Relief of the 'air hunger' of breathholding A role for pulmonary stretch receptors

Respiration Physiology

Volumn 103, Issue 3, 1996, Pages 221-232

  Flume, Patrick A ^a   Eldridge, Frederic L ^b,c   Edwards, Lloyd J ^d   Mattison, Lalaine E ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d IL   (United States)

Author keywords

Air hunger; Breathing; Control of breathing; Heart; Humans; Lung; Mammals; Pulmonary stretch; Rebreathing; Receptors; Respiratory; Respiratory sensation; Sensation; Transplant; Vagus nerve

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEART TRANSPLANTATION; HUMAN; LUNG RECEPTOR; LUNG TRANSPLANTATION; MALE; PRIORITY JOURNAL; RESPIRATION CONTROL;

ADULT; BLOOD GAS ANALYSIS; FEMALE; FORCED EXPIRATORY FLOW RATES; HEART TRANSPLANTATION; HUMANS; LUNG TRANSPLANTATION; MALE; MIDDLE AGED; PULMONARY STRETCH RECEPTORS; REPRODUCIBILITY OF RESULTS; RESPIRATORY MECHANICS; TOTAL LUNG CAPACITY; VAGUS NERVE;

EID: 0030001501     PISSN: 00345687     EISSN: None     Source Type: Journal    
DOI: 10.1016/0034-5687(95)00094-1     Document Type: Article

References (24)

1. CO2 in mechanically ventilated quadriplegics. Respir. Physiol. 76: 53-68.
2. Chen, Z., F.L. Eldridge and P.G. Wagner (1991). Respiratory-associated rhythmic firing of midbrain neurones in cats: relation to level of respiratory drive. J. Physiol. (London) 437: 305-325.
3. Chen, Z., F.L. Eldridge and P.C. Wagner (1992). Respiratory-associated thalamic activity is related to level of respiratory drive. Respir. Physiol. 90: 99-113.
4. Coleridge, H.M. and J.C.G. Coleridge (1986). Reflexes evoked from the tracheo-bronchial tree and lungs. In: Handbook of Physiology: Section 3 The Respiratory System Vol. II: Control of Breathing, Part 1; edited by N.S. Cherniack and J.G. Widdicombe, American Physiological Society, Bethesda, MD, pp. 395-429.
5. Edmunds, L.H., Jr., P.D. Graf and J.A. Nadel (1971). Reinnervation of the reimplanted canine lung. J. Appl. Physiol. 31: 722-727.
6. Egan, T.M. (1992). Lung transplantation in cystic fibrosis. Semin. Respir. Infect. 7: 227-239.
7. Eldridge, F.L. and D.E. Millhom (1986). Oscillation, gating, and memory in the respiratory control system. In: Handbook of Physiology: Section 3. The Respiratory System Vol. II: Control of Breathing, Part 1; edited by N.S. Cherniack and J.G. Widdicombe, American Physiological Society, Bethesda, MD, pp. 93-114.
8. Eldridge, F.L. and Z. Chen (1992). Respiratory-associated rhythmic firing of midbrain neurons is modulated by vagal input. Respir. Physiol. 90: 31-46.
9. Flume, P.A., F.L. Eldridge, L.J. Edwards and L.M. Houser (1994). The Fowler breathholding study revisited: continuous rating of respiratory sensation. Respir. Physiol. 95: 53-66.
10. Flume, P.A., F.L. Eldridge, L.J. Edwards and L.M. Houser (1995). Relief of distress of breathholding. Respir. Physiol. 101: 41-46.
11. Fowler, W.S. (1954). Breaking point of breath-holding. J. Appl. Physiol. 6: 539-545.
12. Godfrey, S. and E.J.M. Campbell (1969). Mechanical and chemical control of breathholding. Quart. J. Exp. Physiol. 54: 117-128.
13. Hathaway, T., T. Higenbottam, R. Lowry and J. Wallwork (1991). Pulmonary reflexes after human heart-lung transplantation. Respir. Med. 85 (Suppl. A): 17-21.
14. Hill, L. and M. Flack (1908). The effect of excess carbon dioxide and of want of oxygen upon the respiration and the circulation. J. Physiol. (London) 37: 77-111.
15. Hong, S.K., Y.C. Lin, D.A. Lally, B.J.B. Yim, N. Koninami, P.W. Hong and T.O. Moore (1971). Alveolar gas exchanges and cardiovascular functions during breath holding with air. J. Appl. Physiol. 30: 540-547.
16. Kahan, B.D., S.M. Flechner, M.I. Lorber, C. Jensen, D. Golden and C.T. Van Buren (1986). Complications of cyclosporin therapy. World J. Surg. 10: 348-360.
17. Lall, A., P.D. Graf, J.A. Nadel and L.H. Edmunds, Jr. (1973). Adrenergic reinnervation of the reimplanted dog lung. J. Appl. Physiol. 35: 439-442.
18. Manning, H.L., S.A. Shea, R.M. Schwartzstein, R.W. Lansing, R. Brown and R.M. Banzett (1992). Reduced tidal volume increases 'air hunger' at fixed Pco in ventilated quadriplegics. Respir. Physiol. 90: 19-30.
19. Mithoefer, J.C. (1965). Breath holding. In: Handbook of Physiology. Section 3. Respiration. Vol. II., edited by W.O. Fenn and H. Rahn. American Physiological Society, Washington, D.C., pp. 1011-1025.
20. CO2 in paralysed patients. J. Physiol. (London) 149: 494-499.
21. Pasque, M.K., J.D. Cooper, L.R. Kaiser, D.A. Haydock, A. Triantafillou and E.P. Trulock (1990). Improved technique for bilateral lung transplantation: rationale and initial clinical experience. Ann. Thorac. Surg. 49: 785-491.
22. Stiefel, F.C., W.S. Breitbert and J.C. Holland (1989). Corticosteroids in cancer: neuropsychiatrie complications. Cancer Invest. 7: 479-491.
23. Trimble, A.S., B. Bharadwaj and P. Bedard (1967). Successful bilateral lung reimplantation in the dog. Canad. J. Surg. 10: 89-93.
24. Truhan, A.P. and A.R. Ahmed (1989). Corticosteroids: a review with emphasis on complications of prolonged systemic therapy. Ann. Allergy 62: 375-390.