Neurally Mediated Airway Constriction in Human and Other Species: A Comparative Study Using Precision-Cut Lung Slices (PCLS)

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Schlepütz, Marco ^a   Rieg, Annette D ^a   Seehase, Sophie ^b,c   Spillner, Jan ^a   Perez Bouza, Alberto ^a   Braunschweig, Till ^a   Schroeder, Thomas ^d   Bernau, Marc ^a   Lambermont, Verena ^e   Schlumbohm, Christina ^c   Sewald, Katherina ^b   Autschbach, Rüdiger ^a   Braun, Armin ^b   Kramer, Boris W ^e   Uhlig, Stefan ^a   Martin, Christian ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

^c Encepharm GmbH   (Germany)

^d Luisenhospital Aachen ^*  (Germany)

^e MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (4 METHOXYPHENYL) 2 [3 (4 METHOXYPHENYL)PROPOXY]ETHYL] 1H IMIDAZOLE; CAPSAICIN; RUTHENIUM;

AIRWAY CONSTRICTION; ANIMAL TISSUE; ARTICLE; BRONCHOSPASM; CALLITRICHINAE; CELL ACTIVATION; COMPARATIVE STUDY; CONTROLLED STUDY; ELECTROSTIMULATION; GUINEA PIG; HUMAN; HUMAN TISSUE; HUMAN VERSUS ANIMAL COMPARISON; LUNG SLICE; MOUSE; NERVE CELL; NERVE POTENTIAL; NONHUMAN; PRECISION CUT LUNG SLICES; RAT; RECEPTOR POTENTIAL; SHEEP; SPECIES DIFFERENTIATION;

ANIMALS; BRONCHOCONSTRICTION; CALCIUM CHANNEL BLOCKERS; CALLITHRIX; CAPSAICIN; ELECTRIC STIMULATION; GUINEA PIGS; HUMANS; IMIDAZOLES; LUNG; MICE; RATS; RUTHENIUM RED; SHEEP;

EID: 84867303418     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047344     Document Type: Article

References (54)

