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Volumn 28, Issue 36, 2010, Pages 5321-5326

Clinical experience with hedgehog pathway inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO N [4 CHLORO 3 (2 PYRIDINYL)PHENYL] 4 METHANESULFONYLBENZAMIDE; ANTINEOPLASTIC AGENT; BEVACIZUMAB; BMS 833923; BORTEZOMIB; CAPECITABINE; CARBOPLATIN; CISPLATIN; DASATINIB; DEXAMETHASONE; ERLOTINIB; ETOPOSIDE; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; IPI 926; IRINOTECAN; LDE 225; LENALIDOMIDE; OXALIPLATIN; PF 04449913; PROTEIN INHIBITOR; RO 4929097; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG; XL 139;

EID: 79951904426     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2010.27.9943     Document Type: Review
Times cited : (170)

References (69)
  • 1
    • 51949085076 scopus 로고    scopus 로고
    • Hedgehog: Functions and mechanisms
    • Varjosalo M, Taipale J: Hedgehog: Functions and mechanisms. Genes Dev 22:2454-2472, 2008
    • (2008) Genes Dev , vol.22 , pp. 2454-2472
    • Varjosalo, M.1    Taipale, J.2
  • 2
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: Paradigms and principles
    • DOI 10.1101/gad.938601
    • Ingham PW, McMahon AP: Hedgehog signaling in animal development: Paradigms and principles. Genes Dev 15:3059-3087, 2001 (Pubitemid 33115673)
    • (2001) Genes and Development , vol.15 , Issue.23 , pp. 3059-3087
    • Ingham, P.W.1    McMahon, A.P.2
  • 3
    • 62449174504 scopus 로고    scopus 로고
    • Selective translocation of intracellular smoothened to the primary cilium in response to hedgehog pathway modulation
    • Wang Y, Zhou Z, Walsh CT, et al: Selective translocation of intracellular smoothened to the primary cilium in response to hedgehog pathway modulation. Proc Natl Acad Sci U S A 106:2623-2628, 2009
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 2623-2628
    • Wang, Y.1    Zhou, Z.2    Walsh, C.T.3
  • 4
    • 75549090700 scopus 로고    scopus 로고
    • Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium
    • Milenkovic L, Scott MP, Rohatgi R: Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium. J Cell Biol 187:365-374, 2009
    • (2009) J Cell Biol , vol.187 , pp. 365-374
    • Milenkovic, L.1    Scott, M.P.2    Rohatgi, R.3
  • 7
    • 34548306769 scopus 로고    scopus 로고
    • Patching the gaps in hedgehog signaling
    • Rohatgi R, Scott MP: Patching the gaps in hedgehog signaling. Nat Cell Biol 9:1005-1009, 2007
    • (2007) Nat Cell Biol , vol.9 , pp. 1005-1009
    • Rohatgi, R.1    Scott, M.P.2
  • 8
    • 33751208606 scopus 로고    scopus 로고
    • Regulation of Hh/Gli signaling by dual ubiquitin pathways
    • Jiang J: Regulation of Hh/Gli signaling by dual ubiquitin pathways. Cell Cycle 5:2457-2463, 2006
    • (2006) Cell Cycle , vol.5 , pp. 2457-2463
    • Jiang, J.1
  • 9
    • 70249114459 scopus 로고    scopus 로고
    • Hedgehog signaling: Kif7 is not that fishy after all
    • Ingham PW, McMahon AP: Hedgehog signaling: Kif7 is not that fishy after all. Curr Biol 19:R729-31, 2009
    • (2009) Curr Biol , vol.19
    • Ingham, P.W.1    McMahon, A.P.2
  • 10
    • 58149333235 scopus 로고    scopus 로고
    • The primary cilium at the crossroads of mammalian hedgehog signaling
    • Wong SY, Reiter JF: The primary cilium at the crossroads of mammalian hedgehog signaling. Curr Top Dev Biol 85:225-260, 2008
    • (2008) Curr Top Dev Biol , vol.85 , pp. 225-260
    • Wong, S.Y.1    Reiter, J.F.2
  • 11
    • 0037118056 scopus 로고    scopus 로고
    • Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin e
    • DOI 10.1038/417299a
    • Duman-Scheel M, Weng L, Xin S, et al: Hedgehog regulates cell growth and proliferation by inducing cyclin D and cyclin E. Nature 417:299-304, 2002 (Pubitemid 34534713)
    • (2002) Nature , vol.417 , Issue.6886 , pp. 299-304
    • Duman-Scheel, M.1    Weng, L.2    Xin, S.3    Du, W.4
  • 17
    • 9244221172 scopus 로고    scopus 로고
    • Tissue repair and stem cell renewal in carcinogenesis
    • DOI 10.1038/nature03100
    • Beachy PA, Karhadkar SS, Berman DM: Tissue repair and stem cell renewal in carcinogenesis. Nature 432:324-331, 2004 (Pubitemid 39551660)
    • (2004) Nature , vol.432 , Issue.7015 , pp. 324-331
    • Beachy, P.A.1    Karhadkar, S.S.2    Berman, D.M.3
  • 18
    • 0015189026 scopus 로고
    • Cyclopia in sheep caused by plant teratogens
    • Bryden MM, Evans HE, Keeler RF: Cyclopia in sheep caused by plant teratogens. J Anat 110:507, 1971
    • (1971) J Anat , vol.110 , pp. 507
    • Bryden, M.M.1    Evans, H.E.2    Keeler, R.F.3
  • 19
    • 0036829397 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
    • DOI 10.1101/gad.1025302
    • Chen JK, Taipale J, Cooper MK, et al: Inhibition of hedgehog signaling by direct binding of cyclopamine to smoothened. Genes Dev 16:2743-2748, 2002 (Pubitemid 35253140)
    • (2002) Genes and Development , vol.16 , Issue.21 , pp. 2743-2748
    • Chen, J.K.1    Taipale, J.2    Cooper, M.K.3    Beachy, P.A.4
  • 20
    • 18644368453 scopus 로고    scopus 로고
    • Small-molecule modulators of hedgehog signaling: Identification and characterization of smoothened agonists and antagonists
    • Frank-Kamenetsky M, Zhang XM, Bottega S, et al: Small-molecule modulators of hedgehog signaling: Identification and characterization of smoothened agonists and antagonists. J Biol 1:10, 2002
    • (2002) J Biol , vol.1 , pp. 10
    • Frank-Kamenetsky, M.1    Zhang, X.M.2    Bottega, S.3
  • 23
    • 68249099424 scopus 로고    scopus 로고
    • Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy
    • Tremblay MR, Nesler M, Weatherhead R, et al: Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy. Expert Opin Ther Pat 19:1039-1056, 2009
    • (2009) Expert Opin Ther Pat , vol.19 , pp. 1039-1056
    • Tremblay, M.R.1    Nesler, M.2    Weatherhead, R.3
  • 24
    • 67649983452 scopus 로고    scopus 로고
    • Hedgehog-Gli signaling pathway inhibitors as anticancer agents
    • Mahindroo N, Punchihewa C, Fujii N: Hedgehog-Gli signaling pathway inhibitors as anticancer agents. J Med Chem 52:3829-3845, 2009
    • (2009) J Med Chem , vol.52 , pp. 3829-3845
    • Mahindroo, N.1    Punchihewa, C.2    Fujii, N.3
  • 26
    • 67149143399 scopus 로고    scopus 로고
    • Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    • Olive KP, Jacobetz MA, Davidson CJ, et al: Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324:1457-1461, 2009
    • (2009) Science , vol.324 , pp. 1457-1461
    • Olive, K.P.1    Jacobetz, M.A.2    Davidson, C.J.3
  • 27
    • 56249121238 scopus 로고    scopus 로고
    • Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists
    • Tremblay MR, Nevalainen M, Nair SJ, et al: Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists. J Med Chem 51:6646-6649, 2008
    • (2008) J Med Chem , vol.51 , pp. 6646-6649
    • Tremblay, M.R.1    Nevalainen, M.2    Nair, S.J.3
  • 28
    • 52149119128 scopus 로고    scopus 로고
    • A paracrine requirement for hedgehog signaling in cancer
