Cough: The emerging role of the trpa1 channel

Lung

Volumn 188, Issue SUPPL., 2010, Pages

  Geppetti, Pierangelo ^a   Patacchini, Riccardo ^b   Nassini, Romina ^a   Materazzi, Serena ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b Chiesi Farmaceutici   (Italy)

Author keywords

Cough; Guinea pig; Sensory neurons; TRPA1

Indexed keywords

4 HYDROXYNONENAL; ACROLEIN; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ALLERGEN; ANKYRIN; CAPSAZEPINE; CHLORINE; CIGARETTE SMOKE; CINNAMALDEHYDE; CROTONALDEHYDE; HC 030031; HYPOCHLORITE; IRRITANT AGENT; OVALBUMIN; REACTIVE OXYGEN METABOLITE; TOLUENE DIISOCYANATE; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

AIRWAY DYNAMICS; ASTHMA; BRONCHOSPASM; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONFERENCE PAPER; COUGHING; HUMAN; IMMUNOSENSOR; INFLAMMATION; MUCUS SECRETION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REFLEX; RESPIRATORY SYSTEM; SENSORY NERVE; SNEEZING;

ANIMALS; ASTHMA; CALCIUM CHANNELS; CAPSAICIN; COUGH; GUINEA PIGS; HUMANS; IRRITANTS; NERVE TISSUE PROTEINS; NOCICEPTORS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; REFLEX; RESPIRATORY SYSTEM; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TRPV CATION CHANNELS;

EID: 77949270744     PISSN: 03412040     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00408-009-9201-3     Document Type: Conference Paper

References (59)

