Endogenous airway acidification: Implications for asthma pathophysiology

American Journal of Respiratory and Critical Care Medicine

Volumn 161, Issue 3 I, 2000, Pages 694-699

  Hunt, John F ^a   Fang, Kezhong ^a   Malik, Rajesh ^a   Snyder, Ashley ^a   Malhotra, Neil ^a   Platts Mills, Thomas A E ^a   Gaston, Benjamin ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; NITRIC OXIDE; NITROGEN; OXYGEN;

ACIDIFICATION; ADULT; AIRWAY DYNAMICS; ARTICLE; ARTIFACT; ASTHMA; CONTROLLED STUDY; DISEASE EXACERBATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PATHOPHYSIOLOGY; PH; PRIORITY JOURNAL; REPRODUCIBILITY;

EID: 0034104692     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.161.3.9911005     Document Type: Article

References (39)

1. Baldwin, S. R., R. H. Simon, C. M. Grum, L. H. Ketai, L. A. Boxer, and L. J. Devall. 1986. Oxidant activity in expired breath of patients with adult respiratory distress syndrome. Lancet 1:11-14.
2. Hunt, J., R. E. Byrns, L. J. Ignarro, and B. Gaston. 1995. Condensed expirate nitrite as a home marker for acute asthma [letter]. Lancet 346: 1235-1236.
3. Antczak, A., D. Nowak, B. Shariati, M. Krol, G. Piasecka, and Z. Kurmanowska. 1997. Increased hydrogen peroxide and thiobarbituric acid-reactive products in expired breath condensate of asthmatic patients. Eur. Respir. J. 10:1235-1241.
4. Hansel, T. T., J. D. Pound, D. Pilling, G. D. Kitas, M. Salmon, T. A. Gentle, S. S. Lee, and R. A. Thompson. 1989. Purification of human blood eosinophils by negative selection using immunomagnetic beads. J. Immunol. Methods 122:97-103.
5. Walsh, G. M. 1997. Mechanisms of human eosinophil survival and apoptosis. Clin. Exp. Allergy 27:482-487.
6. Gong, J., F. Traganos, and Z. Darzynkiewicz. 1994. A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry. Anal. Biochem. 218:314-319.
7. Govindaraju, K., E. A. Cowley, D. H. Eidelman, and D. K. Lloyd. 1997. Microanalysis of lung airway surface fluid by capillary electrophoresis with conductivity detection. Anal. Chem. 69:2793-2797.
8. Silkoff, P. E., P. A. McClean, A. S. Slutsky, H. G. Furlott, E. Hoffstein, S. Wakita, K. R. Chapman, J. P. Szalai, and N. Zamel. 1997. Marked flow-dependence of exhaled nitric oxide using a new technique to exclude nasal nitric oxide. Am. J. Respir. Crit. Care Med. 155:260-267.
9. Lundberg, J. O., S. L. Nordvall, E. Weitzberg, H. Kollberg, and K. Alving. 1996. Exhaled nitric oxide in paediatric asthma and cystic fibrosis. Arch. Dis. Child. 75:323-326.
10. Rennard, S. I., G. Basset, D. Lecossier, K. M. O'Donnell, P. Pinkston, P. G. Martin, and R. G. Crystal. 1986. Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution. J. Appl. Physiol. 60:532-538.
11. Arías-Diaz, J., E. Vara, J. Torres-Melero, C. Garcia, W. Baki, J. A. Ramirez-Armengol, and J. L. Balibrea. 1994. Nitrite/nitrate and cytokine levels in bronchoalveolar lavage fluid of lung cancer patients. Cancer 74:1546-1551.
12. Pheng, L. H., C. Francoeur, and M. Denis. 1995. The involvement of nitric oxide in a mouse model of adult respiratory distress syndrome. Inflammation 19:599-610.
13. Kanazawa, H., S. Shoji, M. Yamada, T. Fujii, T. Kawaguchi, S. Kudoh, K. Hirata, and J. Yoshikawa. 1997. Increased levels of nitric oxide derivatives in induced sputum in patients with asthma. J. Allergy Clin. Immunol. 99:624-629.
14. Becher, G., K. Winsel, E. Beck, G. Neubauer, and E. Stresemann. 1997. [Breath condensate as a method of noninvasive assessment of inflammation mediators from the lower airways]. Pneumologie 51(Suppl. 2): 456-459.
15. Ricciardolo, F. L. M., V. Rado, L. M. Fabbri, P. J. Sterk, G. U. Di Maria, and P. Geppetti. 1999. Bronchoconstriction induced by citric acid inhalation in guinea pigs: role of tachykinins, bradykinin, and nitric oxide. Am. J. Respir. Crit. Care Med. 159:557-562.
16. O'Donnell, W. J., M. Rosenberg, R. W. Niven, J. M. Drazen, and E. Israel. 1992. Acetazolamide and furosemide attenuate asthma induced by hyperventilation of cold, dry air. Am. Rev. Respir. Dis. 146:1518-1523.
17. O'Connor, B. J., C. T. Yeo, Y. M. Chen-Worsdell, P. J. Barnes, and K. F. Chung. 1994. Effect of acetazolamide and amiloride against sodium metabisulphite-induced bronchoconstriction in mild asthma. Thorax 49:1096-1098.
