메뉴 건너뛰기




Volumn 14, Issue 4, 2014, Pages 750-763

Harnessing regulatory t cells for clinical use in transplantation: The end of the beginning

Author keywords

Allograft tolerance; cellular therapy; hematopoietic stem cell transplantation; regulatory T cells; solid organ transplantation

Indexed keywords

ALLOANTIGEN;

EID: 84897116999     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.12647     Document Type: Review
Times cited : (76)

References (138)
  • 1
    • 0027479685 scopus 로고
    • Infectious" transplantation tolerance
    • et al. ".
    • Qin S, Cobbold SP, Pope H, et al. " Infectious" transplantation tolerance. Science 1993; 259: 974-977.
    • (1993) Science , vol.259 , pp. 974-977
    • Qin, S.1    Cobbold, S.P.2    Pope, H.3
  • 2
    • 84864463754 scopus 로고    scopus 로고
    • Low-dose rapamycin treatment increases the ability of human regulatory T cells to inhibit transplant arteriosclerosis in vivo
    • Hester J, Schiopu A, Nadig SN, Wood KJ., Low-dose rapamycin treatment increases the ability of human regulatory T cells to inhibit transplant arteriosclerosis in vivo. Am J Transplant 2012; 12: 2008-2016.
    • (2012) Am J Transplant , vol.12 , pp. 2008-2016
    • Hester, J.1    Schiopu, A.2    Nadig, S.N.3    Wood, K.J.4
  • 3
    • 77954539326 scopus 로고    scopus 로고
    • In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells
    • et al.
    • Nadig SN, Wieckiewicz J, Wu DC, et al. In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells. Nat Med 2010; 16: 809-813.
    • (2010) Nat Med , vol.16 , pp. 809-813
    • Nadig, S.N.1    Wieckiewicz, J.2    Wu, D.C.3
  • 5
    • 0005984244 scopus 로고
    • Actively acquired tolerance of foreign cells
    • Billingham RE, Brent L, Medawar PB., Actively acquired tolerance of foreign cells. Nature 1953; 172: 603-606.
    • (1953) Nature , vol.172 , pp. 603-606
    • Billingham, R.E.1    Brent, L.2    Medawar, P.B.3
  • 6
    • 0015172562 scopus 로고
    • Infectious immunological tolerance
    • Gershon RK, Kondo K., Infectious immunological tolerance. Immunology 1971; 21: 903-914.
    • (1971) Immunology , vol.21 , pp. 903-914
    • Gershon, R.K.1    Kondo, K.2
  • 7
    • 0016812372 scopus 로고
    • Suppressor T-cells in mice made unresponsive to skin allografts
    • Kilshaw PJ, Brent L, Pinto M., Suppressor T-cells in mice made unresponsive to skin allografts. Nature 1975; 255: 489-491.
    • (1975) Nature , vol.255 , pp. 489-491
    • Kilshaw, P.J.1    Brent, L.2    Pinto, M.3
  • 8
    • 0022394410 scopus 로고
    • Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. Mediation of specific suppression by T helper/inducer cells
    • Hall BM, Jelbart ME, Gurley KE, Dorsch SE., Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. Mediation of specific suppression by T helper/inducer cells. J Exp Med 1985; 162: 1683-1694.
    • (1985) J Exp Med , vol.162 , pp. 1683-1694
    • Hall, B.M.1    Jelbart, M.E.2    Gurley, K.E.3    Dorsch, S.E.4
  • 10
    • 0024493013 scopus 로고
    • Transfusion induces blood donor-specific suppressor cells
    • Quigley RL, Wood KJ, Morris PJ., Transfusion induces blood donor-specific suppressor cells. J Immunol 1989; 142: 463-470.
    • (1989) J Immunol , vol.142 , pp. 463-470
    • Quigley, R.L.1    Wood, K.J.2    Morris, P.J.3
  • 11
    • 0027400306 scopus 로고
    • The assessment of transplantation tolerance induced by anti-CD4 monoclonal antibody in the murine model
    • Pearson TC, Darby CR, Bushell AR, West LJ, Morris PJ, Wood KJ., The assessment of transplantation tolerance induced by anti-CD4 monoclonal antibody in the murine model. Transplantation 1993; 55: 361-367.
    • (1993) Transplantation , vol.55 , pp. 361-367
    • Pearson, T.C.1    Darby, C.R.2    Bushell, A.R.3    West, L.J.4    Morris, P.J.5    Wood, K.J.6
  • 12
    • 0024573918 scopus 로고
    • Tolerance induction to murine class II MHC molecules by anti-CD4 antibody
    • Wheelahan J, McKenzie IF., Tolerance induction to murine class II MHC molecules by anti-CD4 antibody. Transplant Proc 1989; 21 (1 Pt 1): 246-247.
    • (1989) Transplant Proc , vol.21 , Issue.1 PART 1 , pp. 246-247
    • Wheelahan, J.1    McKenzie, I.F.2
  • 13
    • 0023707239 scopus 로고
    • Strategies of monoclonal antibody therapy that induce permanent tolerance of organ transplants
    • Herbert J, Roser B., Strategies of monoclonal antibody therapy that induce permanent tolerance of organ transplants. Transplantation 1988; 46: 128S-134S.
    • (1988) Transplantation , vol.46
    • Herbert, J.1    Roser, B.2
  • 14
    • 0029162602 scopus 로고
    • + T cell regulation during the induction phase of the response
    • + T cell regulation during the induction phase of the response. Eur J Immunol 1995; 25: 2643-2649.
    • (1995) Eur J Immunol , vol.25 , pp. 2643-2649
    • Bushell, A.1    Morris, P.J.2    Wood, K.J.3
  • 15
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M., Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995; 155: 1151-1164.
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 17
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor FoxP3
    • Hori S, Nomura T, Sakaguchi S., Control of regulatory T cell development by the transcription factor FoxP3. Science 2003; 299: 1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 19
    • 0348223787 scopus 로고    scopus 로고
    • + regulatory T cells by TGF-beta induction of transcription factor FoxP3
    • et al.
    • + regulatory T cells by TGF-beta induction of transcription factor FoxP3. J Exp Med 2003; 198: 1875-1886.
    • (2003) J Exp Med , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3
  • 20
    • 0037025943 scopus 로고    scopus 로고
    • Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation
    • Hoffmann P, Ermann J, Edinger M, Fathman CG, Strober S., Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J Exp Med 2002; 196: 389-399.