    • Yauch RL, Gould SE, Scales SJ, et al: A paracrine requirement for hedgehog signaling in cancer. Nature 455:406-410, 2008
    • (2008) Nature , vol.455 , pp. 406-410
    • Yauch, R.L.1    Gould, S.E.2    Scales, S.J.3
  • 29
    • 63149124772 scopus 로고    scopus 로고
    • Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
    • Tian H, Callahan CA, DuPree KJ, et al: Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. Proc Natl Acad Sci U S A 106:4254-4259, 2009
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 4254-4259
    • Tian, H.1    Callahan, C.A.2    DuPree, K.J.3
  • 30
    • 58149143021 scopus 로고    scopus 로고
    • Sonic hedgehog promotes desmoplasia in pancreatic cancer
    • Bailey JM, Swanson BJ, Hamada T, et al: Sonic hedgehog promotes desmoplasia in pancreatic cancer. Clin Cancer Res 14:5995-6004, 2008
    • (2008) Clin Cancer Res , vol.14 , pp. 5995-6004
    • Bailey, J.M.1    Swanson, B.J.2    Hamada, T.3
  • 33
    • 58149506283 scopus 로고    scopus 로고
    • GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation
    • Nolan-Stevaux O, Lau J, Truitt ML, et al: GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes Dev 23:24-36, 2009
    • (2009) Genes Dev , vol.23 , pp. 24-36
    • Nolan-Stevaux, O.1    Lau, J.2    Truitt, M.L.3
  • 34
    • 21644458019 scopus 로고    scopus 로고
    • Hedgehog signaling in murine vasculogenesis and angiogenesis
    • DOI 10.1016/j.tcm.2004.09.003, PII S1050173804001434
    • Byrd N, Grabel L: Hedgehog signaling in murine vasculogenesis and angiogenesis. Trends Cardiovasc Med 14:308-313, 2004 (Pubitemid 41110609)
    • (2004) Trends in Cardiovascular Medicine , vol.14 , Issue.8 , pp. 308-313
    • Byrd, N.1    Grabel, L.2
  • 36
    • 57749086958 scopus 로고    scopus 로고
    • Hedgehog-induced survival of B-cell chronic lymphocytic leukemia cells in a stromal cell microenvironment: A potential new therapeutic target
    • Hegde GV, Peterson KJ, Emanuel K, et al: Hedgehog-induced survival of B-cell chronic lymphocytic leukemia cells in a stromal cell microenvironment: A potential new therapeutic target. Mol Cancer Res 6:1928-1936, 2008
    • (2008) Mol Cancer Res , vol.6 , pp. 1928-1936
    • Hegde, G.V.1    Peterson, K.J.2    Emanuel, K.3
  • 37
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions
    • Visvader JE, Lindeman GJ: Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions. Nat Rev Cancer 8:755-768, 2008
    • (2008) Nat Rev Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 39
    • 33847052127 scopus 로고    scopus 로고
    • Identification of pancreatic cancer stem cells
    • Li C, Heidt DG, Dalerba P, et al: Identification of pancreatic cancer stem cells. Cancer Res 67:1030-1037, 2007
    • (2007) Cancer Res , vol.67 , pp. 1030-1037
    • Li, C.1    Heidt, D.G.2    Dalerba, P.3
  • 40
    • 33745728170 scopus 로고    scopus 로고
    • Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells
    • Liu S, Dontu G, Mantle ID, et al: Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res 66:6063-6071, 2006
    • (2006) Cancer Res , vol.66 , pp. 6063-6071
    • Liu, S.1    Dontu, G.2    Mantle, I.D.3
  • 42
    • 64749091867 scopus 로고    scopus 로고
    • Hedgehog signaling is essential for maintenance of cancer stem cells in myeloid leukaemia
    • Zhao C, Chen A, Jamieson CH, et al: Hedgehog signaling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature 458:776-779, 2009
    • (2009) Nature , vol.458 , pp. 776-779