1. MJ Caterina MA Schumacher M Tominaga TA Rosen JD Levine D Julius 1997 The capsaicin receptor: a heat-activated ion channel in the pain pathway Nature 389 816 824 10.1038/39807 1:CAS:528:DyaK2sXmvFSksbs%3D 9349813 (Pubitemid 27462969)
2. S Bevan P Geppetti 1994 Protons: small stimulants of capsaicin-sensitive sensory nerves Trends Neurosci 17 509 512 10.1016/0166-2236(94)90149-X 1:CAS:528:DyaK2MXit1yqsrw%3D 7532332 (Pubitemid 24347911)
3. M Tominaga MJ Caterina AB Malmberg TA Rosen H Gilbert K Skinner BE Raumann AI Basbaum D Julius 1998 The cloned capsaicin receptor integrates multiple pain-producing stimuli Neuron 21 531 543 10.1016/S0896-6273(00)80564-4 1:CAS:528:DyaK1cXms1eht74%3D 9768840 (Pubitemid 28475505)
4. SW Hwang H Cho J Kwak SY Lee CJ Kang J Jung S Cho KH Min YG Suh D Kim U Oh 2000 Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances Proc Natl Acad Sci USA 97 6155 6160 10.1073/pnas.97.11.6155 1:CAS:528:DC%2BD3cXjvFaru74%3D 10823958 (Pubitemid 30367539)
5. SM Huang T Bisogno M Trevisani A Al-Hayani L De Petrocellis F Fezza M Tognetto TJ Petros JF Krey CJ Chu JD Miller SN Davies P Geppetti JM Walker V Di Marzo 2002 An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors Proc Natl Acad Sci USA 99 8400 8405 10.1073/pnas.122196999 1:CAS:528:DC%2BD38XkvVGnsLo%3D 12060783 (Pubitemid 34651064)
6. S Materazzi R Nassini R Gatti M Trevisani P Geppetti 2009 Cough sensors. II. Transient receptor potential membrane receptors on cough sensors Handb Exp Pharmacol 187 49 61 10.1007/978-3-540-79842-2-3 1:CAS:528:DC%2BD1MXhs1Sqsrc%3D 18825335
7. M Fujimura Y Kamio T Hashimoto T Matsuda 1994 Cough receptor sensitivity and bronchial responsiveness in patients with only chronic nonproductive cough: in view of effect of bronchodilator therapy J Asthma 31 463 472 10.3109/02770909409089488 1:STN:280:DyaK2M%2FltVWhtw%3D%3D 7961323
8. CH Wong AH Morice 1999 Cough threshold in patients with chronic obstructive pulmonary disease Thorax 54 62 64 10.1136/thx.54.1.62 1:STN:280:DyaK1M3nsFWjsQ%3D%3D 10343635
9. MJ Doherty R Mister MG Pearson PM Calverley 2000 Capsaicin responsiveness and cough in asthma and chronic obstructive pulmonary disease Thorax 55 643 649 10.1136/thorax.55.8.643 1:STN:280:DC%2BD3czpvFWgtA%3D%3D 10899239 (Pubitemid 30468218)
10. E Millqvist 2000 Cough provocation with capsaicin is an objective way to test sensory hyperreactivity in patients with asthma-like symptoms Allergy 55 546 550 10.1111/j.1398-9995.2000.all2513.x 1:CAS:528:DC%2BD3cXktVCnsrc%3D 10858985
11. T Higenbottam 2002 Chronic cough and the cough reflex in common lung diseases Pulm Pharmacol Ther 15 241 247 10.1006/pupt.2002.0341 1:CAS:528:DC%2BD38XltVKrurc%3D 12099771 (Pubitemid 34754113)
12. DA Groneberg A Niimi QT Dinh B Cosio M Hew A Fischer KF Chung 2004 Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough Am J Respir Crit Care Med 170 1276 1280 10.1164/rccm.200402-174OC 15447941 (Pubitemid 39657190)
13. MJ Caterina TA Rosen M Tominaga AJ Brake D Julius 1999 A capsaicin-receptor homologue with a high threshold for noxious heat Nature 398 436 441 10.1038/18906 1:CAS:528:DyaK1MXisFGks7c%3D 10201375 (Pubitemid 29180377)
14. W Liedtke Y Choe MA Marti-Renom AM Bell CS Denis A Sali AJ Hudspeth JM Friedman S Heller 2000 Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor Cell 103 525 535 10.1016/S0092-8674(00)00143-4 1:CAS:528:DC%2BD3cXnvF2ksbs%3D 11081638
15. DD McKemy WM Neuhausser D Julius 2002 Identification of a cold receptor reveals a general role for TRP channels in thermosensation Nature 416 52 58 10.1038/nature719 1:CAS:528:DC%2BD38XitlSitrc%3D 11882888 (Pubitemid 34215395)