1. Barnes PJ, (1992) Neural mechanisms in asthma. Br Med Bull 48: 149-168.
2. Canning BJ, Fischer A, (2001) Neural regulation of airway smooth muscle tone. Respir Physiol 125: 113-127.
3. Spina D, Matera GM, Riccio MM, Page CP, (1998) A comparison of sensory nerve function in human, guinea-pig, rabbit and marmoset airways. Life Sci 63: 1629-1642.
4. Reinheimer T, Bernedo P, Klapproth H, Oelert H, Zeiske B, et al. (1996) Acetylcholine in isolated airways of rat, guinea pig, and human: species differences in role of airway mucosa. Am J Physiol 270: L722-L728.
5. Belvisi MG, Patacchini R, Barnes PJ, Maggi CA, (1994) Facilitatory effects of selective agonists for tachykinin receptors on cholinergic neurotransmission: evidence for species differences. Br J Pharmacol 111: 103-110.
6. Devillier P, Acker GM, Advenier C, Marsac J, Regoli D, et al. (1992) Activation of an epithelial neurokinin NK-1 receptor induces relaxation of rat trachea through release of prostaglandin E2. J Pharmacol Exp Ther 263: 767-772.
7. Frossard N, Muller F, (1986) Epithelial modulation of tracheal smooth muscle response to antigenic stimulation. J Appl Physiol 61: 1449-1456.
8. Joos GF, Lefebvre RA, Kips JC, Pauwels RA, (1994) Tachykinins contract trachea from Fischer 344 rats by interaction with a tachykinin NK1 receptor. Eur J Pharmacol 271: 47-54.
9. Szarek JL, Stewart NL, Spurlock B, Schneider C, (1995) Sensory nerve- and neuropeptide-mediated relaxation responses in airways of Sprague-Dawley rats. J Appl Physiol 78: 1679-1687.
10. Martin C, Uhlig S, Ullrich V, (1996) Videomicroscopy of methacholine-induced contraction of individual airways in precision-cut lung slices. Eur Respir J 9: 2479-2487.
11. Chew AD, Hirota JA, Ellis R, Wattie J, Inman MD, et al. (2008) Effects of allergen on airway narrowing dynamics as assessed by lung-slice technique. Eur Respir J 31: 532-538.
12. Henjakovic M, Martin C, Hoymann HG, Sewald K, Ressmeyer AR, et al. (2008) Ex vivo lung function measurements in precision-cut lung slices (PCLS) from chemical allergen-sensitized mice represent a suitable alternative to in vivo studies. Toxicol Sci 106: 444-453.
13. Ressmeyer AR, Larsson AK, Vollmer E, Dahlen SE, Uhlig S, et al. (2006) Characterisation of guinea pig precision-cut lung slices: comparison with human tissues. Eur Respir J 28: 603-611.
14. Vietmeier J, Niedorf F, Baumer W, Martin C, Deegen E, et al. (2007) Reactivity of equine airways-a study on precision-cut lung slices. Vet Res Commun 31: 611-619.
15. Schlepütz M, Dassow C, Kramer BW, König P, Uhlig S,et al. (2010) Comparison of airway responses in sheep of different age in precision-cut lung slices (PCLS). Am J Respir Crit Care Med 181:: A:5031.
16. Seehase S, Schlepütz M, Switalla S, Mätz-Rensing K, Kaup FJ, et al. (2011) Bronchoconstriction in non-human primates: a species comparison. J Appl Physiol 111: 791-798.
17. Switalla S, Lauenstein L, Prenzler F, Knothe S, Forster C, et al. (2010) Natural innate cytokine response to immunomodulators and adjuvants in human precision-cut lung slices. Toxicol Appl Pharmacol 246: 107-115.
18. Wohlsen A, Martin C, Vollmer E, Branscheid D, Magnussen H, et al. (2003) The early allergic response in small airways of human precision-cut lung slices. Eur Respir J 21: 1024-1032.
19. Henjakovic M, Sewald K, Switalla S, Kaiser D, Muller M, et al. (2008) Ex vivo testing of immune responses in precision-cut lung slices. Toxicol Appl Pharmacol 231: 68-76.
20. Martin C, Goggel R, Dal P V, Vergelli C, Giovannoni P, et al. (2002) Airway relaxant and anti-inflammatory properties of a PDE4 inhibitor with low affinity for the high-affinity rolipram binding site. Naunyn Schmiedebergs Arch Pharmacol 365: 284-289.
21. Schlepütz M, Uhlig S, Martin C, (2011) Electric field stimulation of precision-cut lung slices. J Appl Physiol 110: 545-554.
22. Wohlsen A, Uhlig S, Martin C, (2001) Immediate allergic response in small airways. Am J Respir Crit Care Med 163: 1462-1469.
23. Nassimi M, Schleh C, Lauenstein HD, Hussein R, Lubbers K, et al. (2009) Low cytotoxicity of solid lipid nanoparticles in in vitro and ex vivo lung models. Inhal Toxicol 21Suppl 1: 104-109.
24. Nassimi M, Schleh C, Lauenstein HD, Hussein R, Hoymann HG, et al. (2010) A toxicological evaluation of inhaled solid lipid nanoparticles used as a potential drug delivery system for the lung. Eur J Pharm Biopharm 75: 107-116.
25. Martin C, Held HD, Uhlig S, (2000) Differential effects of the mixed ET(A)/ET(B)-receptor antagonist bosentan on endothelin-induced bronchoconstriction, vasoconstriction and prostacyclin release. Naunyn Schmiedebergs Arch Pharmacol 362: 128-136.
