell, and C.M.S. Dixon Effect of substance P on cardiovascular and respiratory function in subjects J. Appl. Physiol. 62 1987 1473 1479
43. P. Geppetti, B.M. Fusco, S. Marabini, C.A. Maggi, M. Fanciullacci, and F. Sicuteri Secretion, pain and sneezing induced by application of capsaicin to the nasal mucosa in man Br. J. Pharmacol. 93 1988 503 514
44. P.R. Germonpré, G.F. Joos, E. Everaert, J.C. Kips, and R.A. Pauwels Characterization of neurogenic inflammation in the airways of two highly inbred rat strains Am. J. Respir. Crit. Care Med. 152 1995 1796 1804
45. P.R. Germonpré, G.F. Joos, K. Mekeirele, and R.A. Pauwels Role of the 5-HT receptor in neurogenic inflammation in Fisher 344 rat airways Eur. J. Pharmacol. 324 1997 249 255
46. V. Girard, E. Naline, P. Vilain, X. Emonds-Alt, and C. Advenier Effect of the two tachykinin antagonists, SR 48968 and SR 140333, on cough induced by citric acid in the unanaesthetized guinea pig Eur. Respir. J. 8 1995 1110 1114
47. D.A. Groneberg, D. Quarcoo, N. Frossard, and A. Fischer Neurogenic mechanisms in bronchial inflammatory diseases Allergy 59 2004 1139 1152
48. A.K. Hall, P.J. Barnes, L.A. Meldrum, and J. M. Facilitation by tachykinins of neurotransmission in guinea-pig pulmonary parasympathetic nerves Br. J. Pharmacol. 97 1989 274 280
49. T.T. Hansel, E.M. Erin, and P.J. Barnes The allergen challenge Clin. Exp. Allergy 32 2002 162 167
50. N.K. Harrison, K.E. Dawes, O.J. Kwon, P.J. Barnes, G.J. Laurent, and K.F. Chung Effects of neuropeptides on human lung fibroblast proliferation and chemotaxis Am. J. Physiol. 12 1995 L278 L283
51. T. Higenbottam Chronic cough and the cough reflex in common lung diseases Pulm. Pharmacol. Ther. 15 2002 241 247
52. A. Hirata, P. Baluk, T. Fujiwara, and D.M. McDonald Location of focal silver staining at endothelial gaps in inflamed venules examined by scanning electron microscopy Am. J. Physiol. 13 1995 L403 L418
53. W.-Z. Ho, J.-P. Lai, X.-H. Zhu, M. Uvaydova, and S.D. Douglas Human monocytes and macrophages express substance P and neurokinin-1 receptor J. Immunol. 159 1997 5654 5660
54. I. Honda, H. Kohrogi, T. Yamaguchi, M. Ando, and S. Araki Enkephalinase inhibitor potentiates substance P- and capsaicin-induced bronchial smooth muscle contractions in humans Am. Rev. Respir. Dis. 143 1991 1416 1418
55. I. Honda, H. Kohrogi, T. Yamaguchi, J. Hamamoto, N. Hirata, H. Iwagoe, K. Fujii, E. Goto, and M. Ando Tachykinin antagonist FK224 inhibits neurokinin A-, substance P- and capsaicin-induced human bronchial contraction Fundam. Clin. Pharmacol. 11 1997 260 266
56. D.D. Hunter, A.C. Myers, and B.J. Undem Nerve growth factor-induced phenotypic switch in guinea pig airway sensory neurons Am. J. Respir. Crit.Care Med. 161 2000 1985 1990
57. M. Ichinose, N. Nakajima, T. Takahashi, H. Yamauchi, H. Inoue, and T. Takishima Protection against bradykinin-induced bronchoconstriction in asthmatic patients by neurokinin receptor antagonist Lancet 340 1992 1248 1251
58. M. Ichinose, M. Miura, H. Yamauchi, N. Kageyama, M. Tomaki, T. Oyake, Y. Ohuchi, W. Hida, H. Miki, G. Tamura, and K. Shirato A neurokinin 1-receptor antagonist improves exercise-induced airway narrowing in asthmatic patients Am. J. Respir. Crit. Care Med. 153 1996 936 941