16. AM Peier A Moqrich AC Hergarden AJ Reeve DA Andersson GM Story TJ Earley I Dragoni P McIntyre S Bevan A Patapoutian 2002 A TRP channel that senses cold stimuli and menthol Cell 108 705 715 10.1016/S0092-8674(02)00652-9 1:CAS:528:DC%2BD38XisFOhtLg%3D 11893340 (Pubitemid 34241429)
17. N Alessandri-Haber JJ Yeh AE Boyd CA Parada X Chen DB Reichling JD Levine 2003 Hypotonicity induces TRPV4-mediated nociception in rat Neuron 39 497 511 10.1016/S0896-6273(03)00462-8 1:CAS:528:DC%2BD3sXmsFOks74%3D 12895423 (Pubitemid 36937050)
18. DM Bautista J Siemens JM Glazer PR Tsuruda AI Basbaum CL Stucky SE Jordt D Julius 2007 The menthol receptor TRPM8 is the principal detector of environmental cold Nature 448 204 208 10.1038/nature05910 1:CAS:528: DC%2BD2sXnsFeisLg%3D 17538622 (Pubitemid 47067367)
19. B Nilius 2007 Transient receptor potential (TRP) cation channels: rewarding unique proteins Bull Mem Acad R Med Belg 162 244 253 18075054
20. GM Story AM Peier AJ Reeve SR Eid J Mosbacher TR Hricik TJ Earley AC Hergarden DA Andersson SW Hwang P McIntyre T Jegla S Bevan A Patapoutian 2003 ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures Cell 112 819 829 10.1016/S0092-8674(03)00158-2 1:CAS:528:DC%2BD3sXivVWjsbk%3D 12654248 (Pubitemid 36378884)
21. D Jaquemar T Schenker B Trueb 1999 An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts J Biol Chem 274 7325 7333 10.1074/jbc.274.11.7325 1:CAS:528:DyaK1MXhvFWqsbk%3D 10066796 (Pubitemid 29140550)
22. SE Jordt DM Bautista HH Chuang DD McKemy PM Zygmunt ED Hogestatt ID Meng D Julius 2004 Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1 Nature 427 260 265 10.1038/nature02282 1:CAS:528:DC%2BD2cXjtFKitg%3D%3D 14712238 (Pubitemid 38112043)
23. Geppetti P, Holzer P (1996) Neurogenic inflammation. CRC Press, Boca Raton
24. Y Karashima K Talavera W Everaerts A Janssens KY Kwan R Vennekens B Nilius T Voets 2009 TRPA1 acts as a cold sensor in vitro and in vivo Proc Natl Acad Sci USA 106 1273 1278 10.1073/pnas.0808487106 1:CAS:528: DC%2BD1MXhsFyisbg%3D 19144922
25. C Nassenstein K Kwong T Taylor-Clark M Kollarik DM Macglashan A Braun BJ Undem 2008 Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs J Physiol 586 1595 1604 10.1113/jphysiol.2007. 148379 1:CAS:528:DC%2BD1cXktVersrw%3D 18218683
26. U Anand WR Otto P Facer N Zebda I Selmer MJ Gunthorpe IP Chessell M Sinisi R Birch P Anand 2008 TRPA1 receptor localisation in the human peripheral nervous system and functional studies in cultured human and rat sensory neurons Neurosci Lett 438 221 227 10.1016/j.neulet.2008.04.007 1:CAS:528: DC%2BD1cXmtlWhsrk%3D 18456404
27. DM Bautista SE Jordt T Nikai PR Tsuruda AJ Read J Poblete EN Yamoah AI Basbaum D Julius 2006 TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents Cell 124 1269 1282 10.1016/j.cell.2006.02.023 1:CAS:528:DC%2BD28Xjt1Khs70%3D 16564016
28. CR McNamara J Mandel-Brehm DM Bautista J Siemens KL Deranian M Zhao NJ Hayward JA Chong D Julius MM Moran CM Fanger 2007 TRPA1 mediates formalin-induced pain Proc Natl Acad Sci USA 104 13525 13530 10.1073/pnas.0705924104 1:CAS:528:DC%2BD2sXps1eqsL8%3D 17686976 (Pubitemid 47293978)
29. DA Andersson C Gentry S Moss S Bevan 2008 Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress J Neurosci 28 2485 2494 10.1523/JNEUROSCI.5369-07.2008 1:CAS:528:DC%2BD1cXjt1Ghu7Y%3D 18322093 (Pubitemid 351348185)
30. BF Bessac M Sivula CA von Hehn J Escalera L Cohn SE Jordt 2008 TRPA1 is a major oxidant sensor in murine airway sensory neurons J Clin Invest 118 1899 1910 10.1172/JCI34192 1:CAS:528:DC%2BD1cXlsF2nur0%3D 18398506 (Pubitemid 351632392)