26. Martin C, Ullrich V, Uhlig S, (2000) Effects of the thromboxane receptor agonist U46619 and endothelin-1 on large and small airways. Eur Respir J 16: 316-323.
27. del Castillo J, Engbaek L, (1954) The nature of the neuromuscular block produced by magnesium. J Physiol 124: 370-384.
28. Feldman S, Karalliedde L, (1996) Drug interactions with neuromuscular blockers. Drug Saf 15: 261-273.
29. Undem BJ, Myers AC, Barthlow H, Weinreich D, (1990) Vagal innervation of guinea pig bronchial smooth muscle. J Appl Physiol 69: 1336-1346.
30. Pena F, Ordaz B, (2008) Non-selective cation channel blockers: potential use in nervous system basic research and therapeutics. Mini Rev Med Chem 8: 812-819.
31. Nassenstein C, Kwong K, Taylor-Clark T, Kollarik M, Macglashan DM, et al. (2008) Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs. J Physiol 586: 1595-1604.
32. Bachar O, Adner M, Uddman R, Cardell LO, (2005) Prolonged exposure to NT-3 attenuates cholinergic nerve-mediated contractions in cultured murine airways. Respir Physiol Neurobiol 147: 81-89.
33. Altiere RJ, Diamond L, Thompson DC, (1992) Omega-conotoxin-sensitive calcium channels modulate autonomic neurotransmission in guinea pig airways. J Pharmacol Exp Ther 260: 98-103.
34. Dupont LJ, Pype JL, Demedts MG, De LP, Deneffe G, et al. (1999) The effects of 5-HT on cholinergic contraction in human airways in vitro. Eur Respir J 14: 642-649.
35. Gonzalez O, Santacana GE, (2001) Effect of low temperature on tracheal smooth muscle contractile and relaxing responses evoked by electrical field stimulation. P R Health Sci J 20: 237-244.
36. Sheller JR, Brigham KL, (1982) Bronchomotor responses of isolated sheep airways to electrical field stimulation. J Appl Physiol 53: 1088-1093.
37. Krejci E, Martinez-Pena y Valenzuela I, Ameziane R, Akaaboune M, (2006) Acetylcholinesterase dynamics at the neuromuscular junction of live animals. J Biol Chem 281: 10347-10354.
38. Martinez-Pena y Valenzuela I, Akaaboune M, (2007) Acetylcholinesterase Mobility and Stability at the Neuromuscular Junction of Living Mice. Mol Biol Cell 18: 2904-2911.
39. Rotundo RL, (2003) Expression and localization of acetylcholinesterase at the neuromuscular junction. Journal of Neurocytology 32: 743-766.
40. Barnes PJ, (1987) Cholinergic control of airway smooth muscle. Am Rev Respir Dis 136: S42-S45.
41. Belmonte KE, (2005) Cholinergic pathways in the lungs and anticholinergic therapy for chronic obstructive pulmonary disease. Proc Am Thorac Soc 2: 297-304.
42. Jia Y, Lee LY, (2007) Role of TRPV receptors in respiratory diseases. Biochim Biophys Acta 1772: 915-927.
43. Andersson RG, Grundstrom N, (1987) Innervation of airway smooth muscle. Efferent mechanisms. Pharmacol Ther 32: 107-130.
44. Lundberg JM, Martling CR, Saria A, (1983) Substance P and capsaicin-induced contraction of human bronchi. Acta Physiol Scand 119: 49-53.
45. Manzini S, (1992) Bronchodilatation by tachykinins and capsaicin in the mouse main bronchus. Br J Pharmacol 105: 968-972.
46. Szarek JL, Spurlock B, (1996) Antagonism of cholinergic nerve-mediated contractions by the sensory nerve inhibitory system in rat bronchi. J Appl Physiol 81: 260-265.
47. Doidge JM, Satchell DG, (1982) Adrenergic and non-adrenergic inhibitory nerves in mammalian airways. J Auton Nerv Syst 5: 83-99.
48. Held HD, Martin C, Uhlig S, (1999) Characterization of airway and vascular responses in murine lungs. Br J Pharmacol 126: 1191-1199.
49. Dahlen SE, Hedqvist P, Hammarstrom S, Samuelsson B, (1980) Leukotrienes are potent constrictors of human bronchi. Nature 288: 484-486.
50. Drazen JM, Austen KF, Lewis RA, Clark DA, Goto G, et al. (1980) Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro. Proc Natl Acad Sci U S A 77: 4354-4358.
51. Martin TR, Gerard NP, Galli SJ, Drazen JM, (1988) Pulmonary responses to bronchoconstrictor agonists in the mouse. J Appl Physiol 64: 2318-2323.
52. Muccitelli RM, Tucker SS, Hay DW, Torphy TJ, Wasserman MA, (1987) Is the guinea pig trachea a good in vitro model of human large and central airways? Comparison on leukotriene-, methacholine-, histamine- and antigen-induced contractions. J Pharmacol Exp Ther 243: 467-473.
53. Sundstrom E, Lastbom L, Ryrfeldt A, Dahlen SE, (2003) Interactions among three classes of mediators explain antigen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung. J Pharmacol Exp Ther 307: 408-418.
54. Murphy WJ, Eizirik E, Johnson WE, Zhang YP, Ryder OA, et al. (2001) Molecular phylogenetics and the origins of placental mammals. Nature 409: 614-618.