Rapid suppression of cytokine transcription in human CD4 +CD25- T cells by CD4+Foxp3+ regulatory T cells: Independence of IL-2 consumption, TGF-β, and various inhibitors of TCR signaling

Journal of Immunology

Volumn 179, Issue 6, 2007, Pages 3578-3587

  Oberle, Nina ^a   Eberhardt, Nadine ^a   Falk, Christine S ^a   Krammer, Peter H ^a   Suri Payer, Elisabeth ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FORKHEAD TRANSCRIPTION FACTOR; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; PROTEIN FOXJ1; REPRESSOR OF GATA; REPRESSOR PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; SUPPRESSOR OF CYTOKINE SIGNALING 3; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; CYTOKINE; FOXP3 PROTEIN, HUMAN; LYMPHOCYTE ANTIGEN RECEPTOR; MESSENGER RNA;

ARTICLE; CD4+ T LYMPHOCYTE; CELL FUNCTION; CLONAL ANERGY; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INDUCIBLE CAMP EARLY REPRESSOR GENE; LYMPHOCYTE ACTIVATION GENE 3; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INDUCTION; REGULATORY T LYMPHOCYTE; REPRESSOR GENE; SIGNAL TRANSDUCTION; TH1 CELL; TH2 CELL; TRANSDUCER OF ERBB2 2 GENE; UPREGULATION; ADULT; BIOSYNTHESIS; CELL CULTURE; CLASSIFICATION; COCULTURE; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; IMMUNOPHENOTYPING; METABOLISM; PHYSIOLOGY;

ADULT; CELLS, CULTURED; CLONAL ANERGY; COCULTURE TECHNIQUES; CYTOKINES; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; HUMANS; IMMUNE TOLERANCE; IMMUNOPHENOTYPING; INTERLEUKIN-2; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; RECEPTORS, ANTIGEN, T-CELL; RNA, MESSENGER; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

EID: 35748965021     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.6.3578     Document Type: Article

References (52)

1. + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22: 531-562.
2. Zou, W. 2006. Regulatory T cells, tumor immunity and immunotherapy. Nat. Rev. Immunol. 6: 295-307.
3. Izcue, A., J. L. Coombes, and F. Powrie. 2006. Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation. Immunol. Rev. 212: 256-271.
4. Shevach, E. M., R. S. McHugh, A. M. Thornton, C. Piccirillo, K. Natarajan, and D. H. Margulies. 2001. Control of autoimmunity by regulatory T cells. Adv. Exp. Med. Biol. 490: 21-32.
5. Suri-Payer, E., and B. Fritzsching. 2006. Regulatory T cells in experimental autoimmune disease. Springer Semin. Immunopathol. 28: 3-16.
6. Baecher-Allan, C., and D. A. Hafler. 2006. Human regulatory T cells and their role in autoimmune disease. Immunol. Rev. 212: 203-216.
7. + regulatory T cells can mediate suppressor function in the absence of transforming growth factor β1 production and responsiveness. J. Exp. Med. 196: 237-246.
8. + regulatory T cell activity in both humans and mice. J. Immunol. 172: 834-842.
9. +. Nat. Med. 12: 627-635.
10. + T cell suppressor function. Eur. J. Immunol. 34: 366-376.
11. + regulatory T cell function. Eur. J. Immunol. 34: 2480-2488.
12. + T cells for IL-2 and exploit it for the induction of IL-10 production. Int. Immunol. 17: 279-288.
13. + T cell suppressor function. J. Immunol. 172: 6519-6523.
14. + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2: 389-400.
15. Mueller, D. L. 2004. E3 ubiquitin ligases as T cell anergy factors. Nat. Immunol. 5: 883-890.
16. Yusuf, I., and D. A. Fruman. 2003. Regulation of quiescence in lymphocytes. Trends Immunol. 24: 380-386.
17. high regulatory cells in human peripheral blood. J. Immunol. 167: 1245-1253.
18. + regulatory T cells are highly susceptible to CD95 ligand-but not to TCR-mediated cell death. J. Immunol. 175: 32-36.
19. + regulatory T cells. J. Immunol. 177: 6952-6961.
20. + regulatory cells involves a granzyme B-dependent, perforin-independent mechanism. J. Immunol. 174: 1783-1786.
21. Grossman, W. J., J. W. Verbsky, W. Barchet, M. Colonna, J. P. Atkinson, and T. J. Ley. 2004. Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity 21: 589-601.
22. Li, M. O., Y. Y. Wan, S. Sanjabi, A. K. Robertson, and R. A. Flavell. 2006. Transforming growth factor-β regulation of immune responses. Annu. Rev. Immunol. 24: 99-146.
23. + T cells is facilitated by CTLA-4 signaling. J. Immunol. 177: 2331-2339.
24. Rudensky, A. Y., M. Gavin, and Y. Zheng. 2006. FOXP3 and NFAT: partners in tolerance. Cell 126: 253-256.
25. Lin, L., M. S. Spoor, A. J. Gerth, S. L. Brody, and S. L. Peng. 2004. Modulation of Th1 activation and inflammation by the NF-κB repressor Foxj1. Science 303: 1017-1020.
26. Okochi, K., T. Suzuki, J. Inoue, S. Matsuda, and T. Yamamoto. 2005. Interaction of anti-proliferative protein Tob with poly(A)-binding protein and inducible poly(A)-binding protein: implication of Tob in translational control. Genes Cells 10: 151-163.
27. Tzachanis, D., G. J. Freeman, N. Hirano, A. A. van Puijenbroek, M. W. Delfs, A. Berezovskaya, L. M. Nadler, and V. A. Boussiotis. 2001. Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells. Nat. Immunol. 2: 1174-1182.
28. + T cells. Immunity 18: 535-547.
29. + T cells facilitate the induction of T cell anergy. J. Immunol. 167: 4271-4275.
30. Bodor, J., L. Feigenbaum, J. Bodorova, C. Bare, M. S. Reitz, Jr., and R. E. Gress. 2001. Suppression of T-cell responsiveness by inducible cAMP early repressor (ICER). J. Leukocyte Biol. 69: 1053-1059.
31. Kang, B. Y., S. C. Miaw, and I. C. Ho. 2005. ROG negatively regulates T-cell activation but is dispensable for Th-cell differentiation. Mol. Cell. Biol. 25: 554-562.
32. Hannier, S., M. Tournier, G. Bismuth, and F. Triebel. 1998. CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling. J. Immunol. 161: 4058-4065.
33. Workman, C. J., L. S. Cauley, I. J. Kim, M. A. Blackman, D. L. Woodland, and D. A. Vignali. 2004. Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo. J. Immunol. 172: 5450-5455.
34. Huang, C. T., C. J. Workman, D. Flies, X. Pan, A. L. Marson, G. Zhou, E. L. Hipkiss, S. Ravi, J. Kowalski, H. I. Levitsky, et al. 2004. Role of LAG-3 in regulatory T cells. Immunity 21: 503-513.
35. Li, N., Y. Wang, K. Forbes, K. M. Vignali, B. S. Heale, P. Saftig, D. Hartmann, R. A. Black, J. J. Rossi, C. P. Blobel, et al. 2007. Metalloproteases regulate T-cell proliferation and effector function via LAG-3. EMBO J. 26: 494-504.
36. Avice, M. N., M. Sarfati, F. Triebel, G. Delespesse, and C. E. Demeure. 1999. Lymphocyte activation gene-3, a MHC class II ligand expressed on activated T cells, stimulates TNF-α and IL-12 production by monocytes and dendritic cells. J. Immunol. 162: 2748-2753.
37. Kubo, M., T. Hanada, and A. Yoshimura. 2003. Suppressors of cytokine signaling and immunity. Nat. Immunol. 4: 1169-1176.
38. Matsumoto, A., Y. Seki, R. Watanabe, K. Hayashi, J. A. Johnston, Y. Harada, R. Abe, A. Yoshimura, and M. Kubo. 2003. A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production. J. Exp. Med. 197: 425-436.
39. Banerjee, A., A. S. Banks, M. C. Nawijn, X. P. Chen, and P. B. Rothman. 2002. Cutting edge: suppressor of cytokine signaling 3 inhibits activation of NFATp. J. Immunol. 168: 4277-4281.
40. Cohney, S. J., D. Sanden, N. A. Cacalano, A. Yoshimura, A. Mui, T. S. Migone, and J. A. Johnston. 1999. SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation. Mol. Cell. Biol. 19: 4980-4988.
41. + T helper cells. J. Exp. Med. 196: 255-260.
42. +high regulatory T cell function. J. Immunol. 169: 6210-6217.
43. + regulatory T cell activity. J. Immunol. 175: 7274-7280.
44. Malek, T. R., A. Yu, V. Vincek, P. Scibelli, and L. Kong. 2002. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rβ-deficient mice: implications for the nonredundant function of IL-2. Immunity 17: 167-178.
45. +-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood 105: 750-758.
46. + T suppressor cell clones produce transforming growth factor β, but not interleukin 10, and are distinct from type 1 T regulatory cells. J. Exp. Med. 196: 1335-1346.
47. Chen, M. L., M. J. Pittet, L. Gorelik, R. A. Flavell, R. Weissleder, H. von Boehmer, and K. Khazaie. 2005. Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals in vivo. Proc. Natl. Acad. Sci. USA 102: 419-424.
48. + T regulatory cells inhibit neutrophil function and promote their apoptosis and death. J. Immunol. 177: 7155-7163.
49. +. J. Clin. Invest. 112: 1437-1443.
50. Mantel, P. Y., N. Ouaked, B. Ruckert, C. Karagiannidis, R. Welz, K. Blaser, and C. B. Schmidt-Weber. 2006. Molecular mechanisms underlying FOXP3 induction in human T cells. J. Immunol. 176: 3593-3602.
51. Gavin, M. A., T. R. Torgerson, E. Houston, P. DeRoos, W. Y. Ho, A. Stray-Pedersen, E. L. Ocheltree, P. D. Greenberg, H. D. Ochs, and A. Y. Rudensky. 2006. Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc. Natl. Acad. Sci. USA 103: 6659-6664.
52. + regulatory T cells. Int. Immunol. 16: 1643-1656.