    • (2002) J Exp Med , vol.196 , pp. 389-399
    • Hoffmann, P.1    Ermann, J.2    Edinger, M.3    Fathman, C.G.4    Strober, S.5
  • 21
    • 0037093217 scopus 로고    scopus 로고
    • The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality
    • Taylor PA, Lees CJ, Blazar BR., The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. Blood 2002; 99: 3493-3499.
    • (2002) Blood , vol.99 , pp. 3493-3499
    • Taylor, P.A.1    Lees, C.J.2    Blazar, B.R.3
  • 22
    • 0141461418 scopus 로고    scopus 로고
    • + regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation
    • et al.
    • + regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med 2003; 9: 1144-1150.
    • (2003) Nat Med , vol.9 , pp. 1144-1150
    • Edinger, M.1    Hoffmann, P.2    Ermann, J.3
  • 23
    • 0036467522 scopus 로고    scopus 로고
    • + regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses
    • + regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses. J Immunol 2002; 168: 1080-1086.
    • (2002) J Immunol , vol.168 , pp. 1080-1086
    • Kingsley, C.I.1    Karim, M.2    Bushell, A.R.3    Wood, K.J.4
  • 24
    • 0035806244 scopus 로고    scopus 로고
    • Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood
    • Dieckmann D, Plottner H, Berchtold S, Berger T, Schuler G., Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood. J Exp Med 2001; 193: 1303-1310.
    • (2001) J Exp Med , vol.193 , pp. 1303-1310
    • Dieckmann, D.1    Plottner, H.2    Berchtold, S.3    Berger, T.4    Schuler, G.5
  • 25
    • 0035806290 scopus 로고    scopus 로고
    • Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood
    • Jonuleit H, Schmitt E, Stassen M, Tuettenberg A, Knop J, Enk AH., Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J Exp Med 2001; 193: 1285-1294.
    • (2001) J Exp Med , vol.193 , pp. 1285-1294
    • Jonuleit, H.1    Schmitt, E.2    Stassen, M.3    Tuettenberg, A.4    Knop, J.5    Enk, A.H.6
  • 26
    • 79953809817 scopus 로고    scopus 로고
    • Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
    • et al.
    • Di Ianni M, Falzetti F, Carotti A, et al. Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood 2011; 117: 3921-3928.
    • (2011) Blood , vol.117 , pp. 3921-3928
    • Di Ianni, M.1    Falzetti, F.2    Carotti, A.3
  • 28
    • 78751696183 scopus 로고    scopus 로고
    • Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: Safety profile and detection kinetics
    • et al.
    • Brunstein CG, Miller JS, Cao Q, et al. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: Safety profile and detection kinetics. Blood 2011; 117: 1061-1070.
    • (2011) Blood , vol.117 , pp. 1061-1070
    • Brunstein, C.G.1    Miller, J.S.2    Cao, Q.3
  • 30
    • 84880920749 scopus 로고    scopus 로고
    • The ONE study compares cell therapy products in organ transplantation: Introduction to a review series on suppressive monocyte-derived cells
    • Geissler EK., The ONE study compares cell therapy products in organ transplantation: Introduction to a review series on suppressive monocyte-derived cells. Transplant Res 2012; 1: 11-13.
    • (2012) Transplant Res , vol.1 , pp. 11-13
    • Geissler, E.K.1
  • 31
    • 84861568296 scopus 로고    scopus 로고
    • Regulatory immune cells in transplantation
    • Wood KJ, Bushell A, Hester J., Regulatory immune cells in transplantation. Nat Rev Immunol 2012; 12: 417-430.
    • (2012) Nat Rev Immunol , vol.12 , pp. 417-430
    • Wood, K.J.1    Bushell, A.2    Hester, J.3
  • 33
    • 0031821875 scopus 로고    scopus 로고
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 1998; 188: 287-296.
    • (1998) J Exp Med , vol.188 , pp. 287-296
    • Thornton, A.M.1    Shevach, E.M.2
  • 34
    • 0033523607 scopus 로고    scopus 로고
    • An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
    • Asseman C, Mauze S, Leach MW, Coffman RL, Powrie F., An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med 1999; 190: 995-1004.
    • (1999) J Exp Med , vol.190 , pp. 995-1004
    • Asseman, C.1    Mauze, S.2    Leach, M.W.3    Coffman, R.L.4    Powrie, F.5
  • 35
    • 41549159660 scopus 로고    scopus 로고
    • Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces
    • et al.
    • Rubtsov YP, Rasmussen JP, Chi EY, et al. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 2008; 28: 546-558.
    • (2008) Immunity , vol.28 , pp. 546-558
    • Rubtsov, Y.P.1    Rasmussen, J.P.2    Chi, E.Y.3
  • 36
    • 0034679567 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation
    • Read S, Malmstrom V, Powrie F., Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J Exp Med 2000; 192: 295-302.
    • (2000) J Exp Med , vol.192 , pp. 295-302
    • Read, S.1    Malmstrom, V.2    Powrie, F.3
  • 37
    • 0034679560 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
    • et al.
    • Takahashi T, Tagami T, Yamazaki S, et al. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med 2000; 192: 303-310.
    • (2000) J Exp Med , vol.192 , pp. 303-310
    • Takahashi, T.1    Tagami, T.2    Yamazaki, S.3
  • 38
    • 63049090504 scopus 로고    scopus 로고
    • + regulatory T cells require CTLA-4 for the maintenance of systemic tolerance
    • et al.
    • + regulatory T cells require CTLA-4 for the maintenance of systemic tolerance. J Exp Med 2009; 206: 421-434.
    • (2009) J Exp Med , vol.206 , pp. 421-434
    • Friedline, R.H.1    Brown, D.S.2    Nguyen, H.3
  • 39
    • 0035869432 scopus 로고    scopus 로고
    • IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo
    • et al.
    • Hara M, Kingsley CI, Niimi M, et al. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J Immunol 2001; 166: 3789-3796.
    • (2001) J Immunol , vol.166 , pp. 3789-3796
    • Hara, M.1    Kingsley, C.I.2    Niimi, M.3
  • 40
    • 34547098277 scopus 로고    scopus 로고
    • + Treg cells: Hydrolysis of extracellular ATP and immune suppression
    • et al.
    • + Treg cells: Hydrolysis of extracellular ATP and immune suppression. Blood 2007; 110: 1225-1232.