18. Guerrin, F., C. Voisin, V. Macquet, R. A. Robin, and P. Lequien. 1971. Apport de la pH metrie bronchique in situ. Prog. Respir. Res. 6:372-383.
19. Adler, K., O. Wooten, W. Philippoff, E. Lerner, and M. J. Dulfano. 1972. Physical properties of sputum: 3. Rheologic variability and intrinsic relationships. Am. Rev. Respir. Dis. 106:86-96.
20. Metheny, N. A., B. J. Stewart, L. Smith, H. Yan, M. Diebold, and R. E. Clouse. 1999. pH and concentration of bilirubin in feeding tube aspirates as predictors of tube placement. Nurs. Res. 48:189-197.
21. Klebanoff, S. J. 1993. Reactive nitrogen intermediates and antimicrobial activity: role of nitrite. Free Radic. Biol. Med. 14:351-360.
22. Kharitonov, S. A., D. H. Yates, and P. J. Barnes. 1996. Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients. Am. J. Respir. Crit. Care Med. 153:454-457.
23. Ehrt, S., M. U. Shiloh, J. Ruan, M. Choi, S. Gunzburg, C. Nathan, Q. Xie, and L. W. Riley. 1997. A novel antioxidant gene from Mycobacterium tuberculosis [published erratum appears in J. Exp. Med. 1998; 187:141]. J. Exp. Med. 186:1885-1896.
24. Long, R., B. Light, and J. A. Talbot. 1999. Mycobacteriocidal action of exogenous nitric oxide. Antimicrob. Agents Chemother. 43:403-405.
25. Koppenol, W. H., J. J. Moreno, W. A. Pryor, H. Ischiropoulos, and J. S. Beckman. 1992. Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide. Chem. Res. Toxicol. 5:834-842.
26. Hickman-Davis, J., J. Gibbs-Erwin, J. R. Lindsey, and S. Matalon. 1999. Surfactant protein A mediates mycoplasmacidal activity of alveolar macrophages by production of peroxynitrite. Proc. Null. Acad. Sci. U.S.A. 96:4953-4958.
27. De Groote, M. A., T. Testerman, Y. Xu, G. Stauffer, and F. C. Fang. 1996. Homocysteine antagonism of nitric oxide-related cytostasis in Salmonella typhimitrium. Science 272:414-417.
28. Gaston, B., J. Reilly, J. M. Drazen, J. Fackler, P. Ramdev, D. Arnelle, M. E. Mullins, D. J. Sugarbaker, C. Chee, D. J. Singel. J. Loscalzo, and J. S. Stamler. 1993. Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways. Proc. Natl. Acad. Sci. U.S.A. 90: 10957-10961.
29. Gaston, B., S. Sears, J. Woods, J. Hunt, M. Ponaman, T. McMahon, and J. S. Stamler. 1998. Bronchodilator S-nitrosothiol deficiency in asthmatic respiratory failure. Lancet 351:1317-1319.
30. Nathan, C. 1995. Natural resistance and nitric oxide. Cell 82:873-876.
31. Bousquet, J., P. Chanez, J. Y. Lacoste, G. Barneon, N. Ghavanian, I. Enander, P. Venge, S. Ahlstedt, J. Simony-Lafontaine, P. Godard, and F. Michel. 1990. Eosinophilic inflammation in asthma [see Comments]. N. Engl. J. Med. 323:1033-1039.
32. Woolley, K. L., P. G. Gibson, K. Carty, A. J. Wilson, S. H. Twaddell, and M. J. Woolley. 1996. Eosinophil apoptosis and the resolution of airway inflammation in asthma. Am. J. Respir. Crit. Care Med. 154:237-243.
33. Beauvais, F., L. Michel, and L. Dubertret. 1995. The nitric oxide donors, azide and hydroxylamine, inhibit the programmed cell death of cytokine-deprived human eosinophils. FEBS Lett. 361:229-232.
34. Mannick, J. B., A. Hausladen, L. Liu, D. T. Hess, M. Zeng, Q. X. Miao, L. S. Kane, A. J. Gow, and J. S. Stamler. 1999. Fas-induced caspase denitrosylation. Science 284:651-654.
35. Luk, C. K., and M. J. Dulfano. 1983. Effect of pH, viscosity and ionic-strength changes on ciliary beating frequency of human bronchial explants. Clin. Sci. 64:449-451.
36. Holma, B., and P. O. Hegg. 1989. pH- and protein-dependent buffer capacity and viscosity of respiratory mucus: their interrelationships and influence on health. Sci. Total Environ. 84:71-82.
37. Holma, B., M. Lindegren, and J. M. Andersen. 1977. pH effects on ciliomotility and morphology of respiratory mucosa. Arch. Environ. Health 32:216-226.
38. Bevan, S., and P. Geppetti. 1994. Protons: small stimulants of capsaicin-sensitive sensory nerves. Trends Neurosci. 17:509-512.
39. Lou, Y. P., and J. M. Lundberg. 1992. Inhibition of low pH evoked activation of airway sensory nerves by capsazepine, a novel capsaicin-receptor antagonist. Biochem. Biophys. Res. Commun. 189:537-544.