31. Y Sawada H Hosokawa K Matsumura S Kobayashi 2008 Activation of transient receptor potential ankyrin 1 by hydrogen peroxide Eur J Neurosci 27 1131 1142 10.1111/j.1460-9568.2008.06093.x 18364033
32. M Trevisani J Siemens S Materazzi DM Bautista R Nassini B Campi N Imamachi E Andre R Patacchini GS Cottrell R Gatti AI Basbaum NW Bunnett D Julius P Geppetti 2007 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1 Proc Natl Acad Sci USA 104 13519 13524 10.1073/pnas.0705923104 1:CAS:528: DC%2BD2sXps1eqsrY%3D 17684094 (Pubitemid 47293977)
33. TE Taylor-Clark S Ghatta W Bettner BJ Undem 2009 Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1 Mol Pharmacol 75 820 829 10.1124/mol.108.054445 1:CAS:528:DC%2BD1MXktVSlurs%3D 19171673
34. S Materazzi R Nassini E Andre B Campi S Amadesi M Trevisani NW Bunnett R Patacchini P Geppetti 2008 Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1 Proc Natl Acad Sci USA 105 12045 12050 10.1073/pnas.0802354105 1:CAS:528:DC%2BD1cXhtVCgsLnJ 18687886
35. TE Taylor-Clark BJ Undem DW Macglashan Jr S Ghatta MJ Carr MA McAlexander 2008 Prostaglandin-induced activation of nociceptive neurons via direct interaction with transient receptor potential A1 (TRPA1) Mol Pharmacol 73 274 281 10.1124/mol.107.040832 1:CAS:528:DC%2BD1cXht1ymsL0%3D 18000030 (Pubitemid 351159199)
36. A Hinman HH Chuang DM Bautista D Julius 2006 TRP channel activation by reversible covalent modification Proc Natl Acad Sci USA 103 19564 19568 10.1073/pnas.0609598103 1:CAS:528:DC%2BD2sXhsVGksg%3D%3D 17164327 (Pubitemid 46026070)
37. LJ Macpherson B Xiao KY Kwan MJ Petrus AE Dubin S Hwang B Cravatt DP Corey A Patapoutian 2007 An ion channel essential for sensing chemical damage J Neurosci 27 11412 11415 10.1523/JNEUROSCI.3600-07.2007 1:CAS:528: DC%2BD2sXht1ekurvN 17942735 (Pubitemid 47621302)
38. TE Taylor-Clark MA McAlexander C Nassenstein SA Sheardown S Wilson J Thornton MJ Carr BJ Undem 2008 Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autacoid 4-oxononenal J Physiol 586 3447 3459 10.1113/jphysiol.2008.153585 1:CAS:528:DC%2BD1cXptlantbk%3D 18499726 (Pubitemid 352003876)
39. I Rahman W MacNee 1996 Role of oxidants/antioxidants in smoking-induced lung diseases Free Radic Biol Med 21 669 681 10.1016/0891-5849(96)00155-4 1:CAS:528:DyaK28Xmt12ltr8%3D 8891669 (Pubitemid 26331096)
40. MA Beck J Handy OA Levander 2000 The role of oxidative stress in viral infections Ann NY Acad Sci 917 906 912 1:CAS:528:DC%2BD3cXovFymtbg%3D 11268420
41. K Tanou A Koutsokera TS Kiropoulos M Maniati AI Papaioannou K Georga S Zarogiannis KI Gourgoulianis K Kostikas 2009 Inflammatory and oxidative stress biomarkers in allergic rhinitis: the effect of smoking Clin Exp Allergy 39 345 353 10.1111/j.1365-2222.2008.03149.x 1:CAS:528:DC%2BD1MXjslamurc%3D 19187324
42. MA Riedl AE Nel 2008 Importance of oxidative stress in the pathogenesis and treatment of asthma Curr Opin Allergy Clin Immunol 8 49 56 10.1097/ACI.0b013e3282f3d913 1:CAS:528:DC%2BD1cXitFKgs7c%3D 18188018
43. J Lundberg A Saria 1983 Capsaicin induced desensitization of the airway mucosa to cigarette smoke, mechanical and chemical irritants Nature 302 251 253 10.1038/302251a0 1:CAS:528:DyaL3sXhsFGjtbo%3D 6188055
44. P Geppetti C Bertrand J Baker I Yamawaki G Piedimonte JA Nadel 1993 Ruthenium red, but not capsazepine reduces plasma extravasation by cigarette smoke in rat airways Br J Pharmacol 108 646 650 1:CAS:528:DyaK3sXit1GgsbY%3D 7682132
