Promotion of allograft survival by CD4+CD25+ regulatory T cells: Evidence for in vivo inhibition of effector cell proliferation

Journal of Immunology

Volumn 172, Issue 11, 2004, Pages 6539-6544

  Lee IV, Major K ^a   Moore, Daniel J ^a   Jarrett, Beth P ^a   Lian, Moh Moh ^a   Deng, Shaoping ^a   Huang, Xiaolun ^a   Markmann, Joseph W ^a   Chiaccio, Meredith ^a   Barker, Clyde F ^a   Caton, Andrew J ^b   Markmann, James F ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b WISTAR INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR; T LYMPHOCYTE RECEPTOR;

ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; CELL ACTIVITY; CONTROLLED STUDY; EFFECTOR CELL; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNE RESPONSE; IMMUNOCOMPETENCE; IMMUNOLOGICAL TOLERANCE; IN VIVO STUDY; LYMPH NODE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN GRAFT; T LYMPHOCYTE; TRANSGENIC MOUSE; TRANSPLANTATION TOLERANCE;

EID: 2442641572     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.11.6539     Document Type: Article

References (46)

1. Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1151.
2. Asano, M., M. Toda, N. Sakaguchi, and S. Sakaguchi. 1996. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184:387.
3. + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J. Immunol. 160:1212.
4. + regulatory cells that control intestinal inflammation. J. Exp. Med. 192:295.
5. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 10:1969.
6. + T cell responses to a self peptide. Eur. J. Immunol. 30:136.
7. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:287.
8. + T cells: a highly differentiated and apoptosis-prone population. Eur. J. Immunol. 31:1122.
9. + thymoctyes and peripheral T cells have immune suppressive activity. Eur. J. Immunol. 31:1247.
10. + T cells with regulatory properties isolated from peripheral blood. J. Exp. Med. 193:1285.
11. + T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation. Int. Immunol. 12:1145.
12. + regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses. J. Immunol. 168:1080.
13. - regulatory cells mediate dominant transplantation tolerance. J. Immunol. 168:5558.
14. Hara, M., C. I. Kingsley, M. Niimi, S. Read, S. E. Turvey, A. R. Bushell, P. J. Morris, F. Powrie, and K. J. Wood. 2001. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J. Immunol. 166:3789.
15. + immunoregulatory CD4 T cells mediate acquired central transplantation tolerance. J. Immunol. 170:279.
16. Bird, J. J., D. R. Brown, A. C. Mullen, N. H. Moskowitz, M. A. Mahowald, J. R. Sider, T. F. Gajewski, C. R. Wang, and S. L. Reiner. 1998. Helper T cell differentiation is controlled by the cell cycle. Immunity 9:229.
17. Gudmundsdottir, H., A. D. Wells, and L. A. Turka. 1999. Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: effector function is linked to proliferative capacity. J. Immunol. 162:5212.
18. + single positive cells with a class II major histocompatibility complex-restricted receptor. J. Exp. Med. 180:2511.
19. Cerasoli, D. M., J. McGrath, S. R. Carding, F. F. Shih, B. B. Knowles, and A. J. Caton. 1995. Low avidity recognition of a class II-restricted neo-self peptide by virus-specific T cells. Int. Immunol. 7:935.
20. Shih, F. F., D. M. Cerasoli, and A. J. Caton. 1997. A major T cell determinant from the influenza virus hemagglutinin (HA) can be a cryptic self peptide in HA transgenic mice. Int. Immunol. 9:249.
21. Billingham, R., and P. Medawar. 1951. The technique of free skin grafting in mammals. J. Exp. Biol. 28:385.
22. Lee, M. K., X. Huang, B. P. Jarrett, D. J. Moore, N. M. Desai, M. M. Lian, J. W. Markmann, S. Deng, A. Frank, A. Singer, et al. 2003. Vulnerability of allografts to rejection by MHC class II restricted T cell receptor transgenic mice. Transplantation 75:1415.
23. + regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2:301.
24. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192:303.
25. + immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 16:311.
26. + regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 3:135.
27. - regulatory T cells. Proc. Natl. Acad. Sci. USA 99:13031.
28. Goldstein, D. R., B. M. Tesar, S. Akira, and F. G. Lakkis. 2003. Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection. J. Clin. Invest. 111:1571.
29. Caramalho, I., T. Lopes-Carvalho, D. Ostler, S. Zelenay, M. Haury, and J. Demengoet. 2003. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J. Exp. Med. 197:403.
30. + T cell-mediated suppression by dendritic cells. Science 299:1033.
31. + T cells in prevention of allograft rejection. Front. Biosci. 8:s968.
32. Sanchez-Fueyo, A., M. Weber, C. Domenig, T. B. Strom, and X. X. Zheng. 2002. Tracking the immunoregulatory mechanisms active during allograft tolerance. J. Immunol. 168:2274.
33. + regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease. J. Immunol. 168:5979.
34. + T cell function but not expansion. Nat. Immunol. 3:1208.
35. + regulatory cells? Immunity 14:399.
36. + immunoregulatory T cells is antigen nonspecific. J. Immunol. 164:183.
37. + regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 182:18.
38. + suppressor T cells in vivo. Nat. Immunol. 3:33.
39. + T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J. Immunol. 166:3008.
40. + regulatory T cells in vivo. J. Exp. Med. 198:249.
41. Graca, L., S. P. Cobbold, and H. Waldmann. 2002. Identification of regulatory T cells in tolerated allografts. J. Exp. Med. 195:1641.
42. Zelenika, D., E. Adams, S. Humm, L. Graca, S. Thompson, S. P. Cobbold, and H. Waldmann. 2002. Regulatory T cells overexpress a subset of Th2 gene transcripts. J. Immunol. 168:1069.
43. Zinkernagel, R. M., S. Ehl, P. Aichele, S. Oehen, T. Kundig, and H. Hengartner. 1997. Antigen localisation regulates immune responses in a dose- and time-dependent fashion: a geographical view of immune reactivity. Immunol. Rev. 156:199.
44. Barker, C. F., and R. E. Billingham. 1968. The role of afferent lymphatics in the rejection of skin homografts. J. Exp. Med. 128:197.
45. Miyawaki, S., Y. Nakamura, H. Suzuka, M. Koba, R. Yasumizu, S. Ikehara, and Y. Shibata. 1994. A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice. Eur. J. Immunol. 24:429.
46. Lakkis, F. G., A. Arakelov, B. T. Konieczny, and Y. Inoue. 2000. Immunologic 'ignorance' of vascularized organ transplants in the absence of secondary lymphoid tissue. Nat. Med. 6:686.