59. S.J. Ireland, F. Bailey, A. Cook, R.M. Hagan, C.C. Jordan, and M.L. Stephens-Smith Receptors mediating tachykinin-induced contractile responses in guinea-pig trachea Br. J. Pharmacol. 103 1991 1463 1469
60. G.F. Joos, and R.A. Pauwels The in vivo effect of tachykinins on airway mast cells in the rat Am. Rev. Respir. Dis. 148 1993 922 926
61. G.F. Joos, and R.A. Pauwels Pro-inflammatory effects of substance P: new perspectives for the treatment of airway diseases? Trends Pharmacol. Sci. 21 2000 131 133
62. G.F. Joos, and R.A. Pauwels Tachykinin receptor antagonists: potential in airways disease Curr. Opin. Pharmacol. 1 2001 235 241
63. G. Joos, R. Pauwels, and M. Van Der Straeten The effect of inhaled substance P and neurokinin A on the airways of normal and asthmatic subjects Thorax 42 1987 779 783
64. G.F. Joos, R.A. Pauwels, and M.E. Van Der Straeten The effect of oxitropiumbromide on neurokinin A-induced bronchoconstriction in asthmatics Pulm. Pharmacol. 1 1988 41 45
65. G.F. Joos, J.C. Kips, and R.A. Pauwels In vivo characterization of the tachykinin receptors involved in the direct and indirect bronchoconstrictor effect of tachykinins in the rat Am. J. Respir. Crit. Care Med. 149 1994 1160 1166
66. 1 receptor Eur. J. Pharmacol. 271 1994 47 54
67. G.F. Joos, J. Van Schoor, J.C. Kips, and R.A. Pauwels The effect of inhaled FK244, a tachykinin NK-1 and NK-2 receptor antagonist, on neurokinin A-induced bronchoconstriction in asthmatics Am. J. Respir. Crit. Care Med. 153 1996 1781 1784
68. G.F. Joos, P.R. Germonpre, and R.A. Pauwels Role of tachykinins in asthma Allergy 55 2000 321 337
69. G. Joos, V. Schelfhout, V. Van De Velde, and R. Pauwels The effect of the tachykinin NK2 receptor antagonist MEN11420 (nepadutant) on neurokinin A-induced bronchoconstriction in patients with asthma Am. J. Respir. Crit. Care Med. 163 2001 A628
70. G.F. Joos, K.O. De Swert, and R.A. Pauwels Airway inflammation and tachykinins: prospects for the development of tachykinin receptor antagonists Eur. J. Pharmacol. 429 2001 239 250
71. G.F. Joos, W. Vincken, R.E. Louis, V.J. Schelfhout, M.J. Shaw, J. Wang, G. Della Ciopa, and R.A. Pauwels Dual NK1/NK2 tachykinin receptor antagonist DNK333 inhibits neurokinin A-induced bronchoconstriction in asthma patients Eur. Respir. J. 23 2004 76 81
72. S. Khan, Y.-C. Liu, A.M. Khawaja, S. Manzini, and D.F. Rogers Effect of the long-acting tachykinin NK1 receptor antagonist MEN 11467 on tracheal mucus secretion in allergic ferrets Br. J. Pharmacol. 132 2001 189 196
73. J.S. Kim, K.F. Rabe, H. Magnussen, J.M. Green, and S.R. White Migration and proliferation of guinea pig and human airway epithelial cells in response to tachykinins Am. J. Physiol. 269 1995 L119 L126
74. H. Kohrogi, P.D. Graf, K. Sekizawa, D.B. Borson, and J.A. Nadel Neutral endopeptidase inhibitors potentiate substance P- and capsaicin-induced cough in awake guinea pigs J. Clin. Invest. 82 1988 2063 2068