45. C Fletcher R Peto 1977 The natural history of chronic airflow obstruction Br Med J 1 1645 1648 10.1136/bmj.1.6077.1645 1:STN:280:DyaE2s3gt1Gisw%3D%3D 871704
46. W MacNee 2005 Pathogenesis of chronic obstructive pulmonary disease Proc Am Thorac Soc 2 258 266 10.1513/pats.200504-045SR 1:CAS:528:DC%2BD2MXhtlams7rE 16267346 (Pubitemid 41566933)
47. E Andre B Campi S Materazzi M Trevisani S Amadesi D Massi C Creminon N Vaksman R Nassini M Civelli PG Baraldi DP Poole NW Bunnett P Geppetti R Patacchini 2008 Cigarette smoke-induced neurogenic inflammation is mediated by alpha, beta-unsaturated aldehydes and the TRPA1 receptor in rodents J Clin Invest 118 2574 2582 1:CAS:528:DC%2BD1cXot1OntbY%3D 18568077
48. S Bang KY Kim S Yoo YG Kim SW Hwang 2007 Transient receptor potential A1 mediates acetaldehyde-evoked pain sensation Eur J Neurosci 26 2516 2523 10.1111/j.1460-9568.2007.05882.x 17970723 (Pubitemid 350050447)
49. I Rahman 2002 Oxidative stress and gene transcription in asthma and chronic obstructive pulmonary disease: antioxidant therapeutic targets Curr Drug Targets Inflamm Allergy 1 291 315 10.2174/1568010023344607 1:CAS:528: DC%2BD38XmtF2rsLo%3D 14561194
50. AI Caceres M Brackmann MD Elia BF Bessac D del Camino M D'Amours JS Witek CM Fanger JA Chong NJ Hayward RJ Homer L Cohn X Huang MM Moran SE Jordt 2009 A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma Proc Natl Acad Sci USA 106 9099 9104 1:CAS:528:DC%2BD1MXntlyrsbc%3D 19458046
51. C Bertrand P Geppetti 1996 Tachykinin and kinin receptor antagonists: therapeutic perspectives in allergic disease Trends Pharmacol Sci 17 255 259 10.1016/0165-6147(96)10027-4 1:CAS:528:DyaK28Xks1eisrs%3D 8756184 (Pubitemid 26233106)
52. R Pecova M Vrlik M Tatar 2005 Cough sensitivity in allergic rhinitis J Physiol Pharmacol 56 171 178 16204790
53. M Ferrari L Benini E Brotto F Locatelli F De Iorio F Bonella N Tacchella G Corradini V Lo Cascio I Vantini 2007 Omeprazole reduces the response to capsaicin but not to methacholine in asthmatic patients with proximal reflux Scand J Gastroenterol 42 299 307 10.1080/00365520600883777 1:CAS:528: DC%2BD2sXkt12ntL0%3D 17354108 (Pubitemid 46303822)
54. M Trevisani A Milan R Gatti A Zanasi S Harrison G Fontana AH Morice P Geppetti 2004 Antitussive activity of iodo-resiniferatoxin in guinea pigs Thorax 59 769 772 10.1136/thx.2003.012930 1:STN:280:DC%2BD2cvivFSntQ%3D%3D 15333853 (Pubitemid 39215373)
55. UG Lalloo AJ Fox MG Belvisi KF Chung PJ Barnes 1995 Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs J Appl Physiol 79 1082 1087 1:CAS:528:DyaK2MXptlSitrw%3D 8567546
56. AH Morice AE Marshall KS Higgins TJ Grattan 1994 Effect of inhaled menthol on citric acid induced cough in normal subjects Thorax 49 1024 1026 10.1136/thx.49.10.1024 1:STN:280:DyaK2M%2FmsVKisw%3D%3D 7974298
57. E Andre R Gatti M Trevisani D Preti PG Baraldi R Patacchini P Geppetti 2009 Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents Br J Pharmacol 158 1621 1628 10.1111/j.1476-5381.2009.00438.x 1:CAS:528:DC%2BD1MXhsFSkurjJ 19845671
58. MA Birrell MG Belvisi M Grace L Sadofsky S Faruqi DJ Hele SA Maher V Freund-Michel AH Morice 2009 TRPA1 Agonists evoke coughing in guinea-pig and human volunteers Am J Respir Crit Care Med 180 1042 1047 10.1164/rccm.200905- 0665OC 1:CAS:528:DC%2BD1MXhsFynu7zP 19729665
59. TE Taylor-Clark F Kiros MJ Carr MA McAlexander 2009 Transient receptor potential ankyrin 1 mediates toluene diisocyanate-evoked respiratory irritation Am J Respir Cell Mol Biol 40 756 762 10.1165/rcmb.2008-0292OC 1:CAS:528:DC%2BD1MXmvVCru7Y%3D 19059884