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Bioorganic and Medicinal Chemistry

Volumn 20, Issue 21, 2012, Pages 6465-6481

Potent small molecule Hedgehog agonists induce VEGF expression in vitro

(6) Seifert, Katrin a Büttner, Anita a Rigol, Stephan a Eilert, Nicole a Wandel, Elke b Giannis, Athanassios a

a UNIVERSITY OF LEIPZIG (Germany)

b TRM Leipzig/Research Laboratories (Germany)

Author keywords

Hedgehog; SAG; VEGF

Indexed keywords

1,4 DIAMINOCYCLOHEXANE DERIVATIVE; 3 METHYL N [TRANS 4 (METHYLAMINO)CYCLOHEXYL] N (3 PYRIDIN 4 YLBENZYL)BENZO[B] FURAN 2 CARBOXAMIDE 10J; 3 PYRIDIN 4 YLBENZALDEHYDE 17; ANGIOGENESIS INHIBITOR; CIS 4 [(TERT BUOXYCARBONYL)(METHYL)AMINO]CYCLOHEXYL BENZOIC ACID; ETHYL 3 CHLORO 1H INDOLE 2 CARBOXYLIC ACID 20; SAG DERIVA TIVE; SONIC HEDGEHOG PROTEIN; TERT BUTYL (CIS 4 AZIDOCYCLOHEXYL)METHYLCARBAMIC ACID 7; TERT BUTYL (CIS 4 HYDOXYCYCLOHEXYL)METHYLCARBAMIC ACID 5; TERT BUTYL (TRANS 4 AMINOCYCLOHEXYL)METHYLCARBAMIC ACID 1A; TERT BUTYL (TRANS 4 AMINOCYCLOHEXYL)METHYLCARBAMIC ACID 1B; TERT BUTYL (TRANS 4 AZIDOCYCLOHEXYL)METHYLCARBAMIC ACID 6; TERT BUTYL (TRANS 4 HYDROXYCYCLOHEXYL)METHYLCARBAMIC ACID; TERT BUTYL 4 AMINOPIPERIDINE 1 CARBOXYLIC ACID 11; TERT BUTYL [CIS 4 [[(3 CHLOROBENZO[B]THIOPHENE 2 YL)CARBONYL] (3 PYRIDIN 4 YL BENZYL)AMINO]CYCLOHEXYL]METHYLCARBAMIC ACID 9E; TERT BUTYL [CIS 4 [[(3,4 DICHLOROBENZO[B]THIOPHENE 2 YL)CARBONYL] (3 PYRIDIN 4 YL BENZYL)AMINO]CYCLOHEXYL]METHYLCARBAMIC ACID 9B; TERT BUTYL [CIS 4 [[(3,4 DICHLOROBENZO[B]THIOPHENE 2 YL)CARBONYL] (3 PYRIDIN 4 YL BENZYL)AMINO]CYCLOHEXYL]METHYLCARBAMIC ACID 9C; TERT BUTYL [TRANS 4 [[(3 CHLORO 6 FLUOROBENZO[B]THIOPHENE 2 YL)CARBONYL] (3 PYRIDIN 4 YLBENZYL)AMINO]CYCLOHEXYL]METHYLCARBAMIC ACID 9G; TERT BUTYL [TRANS 4 [[(3 CHLOROBENZO[B]THIOPHENE 2 YL)CARBONYL] (3 PYRIDIN 4 YL BENZYL)AMINO]CYCLOHEXYL]METHYLCARBAMIC ACID 9A; TERT BUTYL [TRANS 4 [[(3,4 DICHLOROBENZO[B]THIOPHENE 2 YL)CARBONYL] (3 PYRIDIN 4 YL BENZYL)AMINO]CYCLOHEXYL]METHYLCARBAMIC ACID 9C; TERT BUTYL [TRANS 4 [[(3,6 DICHLOROBENZO[B]THIOPHENE 2 YL)CARBONYL] (3 PYRIDIN 4 YLBENZYL)AMINO]CYCLOHEXYL]METHYLCARBAMIC ACID 9H; TERT BUTYL METHYL [CIS 4 [(3 PYRIDIN 4 YLBENZYL)AMINO]CYCLOHEXYL]CARBAMIC ACID 8B; TERT BUTYL METHYL [TRANS 4 [(3 PYRIDIN 4 YLBENZYL)AMINO]CYCLOHEXYL]CARBAMIC ACID 8A; TERT BUTYL METHYL [TRANS 4 [(5 PHENYL 2 FUROYL) (3 PYRIDIN 4 YLBENZYL)AMINO]CYCLOHEXYL]CARBAMIC ACID 9D; TERT BUTYL METHYL [TRANS 4 [(PYRIDIN 4 YLMETHYL)AMINO]CYCLOHEXYL]CARBAMIC ACID 8D; TERT BUTYL METHYL [TRANS 4 [(QUINOLIN 4 YLMETHYL)AMINO]CYCLOHEXYL]CARBAMIC ACID 8C; TRANSCRIPTION FACTOR GLI1; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN;

ACYLATION; AMINATION; ANTIANGIOGENIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYTOTOXICITY; DEPROTECTION REACTION; DRUG SYNTHESIS; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; REPORTER GENE; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; ULTRASOUND;

ANIMALS; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; HEDGEHOG PROTEINS; HUMANS; MOLECULAR STRUCTURE; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

ERINACEIDAE;

EID: 84867575656 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2012.08.026 Document Type: Article

Times cited : (20)

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