75. J. Kraan, H. Vink-Klooster, and D.S. Postma The NK-2 receptor antagonist SR 48968C does not improve adenosine hyperresponsiveness and airway obstruction in allergic asthma Clin. Exp. Allergy 31 2001 274 278
76. A.D. Kraneveld, F.P. Nijkamp, and A.J.M. Van Oosterhout Role for neurokinin-2 receptor in interleukin-5-induced airway hyperresponsiveness but not eosinophilia in guinea pigs Am. J. Respir. Crit. Care Med. 156 1997 367 374
77. S.A. Krumins, and C.A. Broomfield C-terminal substance-P fragments elicit histamine release from a murine mast cell line Neuropeptides 24 1993 5 10
78. E.M. Kudlacz, R.W. Knippenberg, D.E. Logan, and T.P. Burkholder Effect of MDL 105,212, a nonpeptide NK-1/NK-2 receptor antagonist in an allergic guinea pig model J. Pharmacol. Exp. Ther. 279 1996 732 739
79. M.M. Kurtz, R. Wang, M.K. Clements, M.A. Cascieri, C.P. Austin, B.R. Cunningham, G.G. Chicchi, and Q. Liu Identification, localization and receptor characterization of novel mammalian substance P-like peptides Gene 296 2002 205 212
80. J.-P. Lai, S.D. Douglas, and W.-Z. Ho Human lymphocytes express substance P and its receptor J. Neuroimmunol. 86 1998 80 86
81. B.N. Lambrecht, P.R. Germonpre, E.G. Everaert, I. Carro-Muino, M. De Veerman, C. De Felipe, S.P. Hunt, K. Thielemans, G.F. Joos, and R.A. Pauwels Endogenously produced substance P contributes to lymphocyte proliferation induced by dendritic cells and direct TCR ligation Eur. J. Immunol. 29 1999 3815 3825
82. F. Lembeck, and P. Holzer Substance P as neurogenic mediator of antidromic vasodilatation and neurogenic plasma extravasation N-S Arch. Pharmacol. 310 1979 175 183
83. C.M. Lilly, T.R. Bai, S.A. Shore, A.E. Hall, and J.M. Drazen Neuropeptide content of lungs from asthmatic and nonasthmatic patients Am. J. Respir. Crit. Care Med. 151 1995 548 553
84. J.M. Lundberg Pharmacology of Cotransmission in the Autonomic Nervous System: integrative aspects on amines, neuropeptides, adenosine triphosphate, amino acids and nitric oxide Pharmacol. Rev. 48 1996 113 178
85. J.M. Lundberg, and A. Saria Capsaicin-sensitive vagal neurons involved in control of vascular permeability in rat trachea Acta Physiol. Scand. 115 1982 521 523
86. J.M. Lundberg, and A. Saria Capsaicin-induced desensitization of airway mucosa to cigarette smoke, mechanical and chemical irritants Nature 302 1983 215 253
87. J.M. Lundberg, and A. Saria Polypeptide-containing neurons in airway smooth muscle Annu. Rev. Physiol. 49 1987 557 572
88. J.M. Lundberg, E. Brodin, and A. Saria Effects and distribution of vagal capsaicin-sensitive substance P neurons with special reference to the trachea and lungs Acta Physiol. Scand. 119 1983 243 252
89. J.M. Lundberg, C.-R. Martling, and A. Saria Substance P and capsaicin-induced contraction of human bronchi Acta Physiol. Scand. 119 1983 49 53
90. J.M. Lundberg, A. Saria, E. Brodin, S. Rossel, and K. Folkers A substance P antagonist inhibits vagally induced increase in vascular permeability and bronchial smooth muscle contraction in the guinea-pig Proc. Natl. Acad. Sci. U. S. A. 83 1983 1120 1124
