Multiple unit pooled umbilical cord blood is a viable source of therapeutic regulatory T cells

Transplantation

Volumn 95, Issue 1, 2013, Pages 85-93

  Milward, Kate ^a   Issa, Fadi ^a   Hester, Joanna ^a   Figueroa Tentori, Daniel ^b   Madrigal, Alejandro ^b   Wood, Kathryn J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Graft versus host disease; Multiple unit cord blood transplantation; Regulatory T cells; Skin; Transplantation; Treg; Umbilical cord blood

Indexed keywords

HLA ANTIGEN;

ALLOIMMUNITY; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; BLOOD DONOR; CELL ISOLATION; CELL VIABILITY; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; CORD BLOOD STEM CELL TRANSPLANTATION; GRAFT SURVIVAL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SKIN ALLOGRAFT;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD45; CELL SURVIVAL; FETAL BLOOD; HUMANS; IMMUNOPHENOTYPING; MICE; MICE, INBRED BALB C; T-LYMPHOCYTES, REGULATORY;

EID: 84872072150     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e31827722ed     Document Type: Article

References (44)

1. Wood KJ, Bushell A, Hester J. Regulatory immune cells in transplantation. Nat Rev Immunol 2012; 12: 417.
2. Wood KJ, Goto R. Mechanisms of rejection: current perspectives. Transplantation 2012; 93: 1.
3. Wood KJ, Bushell A, Jones ND. Immunologic unresponsiveness to alloantigen in vivo: a role for regulatory T cells. Immunol Rev 2011; 241: 119.
4. Brusko TM, Putnam AL, Bluestone JA. Human regulatory T cells: role in autoimmune disease and therapeutic opportunities. Immunol Rev 2008; 223: 371.
5. Safinia N, Sagoo P, Lechler R, et al. Adoptive regulatory T cell therapy: challenges in clinical transplantation. Curr Opin Organ Transplant 2010; 15: 427.
6. Taylor AL, Watson CJ, Bradley JA. Immunosuppressive agents in solid organ transplantation: mechanisms of action and therapeutic efficacy. Crit Rev Oncol Hematol 2005; 56: 23.
7. Wing K, Ekmark A, Karlsson H, et al. Characterization of human CD25+ CD4+ T cells in thymus, cord and adult blood. Immunology 2002; 106: 190.
8. Thornton CA, Upham JW, Wikstrom ME, et al. Functional maturation of CD4+CD25+CTLA4+CD45RA+ T regulatory cells in human neonatal T cell responses to environmental antigens/allergens. J Immunol 2004; 173: 3084.
9. Valmori D, Merlo A, Souleimanian NE, et al. A peripheral circulating compartment of natural naive CD4 Tregs. J Clin Invest 2005; 115: 1953.
10. Takahata Y, Nomura A, Takada H, et al. CD25+CD4+ T cells in human cord blood: an immunoregulatory subset with naive phenotype and specific expression of forkhead box p3 (Foxp3) gene. Exp Hematol 2004; 32: 622.
11. Figueroa-Tentori D, Querol S, Dodi IA, et al. High purity and yield of natural Tregs from cord blood using a single step selection method. J Immunol Methods 2008; 339: 228.
12. Bresatz S, Sadlon T, Millard D, et al. Isolation, propagation and characterization of cord blood derived CD4+ CD25+ regulatory T cells. J Immunol Methods 2007; 327: 53.
13. Liu W, Putnam AL, Xu-Yu Z, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006; 203: 1701.
14. Brown JA, Boussiotis VA. Umbilical cord blood transplantation: basic biology and clinical challenges to immune reconstitution. Clin Immunol 2008; 127: 286.
15. Miyara M, Yoshioka Y, Kitoh A, et al. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 2009; 30: 899.
16. Duhen T, Duhen R, Lanzavecchia A, et al. Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells. Blood 2012; 119: 4430.
17. Wing K, Lindgren S, Kollberg G, et al. CD4 T cell activation by myelin oligodendrocyte glycoprotein is suppressed by adult but not cord blood CD25+ T cells. Eur J Immunol 2003; 33: 579.
18. Chang CC, Satwani P, Oberfield N, et al. Increased induction of allogeneic-specific cord blood CD4+CD25+ regulatory T (Treg) cells: a comparative study of naive and antigenic-specific cord blood Treg cells. Exp Hematol 2005; 33: 1508.