    • (2007) Blood , vol.110 , pp. 1225-1232
    • Borsellino, G.1    Kleinewietfeld, M.2    Di Mitri, D.3
  • 41
    • 73349127157 scopus 로고    scopus 로고
    • + regulatory T cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis
    • et al.
    • + regulatory T cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis. J Immunol 2009; 183: 7602-7610.
    • (2009) J Immunol , vol.183 , pp. 7602-7610
    • Fletcher, J.M.1    Lonergan, R.2    Costelloe, L.3
  • 42
  • 43
    • 34250351459 scopus 로고    scopus 로고
    • Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
    • et al.
    • Deaglio S, Dwyer KM, Gao W, et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med 2007; 204: 1257-1265.
    • (2007) J Exp Med , vol.204 , pp. 1257-1265
    • Deaglio, S.1    Dwyer, K.M.2    Gao, W.3
  • 44
    • 0036195161 scopus 로고    scopus 로고
    • CD4(+)CD25(+) immunoregulatory T cells: Gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor
    • et al.
    • McHugh RS, Whitters MJ, Piccirillo CA, et al. CD4(+)CD25(+) immunoregulatory T cells: Gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 2002; 16: 311-323.
    • (2002) Immunity , vol.16 , pp. 311-323
    • McHugh, R.S.1    Whitters, M.J.2    Piccirillo, C.A.3
  • 45
    • 0036170938 scopus 로고    scopus 로고
    • Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
    • Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S., Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 2002; 3: 135-142.
    • (2002) Nat Immunol , vol.3 , pp. 135-142
    • Shimizu, J.1    Yamazaki, S.2    Takahashi, T.3    Ishida, Y.4    Sakaguchi, S.5
  • 46
    • 33947667952 scopus 로고    scopus 로고
    • + regulatory T cells without enhancing effector T-cell function
    • + regulatory T cells without enhancing effector T-cell function. Am J Transplant 2007; 7: 759-768.
    • (2007) Am J Transplant , vol.7 , pp. 759-768
    • Bushell, A.1    Wood, K.2
  • 47
    • 73849110532 scopus 로고    scopus 로고
    • GITR blockade facilitates Treg mediated allograft survival
    • et al.
    • Sonawane SB, Kim JI, Lee MK, et al. GITR blockade facilitates Treg mediated allograft survival. Transplantation 2009; 88: 1169-1177.
    • (2009) Transplantation , vol.88 , pp. 1169-1177
    • Sonawane, S.B.1    Kim, J.I.2    Lee, M.K.3
  • 48
    • 67749091321 scopus 로고    scopus 로고
    • Infectious tolerance via the consumption of essential amino acids and mTOR signaling
    • et al.
    • Cobbold SP, Adams E, Farquhar CA, et al. Infectious tolerance via the consumption of essential amino acids and mTOR signaling. Proc Natl Acad Sci USA 2009; 106: 12055-12060.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 12055-12060
    • Cobbold, S.P.1    Adams, E.2    Farquhar, C.A.3
  • 49
    • 84855370788 scopus 로고    scopus 로고
    • IDO and regulatory T cell support are critical for cytotoxic T lymphocyte-associated Ag-4 Ig-mediated long-term solid organ allograft survival
    • et al.
    • Sucher R, Fischler K, Oberhuber R, et al. IDO and regulatory T cell support are critical for cytotoxic T lymphocyte-associated Ag-4 Ig-mediated long-term solid organ allograft survival. J Immunol 2012; 188: 37-46.
    • (2012) J Immunol , vol.188 , pp. 37-46
    • Sucher, R.1    Fischler, K.2    Oberhuber, R.3
  • 50
    • 84866183753 scopus 로고    scopus 로고
    • + regulatory T cells is essential for preventing experimental graft-versus-host disease
    • et al.
    • + regulatory T cells is essential for preventing experimental graft-versus-host disease. J Immunol 2012; 189: 2890-2896.
    • (2012) J Immunol , vol.189 , pp. 2890-2896
    • Koenecke, C.1    Lee, C.W.2    Thamm, K.3
  • 51
    • 22344434572 scopus 로고    scopus 로고
    • IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
    • Sawitzki B, Kingsley CI, Oliveira V, Karim M, Herber M, Wood KJ., IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo. J Exp Med 2005; 201: 1925-1935.
    • (2005) J Exp Med , vol.201 , pp. 1925-1935
    • Sawitzki, B.1    Kingsley, C.I.2    Oliveira, V.3    Karim, M.4    Herber, M.5    Wood, K.J.6
  • 52
    • 72549089070 scopus 로고    scopus 로고
    • IFN-gamma triggered STAT1-PKB/AKT signalling pathway influences the function of alloantigen reactive regulatory T cells
    • Wei B, Baker S, Wieckiewicz J, Wood KJ., IFN-gamma triggered STAT1-PKB/AKT signalling pathway influences the function of alloantigen reactive regulatory T cells. Am J Transplant 2010; 10: 69-80.
    • (2010) Am J Transplant , vol.10 , pp. 69-80
    • Wei, B.1    Baker, S.2    Wieckiewicz, J.3    Wood, K.J.4
  • 53
    • 0027333549 scopus 로고
    • Interferon-gamma prevents graft-versus-host disease after allogeneic bone marrow transplantation in mice
    • Brok HP, Heidt PJ, van der Meide PH, Zurcher C, Vossen JM., Interferon-gamma prevents graft-versus-host disease after allogeneic bone marrow transplantation in mice. J Immunol 1993; 151: 6451-6459.
    • (1993) J Immunol , vol.151 , pp. 6451-6459
    • Brok, H.P.1    Heidt, P.J.2    Van Der Meide, P.H.3    Zurcher, C.4    Vossen, J.M.5
  • 55
    • 34548729257 scopus 로고    scopus 로고
    • + T cells during mycobacterial infection to promote apoptosis by inducing components of the intracellular apoptosis machinery and by inducing extracellular proapoptotic signals
    • + T cells during mycobacterial infection to promote apoptosis by inducing components of the intracellular apoptosis machinery and by inducing extracellular proapoptotic signals. J Immunol 2007; 179: 939-949.
    • (2007) J Immunol , vol.179 , pp. 939-949
    • Li, X.1    McKinstry, K.K.2    Swain, S.L.3    Dalton, D.K.4
  • 56
    • 0037037582 scopus 로고    scopus 로고
    • Interferon gamma is required for activation-induced death of T lymphocytes
    • Refaeli Y, Van Parijs L, Alexander SI, Abbas AK., Interferon gamma is required for activation-induced death of T lymphocytes. J Exp Med 2002; 196: 999-1005.