91. J.M. Lundberg, T. Hökfeldt, C.-R. Martling, A. Saria, and C. Cuello Substance P-immunoreactive sensory nerves in the lower respiratory tract of various mammals including man Cell Tissue Res. 235 1984 251 261
92. A. Luts, R. Uddman, P. Alm, J. Basterra, and F. Sundler Peptide-containing nerve fibers in human airways: distribution and coexistence pattern Int. Arch. Allergy Appl. Immunol. 101 1993 52 60
93. C.A. Maggi Tachykinin receptors and airway pathophysiology Eur. Respir. J. 6 1993 735 742
94. C.A. Maggi The troubled story of tachykinins and neurokinins Trends Pharmacol. Sci. 21 2000 173 175
95. C.A. Maggi, R. Patacchini, P. Rovero, and A. Giachetti Tachykinin receptors and tachykinin receptor antagonists J. Auton. Pharmacol. 13 1993 23 93
96. K. Maghni, R. Taha, W. Afif, Q. Hamid, and J.G. Martin Dichotomy between Neurokinin Receptor Actions in Modulating Allergic Airway Responses in an Animal Model of Helper T Cell Type 2 Cytokine-associated Inflammation Am. J. Respir. Crit. Care Med. 162 2000 1068 1074
97. K. Maghni, M.C. Michoud, M. Alles, A. Rubin, V. Govindaraju, C. Meloche, and J.G. Martin Airway smooth muscle cells express functional neurokinin-1 receptors and the nerve-derived preprotachykinin-a gene: regulation by passive sensitization Am. J. Respir. Cell Mol. Biol. 28 2003 103 110
98. C.E. Mapp, D. Miotto, F. Braccioni, M. Saetta, G. Turato, P. Maestrelli, J.E. Krause, V. Karpitskiy, N. Boyd, P. Geppetti, and L.M. Fabbri The distribution of neurokinin-1 and neurokinin-2 receptors in human central airways Am. J. Respir. Crit. Care Med. 161 2000 207 215
99. C.A.E. Martin, E. Naline, X. Emonds-Alt, and C. Advenier Influence of (+/-)-CP-96,345 and SR 48968 on electrical field stimulation of the isolated guinea-pig main bronchus Eur. J. Pharmacol. 224 1992 137 143
100. C.-R. Martling, E. Theodorsson-Norheim, and J.M. Lundberg Occurrence and effects of multiple tachykinins; substance P, neurokinin A and neuropeptide K in human lower airways Life Sci. 40 1987 1633 1643
101. D.M. McDonald Endothelial gaps and permeability of venues in rat tracheas exposed to inflammatory stimuli Am. Rev. Respir. Dis. 137 1994 1432 1440
102. H. Mechiche, A. Koroglu, L. Candenas, F.M. Pinto, P. Birembaut, M. Bardou, J. Elaerts, and P. Devillier Neurokinins induce relaxation of human pulmonary vessels through stimulation of endothelial NK1 receptors J. Cardiovasc. Pharmacol. 41 2003 343 355
103. B. Moreaux, A. Nemmar, G. Vincke, D. Halloy, D. Beerens, C. Advenier, and P. Gustin Role of substance P and tachykinin receptor antagonists in citric acid-induced cough in pigs Eur. J. Pharmacol. 408 2000 305 312
104. M. Mousli, C. Bronner, Y. Landry, J. Bockaert, and B. Rouot Direct activation of GTP-binding regulatory proteins (G-proteins) by substance P and compound 48/80 FEBS Lett. 259 1990 260 262
105. T. Mutoh, A.C. Bonham, and J.P. Joad Substance P in the nucleus of the solitary tract augments bronchopulmonary C fiber reflex output Am. J. Physiol., Regul. Integr. Comp. Physiol. 279 2000 R1215 R1223
106. A.C. Myers, R.G. Goldie, and D.W. Hay A novel role for tachykinin neurokinin-3 receptors in regulation of human bronchial ganglia neurons Am. J. Respir. Crit. Care Med. 171 2005 212 216
