메뉴 건너뛰기




Volumn 122, Issue 13, 2013, Pages 2251-2261

Human regulatory T cells against minor histocompatibility antigens: Ex vivo expansion for prevention of graft-versus-host disease

Author keywords

[No Author keywords available]

Indexed keywords

HLA A ANTIGEN; HLA B ANTIGEN; HLA C ANTIGEN; HLA DPB1 ANTIGEN; HLA DQB1 ANTIGEN; HLA DRB1 ANTIGEN; HY ANTIGEN; INTERLEUKIN 15; INTERLEUKIN 2; MINOR HISTOCOMPATIBILITY ANTIGEN; RAPAMYCIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR;

EID: 84887347546     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-03-492397     Document Type: Article
Times cited : (38)

References (55)
  • 1
    • 84861576998 scopus 로고    scopus 로고
    • Advances in graft-versus-host disease biology and therapy
    • Blazar BR, Murphy WJ, Abedi M. Advances in graft-versus-host disease biology and therapy. Nat Rev Immunol. 2012;12(6):443- 458.
    • (2012) Nat Rev Immunol , vol.12 , Issue.6 , pp. 443-458
    • Blazar, B.R.1    Murphy, W.J.2    Abedi, M.3
  • 2
    • 84867303407 scopus 로고    scopus 로고
    • Effect of MHC and non-MHC donor/recipient genetic disparity on the outcome of allogeneic HCT
    • Warren EH, Zhang XC, Li S, et al. Effect of MHC and non-MHC donor/recipient genetic disparity on the outcome of allogeneic HCT. Blood. 2012;120(14): 2796-2806.
    • (2012) Blood , vol.120 , Issue.14 , pp. 2796-2806
    • Warren, E.H.1    Zhang, X.C.2    Li, S.3
  • 4
    • 0034141691 scopus 로고    scopus 로고
    • DFFRY codes for a new human male-specific minor transplantation antigen involved in bone marrow graft rejection
    • Vogt MH, de Paus RA, Voogt PJ, Willemze R, Falkenburg JH. DFFRY codes for a new human male-specific minor transplantation antigen involved in bone marrow graft rejection. Blood. 2000;95(3):1100-1105.
    • (2000) Blood , vol.95 , Issue.3 , pp. 1100-1105
    • Vogt, M.H.1    De Paus, R.A.2    Voogt, P.J.3    Willemze, R.4    Falkenburg, J.H.5
  • 5
    • 0034330843 scopus 로고    scopus 로고
    • UTY gene codes for an HLA-B60-restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: Characterization of the critical polymorphic amino acid residues for T-cell recognition
    • Vogt MH, Goulmy E, Kloosterboer FM, Blokland E, de Paus RA, Willemze R, Falkenburg JH. UTY gene codes for an HLA-B60-restricted human male-specific minor histocompatibility antigen involved in stem cell graft rejection: characterization of the critical polymorphic amino acid residues for T-cell recognition. Blood. 2000; 96(9):3126-3132.
    • (2000) Blood , vol.96 , Issue.9 , pp. 3126-3132
    • Vogt, M.H.1    Goulmy, E.2    Kloosterboer, F.M.3    Blokland, E.4    De Paus, R.A.5    Willemze, R.6    Falkenburg, J.H.7
  • 6
    • 0037089335 scopus 로고    scopus 로고
    • The DBY gene codes for an HLA-DQ5- restricted human male-specific minor histocompatibility antigen involved in graftversus- host disease
    • Vogt MH, van den Muijsenberg JW, Goulmy E, et al. The DBY gene codes for an HLA-DQ5- restricted human male-specific minor histocompatibility antigen involved in graftversus- host disease. Blood. 2002;99(8):3027-3032.
    • (2002) Blood , vol.99 , Issue.8 , pp. 3027-3032
    • Vogt, M.H.1    Van Den Muijsenberg, J.W.2    Goulmy, E.3
  • 7
    • 0029092140 scopus 로고
    • Human H-Y: A male-specific histocompatibility antigen derived from the SMCY protein
    • Wang W, Meadows LR, den Haan JM, et al. Human H-Y: A male-specific histocompatibility antigen derived from the SMCY protein. Science. 1995;269(5230):1588-1590.