    • (2002) J Exp Med , vol.196 , pp. 999-1005
    • Refaeli, Y.1    Van Parijs, L.2    Alexander, S.I.3    Abbas, A.K.4
  • 57
    • 33748320914 scopus 로고    scopus 로고
    • Mast cells are essential intermediaries in regulatory T-cell tolerance
    • et al.
    • Lu LF, Lind EF, Gondek DC, et al. Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature 2006; 442: 997-1002.
    • (2006) Nature , vol.442 , pp. 997-1002
    • Lu, L.F.1    Lind, E.F.2    Gondek, D.C.3
  • 58
    • 84860338555 scopus 로고    scopus 로고
    • Regulation generation: The suppressive functions of human regulatory T cells
    • Goodman WA, Cooper KD, McCormick TS., Regulation generation: The suppressive functions of human regulatory T cells. Crit Rev Immunol 2012; 32: 65-79.
    • (2012) Crit Rev Immunol , vol.32 , pp. 65-79
    • Goodman, W.A.1    Cooper, K.D.2    McCormick, T.S.3
  • 59
    • 79959572627 scopus 로고    scopus 로고
    • Cutting edge: Human regulatory T cells require IL-35 to mediate suppression and infectious tolerance
    • Chaturvedi V, Collison LW, Guy CS, Workman CJ, Vignali DA., Cutting edge: Human regulatory T cells require IL-35 to mediate suppression and infectious tolerance. J Immunol 2011; 186: 6661-6666.
    • (2011) J Immunol , vol.186 , pp. 6661-6666
    • Chaturvedi, V.1    Collison, L.W.2    Guy, C.S.3    Workman, C.J.4    Vignali, D.A.5
  • 60
    • 53349153303 scopus 로고    scopus 로고
    • Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells
    • et al.
    • Clark RA, Huang SJ, Murphy GF, et al. Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells. J Exp Med 2008; 205: 2221-2234.
    • (2008) J Exp Med , vol.205 , pp. 2221-2234
    • Clark, R.A.1    Huang, S.J.2    Murphy, G.F.3
  • 61
    • 5644302161 scopus 로고    scopus 로고
    • Human T regulatory cells can use the perforin pathway to cause autologous target cell death
    • Grossman WJ, Verbsky JW, Barchet W, Colonna M, Atkinson JP, Ley TJ., Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity 2004; 21: 589-601.
    • (2004) Immunity , vol.21 , pp. 589-601
    • Grossman, W.J.1    Verbsky, J.W.2    Barchet, W.3    Colonna, M.4    Atkinson, J.P.5    Ley, T.J.6
  • 62
    • 35748965021 scopus 로고    scopus 로고
    • + regulatory T cells: Independence of IL-2 consumption, TGF-beta, and various inhibitors of TCR signaling
    • + regulatory T cells: Independence of IL-2 consumption, TGF-beta, and various inhibitors of TCR signaling. J Immunol 2007; 179: 3578-3587.
    • (2007) J Immunol , vol.179 , pp. 3578-3587
    • Oberle, N.1    Eberhardt, N.2    Falk, C.S.3    Krammer, P.H.4    Suri-Payer, E.5
  • 64
    • 69149083248 scopus 로고    scopus 로고
    • Contribution of naive and memory T-cell populations to the human alloimmune response
    • et al.
    • Macedo C, Orkis EA, Popescu I, et al. Contribution of naive and memory T-cell populations to the human alloimmune response. Am J Transplant 2009; 9: 2057-2066.
    • (2009) Am J Transplant , vol.9 , pp. 2057-2066
    • Macedo, C.1    Orkis, E.A.2    Popescu, I.3
  • 65
    • 38049146019 scopus 로고    scopus 로고
    • Allograft rejection mediated by memory T cells is resistant to regulation
    • et al.
    • Yang J, Brook MO, Carvalho-Gaspar M, et al. Allograft rejection mediated by memory T cells is resistant to regulation. Proc Natl Acad Sci USA 2007; 104: 19954-19959.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 19954-19959
    • Yang, J.1    Brook, M.O.2    Carvalho-Gaspar, M.3
  • 66
    • 79961029064 scopus 로고    scopus 로고
    • Relative resistance of human CD4(+) memory T cells to suppression by CD4(+) CD25(+) regulatory T cells
    • et al.
    • Afzali B, Mitchell PJ, Scotta C, et al. Relative resistance of human CD4(+) memory T cells to suppression by CD4(+) CD25(+) regulatory T cells. Am J Transplant 2011; 11: 1734-1742.
    • (2011) Am J Transplant , vol.11 , pp. 1734-1742
    • Afzali, B.1    Mitchell, P.J.2    Scotta, C.3
  • 67
    • 78349233811 scopus 로고    scopus 로고
    • Non-human primate regulatory T cells: Current biology and implications for transplantation
    • Dons EM, Raimondi G, Cooper DK, Thomson AW., Non-human primate regulatory T cells: Current biology and implications for transplantation. Transplantation 2010; 90: 811-816.
    • (2010) Transplantation , vol.90 , pp. 811-816
    • Dons, E.M.1    Raimondi, G.2    Cooper, D.K.3    Thomson, A.W.4
  • 68
    • 29244482759 scopus 로고    scopus 로고
    • Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice
    • et al.
    • Tang Q, Adams JY, Tooley AJ, et al. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol 2006; 7: 83-92.
    • (2006) Nat Immunol , vol.7 , pp. 83-92
    • Tang, Q.1    Adams, J.Y.2    Tooley, A.J.3
  • 70
    • 45549097247 scopus 로고    scopus 로고
    • Location and time-dependent control of rejection by regulatory T cells culminates in a failure to generate memory T cells
    • Carvalho-Gaspar M, Jones ND, Luo S, Martin L, Brook MO, Wood KJ., Location and time-dependent control of rejection by regulatory T cells culminates in a failure to generate memory T cells. J Immunol 2008; 180: 6640-6648.
    • (2008) J Immunol , vol.180 , pp. 6640-6648
    • Carvalho-Gaspar, M.1    Jones, N.D.2    Luo, S.3    Martin, L.4    Brook, M.O.5    Wood, K.J.6
  • 72
    • 2442641572 scopus 로고    scopus 로고
    • + regulatory T cells: Evidence for in vivo inhibition of effector cell proliferation
    • et al.