107. E. Naline, M. Molimard, D. Regoli, X. Emonds-Alt, J.F. Bellamy, and C. Advenier Evidence for functional tachykinin NK1 receptors on human isolated small bronchi Am. J. Physiol. 271 1996 L763 L767
108. S. Nénan, N. Germain, V. Lagente, X. Edmonds-Alt, C. Advenier, and E. Boichot Inhibition of inflammatory cell recruitment by the tachykinin NK3-receptor antagonist, SR 14280, in a murine model of asthma Eur. J. Pharmacol. 421 2001 210-205
109. G. Nilsson, K. Alving, S. Ahlsteddt, T. Hökfelt, and J.M. Lundberg Peptidergic innervation of rat lymphoid tissue and lung: relation to mast cells and sensitivity to capsaicin and immunization Cell Tissue Res. 262 1990 125 133
110. J.P. Noveral, and M.M. Grunstein Tachykinin regulation of airway smooth muscle cell proliferation Am. J. Physiol. 269 1995 L339 L343
111. T.M. O'Connor, J. O'Connell, D.I. O'Brien, T. Goode, C.P. Bredin, and F. Shanahan The role of substance P in inflammatory disease J. Cell Physiol. 201 2004 167 180
112. N.M. Page, N.J. Bell, S.M. Gardiner, I.T. Manyonda, K.J. Brayley, P.G. Strange, and P.J. Lowry Characterization of the endokinins: human tachykinins with cardiovascular activity Proc. Natl. Acad. Sci. U. S. A. 100 2003 6245 6250
113. R. Patacchini, A. Lecci, P. Holzer, and C.A. Maggi Newly discovered tachykinins raise new questions about their peripheral roles and the tachykinin nomenclature Trends Pharmacol. Sci. 25 2004 1 3
114. R.A. Pauwels, A.S. Buist, P.M. Calverley, C.R. Jenkins, and S.S. Hurd Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary Am. J. Respir. Crit. Care Med. 163 2001 1256 1276
115. K.E. Pedersen, S.N. Meeker, M.M. Riccio, and B.J. Undem Selective stimulation of jugular ganglion afferent neurons in guinea pig airways by hypertonic saline J. Appl. Physiol. 84 1998 499 506
116. J.N. Pennefather, A. Lecci, M.L. Candenas, E. Patak, F.M. Pinto, and C.A. Maggi Tachykinins and tachykinin receptors: a growing family Life Sci. 74 2004 1445 1463
117. J.E. Phillips, J.A. Hey, and M.R. Corboz Tachykinin NK(3) and NK(1) receptor activation elicits secretion from porcine airway submucosal glands Br. J. Pharmacol. 138 2003 254 260
118. G. Piedimonte, C. Bertrand, P. Geppetti, R.M. Snider, M.C. Desai, and J.A. Nadel A new NK1 receptor antagonist (CP-99,994) prevents the increase in tracheal vascular permeability produced by hypertonic saline J. Pharmacol. Exp. Ther. 266 1993 270 273
119. G. Piedimonte, J.I. Hoffman, W.K. Husseini, R.M. Snider, M.C. Desai, and J.A. Nadel NK1 receptors mediate neurogenic inflammatory increase in blood flow in rat airways J. Appl. Physiol. 74 1993 2462 2468
120. G. Piedimonte, M.M. Rodriguez, K.A. King, S. McLean, and X. Jiang Respiratory syncytial virus upregulates expression of the substance P receptor in rat lungs Am. J. Physiol. 277 1999 L831 L840
121. F.M. Pinto, T.A. Almeida, M. Hernandez, P. Devillier, C. Advenier, and M.L. Candenas mRNA expression of tachykinins and tachykinin receptors in different human tissues Eur. J. Pharmacol. 494 2004 233 239