    • (1995) Science , vol.269 , Issue.5230 , pp. 1588-1590
    • Wang, W.1    Meadows, L.R.2    Den, H.J.M.3
  • 8
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • Sakaguchi S, Yamaguchi T, Nomura T, Ono M. Regulatory T cells and immune tolerance. Cell. 2008;133(5):775-787.
    • (2008) Cell , vol.133 , Issue.5 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4
  • 9
    • 0029150110 scopus 로고
    • Immunologic self-Tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-Tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-Tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-Tolerance causes various autoimmune diseases. J Immunol. 1995;155(3): 1151-1164.
    • (1995) J Immunol , vol.155 , Issue.3 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 10
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD41CD251 regulatory T cells
    • Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD41CD251 regulatory T cells. Nat Immunol. 2003;4(4):330-336.
    • (2003) Nat Immunol , vol.4 , Issue.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 11
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003;299(5609):1057-1061.
    • (2003) Science , vol.299 , Issue.5609 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 12
    • 0035525739 scopus 로고    scopus 로고
    • Human CD4(1)CD25(1) cells: A naturally occurring population of regulatory T cells
    • Ng WF, Duggan PJ, Ponchel F, et al. Human CD4(1)CD25(1) cells: A naturally occurring population of regulatory T cells. Blood. 2001; 98(9):2736-2744.
    • (2001) Blood , vol.98 , Issue.9 , pp. 2736-2744
    • Ng, W.F.1    Duggan, P.J.2    Ponchel, F.3
  • 13
    • 0037093217 scopus 로고    scopus 로고
    • The infusion of ex vivo activated and expanded CD4(1)CD25(1) immune regulatory cells inhibits graft-versus-host disease lethality
    • Taylor PA, Lees CJ, Blazar BR. The infusion of ex vivo activated and expanded CD4(1)CD25(1) immune regulatory cells inhibits graft-versus-host disease lethality. Blood. 2002;99(10):3493-3499.
    • (2002) Blood , vol.99 , Issue.10 , pp. 3493-3499
    • Taylor, P.A.1    Lees, C.J.2    Blazar, B.R.3
  • 14
    • 0037025943 scopus 로고    scopus 로고
    • Donor-Type CD4(1)CD25(1) regulatory T cells suppress lethal acute graftversus- host disease after allogeneic bone marrow transplantation
    • Hoffmann P, Ermann J, Edinger M, Fathman CG, Strober S. Donor-Type CD4(1)CD25(1) regulatory T cells suppress lethal acute graftversus- host disease after allogeneic bone marrow transplantation. J Exp Med. 2002;196(3):389-399.
    • (2002) J Exp Med , vol.196 , Issue.3 , pp. 389-399
    • Hoffmann, P.1    Ermann, J.2    Edinger, M.3    Fathman, C.G.4    Strober, S.5
  • 15
    • 0346690399 scopus 로고    scopus 로고
    • Recipienttype specific CD41CD251 regulatory T cells favor immune reconstitution and control graftversus- host disease while maintaining graftversus- leukemia
    • Trenado A, Charlotte F, Fisson S, Yagello M, Klatzmann D, Salomon BL, Cohen JL. Recipienttype specific CD41CD251 regulatory T cells favor immune reconstitution and control graftversus- host disease while maintaining graftversus- leukemia. J Clin Invest. 2003;112(11): 1688-1696.
    • (2003) J Clin Invest , vol.112 , Issue.11 , pp. 1688-1696
    • Trenado, A.1    Charlotte, F.2    Fisson, S.3    Yagello, M.4    Klatzmann, D.5    Salomon, B.L.6    Cohen, J.L.7
  • 16
    • 0141461418 scopus 로고    scopus 로고
    • CD41 CD251 regulatory T cells preserve graft-versustumor activity while inhibiting graft-versus-host disease after bone marrow transplantation
    • Edinger M, Hoffmann P, Ermann J, Drago K, Fathman CG, Strober S, Negrin RS. CD41 CD251 regulatory T cells preserve graft-versustumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med. 2003;9(9):1144-1150.