    • + regulatory T cells: Evidence for in vivo inhibition of effector cell proliferation. J Immunol 2004; 172: 6539-6544.
    • (2004) J Immunol , vol.172 , pp. 6539-6544
    • Lee, M.K.1    Moore, D.J.2    Jarrett, B.P.3
  • 74
    • 9444280125 scopus 로고    scopus 로고
    • + T-regulatory cells are potent inhibitors of GVHD and BM graft rejection
    • et al.
    • + T-regulatory cells are potent inhibitors of GVHD and BM graft rejection. Blood 2004; 104: 3804-3812.
    • (2004) Blood , vol.104 , pp. 3804-3812
    • Taylor, P.A.1    Panoskaltsis-Mortari, A.2    Swedin, J.M.3
  • 75
    • 0025362298 scopus 로고
    • Transplantation in miniature swine: Analysis of graft-infiltrating lymphocytes provides evidence for local suppression
    • et al.
    • Rosengard BR, Kortz EO, Guzzetta PC, et al. Transplantation in miniature swine: Analysis of graft-infiltrating lymphocytes provides evidence for local suppression. Hum Immunol 1990; 28: 153-158.
    • (1990) Hum Immunol , vol.28 , pp. 153-158
    • Rosengard, B.R.1    Kortz, E.O.2    Guzzetta, P.C.3
  • 76
    • 0037124359 scopus 로고    scopus 로고
    • Identification of regulatory T cells in tolerated allografts
    • Graca L, Cobbold SP, Waldmann H., Identification of regulatory T cells in tolerated allografts. J Exp Med 2002; 195: 1641-1646.
    • (2002) J Exp Med , vol.195 , pp. 1641-1646
    • Graca, L.1    Cobbold, S.P.2    Waldmann, H.3
  • 77
    • 61949334905 scopus 로고    scopus 로고
    • Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response
    • et al.
    • Zhang N, Schroppel B, Lal G, et al. Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response. Immunity 2009; 30: 458-469.
    • (2009) Immunity , vol.30 , pp. 458-469
    • Zhang, N.1    Schroppel, B.2    Lal, G.3
  • 78
    • 84863840517 scopus 로고    scopus 로고
    • Regulatory T-cell therapy for transplantation: How many cells do we need
    • Tang Q, Lee K., Regulatory T-cell therapy for transplantation: How many cells do we need ? Curr Opin Organ Transplant 2012; 17: 349-354.
    • (2012) Curr Opin Organ Transplant , vol.17 , pp. 349-354
    • Tang, Q.1    Lee, K.2
  • 79
    • 0036604283 scopus 로고    scopus 로고
    • Both CD4(+)CD25(+) and CD4(+)CD25(-) regulatory cells mediate dominant transplantation tolerance
    • Graca L, Thompson S, Lin CY, Adams E, Cobbold SP, Waldmann H., Both CD4(+)CD25(+) and CD4(+)CD25(-) regulatory cells mediate dominant transplantation tolerance. J Immunol 2002; 168: 5558-5565.
    • (2002) J Immunol , vol.168 , pp. 5558-5565
    • Graca, L.1    Thompson, S.2    Lin, C.Y.3    Adams, E.4    Cobbold, S.P.5    Waldmann, H.6
  • 80
    • 79956258982 scopus 로고    scopus 로고
    • Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity
    • et al.
    • Hippen KL, Merkel SC, Schirm DK, et al. Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity. Sci Transl Med 2011; 3: 83ra41.
    • (2011) Sci Transl Med , vol.3
    • Hippen, K.L.1    Merkel, S.C.2    Schirm, D.K.3
  • 82
    • 3242801352 scopus 로고    scopus 로고
    • Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells
    • Hoffmann P, Eder R, Kunz-Schughart LA, Andreesen R, Edinger M., Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells. Blood 2004; 104: 895-903.
    • (2004) Blood , vol.104 , pp. 895-903
    • Hoffmann, P.1    Eder, R.2    Kunz-Schughart, L.A.3    Andreesen, R.4    Edinger, M.5
  • 83
    • 79958814636 scopus 로고    scopus 로고
    • Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease
    • et al.
    • Hippen KL, Merkel SC, Schirm DK, et al. Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease. Am J Transplant 2011; 11: 1148-1157.
    • (2011) Am J Transplant , vol.11 , pp. 1148-1157
    • Hippen, K.L.1    Merkel, S.C.2    Schirm, D.K.3
  • 84
    • 79956288367 scopus 로고    scopus 로고
    • Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells
    • Sagoo P, Ali N, Garg G, Nestle FO, Lechler RI, Lombardi G., Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells. Sci Transl Med 2011; 3: 83ra42.
    • (2011) Sci Transl Med , vol.3
    • Sagoo, P.1    Ali, N.2    Garg, G.3    Nestle, F.O.4    Lechler, R.I.5    Lombardi, G.6
  • 85
    • 81555214616 scopus 로고    scopus 로고
    • Ex vivo expansion of human Tregs specific for alloantigens presented directly or indirectly
    • Veerapathran A, Pidala J, Beato F, Yu XZ, Anasetti C., Ex vivo expansion of human Tregs specific for alloantigens presented directly or indirectly. Blood 2011; 118: 5671-5680.
    • (2011) Blood , vol.118 , pp. 5671-5680
    • Veerapathran, A.1    Pidala, J.2    Beato, F.3    Yu, X.Z.4    Anasetti, C.5
  • 86
    • 84886786872 scopus 로고    scopus 로고
    • Clinical grade manufacturing of human alloantigen-reactive regulatory T cells for use in transplantation
    • et al.
    • Putnam AL, Safinia N, Medvec A, et al. Clinical grade manufacturing of human alloantigen-reactive regulatory T cells for use in transplantation. Am J Transplant 2013; 13: 3010-3020.
    • (2013) Am J Transplant , vol.13 , pp. 3010-3020
    • Putnam, A.L.1    Safinia, N.2    Medvec, A.3
  • 87
    • 53149092106 scopus 로고    scopus 로고
    • CD28 costimulation is essential for human T regulatory expansion and function
    • et al.
    • Golovina TN, Mikheeva T, Suhoski MM, et al. CD28 costimulation is essential for human T regulatory expansion and function. J Immunol 2008; 181: 2855-2868.
