Discovery, molecular and pharmacological characterization of gsa-10, a novel small-molecule positive modulator of smootheneds

Molecular Pharmacology

Volumn 83, Issue 5, 2013, Pages 1020-1029

  Gorojankina, Tatiana ^a   Hoch, Lucile ^a   Faure, Héléne ^a   Roudaut, Hermine ^a   Traiffort, Elisabeth ^a   Schoenfelder, Angéle ^b   Girard, Nicolas ^b   Mann, André ^b   Manetti, Fabrizio ^c   Solinas, Antonio ^c   Petricci, Elena ^c   Taddei, Maurizio ^c   Ruat, Martial ^a  

^a CNRS   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c UNIVERSITY OF SIENA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLERA TOXIN; FORSKOLIN; GSA 10; QUINOLINE DERIVATIVE; SMOOTHENED PROTEIN; SONIDEGIB; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG BINDING; DRUG MECHANISM; HUMAN; HUMAN CELL; HYDROGEN BOND; MESENCHYMAL STEM CELL; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL;

BENZOATES; BINDING SITES; BONE MORPHOGENETIC PROTEIN RECEPTORS; CELL DIFFERENTIATION; CELL LINE; CYCLIC AMP; CYCLOHEXYLAMINES; HEDGEHOG PROTEINS; HEK293 CELLS; HUMANS; LIGANDS; QUINOLINES; RECEPTORS, G-PROTEIN-COUPLED; SMALL MOLECULE LIBRARIES; THIOPHENES; TRANSCRIPTION FACTORS; WNT PROTEINS;

EID: 84876525471     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.112.084590     Document Type: Article

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