    • (2003) Nat Med , vol.9 , Issue.9 , pp. 1144-1150
    • Edinger, M.1    Hoffmann, P.2    Ermann, J.3    Drago, K.4    Fathman, C.G.5    Strober, S.6    Negrin, R.S.7
  • 17
    • 2942692039 scopus 로고    scopus 로고
    • CD251 CD41 T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes
    • Tarbell KV, Yamazaki S, Olson K, Toy P, Steinman RM. CD251 CD41 T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J Exp Med. 2004;199(11):1467-1477.
    • (2004) J Exp Med , vol.199 , Issue.11 , pp. 1467-1477
    • Tarbell, K.V.1    Yamazaki, S.2    Olson, K.3    Toy, P.4    Steinman, R.M.5
  • 18
    • 81555214616 scopus 로고    scopus 로고
    • Ex vivo expansion of human Tregs specific for alloantigens presented directly or indirectly
    • Veerapathran A, Pidala J, Beato F, Yu XZ, Anasetti C. Ex vivo expansion of human Tregs specific for alloantigens presented directly or indirectly. Blood. 2011;118(20):5671-5680.
    • (2011) Blood , vol.118 , Issue.20 , pp. 5671-5680
    • Veerapathran, A.1    Pidala, J.2    Beato, F.3    Yu, X.Z.4    Anasetti, C.5
  • 19
    • 0037026001 scopus 로고    scopus 로고
    • CD4(1)CD25(1) immunoregulatory T cells: New therapeutics for graft-versus-host disease
    • Cohen JL, Trenado A, Vasey D, Klatzmann D, Salomon BL. CD4(1)CD25(1) immunoregulatory T cells: new therapeutics for graft-versus-host disease. J Exp Med. 2002;196(3):401-406.
    • (2002) J Exp Med , vol.196 , Issue.3 , pp. 401-406
    • Cohen, J.L.1    Trenado, A.2    Vasey, D.3    Klatzmann, D.4    Salomon, B.L.5
  • 20
    • 3142519564 scopus 로고    scopus 로고
    • In vitro-expanded human CD4(1)CD25(1) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures
    • Godfrey WR, Ge YG, Spoden DJ, Levine BL, June CH, Blazar BR, Porter SB. In vitro-expanded human CD4(1)CD25(1) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures. Blood. 2004;104(2):453-461.
    • (2004) Blood , vol.104 , Issue.2 , pp. 453-461
    • Godfrey, W.R.1    Ge, Y.G.2    Spoden, D.J.3    Levine, B.L.4    June, C.H.5    Blazar, B.R.6    Porter, S.B.7
  • 21
    • 3242801352 scopus 로고    scopus 로고
    • Large-scale in vitro expansion of polyclonal human CD4(1)CD25high regulatory T cells
    • Hoffmann P, Eder R, Kunz-Schughart LA, Andreesen R, Edinger M. Large-scale in vitro expansion of polyclonal human CD4(1)CD25high regulatory T cells. Blood. 2004;104(3):895-903.
    • (2004) Blood , vol.104 , Issue.3 , pp. 895-903
    • Hoffmann, P.1    Eder, R.2    Kunz-Schughart, L.A.3    Andreesen, R.4    Edinger, M.5
  • 22
    • 26044458206 scopus 로고    scopus 로고
    • Antigendependent suppression of alloresponses by Foxp3-induced regulatory T cells in transplantation
    • Albert MH, Liu Y, Anasetti C, Yu XZ. Antigendependent suppression of alloresponses by Foxp3-induced regulatory T cells in transplantation. Eur J Immunol. 2005;35(9): 2598-2607.