    • (2008) J Immunol , vol.181 , pp. 2855-2868
    • Golovina, T.N.1    Mikheeva, T.2    Suhoski, M.M.3
  • 89
    • 79251589897 scopus 로고    scopus 로고
    • Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells
    • Golovina TN, Mikheeva T, Brusko TM, Blazar BR, Bluestone JA, Riley JL., Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells. PLoS ONE 2011; 6: e15868.
    • (2011) PLoS ONE , vol.6
    • Golovina, T.N.1    Mikheeva, T.2    Brusko, T.M.3    Blazar, B.R.4    Bluestone, J.A.5    Riley, J.L.6
  • 91
    • 0035806323 scopus 로고    scopus 로고
    • Human CD25(+)CD4(+) T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function
    • Levings MK, Sangregorio R, Roncarolo MG., Human CD25(+)CD4(+) T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med 2001; 193: 1295-1302.
    • (2001) J Exp Med , vol.193 , pp. 1295-1302
    • Levings, M.K.1    Sangregorio, R.2    Roncarolo, M.G.3
  • 92
    • 78649881395 scopus 로고    scopus 로고
    • L-selectin is dispensable for T regulatory cell function postallogeneic bone marrow transplantation
    • et al.
    • Carlson MJ, Fulton LM, Coghill JM, et al. L-selectin is dispensable for T regulatory cell function postallogeneic bone marrow transplantation. Am J Transplant 2010; 10: 2596-2603.
    • (2010) Am J Transplant , vol.10 , pp. 2596-2603
    • Carlson, M.J.1    Fulton, L.M.2    Coghill, J.M.3
  • 95
    • 0032558759 scopus 로고    scopus 로고
    • Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype
    • et al.
    • Aversa F, Tabilio A, Velardi A, et al. Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype. N Engl J Med 1998; 339: 1186-1193.
    • (1998) N Engl J Med , vol.339 , pp. 1186-1193
    • Aversa, F.1    Tabilio, A.2    Velardi, A.3
  • 96
    • 0028125191 scopus 로고
    • Successful engraftment of T-cell-depleted haploidentical "three-loci" incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum
    • et al.
    • Aversa F, Tabilio A, Terenzi A, et al. Successful engraftment of T-cell-depleted haploidentical "three-loci" incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum. Blood 1994; 84: 3948-3955.
    • (1994) Blood , vol.84 , pp. 3948-3955
    • Aversa, F.1    Tabilio, A.2    Terenzi, A.3
  • 97
    • 0025182977 scopus 로고
    • European experience of bone-marrow transplantation for severe combined immunodeficiency
    • et al.
    • Fischer A, Landais P, Friedrich W, et al. European experience of bone-marrow transplantation for severe combined immunodeficiency. Lancet 1990; 336: 850-854.
    • (1990) Lancet , vol.336 , pp. 850-854
    • Fischer, A.1    Landais, P.2    Friedrich, W.3
  • 98
    • 78650835204 scopus 로고    scopus 로고
    • Ex vivo-expanded human regulatory T cells prevent the rejection of skin allografts in a humanized mouse model
    • Issa F, Hester J, Goto R, Nadig SN, Goodacre TE, Wood K., Ex vivo-expanded human regulatory T cells prevent the rejection of skin allografts in a humanized mouse model. Transplantation 2010; 90: 1321-1327.
    • (2010) Transplantation , vol.90 , pp. 1321-1327
    • Issa, F.1    Hester, J.2    Goto, R.3    Nadig, S.N.4    Goodacre, T.E.5    Wood, K.6
  • 99
    • 84886092766 scopus 로고    scopus 로고
    • Ex vivo expanded human regulatory T cells can prolong survival of a human islet allograft in a humanized mouse model
    • et al.
    • Wu DC, Hester J, Nadig SN, et al. Ex vivo expanded human regulatory T cells can prolong survival of a human islet allograft in a humanized mouse model. Transplantation 2013; 96: 707-716.
    • (2013) Transplantation , vol.96 , pp. 707-716
    • Wu, D.C.1    Hester, J.2    Nadig, S.N.3
  • 100
    • 33846980131 scopus 로고    scopus 로고
    • Epigenetic control of the FoxP3 locus in regulatory T cells
    • et al.
    • Floess S, Freyer J, Siewert C, et al. Epigenetic control of the FoxP3 locus in regulatory T cells. PLoS Biol 2007; 5: e38.
    • (2007) PLoS Biol , vol.5
    • Floess, S.1    Freyer, J.2    Siewert, C.3
  • 101
    • 84887347546 scopus 로고    scopus 로고
    • Human regulatory T cells against minor histocompatibility antigens: Ex vivo expansion for prevention of graft-versus-host disease
    • et al.
    • Veerapathran A, Pidala J, Beato F, et al. Human regulatory T cells against minor histocompatibility antigens: Ex vivo expansion for prevention of graft-versus-host disease. Blood 2013; 122: 2251-2261.
    • (2013) Blood , vol.122 , pp. 2251-2261
    • Veerapathran, A.1    Pidala, J.2    Beato, F.3
  • 102
  • 103
    • 12844273651 scopus 로고    scopus 로고
    • Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy
    • et al.
    • Barker JN, Weisdorf DJ, DeFor TE, et al. Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood 2005; 105: 1343-1347.
    • (2005) Blood , vol.105 , pp. 1343-1347
    • Barker, J.N.1    Weisdorf, D.J.2    Defor, T.E.3
  • 104
    • 64049100784 scopus 로고    scopus 로고
    • Acute graft-versus-host disease after unrelated donor umbilical cord blood transplantation: Analysis of risk factors
    • et al.
    • MacMillan ML, Weisdorf DJ, Brunstein CG, et al. Acute graft-versus-host disease after unrelated donor umbilical cord blood transplantation: Analysis of risk factors. Blood 2009; 113: 2410-2415.
    • (2009) Blood , vol.113 , pp. 2410-2415
    • Macmillan, M.L.1    Weisdorf, D.J.2    Brunstein, C.G.3
  • 106
    • 56049087273 scopus 로고    scopus 로고
    • High purity and yield of natural Tregs from cord blood using a single step selection method
    • Figueroa-Tentori D, Querol S, Dodi IA, Madrigal A, Duggleby R., High purity and yield of natural Tregs from cord blood using a single step selection method. J Immunol Methods 2008; 339: 228-235.
