Non-human primate regulatory T cells: Current biology and implications for transplantation

Transplantation

Volumn 90, Issue 8, 2010, Pages 811-816

  Dons, Eefje M ^a,b   Raimondi, Giorgio ^a   Cooper, David K C ^a   Thomson, Angus W ^a,c  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Non human primates; Regulatory T cells; Transplantation; Xenotransplantation

Indexed keywords

TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; IMMUNOSUPPRESSIVE AGENT; LEUKOCYTE ANTIGEN;

ALLOIMMUNITY; ALLOTRANSPLANTATION; ARTICLE; CD25+ T LYMPHOCYTE; CD4+ CD25+ T LYMPHOCYTE; CELL ACTIVITY; CELL EXPANSION; CELL TRANSPLANTATION; HUMAN; IMMUNOREACTIVITY; IMMUNOREGULATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE MIGRATION; LYMPHOCYTE TRANSFER; MEMORY T LYMPHOCYTE; NONHUMAN; PRIMATE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; XENOTRANSPLANTATION; ADOPTIVE TRANSFER; ANIMAL; CELL DIVISION; CYTOLOGY; EDITORIAL; FLOW CYTOMETRY; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DEPLETION; MACACA; METHODOLOGY; PHYSIOLOGY; RODENT; TRANSPLANTATION; XENOGRAFT;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD; CELL DIVISION; FLOW CYTOMETRY; HUMANS; IMMUNOLOGIC MEMORY; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DEPLETION; MACACA FASCICULARIS; PRIMATES; RODENTIA; T-LYMPHOCYTES, REGULATORY; TRANSPLANTATION, HETEROLOGOUS;

EID: 78349233811     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181ebf782     Document Type: Article

References (40)

1. Sakaguchi S, Yamaguchi T, Nomura T, et al. Regulatory T cells and immune tolerance. Cell2008; 133: 775.
2. Wood KJ, Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat Rev Immunol 2003; 3: 199.
3. Roncarolo MG, Battaglia M. Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans. Nat Rev Immunol 2007; 7: 585.
4. Bluestone JA. Regulatory T-cell therapy: Is it ready for the clinic? Nat Rev Immunol 2005; 5: 343.
5. Bluestone JA, Thomson AW, Shevach EM, et al. What does the future hold for cell-based tolerogenic therapy? Nat Rev Immunol 2007; 7:650.
6. Zheng Y, Rudensky AY. Foxp3 in control of the regulatory T cell lineage. Nat Immunol 2007; 8: 457.
7. Raimondi G, Turner MS, Thomson AW, et al. Naturally-occurring regulatory T cells: Recent insights in health and disease. Crit Rev Immunol 2007; 27: 61.
8. + T regulatory cell-mediated suppression. Immunity 2009; 30: 636.
9. Sachs DH. Tolerance: Of mice and men. J Clin Invest 2003; 111: 1819.
10. + regulatory T cells in rhesus monkeys. Transplantation 2008; 85: 1185.
11. Anderson A, Martens CL, Hendrix R, et al. Expanded nonhuman primate Tregs exhibit a unique gene expression signature and potently downregulate alloimmune responses. Am J Transplant 2008; 8: 2252.
12. Bashuda H, Kimikawa M, Seino K, et al. Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates. J Clin Invest 2005; 115: 1896.
13. Riley JL, June CH, Blazar BR. Human T regulatory cell therapy: Take a billion or so and call me in the morning. Immunity 2009; 30: 656.
14. Moreau A, Chiffoleau E, Beriou G, et al. Superiority of bone marrow-derived dendritic cells over monocyte-derived ones for the expansion of regulatory T cells in the macaque. Transplantation 2008; 85: 1351.
15. Ma A, Xiong Z, Hu Y, et al. Dysfunction of IL-10-producing type 1 regulatory T cells and CD4(+)CD25( + ) regulatory T cells in a mimic model of human multiple sclerosis in Cynomolgus monkeys. Int Im-munopharmacol 2009; 9: 599.
16. + suppressive regulatory T cells from rhesus macaque peripheral blood by FN18/antihuman CD28-coated Dynal beads. Hum Immunol 2007; 68: 478.
17. + T cells by infant but not adult macaque regulatory T cells: Implications for SIV disease progression. J Exp Med 2007; 204:2679.
18. + Treg cells for potential use in a non-human primate xenotransplantation model. Xenotransplantation 2007; 14: 298.
19. lo T cells. Transplantation 2009; 88: 1057.
20. +CD25~ T cells. J Clin Invest 2003; 112: 1437.
21. +FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype. Blood 2007; 110: 2983.
22. Mucida D, Park Y, Kim G, et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 2007; 317: 256.
23. + regulatory T cells by retinoic acid. J Immunol 2009; 183: 4119.
24. van der Windt DJ, Smetanka C, Macedo C, et al. Investigation of lymphocyte depletion and repopulation using alemtuzumab (CAMPATH-1H) in cynomolgus monkeys. Am J Transplant 2010; 10: 773.
25. Rebello P, Cwynarski K, Varughese M, et al. Pharmacokinetics of CAMPATH-1H in BMT patients. Cytotherapy 2001; 3: 261.
26. Morris EC, Rebello P, Thomson KJ, et al. Pharmacokinetics of alemtuzu used for in vivo and in vitro T-cell depletion in allogeneic transplantations: Relevance for early adoptive immunotherapy and infectious complications. Blood 2003; 102: 404.
27. Chen D, Bromberg JS. T regulatory cells and migration. Am J Transplant 2006; 6: 1518.
28. Haanstra KG, Wubben JA, Korevaar SS, et al. Expression patterns of regulatory T-cell markers in accepted and rejected nonhuman primate kidney allografts. Am J Transplant 2007; 7: 2236.
29. + T regulatory cell infiltrates. J Immunol 2004; 172: 5753.
30. Izcue A, Coombes JL, Powrie F. Regulatory lymphocytes and intestinal inflammation. Annu Rev Immunol 2009; 27: 313.
31. Zhang N, Schroppel B, Lal G, et al. Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response. Immunity 2009; 30: 458.
32. Qin S, Sui Y, Soloff AC, et al. Chemokine and cytokine mediated loss of regulatory T cells in lymph nodes during pathogenic simian immunodeficiency virus infection. J Immunol 2008; 180: 5530.
33. Sener A, Tang AL, Farber DL. Memory T-cell predominance following T-cell depletional therapy derives from homeostatic expansion of naive T cells. Am J Transplant 2009; 9: 2615.
34. Yang J, Brook MO, Carvalho-Gaspar M, et al. Allograft rejection mediated by memory T cells is resistant to regulation. Proc Natl Acad Sci USA 2007; 104: 19954.
35. + T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med 2001; 193: 1295.
36. Kim JS, Lee JI, Shin JY, et al. Bortezomib can suppress activation of rapamycin-resistant memory T cells without affecting regulatory T-cell viability in non-human primates. Transplantation 2009; 88: 1349.
37. + regulatory T cells suppress anti-porcine xenogeneic responses. Am J Transplant 2005; 5:2052.
38. Muller YD, Golshayan D, Ehirchiou D, et al. T regulatory cells in xenotransplantation. Xenotransplantation 2009; 16: 121.
39. +CD127~ T regulatory cells. Clin Immunol 2009; 133: 22.
40. Shultz LD, Ishikawa F, Greiner DL. Humanized mice in translational biomedical research. Nat Rev Immunol 2007; 7: 118.