    • (2005) Eur J Immunol , vol.35 , Issue.9 , pp. 2598-2607
    • Albert, M.H.1    Liu, Y.2    Anasetti, C.3    Yu, X.Z.4
  • 23
    • 33846214275 scopus 로고    scopus 로고
    • In vitro-expanded donor alloantigen-specific CD41CD251 regulatory T cells promote experimental transplantation tolerance
    • Golshayan D, Jiang S, Tsang J, Garin MI, Mottet C, Lechler RI. In vitro-expanded donor alloantigen-specific CD41CD251 regulatory T cells promote experimental transplantation tolerance. Blood. 2007;109(2):827-835.
    • (2007) Blood , vol.109 , Issue.2 , pp. 827-835
    • Golshayan, D.1    Jiang, S.2    Tsang, J.3    Garin, M.I.4    Mottet, C.5    Lechler, R.I.6
  • 24
    • 4344653864 scopus 로고    scopus 로고
    • Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp31CD251CD41 regulatory T cells
    • Nishimura E, Sakihama T, Setoguchi R, Tanaka K, Sakaguchi S. Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp31CD251CD41 regulatory T cells. Int Immunol. 2004;16(8):1189-1201.
    • (2004) Int Immunol , vol.16 , Issue.8 , pp. 1189-1201
    • Nishimura, E.1    Sakihama, T.2    Setoguchi, R.3    Tanaka, K.4    Sakaguchi, S.5
  • 25
    • 77954730585 scopus 로고    scopus 로고
    • Leukemia-Associated minor histocompatibility antigen discovery using T-cell clones isolated by in vitro stimulation of naive CD81 T cells
    • Bleakley M, Otterud BE, Richardt JL, et al. Leukemia-Associated minor histocompatibility antigen discovery using T-cell clones isolated by in vitro stimulation of naive CD81 T cells. Blood. 2010;115(23):4923-4933.
    • (2010) Blood , vol.115 , Issue.23 , pp. 4923-4933
    • Bleakley, M.1    Otterud, B.E.2    Richardt, J.L.3
  • 26
    • 67650105331 scopus 로고    scopus 로고
    • Differential responses of human regulatory T cells (Treg) and effector T cells to rapamycin
    • Strauss L, Czystowska M, Szajnik M, Mandapathil M, Whiteside TL. Differential responses of human regulatory T cells (Treg) and effector T cells to rapamycin. PLoS ONE. 2009;4(6):e5994.
    • (2009) PLoS ONE , vol.4 , Issue.6 , pp. e5994
    • Strauss, L.1    Czystowska, M.2    Szajnik, M.3    Mandapathil, M.4    Whiteside, T.L.5
  • 27
    • 17444379333 scopus 로고    scopus 로고
    • Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans
    • Hellerstein M, Hanley MB, Cesar D, et al. Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans. Nat Med. 1999;5(1):83-89.
    • (1999) Nat Med , vol.5 , Issue.1 , pp. 83-89
    • Hellerstein, M.1    Hanley, M.B.2    Cesar, D.3
  • 28
    • 0034060982 scopus 로고    scopus 로고
    • Factors influencing T-cell turnover in HIV-1-seropositive patients
    • McCune JM, Hanley MB, Cesar D, et al. Factors influencing T-cell turnover in HIV-1-seropositive patients. J Clin Invest. 2000;105(5):R1-R8.
    • (2000) J Clin Invest , vol.105 , Issue.5 , pp. R1-R8
    • McCune, J.M.1    Hanley, M.B.2    Cesar, D.3
  • 30
    • 3042524776 scopus 로고    scopus 로고
    • Use of cell-Tracking dyes to determine proliferation precursor frequencies of antigen-specific T cells
    • Givan AL, Fisher JL, Waugh MG, Bercovici N, Wallace PK. Use of cell-Tracking dyes to determine proliferation precursor frequencies of antigen-specific T cells. Methods Mol Biol. 2004; 263:109-124.
    • (2004) Methods Mol Biol , vol.263 , pp. 109-124
    • Givan, A.L.1    Fisher, J.L.2    Waugh, M.G.3    Bercovici, N.4    Wallace, P.K.5
  • 31
    • 58349116249 scopus 로고    scopus 로고
    • Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue
    • Wieczorek G, Asemissen A, Model F, et al. Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue. Cancer Res. 2009;69(2):599-608.
