Pulmonary chemoreflexes elicited by intravenous injection of lactic acid in anesthetized rats

Journal of Applied Physiology

Volumn 81, Issue 6, 1996, Pages 2349-2357

  Lee, Lu Yuan ^a   Morton, Robert F ^b   Lundberg, Jan M ^b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b NONE

Author keywords

apnea; capsaicin; hyperpnea; perineural capsaicin treatment; pulmonary C fibers; vagal reflexes

Indexed keywords

CAPSAICIN; LACTIC ACID;

ANESTHESIA; ANIMAL EXPERIMENT; APNEA; ARTICLE; BRADYCARDIA; BREATHING; CAROTID BODY; CHEMORECEPTOR REFLEX; CONTROLLED STUDY; DENERVATION; DOSE RESPONSE; FEMALE; HYPERPNEA; HYPOTENSION; LUNG; MALE; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; RAT; VAGOTOMY; VAGUS NERVE; VAGUS REFLEX;

EID: 0030469623     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1996.81.6.2349     Document Type: Article

References (30)

1. Bainton, C. R. Canine ventilation after acid-base infusions, exercise, and carotid body denervation. J. Appl. Physiol. 44: 28-35, 1978.
2. Bevan, S., and J. Yeats. Protons activate a cation conductance in a sub-population of rat dorsal root ganglion neurones. J. Physiol. Lond. 433: 145-161, 1991.
3. Coleridge, J. C. G., and H. M. Coleridge. Afferent vagal C fibre innervation of the lungs and airways and its functional significance. Rev. Physiol. Biochem. Pharmacol. 99: 1-110, 1984.
4. Dawes, G. S., and J. H. Comroe. Chemoreflexes from the heart and lungs. Physiol. Rev. 34: 167-201, 1954.
5. Ducros, G., and T. Trippenbach. Respiratory effects of lactic acid injected into the jugular vein of newborn rabbits. Pediatr. Res. 29: 548-552, 1991.
6. Fox, A. J., L. Urban, P. J. Barnes, and A. Dray. Effects of capsazepine against capsaicin- and proton-evoked excitation of single airway C-fibres and vagus nerve from the guinea-pig. Neuroscience 67: 741-752, 1995.
7. Franco-Cereceda, A., G. Kallner, and J. M. Lundberg. Cyclo-oxygenase products released by low pH have capsaicin-like actions on sensory nerves in the isolated guinea-pig heart. Cardiovasc. Res. 28: 365-369, 1994.
8. Guz, A., M. I. M. Noble, J. H. Eisele, and D. Trenchard. Experimental results of vagal block in cardiopulmonary disease. In: Breathing: Hering-Breuer Centenary Symposium, edited by R. Porter. London: Churchill, 1970, p. 315-329.
9. Haddy, F. J., and J. B. Scott. Metabolically linked vasoactive chemicals in local regulation of blood flow. Physiol. Rev. 48: 688-707, 1968.
10. Hermansen, L., and O. Vaage. Lactate disappearance and glycogen synthesis in human muscle after maximal exercise. Am. J. Physiol. 233 (Endocrinol. Metab. Gastrointest. Physiol. 2): E422-E429, 1977.
11. Hong, J.-L., I. W. Rodger, and L. Y. Lee. Cigarette smoke-induced bronchoconstriction: involvements of cholinergic mechanisms, tachykinins, and cyclooxygenase products. J. Appl. Physiol. 78: 2260-2266, 1995.
12. Jancso, G., and G. Such. Effects of capsaicin applied perineurally to the vagus nerve on cardiovascular and respiratory functions in the cat. J. Physiol. Lond. 341: 359-370, 1983.
13. 2 mimetic, U46,619, on pulmonary vagal afferents in the cat. Respir. Physiol. 87: 383-396, 1992.
14. Lee, B. P., R. F. Morton, and L.-Y. Lee. Acute effects of acrolein on breathing: role of vagal bronchopulmonary afferents. J. Appl. Physiol. 72: 1050-1056, 1992.
15. Lee, L.-Y., Y. R. Kou, D. T. Frazier, E. R. Beck, T. E. Pisarri, H. M. Coleridge, and J. C. G. Coleridge. Stimulation of vagal pulmonary C fibers by a single breath of cigarette smoke in dogs. J. Appl. Physiol. 66: 2032-2038, 1989.
16. 2 in anesthetized rats. J. Appl. Physiol. 79: 1679-1686, 1995.
17. Longhurst, J. C., D. M. Rotto, M. P. Kaufman, and G. L. Stahl. Ischemically sensitive abdominal visceral afferents: response to cyclooxygenase blockade. Am. J. Physiol. 261 (Heart Circ. Physiol. 30): H2075-H2081, 1991.
18. Lou, Y.-P., and J. M. Lundberg. Inhibition of low pH evoked activation of airway sensory nerves by capsazepine, a novel capsaicin-receptor antagonist. Biochem. Biophys. Res. Commun. 189: 537-544, 1992.
19. McLoughlin, P., R. A. F. Linton, and D. M. Band. Effects of potassium and lactic acid on ventilation in anaesthetized cats. Respir. Physiol. 95: 171-179, 1994.
20. Mead, J., and C. Collier. Relationship of volume history of lungs to respiratory mechanics in anesthetized dogs. J. Appl. Physiol. 14: 669-678, 1959.
21. Paintal, A. S. The mechanism of excitation of type J receptors, and the J reflex. In: Breathing: Hering-Breuer Centenary Symposium, edited by R. Porter. London: Churchill, 1970, p. 59-71.
22. Paintal, A. S. Vagal sensory receptors and their reflex effects. Physiol. Rev. 53: 159-227: 1973.
23. Petersen, M., and R. H. LaMotte. Effect of protons on the inward current evoked by capsaicin in isolated dorsal root ganglion cells. Pain 54: 37-42, 1993.
24. Rotto, D. M., and M. P. Kaufman. Effect of metabolic products of muscular contraction on discharge of group III and FV afferents. J. Appl. Physiol. 64: 2306-2313, 1988.
25. + activity in cat hindlimb muscle. J. Appl. Physiol. 67: 256-263, 1989.
26. 2-mediated effects on respiration and pulmonary hemodynamics in the cat. Respir. Physiol. 71: 169-183, 1988.
27. + derived from lactic acid and hypercapnia. Am. J. Physiol. 262 (Heart Circ. Physiol. 31): H748-H753, 1992.
28. Thimm, F., and K. Baum. Response of chemosensitive nerve fibers of group III and IV to metabolic changes in rat muscles. Pfluegers Arch. 410: 143-152, 1987.
29. Thimm, F., M. Carvalho, M. Babka, and E. Meier zu Verl. Reflex increases in heart-rate induced by perfusing the hind leg of the rat with solutions containing lactic acid. Pfluegers Arch. 400: 286-293, 1984.
30. Uchida, Y., and S. Murao. Acid-induced excitation of afferent cardiac sympathetic nerve fibers. Am. J. Physiol. 228: 27-33, 1975.