Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis

Annals of the Rheumatic Diseases

Volumn 71, Issue 5, 2012, Pages 785-789

  Horn, Angelika ^a   Kireva, Trayana ^a   Palumbo Zerr, Katrin ^a   Dees, Clara ^a   Tomcik, Michal ^a,b   Cordazzo, Cinzia ^a,c   Zerr, Pawel ^a   Akhmetshina, Alfiya ^a   Ruat, Martial ^d   Distler, Oliver ^e   Beyer, Christian ^a   Schett, Georg ^a   Distler, Jörg H W ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b CHARLES UNIVERSITY   (Czech Republic)

^c UNIVERSITY OF PISA   (Italy)

^d CNRS   (France)

^e UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; COLLAGEN; LDE 223; PROTEIN INHIBITOR; SMALL INTERFERING RNA; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GLI; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DERMAL THICKENING; GENE; HEDGEHOG GENE; MOUSE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; REMISSION; SKIN FIBROSIS; SYSTEMIC SCLEROSIS;

ANIMALS; BIPHENYL COMPOUNDS; BLEOMYCIN; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; FIBROSIS; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; RECEPTORS, G-PROTEIN-COUPLED; RNA, SMALL INTERFERING; SCLERODERMA, SYSTEMIC; SIGNAL TRANSDUCTION; SKIN; SKIN DISEASES;

EID: 84859503196     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2011-200883     Document Type: Article

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