    • (2009) Cancer Res , vol.69 , Issue.2 , pp. 599-608
    • Wieczorek, G.1    Asemissen, A.2    Model, F.3
  • 32
    • 0029027351 scopus 로고
    • Identification of a graft versus host diseaseassociated human minor histocompatibility antigen
    • den Haan JM, Sherman NE, Blokland E, et al. Identification of a graft versus host diseaseassociated human minor histocompatibility antigen. Science. 1995;268(5216):1476-1480.
    • (1995) Science , vol.268 , Issue.5216 , pp. 1476-1480
    • Den Haan, J.M.1    Sherman, N.E.2    Blokland, E.3
  • 33
    • 0020700847 scopus 로고
    • A minor transplantation antigen detected by MHC-restricted cytotoxic T lymphocytes during graft-versus-host disease
    • Goulmy E, Gratama JW, Blokland E, Zwaan FE, van Rood JJ. A minor transplantation antigen detected by MHC-restricted cytotoxic T lymphocytes during graft-versus-host disease. Nature. 1983;302(5904):159-161.
    • (1983) Nature , vol.302 , Issue.5904 , pp. 159-161
    • Goulmy, E.1    Gratama, J.W.2    Blokland, E.3    Zwaan, F.E.4    Van, R.J.J.5
  • 34
    • 2342484524 scopus 로고    scopus 로고
    • Molecules and mechanisms of the graft-versus-leukaemia effect
    • Bleakley M, Riddell SR. Molecules and mechanisms of the graft-versus-leukaemia effect. Nat Rev Cancer. 2004;4(5):371-380.
    • (2004) Nat Rev Cancer , vol.4 , Issue.5 , pp. 371-380
    • Bleakley, M.1    Riddell, S.R.2
  • 35
    • 0034161723 scopus 로고    scopus 로고
    • The human UTY gene encodes a novel HLA-B8- restricted H-Y antigen
    • Warren EH, Gavin MA, Simpson E, et al. The human UTY gene encodes a novel HLA-B8- restricted H-Y antigen. J Immunol. 2000;164(5): 2807-2814.
    • (2000) J Immunol , vol.164 , Issue.5 , pp. 2807-2814
    • Warren, E.H.1    Gavin, M.A.2    Simpson, E.3
  • 36
    • 84859416933 scopus 로고    scopus 로고
    • Regulatory T cells: Mechanisms of differentiation and function
    • Josefowicz SZ, Lu LF, Rudensky AY. Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol. 2012;30:531-564.
    • (2012) Annu Rev Immunol , vol.30 , pp. 531-564
    • Josefowicz, S.Z.1    Lu, L.F.2    Rudensky, A.Y.3
  • 37
    • 36549030784 scopus 로고    scopus 로고
    • The inhibitory cytokine IL-35 contributes to regulatory T-cell function
    • Collison LW, Workman CJ, Kuo TT, et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature. 2007;450(7169):566-569.
    • (2007) Nature , vol.450 , Issue.7169 , pp. 566-569
    • Collison, L.W.1    Workman, C.J.2    Kuo, T.T.3
  • 39
    • 0027465548 scopus 로고
    • Frequency of anti-recipient alloreactive helper T-cell precursors in donor blood and graft-versushost disease after HLA-identical sibling bonemarrow transplantation
    • Schwarer AP, Jiang YZ, Brookes PA, Barrett AJ, Batchelor JR, Goldman JM, Lechler RI. Frequency of anti-recipient alloreactive helper T-cell precursors in donor blood and graft-versushost disease after HLA-identical sibling bonemarrow transplantation. Lancet. 1993;341(8839): 203-205.
    • (1993) Lancet , vol.341 , Issue.8839 , pp. 203-205
    • Schwarer, A.P.1    Jiang, Y.Z.2    Brookes, P.A.3    Barrett, A.J.4    Batchelor, J.R.5    Goldman, J.M.6    Lechler, R.I.7
  • 40
    • 0032532496 scopus 로고    scopus 로고
    • Predicting graftversus- host disease in HLA-identical bone marrow transplant: A comparison of T-cell frequency analysis and a human skin explant model
    • Dickinson AM, Sviland L, Wang XN, Jackson G, Taylor PR, Dunn A, Proctor SJ. Predicting graftversus- host disease in HLA-identical bone marrow transplant: A comparison of T-cell frequency analysis and a human skin explant model. Transplantation. 1998;66(7):857-863.
