Smoothened oligomerization/higher order clustering in lipid rafts is essential for high hedgehog activity transduction

Journal of Biological Chemistry

Volumn 288, Issue 18, 2013, Pages 12605-12614

  Shi, Dawei ^a   Lv, Xiangdong ^a   Zhang, Zhao ^a   Yang, Xiaofeng ^a   Zhou, Zhaocai ^a   Zhang, Lei ^a   Zhao, Yun ^a  

^a Chinese Academy of Sciences   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PLASMA MEMBRANES; CONGENITAL DISORDERS; EMBRYONIC DEVELOPMENT; EXTRACELLULAR DOMAINS; NANO-SCALE CLUSTERS; PROTEIN-LIPID INTERACTIONS; SIGNALING CASCADES; TRANS-MEMBRANE DOMAINS;

ACTIVATION ANALYSIS; BACTERIOPHAGES; CELL MEMBRANES; CELL SIGNALING; OLIGOMERS; PROTEINS;

SIGNAL TRANSDUCTION;

OLIGOMER; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE TRANSPORT; CYTOPLASM; EXTRACELLULAR SPACE; LIPID RAFT; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

CANCER; DROSOPHILA; HEDGEHOG; LIPID RAFT; OLIGOMER; SIGNAL TRANSDUCTION; SMO;

ANIMALS; CELL LINE; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; HEDGEHOG PROTEINS; HUMANS; MEMBRANE MICRODOMAINS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

ERINACEIDAE; METAZOA;

EID: 84877101725     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.399477     Document Type: Article

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