122. J.D. Richardson, and M.R. Vasko Cellular mechanisms of neurogenic inflammation J. Pharmacol. Exp. Ther. 302 2002 839 845
123. D.F. Rogers Motor control of airway goblet cells and glands Respir. Physiol. 125 2001 129 144
124. W.L. Rumsey, D. Aharony, R.A. Bialecki, B.M. Abbott, H.G. Barthlow, R. Caccese, S. Ghanekar, D. Lengel, M. McCarthy, B. Wenrich, B. Undem, C. Ohnmacht, A. Shenvi, J.S. Albert, F. Brown, P.R. Bernstein, and K. Russell Pharmacological characterization of zd6021: a novel, orally active antagonist of the tachykinin receptors J. Pharmacol. Exp. Ther. 298 2001 307 315
125. V. Schelfhout, R. Louis, W. Lenz, R. Pauwels, and G. Joos The triple neurokinin receptor antagonist CS-003 inhibits neurokinin A (NKA)-induced bronchoconstriction in patients with asthma Eur. Respir. J. 22 Suppl 45 2003 415s (Ref Type: Journal (Full))
126. D. Schmidt, R.A. Jorres, K.F. Rabe, and H. Magnussen Reproducibility of airway response to inhaled bradykinin and effect of the neurokinin receptor antagonist FK-224 in asthmatic subjects Eur. J. Clin. Pharmacol. 50 1996 269 273
127. M. Schuiling, A. Zuidhof, H. Meurs, and J. Zaagsma Role of tachykinin NK2-receptor activation in the allergen-induced late asthmatic reaction, airway hyperreactivity and airway inflammation cell influx in conscious, unrestrained guinea-pigs Br. J. Pharmacol. 127 1999 1030 1038
128. M. Schuiling, A. Zuidhof, J. Zaagsma, and H. Meurs Involvement of tachykinin NK1 receptor in the development of allergen-induced airway hyperreactivity and airway inflammation in conscious, unrestrained guinea-pigs Am. J. Respir. Crit. Care Med. 159 1999 423 430
129. C. Severini, G. Improta, G. Falconieri-Erspamer, S. Salvadori, and V. Erspamer The tachykinin Peptide family Pharmacol. Rev. 54 2002 285 322
130. R.L.G. Sheldrick, K.F. Rabe, A. Fischer, H. Magnussen, and R.A. Coleman Further evidence that tachykinin-induced contraction of human isolated bronchusis mediated only by NK2 receptors Neuropeptides 29 1995 281 292
131. R.M. Snider, J.W. Constantine, J.A. Lowe III, K.P. Longo, W.S. Lebel, H.A. Woody, S.E. Drzda, M.C. Desai, F.J. Vinick, R.W. Spence, and H.J. Hess A potent nonpeptide antagonist of the substance P (NK1) receptor Science 251 1991 435 437
132. J. Springer, D.A. Groneberg, R. Pregla, and A. Fischer Inflammatory cells as source of tachykinin-induced mucus secretion in chronic bronchitis Regul. Pept. 124 2005 195 201
133. D.T. Tanaka, and M.M. Grunstein Mechanisms of substance P-induced contraction of rabbit airway smooth muscle J. Appl. Physiol. 57 1984 1551 1557
134. K.G. Tournoy, K.O. De Swert, P.G. Leclere, R.A. Lefebvre, R.A. Pauwels, and G.F. Joos Modulatory role of tachykinin NK1 receptor in cholinergic contraction of mouse trachea Eur. Respir. J. 21 2003 3 10
135. C. Tousignant, C.C. Chan, D. Guevremont, C. Brideau, J.J. Hale, M. Maccoss, and I.W. Rodger NK2 receptors mediate plasma extravasation in guinea-pig lower airways Br. J. Pharmacol. 108 1993 383 386
136. L. Trout, M.R. Corboz, and S.T. Ballard Mechanism of substance P-induced liquid secretion across bronchial epithelium Am. J. Physiol., Lung Cell Mol. Physiol. 281 2001 L639 L645