    • (1998) Transplantation , vol.66 , Issue.7 , pp. 857-863
    • Dickinson, A.M.1    Sviland, L.2    Wang, X.N.3    Jackson, G.4    Taylor, P.R.5    Dunn, A.6    Proctor, S.J.7
  • 41
    • 0026457877 scopus 로고
    • Host-specific interleukin-2-secreting donor T-cell precursors as predictors of acute graft-versus-host disease in bone marrow transplantation between HLA-identical siblings
    • Theobald M, Nierle T, Bunjes D, Arnold R, Heimpel H. Host-specific interleukin-2-secreting donor T-cell precursors as predictors of acute graft-versus-host disease in bone marrow transplantation between HLA-identical siblings. N Engl J Med. 1992;327(23):1613-1617.
    • (1992) N Engl J Med , vol.327 , Issue.23 , pp. 1613-1617
    • Theobald, M.1    Nierle, T.2    Bunjes, D.3    Arnold, R.4    Heimpel, H.5
  • 42
    • 84871254519 scopus 로고    scopus 로고
    • Human regulatory T cells of G-CSF mobilized allogeneic stem cell donors qualify for clinical application
    • Ukena SN, Velaga S, Goudeva L, et al. Human regulatory T cells of G-CSF mobilized allogeneic stem cell donors qualify for clinical application. PLoS ONE. 2012;7(12):e51644.
    • (2012) PLoS ONE , vol.7 , Issue.12 , pp. e51644
    • Ukena, S.N.1    Velaga, S.2    Goudeva, L.3
  • 43
    • 65549127618 scopus 로고    scopus 로고
    • Human T regulatory cell therapy: Take a billion or so and call me in the morning
    • Riley JL, June CH, Blazar BR. Human T regulatory cell therapy: Take a billion or so and call me in the morning. Immunity. 2009;30(5): 656-665.
    • (2009) Immunity , vol.30 , Issue.5 , pp. 656-665
    • Riley, J.L.1    June, C.H.2    Blazar, B.R.3
  • 44
    • 79956288367 scopus 로고    scopus 로고
    • Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells
    • Sagoo P, Ali N, Garg G, Nestle FO, Lechler RI, Lombardi G. Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells. Sci Transl Med. 2011;3(83): 83ra42.
    • (2011) Sci Transl Med , vol.3 , Issue.83 , pp. 83ra42
    • Sagoo, P.1    Ali, N.2    Garg, G.3    Nestle, F.O.4    Lechler, R.I.5    Lombardi, G.6
  • 45
    • 33845491455 scopus 로고    scopus 로고
    • Only the CD45RA1 subpopulation of CD41CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion
    • Hoffmann P, Eder R, Boeld TJ, Doser K, Piseshka B, Andreesen R, Edinger M. Only the CD45RA1 subpopulation of CD41CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood. 2006;108(13): 4260-4267.
    • (2006) Blood , vol.108 , Issue.13 , pp. 4260-4267
    • Hoffmann, P.1    Eder, R.2    Boeld, T.J.3    Doser, K.4    Piseshka, B.5    Andreesen, R.6    Edinger, M.7
  • 46
    • 79953809817 scopus 로고    scopus 로고
    • Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
    • Di Ianni M, Falzetti F, Carotti A, et al. Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood. 2011;117(14):3921-3928.
    • (2011) Blood , vol.117 , Issue.14 , pp. 3921-3928
    • Dianni, M.1    Falzetti, F.2    Carotti, A.3
  • 47
    • 38049177784 scopus 로고    scopus 로고
    • Differential impact of mammalian target of rapamycin inhibition on CD41CD251Foxp31 regulatory T cells compared with conventional CD41 T cells
    • Zeiser R, Leveson-Gower DB, Zambricki EA, et al. Differential impact of mammalian target of rapamycin inhibition on CD41CD251Foxp31 regulatory T cells compared with conventional CD41 T cells. Blood. 2008;111(1):453-462.
