Bradykinin-evoked sensitization of airway sensory nerves: A mechanism for ACE-inhibitor cough

Nature Medicine

Volumn 2, Issue 7, 1996, Pages 814-817

  Fox, Alyson J ^a   Lalloo, Umesh G ^a   Belvisi, Maria G ^a   Bernareggi, Micaela ^a   Chung, K Fan ^a   Barnes, Peter J ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BRADYKININ; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR;

AIRWAY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; COUGHING; GUINEA PIG; NONHUMAN; PRIORITY JOURNAL;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; BRADYKININ; CAPTOPRIL; COUGH; GUINEA PIGS; MALE; RECEPTOR, BRADYKININ B2; RECEPTORS, BRADYKININ; TRACHEA;

ANIMALIA; CAVIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0029995843     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0796-814     Document Type: Article

References (20)

1. Choudry, F. & Fuller, R.W. Sensitivity of the cough reflex in patients with chronic cough. Eur. Resp. J. 5, 296-300 (1992).
2. Israili, Z.H. & Hall, W.D. Cough and angioneurotic edema associated with angiotensin-converting enzyme inhibitor therapy - a review of the literature and pathophysiology. Ann. Intern. Med. 117, 234-242 (1992).
3. Hargreaves, M.R. & Benson, M.K.. Inhaled sodium cromoglycate in angiotensin-converting enzyme inhibitor cough. Lancet 345, 13-16 (1995).
4. McEwan, J.R., Choudry, N., Street, R. & Fuller, R.W. Change in cough reflex after treatment with enalapril and ramipril. Br. Med. J. 299, 13-16 (1989).
5. Karlsson, J-A., Sant'Ambrogio, G. & Widdicombe, J. Afferent neural pathways in cough and reflex bronchoconstriction. J. Appl. Physiol. 65, 1007-1023 (1988).
6. Widdicombe, J. Neurophysiology of the cough reflex. Eur. Respir. J. 8, 1193-1202 (1995).
7. Fox, A.J., Urban, L., Barnes, P.J. & Dray, A. Effects of capsazepine against capsaicin and proton-evoked excitation of single C-fibres and vagus nerve from the guinea-pig. Neuroscience 67, 741-752 (1995).
8. Fox, A.J., Barnes, P.J., Urban, L. & Dray, A. An in vitro study of the properties of single vagal afferents innervating guinea-pig airways. J. Physiol. (Lond.) 469, 21-35 (1993).
9. Bucknall, C., Neilly, J.B., Carter, R., Stevenson, R.D. & Semple, P.F. Bronchial hyperreactivity in patients who cough after receiving angiotensin converting enzyme inhibitors. Br. Med. J. 296, 86-88 (1988).
10. O'Connell, F., Thomas, V.E., Fuller, R.W. & Pride, N.B. Cough sensitivity to inhaled capsaicin decreases with successful treatment of chronic cough. Am. J. Resp. Crit. Care Med. 150, 374-380 (1993).
11. Empey, D.W., Laitinen, L.A., Jacobs, L., Gold, W.M. & Nadel, J.A. Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection. Am. Rev. Respir. Dis. 113 131-176 (1976).
12. O'Connell, F. et al. Abnormal intraepithelial airway nerves in persistent unexplained cough? Am. J. Resp. Crit. Care Med. 152, 2068-2075 (1995).
13. Fox, A.J., Barnes, P.J. & Dray, A. Stimulation of guinea-pig tracheal afferent fibres by non-isosmotic and low chloride stimuli and the effect of frusemide. J. Physiol. (Lond.) 482, 179-187 (1995).
14. Lalloo, U.G., Fox, A.J., Belvisi, M.G., Chung, K.F. & Barnes, P.J. Inhibition by capsazepine of cough induced by capsaicin and citric acid but not by hypertonic saline in awake guinea pigs. J. Appl. Physiol. 79, 1082-1087 (1995).
15. Coleridge, J.C.G. & Coleridge, H.M. Afferent vagal C-fibre innervation of the lungs and airways and its functional significance. Rev. Physiol. Biochem. Pharmacol. 99, 1-110 (1984).
16. 2 on airway sensory receptors of anaesthetised cats. J. Physiol. (Lond.) 469, 51-66 (1993).
17. Holzer, P. Capsaicin: Cellular targets, mechanisms of action, and selectivity for thin sensory neurons. Pharmacol. Rev. 43, 143-201.
18. Forsberg, K., Karlsson, J-A., Theodorsson, E., Lundberg, J.M. & Persson, C.G.A. Cough and bronchoconstriction mediated by capsaicin-sensitive sensory neurons in the guinea-pig. Pulm. Pharmacol. 1, 33-39 (1988).
19. Tsubone, H., Sant'Ambrogio, G., Anderson, J.W. & Orani, G.P. Laryngeal afferent activity and reflexes in the guinea-pig. Respir. Physiol. 86, 215-231 (1991).
20. Dray, A., Urban, L. & Dickenson, A. The pharmacology of chronic pain. Trends Pharmacol. Sci. 15, 190-197 (1994).