19. Fujimaki W, Takahashi N, Ohnuma K, et al. Comparative study of regulatory T cell function of human CD25CD4 T cells from thymocytes, cord blood, and adult peripheral blood. Clin Dev Immunol 2008; 2008: 305859.
20. Godfrey WR, Spoden DJ, Ge YG, et al. Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood 2005; 105: 750.
21. Fan H, Yang J, Hao J, et al. Comparative study of regulatory T cells expanded ex vivo from cord blood and adult peripheral blood. Immunology 2012; 136: 218.
22. Hippen KL, Harker-Murray P, Porter SB, et al. Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells. Blood 2008; 112: 2847.
23. Wing K, Larsson P, Sandstrom K, et al. CD4+ CD25+ FOXP3+ regulatory T cells from human thymus and cord blood suppress antigen-specific T cell responses. Immunology 2005; 115: 516.
24. Seddiki N, Santner-Nanan B, Tangye SG, et al. Persistence of naive CD45RA+ regulatory T cells in adult life. Blood 2006; 107: 2830.
25. Seddiki N, Santner-Nanan B, Martinson J, et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 2006; 203: 1693.
26. Brunstein CG, Miller JS, Cao Q, et al. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood 2011; 117: 1061.
27. Lee CC, Lin SJ, Cheng PJ, et al. The regulatory function of umbilical cord blood CD4(+) CD25(+) T cells stimulated with anti-CD3/anti-CD28 and exogenous interleukin (IL)-2 or IL-15. Pediatr Allergy Immunol 2009; 20: 624.
28. Peters JH, Preijers FW, Woestenenk R, et al. Clinical grade Treg: GMP isolation, improvement of purity by CD127 depletion, Treg expansion, and Treg cryopreservation. PLoS One 2008; 3: e3161.
29. Ng WF, Duggan PJ, Ponchel F, et al. Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells. Blood 2001; 98: 2736.
30. Borsellino G, Kleinewietfeld M, Di Mitri D, et al. Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood 2007; 110: 1225.
31. Grossman WJ, Verbsky JW, Barchet W, et al. Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity 2004; 21: 589.
32. Tang Q, Boden EK, Henriksen KJ, et al. Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function. Eur J Immunol 2004; 34: 2996.
33. Oida T, Xu L, Weiner HL, et al. TGF-beta-mediated suppression by CD4+CD25+ T cells is facilitated by CTLA-4 signaling. J Immunol 2006; 177: 2331.
34. Issa F, Hester J, Goto R, et al. Ex vivo-expanded human regulatory T cells prevent the rejection of skin allografts in a humanized mouse model. Transplantation 2010; 90: 1321.
35. Nguyen VH, Zeiser R, Dasilva DL, et al. In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation. Blood 2007; 109: 2649.
36. Hoffmann P, Eder R, Boeld TJ, et al. Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood 2006; 108: 4260.
37. Gluckman E, Rocha V, Boyer-Chammard A, et al. Outcome of cordblood transplantation from related and unrelated donors. Eurocord Transplant Group and the European Blood and Marrow Transplantation Group. N Engl J Med 1997; 337: 373.
38. Madrigal JA, Cohen SB, Gluckman E, et al. Does cord blood transplantation result in lower graft-versus-host disease? It takes more than two to tango. Hum Immunol 1997; 56: 1.
39. Canto E, Rodriguez-Sanchez JL, Vidal S. Distinctive response of naive lymphocytes from cord blood to primary activation via TCR. J Leukoc Biol 2003; 74: 998.
40. Li L, Boussiotis VA. Molecular and functional heterogeneity of T regulatory cells. Clin Immunol 2011; 141: 244.
41. Hori S. Developmental plasticity of Foxp3+ regulatory T cells. Curr Opin Immunol 2010; 22: 575.
42. Nadig SN, Wieckiewicz J, Wu DC, et al. In vivo prevention of transplant arteriosclerosis by ex vivo expanded human regulatory T cells. Nat Med 2010; 16: 809.
43. Li L, Godfrey WR, Porter SB, et al. CD4+CD25+ regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergy. Blood 2005; 106: 3068.
44. Chen L, Cohen AC, Lewis DB. Impaired allogeneic activation and T-helper 1 differentiation of human cord blood naive CD4 T cells. Biol Blood Marrow Transplant 2006; 12: 160.