    • Zhao, C.1    Chen, A.2    Jamieson, C.H.3
  • 43
    • 50649118068 scopus 로고    scopus 로고
    • Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation
    • Dierks C, Beigi R, Guo GR, et al: Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation. Cancer Cell 14:238-249, 2008
    • (2008) Cancer Cell , vol.14 , pp. 238-249
    • Dierks, C.1    Beigi, R.2    Guo, G.R.3
  • 44
    • 0030866154 scopus 로고    scopus 로고
    • Altered neural cell fates and medulloblastoma in mouse patched mutants
    • DOI 10.1126/science.277.5329.1109
    • Goodrich LV, Milenkovic L, Higgins KM, et al: Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277:1109-1113, 1997 (Pubitemid 27371635)
    • (1997) Science , vol.277 , Issue.5329 , pp. 1109-1113
    • Goodrich, L.V.1    Milenkovic, L.2    Higgins, K.M.3    Scott, M.P.4
  • 46
    • 52649111039 scopus 로고    scopus 로고
    • Basal cell carcinomas: Attack of the hedgehog
    • Epstein EH: Basal cell carcinomas: Attack of the hedgehog. Nat Rev Cancer 8:743-754, 2008
    • (2008) Nat Rev Cancer , vol.8 , pp. 743-754
    • Epstein, E.H.1
  • 47
    • 0030844141 scopus 로고    scopus 로고
    • Activation of the transcription factor Gli1 and the sonic hedgehog signalling pathway in skin tumours
    • DOI 10.1038/39918
    • Dahmane N, Lee J, Robins P, et al: Activation of the transcription factor Gli1 and the sonic hedgehog signaling pathway in skin tumours. Nature 389: 876-881, 1997 (Pubitemid 27462984)
    • (1997) Nature , vol.389 , Issue.6653 , pp. 876-881
    • Dahmane, N.1    Lee, J.2    Robins, P.3    Heller, P.4    Ruiz, I.A.A.5
  • 48
    • 0030990735 scopus 로고    scopus 로고
    • Human patched (PTCH) mRNA is overexpressed consistently in tumor cells of both familial and sporadic basal cell carcinoma
    • Unden AB, Zaphiropoulos PG, Bruce K, et al: Human patched (PTCH) mRNA is overexpressed consistently in tumor cells of both familial and sporadic basal cell carcinoma. Cancer Res 57:2336-2340, 1997 (Pubitemid 27255884)
    • (1997) Cancer Research , vol.57 , Issue.12 , pp. 2336-2340
    • Unden, A.B.1    Zaphiropoulos, P.G.2    Bruce, K.3    Toftgard, R.4    Stahle-Backdahl, M.5
  • 50
    • 0032080853 scopus 로고    scopus 로고
    • Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system
    • Reifenberger J, Wolter M, Weber RG, et al: Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res 58:1798-1803, 1998 (Pubitemid 28217449)
    • (1998) Cancer Research , vol.58 , Issue.9 , pp. 1798-1803
    • Reifenberger, J.1    Wolter, M.2    Weber, R.G.3    Megahed, M.4    Ruzicka, T.5    Lichter, P.6    Reifenberger, G.7
  • 51
    • 33646362581 scopus 로고    scopus 로고
    • Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations
    • Thompson MC, Fuller C, Hogg TL, et al: Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J Clin Oncol 24:1924-1931, 2006
    • (2006) J Clin Oncol , vol.24 , pp. 1924-1931
    • Thompson, M.C.1    Fuller, C.2    Hogg, T.L.3
  • 52
    • 0034753859 scopus 로고    scopus 로고
    • A mouse model for medulloblastoma and basal cell nevus syndrome
    • DOI 10.1023/A:1012260318979
    • Corcoran RB, Scott MP: A mouse model for medulloblastoma and basal cell nevus syndrome. J Neurooncol 53:307-318, 2001 (Pubitemid 33034682)
    • (2001) Journal of Neuro-Oncology , vol.53 , Issue.3 , pp. 307-318
    • Corcoran, R.B.1    Scott, M.P.2
  • 54
    • 0030802458 scopus 로고    scopus 로고
    • Induction of basal cell carcinoma features in transgenic human skin expressing sonic hedgehog