    • (2008) J Immunol Methods , vol.339 , pp. 228-235
    • Figueroa-Tentori, D.1    Querol, S.2    Dodi, I.A.3    Madrigal, A.4    Duggleby, R.5
  • 107
  • 108
    • 33845491455 scopus 로고    scopus 로고
    • + CD25 high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion
    • et al.
    • + CD25 high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood 2006; 108: 4260-4267.
    • (2006) Blood , vol.108 , pp. 4260-4267
    • Hoffmann, P.1    Eder, R.2    Boeld, T.J.3
  • 109
    • 66949171924 scopus 로고    scopus 로고
    • + T cells expressing the FoxP3 transcription factor
    • et al.
    • + T cells expressing the FoxP3 transcription factor. Immunity 2009; 30: 899-911.
    • (2009) Immunity , vol.30 , pp. 899-911
    • Miyara, M.1    Yoshioka, Y.2    Kitoh, A.3
  • 111
    • 37349034394 scopus 로고    scopus 로고
    • Reduced exposure to calcineurin inhibitors in renal transplantation
    • et al.
    • Ekberg H, Tedesco-Silva H, Demirbas A, et al. Reduced exposure to calcineurin inhibitors in renal transplantation. N Engl J Med 2007; 357: 2562-2575.
    • (2007) N Engl J Med , vol.357 , pp. 2562-2575
    • Ekberg, H.1    Tedesco-Silva, H.2    Demirbas, A.3
  • 113
    • 65449125930 scopus 로고    scopus 로고
    • Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions
    • Duarte JH, Zelenay S, Bergman ML, Martins AC, Demengeot J., Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions. Eur J Immunol 2009; 39: 948-955.
    • (2009) Eur J Immunol , vol.39 , pp. 948-955
    • Duarte, J.H.1    Zelenay, S.2    Bergman, M.L.3    Martins, A.C.4    Demengeot, J.5
  • 114
    • 69049107358 scopus 로고    scopus 로고
    • Instability of the transcription factor FoxP3 leads to the generation of pathogenic memory T cells in vivo
    • et al.
    • Zhou XY, Bailey-Bucktrout SL, Jeker LT, et al. Instability of the transcription factor FoxP3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol 2009; 10: U1000-U1104.
    • (2009) Nat Immunol , vol.10
    • Zhou, X.Y.1    Bailey-Bucktrout, S.L.2    Jeker, L.T.3
  • 115
    • 84857416489 scopus 로고    scopus 로고
    • Plasticity of FoxP3(+) T cells reflects promiscuous FoxP3 expression in conventional T cells but not reprogramming of regulatory T cells
    • et al.
    • Miyao T, Floess S, Setoguchi R, et al. Plasticity of FoxP3(+) T cells reflects promiscuous FoxP3 expression in conventional T cells but not reprogramming of regulatory T cells. Immunity 2012; 36: 262-275.
    • (2012) Immunity , vol.36 , pp. 262-275
    • Miyao, T.1    Floess, S.2    Setoguchi, R.3
  • 117
    • 84887416283 scopus 로고    scopus 로고
    • Induced regulatory T cells promote tolerance when stabilized by rapamycin and IL-2 in vivo
    • et al.
    • Zhang P, Tey SK, Koyama M, et al. Induced regulatory T cells promote tolerance when stabilized by rapamycin and IL-2 in vivo. J Immunol 2013; 191: 5291-5303.
    • (2013) J Immunol , vol.191 , pp. 5291-5303
    • Zhang, P.1    Tey, S.K.2    Koyama, M.3
  • 118
    • 79959268660 scopus 로고    scopus 로고
    • Instability of FoxP3 expression limits the ability of induced regulatory T cells to mitigate graft versus host disease
    • Beres A, Komorowski R, Mihara M, Drobyski WR., Instability of FoxP3 expression limits the ability of induced regulatory T cells to mitigate graft versus host disease. Clin Cancer Res 2011; 17: 3969-3983.
    • (2011) Clin Cancer Res , vol.17 , pp. 3969-3983
    • Beres, A.1    Komorowski, R.2    Mihara, M.3    Drobyski, W.R.4
  • 119
    • 80054731732 scopus 로고    scopus 로고
    • In vivo SPECT reporter gene imaging of regulatory T cells
    • et al.
    • Sharif-Paghaleh E, Sunassee K, Tavare R, et al. In vivo SPECT reporter gene imaging of regulatory T cells. PLoS ONE 2011; 6: e25857.
    • (2011) PLoS ONE , vol.6
    • Sharif-Paghaleh, E.1    Sunassee, K.2    Tavare, R.3
  • 120
    • 84888345629 scopus 로고    scopus 로고
    • + T cells by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)
    • et al.
    • + T cells by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). Anal Chem 2013; 85: 10627-10634.
    • (2013) Anal Chem , vol.85 , pp. 10627-10634
    • Managh, A.J.1    Edwards, S.L.2    Bushell, A.3
  • 121
    • 0035886032 scopus 로고    scopus 로고
    • Rapamycin: Clinical results and future opportunities
    • Kahan BD, Camardo JS., Rapamycin: Clinical results and future opportunities. Transplantation 2001; 72: 1181-1193.
    • (2001) Transplantation , vol.72 , pp. 1181-1193
    • Kahan, B.D.1    Camardo, J.S.2
  • 122
    • 33745633856 scopus 로고    scopus 로고
    • + regulatory T-cell function by calcineurin-dependent interleukin-2 production
    • et al.
    • + regulatory T-cell function by calcineurin-dependent interleukin-2 production. Blood 2006; 108: 390-399.
    • (2006) Blood , vol.108 , pp. 390-399
    • Zeiser, R.1    Nguyen, V.H.2    Beilhack, A.3
  • 124
    • 84860187314 scopus 로고    scopus 로고
    • + regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo
    • et al.
    • + regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo. PLoS ONE 2012; 7: e35572.
    • (2012) PLoS ONE , vol.7
    • Yurchenko, E.1    Shio, M.T.2    Huang, T.C.3
  • 125
    • 75149182766 scopus 로고    scopus 로고
    • + cells during treatment of human lung transplant recipients with rapamycin
    • et al.
    • + cells during treatment of human lung transplant recipients with rapamycin. Transpl Int 2010; 23: 266-276.
    • (2010) Transpl Int , vol.23 , pp. 266-276
    • Lange, C.M.1    Tran, T.Y.2    Farnik, H.3
  • 126
    • 76249084928 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients
    • et al.