137. E. Umeno, D.M. McDonald, and J.A. Nadel Hypertonic saline increases vascular permeability in the rat by producing neurogenic inflammation J. Clin. Invest. 85 1990 1905 1908
138. E.L. Van Rensen, P.S. Hiemstra, K.F. Rabe, and P.J. Sterk Assessment of microvascular leakage via sputum induction: the role of substance P and neurokinin A in patients with asthma Am. J. Respir. Crit. Care Med. 165 2002 1275 1279
139. J. Van Schoor, G. Joos, B. Chasson, R. Brouard, and R. Pauwels The effect of the NK2 receptor antagonist SR48968 (saredutant) on neurokinin A-induced bronchoconstrction in asthmatics Eur. Respir. J. 12 1998 17 23
140. S.R. White, A. Garland, B. Gitter, I. Rodger, L.E. Alger, J. Necheles, A.R. Nawrocki, and J. Solway Proliferation of guinea pig tracheal epithelial cells in coculture with rat dorsal root ganglion neural cells Am. J. Physiol. 268 1995 L957 L965
141. C.J. Wiedermann, F.J. Wieddermann, A. Apperl, G. Kieselbach, G. Konwalinka, and H. Braunsteiner In vitro human polymorphonuclear leukocyte chemokinesis and human monocyte chemotaxis are different activities of aminoterminal and carboxyterminal substance P N-S Arch. Pharmacol. 340 1989 185 190
142. C.J. Wiedermann, B. Auer, B. Sitte, N. Reinisch, P. Schratzberger, and C.M. Kahler Induction of endothelial cell differentiation into capillary-like structures by substance P Eur. J. Pharmacol. 298 1996 335 338
143. K. Woie, M.E. Koller, K.J. Heyeraas, and R.K. Reed Neurogenic inflammation in rat trachea is accompanied by increased negativity of interstitial fluid pressure Circ. Res. 73 1993 839 845
144. Z.X. Wu, and L.Y. Lee Airway hyperresponsiveness induced by chronic exposure to cigarette smoke in guinea pigs: role of tachykinins J. Appl. Physiol. 87 1999 1621 1628
145. X.X. Yang, W.S. Powell, M. Hojo, and J.G. Martin Hyperpnea-induced bronchoconstriction is dependent on tachykinin-induced cysteinyl leukotriene synthesis J. Appl. Physiol. 82 1997 538 544
146. S. Yoshihara, B. Chan, I. Yamawaki, P. Geppetti, F.L.M. Ricciardolo, P.P. Massion, and J.A. Nadel Plasma extravasation in the rat trachea induced by cold air is mediated by tachykinin release from sensory nerves Am. J. Respir. Crit. Care Med. 151 1995 1011 1017
147. S. Yoshihara, P. Geppetti, M. Hara, A. Linden, F.L. Ricciardolo, B. Chan, and J.A. Nadel Cold air-induced bronchoconstriction is mediated by tachykinin and kinin release in guinea pigs Eur. J. Pharmacol. 296 1996 291 296
148. M. Ziche, L. Morbidelli, M. Pacini, P. dolara, and C.A. Maggi NK1-receptors mediate the proliferative response of human fibroblasts to tachykinins Br. J. Pharmacol. 100 1990 11 14
149. M. Ziche, L. Morbidelli, P. Geppetti, C.A. Maggi, and P. dolara Substance P induces migration of capillary endothelial cells: a novel NK-1 selective receptor mediated activity Life Sci. 48 1991 L7 L11
150. M. Ziche, A. Parenti, S. Amerini, D. Zawieja, C.A. Maggi, and F. Ledda Effect of the non-peptide blocker (+/-) CP 96,345 on the cellular mechanism involved in the response to NK1 receptor stimulation in human skin fibroblasts Neuropeptides 30 1996 345 354