    • Fan H, Oro AE, Scott MP, et al: Induction of basal cell carcinoma features in transgenic human skin expressing sonic hedgehog. Nat Med 3:788-792, 1997
    • (1997) Nat Med , vol.3 , pp. 788-792
    • Fan, H.1    Oro, A.E.2    Scott, M.P.3
  • 59
    • 33646231995 scopus 로고    scopus 로고
    • Shh pathway activity is down-regulated in cultured medulloblastoma cells: Implications for preclinical studies
    • Sasai K, Romer JT, Lee Y, et al: Shh pathway activity is down-regulated in cultured medulloblastoma cells: Implications for preclinical studies. Cancer Res 66:4215-4222, 2006
    • (2006) Cancer Res , vol.66 , pp. 4215-4222
    • Sasai, K.1    Romer, J.T.2    Lee, Y.3
  • 61
    • 67650385302 scopus 로고    scopus 로고
    • American Cancer Society: Cancer Facts and Figures 2009. http://www.cancer.org/acs/groups/content/@nho/documents/document/500809webpdf. pdf
    • (2009) Cancer Facts and Figures
  • 63
    • 70349238733 scopus 로고    scopus 로고
    • Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
    • Von Hoff DD, LoRusso PM, Rudin CM, et al: Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med 361:1164-1172, 2009
    • (2009) N Engl J Med , vol.361 , pp. 1164-1172
    • Von Hoff, D.D.1    LoRusso, P.M.2    Rudin, C.M.3
  • 64
    • 84861360955 scopus 로고    scopus 로고
    • A first-inhuman phase 1 study of an oral hedgehog pathway antagonist, BMS-833923 (XL139), in subjects with advanced or metastatic solid tumors
    • Boston, MA, November 15-19, abstr 55
    • Siu L, Papadopoulos KP, Alberts S: A first-inhuman phase 1 study of an oral hedgehog pathway antagonist, BMS-833923 (XL139), in subjects with advanced or metastatic solid tumors. AACR-NCIEORTC Molecular Targets and Cancer Therapeutics, Boston, MA, November 15-19, 2009 (abstr 55)
    • (2009) AACR-NCIEORTC Molecular Targets and Cancer Therapeutics
    • Siu, L.1    Papadopoulos, K.P.2    Alberts, S.3
  • 65
    • 0033157176 scopus 로고    scopus 로고
    • Medulloblastoma: Clinical and biologic aspects
    • Packer RJ, Cogen P, Vezina G, et al: Medulloblastoma: Clinical and biologic aspects. Neuro Oncol 1:232-250, 1999
    • (1999) Neuro Oncol , vol.1 , pp. 232-250
    • Packer, R.J.1    Cogen, P.2    Vezina, G.3
  • 67
    • 40149091426 scopus 로고    scopus 로고
    • Transient Inhibition of the Hedgehog Pathway in Young Mice Causes Permanent Defects in Bone Structure
    • DOI 10.1016/j.ccr.2008.01.027, PII S1535610808000378
    • Kimura H, Ng JM, Curran T: Transient inhibition of the hedgehog pathway in young mice causes permanent defects in bone structure. Cancer Cell 13:249-260, 2008 (Pubitemid 351324879)
    • (2008) Cancer Cell , vol.13 , Issue.3 , pp. 249-260
    • Kimura, H.1    Ng, J.M.Y.2    Curran, T.3
  • 68
    • 70349244812 scopus 로고    scopus 로고
    • Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449
    • Rudin CM, Hann CL, Laterra J, et al: Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N Engl J Med 361:1173-1178, 2009
    • (2009) N Engl J Med , vol.361 , pp. 1173-1178
    • Rudin, C.M.1    Hann, C.L.2    Laterra, J.3
  • 69
    • 70350496540 scopus 로고    scopus 로고
    • Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma
    • Yauch RL, Dijkgraaf GJ, Alicke B, et al: Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma. Science 326:572-574, 2009
    • (2009) Science , vol.326 , pp. 572-574
    • Yauch, R.L.1    Dijkgraaf, G.J.2    Alicke, B.3


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