    • (2008) Blood , vol.111 , Issue.1 , pp. 453-462
    • Zeiser, R.1    Leveson-Gower, D.B.2    Zambricki, E.A.3
  • 48
    • 78751696183 scopus 로고    scopus 로고
    • Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: Safety profile and detection kinetics
    • Brunstein CG, Miller JS, Cao Q, et al. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood. 2011;117(3): 1061-1070.
    • (2011) Blood , vol.117 , Issue.3 , pp. 1061-1070
    • Brunstein, C.G.1    Miller, J.S.2    Cao, Q.3
  • 50
    • 0029850825 scopus 로고    scopus 로고
    • CD41 CD45RA1 T cells from adults respond to recall antigens after CD28 ligation
    • Pilling D, Akbar AN, Bacon PA, Salmon M. CD41 CD45RA1 T cells from adults respond to recall antigens after CD28 ligation. Int Immunol. 1996; 8(11):1737-1742.
    • (1996) Int Immunol , vol.8 , Issue.11 , pp. 1737-1742
    • Pilling, D.1    Akbar, A.N.2    Bacon, P.A.3    Salmon, M.4
  • 51
    • 33745861719 scopus 로고    scopus 로고
    • Rapamycinmediated enrichment of T cells with regulatory activity in stimulated CD41 T cell cultures is not due to the selective expansion of naturally occurring regulatory T cells but to the induction of regulatory functions in conventional CD41 T cells
    • Valmori D, Tosello V, Souleimanian NE, Godefroy E, Scotto L, Wang Y, Ayyoub M. Rapamycinmediated enrichment of T cells with regulatory activity in stimulated CD41 T cell cultures is not due to the selective expansion of naturally occurring regulatory T cells but to the induction of regulatory functions in conventional CD41 T cells. J Immunol. 2006;177(2):944-949.
    • (2006) J Immunol , vol.177 , Issue.2 , pp. 944-949
    • Valmori, D.1    Tosello, V.2    Souleimanian, N.E.3    Godefroy, E.4    Scotto, L.5    Wang, Y.6    Ayyoub, M.7
  • 52
    • 84880968811 scopus 로고    scopus 로고
    • Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD41CD251FOXP31 Treg subpopulations
    • Scotta C, Esposito M, Fazekasova H, et al. Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD41CD251FOXP31 Treg subpopulations. Haematologica. 2013;98(8): 1291-1299.
    • (2013) Haematologica , vol.98 , Issue.8 , pp. 1291-1299
    • Scotta, C.1    Esposito, M.2    Fazekasova, H.3
  • 53
    • 79251589897 scopus 로고    scopus 로고
    • Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells
    • Golovina TN, Mikheeva T, Brusko TM, Blazar BR, Bluestone JA, Riley JL. Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells. PLoS ONE. 2011;6(1):e15868.
    • (2011) PLoS ONE , vol.6 , Issue.1 , pp. e15868
    • Golovina, T.N.1    Mikheeva, T.2    Brusko, T.M.3    Blazar, B.R.4    Bluestone, J.A.5    Riley, J.L.6
  • 54
    • 0030001675 scopus 로고    scopus 로고
    • Lymphocyte homing and homeostasis
    • Butcher EC, Picker LJ. Lymphocyte homing and homeostasis. Science. 1996;272(5258):60-66.
    • (1996) Science , vol.272 , Issue.5258 , pp. 60-66
    • Butcher, E.C.1    Picker, L.J.2
  • 55
    • 34548755672 scopus 로고    scopus 로고
    • DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(1) conventional T cells
    • Baron U, Floess S, Wieczorek G, et al. DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(1) conventional T cells. Eur J Immunol. 2007;37(9):2378-2389.
    • (2007) Eur J Immunol , vol.37 , Issue.9 , pp. 2378-2389
    • Baron, U.1    Floess, S.2    Wieczorek, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.