    • Raimondi G, Sumpter TL, Matta BM, et al. Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients. J Immunol 2010; 184: 624-636.
    • (2010) J Immunol , vol.184 , pp. 624-636
    • Raimondi, G.1    Sumpter, T.L.2    Matta, B.M.3
  • 127
    • 79954787760 scopus 로고    scopus 로고
    • Th17 cells in alemtuzumab-treated patients: The effect of long-term maintenance immunosuppressive therapy
    • Hester J, Mills N, Shankar S, Carvalho-Gaspar M, Friend P, Wood KJ., Th17 cells in alemtuzumab-treated patients: The effect of long-term maintenance immunosuppressive therapy. Transplantation 2011; 91: 744-750.
    • (2011) Transplantation , vol.91 , pp. 744-750
    • Hester, J.1    Mills, N.2    Shankar, S.3    Carvalho-Gaspar, M.4    Friend, P.5    Wood, K.J.6
  • 128
    • 33947249410 scopus 로고    scopus 로고
    • Regulatory T cells and T cell depletion: Role of immunosuppressive drugs
    • et al.
    • Noris M, Casiraghi F, Todeschini M, et al. Regulatory T cells and T cell depletion: Role of immunosuppressive drugs. J Am Soc Nephrol 2007; 18: 1007-1018.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1007-1018
    • Noris, M.1    Casiraghi, F.2    Todeschini, M.3
  • 130
    • 68949200877 scopus 로고    scopus 로고
    • Differential kinetics of effector and regulatory T cells in patients on calcineurin inhibitor-based drug regimens
    • Presser D, Sester U, Mohrbach J, Janssen M, Kohler H, Sester M., Differential kinetics of effector and regulatory T cells in patients on calcineurin inhibitor-based drug regimens. Kidney Int 2009; 76: 557-566.
    • (2009) Kidney Int , vol.76 , pp. 557-566
    • Presser, D.1    Sester, U.2    Mohrbach, J.3    Janssen, M.4    Kohler, H.5    Sester, M.6
  • 131
    • 84865598850 scopus 로고    scopus 로고
    • Permanent CNI treatment for prevention of renal allograft rejection in sensitized hosts can be replaced by regulatory T cells
    • et al.
    • Siepert A, Ahrlich S, Vogt K, et al. Permanent CNI treatment for prevention of renal allograft rejection in sensitized hosts can be replaced by regulatory T cells. Am J Transplant 2012; 12: 2384-2394.
    • (2012) Am J Transplant , vol.12 , pp. 2384-2394
    • Siepert, A.1    Ahrlich, S.2    Vogt, K.3
  • 132
    • 77956181782 scopus 로고    scopus 로고
    • Influence of combined treatment of low dose rapamycin and cyclosporin A on corneal allograft survival
    • et al.
    • Stanojlovic S, Schlickeiser S, Appelt C, et al. Influence of combined treatment of low dose rapamycin and cyclosporin A on corneal allograft survival. Graefes Arch Clin Exp Ophthalmol 2010; 248: 1447-1456.
    • (2010) Graefes Arch Clin Exp Ophthalmol , vol.248 , pp. 1447-1456
    • Stanojlovic, S.1    Schlickeiser, S.2    Appelt, C.3
  • 133
    • 84869078744 scopus 로고    scopus 로고
    • Corticosteroids do not reverse the inhibitory effect of cyclosporine on regulatory T-cell activity in contrast to mycophenolate mofetil
    • et al.
    • Miroux C, Morales O, Ouaguia L, et al. Corticosteroids do not reverse the inhibitory effect of cyclosporine on regulatory T-cell activity in contrast to mycophenolate mofetil. Transplant Proc 2012; 44: 2834-2839.
    • (2012) Transplant Proc , vol.44 , pp. 2834-2839
    • Miroux, C.1    Morales, O.2    Ouaguia, L.3
  • 134
    • 0032490341 scopus 로고    scopus 로고
    • Prope tolerance, perioperative campath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients
    • et al.
    • Calne R, Friend P, Moffatt S, et al. Prope tolerance, perioperative campath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients. Lancet 1998; 351: 1701-1702.
    • (1998) Lancet , vol.351 , pp. 1701-1702
    • Calne, R.1    Friend, P.2    Moffatt, S.3
  • 135
    • 47249132479 scopus 로고    scopus 로고
    • Calcineurin inhibitor withdrawal after renal transplantation with alemtuzumab: Clinical outcomes and effect on T-regulatory cells
    • et al.
    • Pascual J, Bloom D, Torrealba J, et al. Calcineurin inhibitor withdrawal after renal transplantation with alemtuzumab: Clinical outcomes and effect on T-regulatory cells. Am J Transplant 2008; 8: 1529-1536.
    • (2008) Am J Transplant , vol.8 , pp. 1529-1536
    • Pascual, J.1    Bloom, D.2    Torrealba, J.3
  • 136
    • 84877249792 scopus 로고    scopus 로고
    • Once-daily extended-release versus twice-daily standard-release tacrolimus in kidney transplant recipients: A systematic review
    • Ho ET, Wong G, Craig JC, Chapman JR., Once-daily extended-release versus twice-daily standard-release tacrolimus in kidney transplant recipients: A systematic review. Transplantation 2013; 95: 1120-1128.
    • (2013) Transplantation , vol.95 , pp. 1120-1128
    • Ho, E.T.1    Wong, G.2    Craig, J.C.3    Chapman, J.R.4
  • 137
    • 84856106564 scopus 로고    scopus 로고
    • Immunologic monitoring in transplantation revisited
    • Cravedi P, Heeger PS., Immunologic monitoring in transplantation revisited. Curr Opin Organ Transplant 2012; 17: 26-32.
    • (2012) Curr Opin Organ Transplant , vol.17 , pp. 26-32
    • Cravedi, P.1    Heeger, P.S.2
  • 138
    • 37849054599 scopus 로고    scopus 로고
    • Intravascular ultrasound correlates with coronary flow reserve and predicts the survival in angiographically normal cardiac transplant recipients
    • et al.
    • Lee CM, Wu YW, Jui HY, et al. Intravascular ultrasound correlates with coronary flow reserve and predicts the survival in angiographically normal cardiac transplant recipients. Cardiology 2008; 109: 93-98.
    • (2008) Cardiology , vol.109 , pp. 93-98
    • Lee, C.M.1    Wu, Y.W.2    Jui, H.Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.