IFN-γ triggered STAT1-PKB/AKT signalling pathway influences the function of alloantigen reactive regulatory T cells

American Journal of Transplantation

Volumn 10, Issue 1, 2010, Pages 69-80

  Wei, B ^a,b   Baker, S ^a   Wieckiewicz, J ^a   Wood, K J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

Akt survival pathway; Allograft survival; Interferon gamma (IFN ); Regulatory T cells; STAT 1

Indexed keywords

ALLOANTIGEN; GAMMA INTERFERON; PROTEIN KINASE B; STAT1 PROTEIN; TRANSCRIPTION FACTOR FOXP3;

ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CONTROLLED STUDY; DENSITOMETRY; DOWN REGULATION; ENZYME ACTIVATION; FLOW CYTOMETRY; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNE RESPONSE; IMMUNOBLOTTING; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION;

ANIMALS; GRAFT REJECTION; IMMUNOSUPPRESSION; INTERFERON-GAMMA; ISOANTIGENS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, IMMUNOLOGICAL; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, INTERFERON; SIGNAL TRANSDUCTION; SKIN TRANSPLANTATION; STAT1 TRANSCRIPTION FACTOR; T-LYMPHOCYTES, REGULATORY; TRANSPLANTATION, HOMOLOGOUS;

EID: 72549089070     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2009.02858.x     Document Type: Article

References (28)

1. Wood KJ, Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat Rev Immunol 2003 3 : 199 210.
2. Kitching AR, Turner AL, Semple T et al. Experimental autoimmune anti-glomerular basement membrane glomerulonephritis: A protective role for IFN-gamma. J Am Soc Nephrol 2004 15 : 1764 1774.
3. Konieczny BT, Dai Z, Elwood ET et al. IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways. J Immunol 1998 160 : 2059 2064.
4. Yu XZ, Albert MH, Martin PJ, Anasetti C. CD28 ligation induces transplantation tolerance by IFN-gamma-dependent depletion of T cells that recognize alloantigens. J Clin Invest 2004 113 : 1624 1630.
5. Williams LM, Rudensky AY. Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat Immunol 2007 8 : 277 284.
6. Kelchtermans H, De Klerck B, Mitera T et al. Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis: An important factor in pathogenesis, counter-regulated by endogenous IFN-gamma. Arthritis Res Ther 2005 7 : R402 R415.
7. Sawitzki B, Kingsley CI, Oliveira V, Karim M, Herber M, Wood KJ. IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo. J Exp Med 2005 201 : 1925 1935.
8. Bach EA, Aguet M, Schreiber RD. The IFN gamma receptor: A paradigm for cytokine receptor signaling. Annu Rev Immunol 1997 15 : 563 591.
9. Ramana CV, Gil MP, Schreiber RD, Stark GR. Stat1-dependent and -independent pathways in IFN-gamma-dependent signaling. Trends Immunol 2002 23 : 96 101.
10. Nishibori T, Tanabe Y, Su L, David M. Impaired development of CD4+ CD25+ regulatory T cells in the absence of STAT1: Increased susceptibility to autoimmune disease. J Exp Med 2004 199 : 25 34.
11. Bensinger SJ, Walsh PT, Zhang J et al. Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. J Immunol 2004 172 : 5287 5296.
12. Haxhinasto S, Mathis D, Benoist C. The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells. J Exp Med 2008 205 : 565 574.
13. Sauer S, Bruno L, Hertweck A et al. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc Natl Acad Sci USA 2008 105 : 7797 7802.
14. Sakaguchi S, Yamaguchi T, Nomura T, Ono M. Regulatory T cells and immune tolerance. Cell 2008 133 : 775 787.
15. Zorn E, Nelson EA, Mohseni M et al. IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. Blood 2006 108 : 1571 1579.
16. Karim M, Feng G, Wood KJ, Bushell AR. CD25+CD4+ regulatory T cells generated by exposure to a model protein antigen prevent allograft rejection: Antigen-specific reactivation in vivo is critical for bystander regulation. Blood 2005 105 : 4871 4877.
17. Kingsley CI, Karim M, Bushell AR, Wood KJ. CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses. J Immunol 2002 168 : 1080 1086.
18. Yang J, Brook MO, Carvalho-Gaspar M et al. Allograft rejection mediated by memory T cells is resistant to regulation. Proc Natl Acad Sci USA 2007 104 : 19954 19959.
19. Frank DA, Mahajan S, Ritz J. Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling. Nat Med 1999 5 : 444 447.
20. Kovarik P, Stoiber D, Novy M, Decker T. Stat1 combines signals derived from IFN-gamma and LPS receptors during macrophage activation. EMBO J 1998 17 : 3660 3668.
21. Wen Z, Zhong Z, Darnell JEJ. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 1995 82 : 241 250.
22. Halupa A, Bailey ML, Huang K, Iscove NN, Levy DE, Barber DL. A novel role for STAT1 in regulating murine erythropoiesis: Deletion of STAT1 results in overall reduction of erythroid progenitors and alters their distribution. Blood 2005 105 : 552 561.
23. Carvalho-Gaspar M, Jones ND, Luo S, Martin L, Brook MO, Wood KJ. Location and time-dependent control of rejection by regulatory T cells culminates in a failure to generate memory T cells. J Immunol 2008 180 : 6640 6648.
24. Hu Y, Hu X, Boumsell L, Ivashkiv LB. IFN-gamma and STAT1 arrest monocyte migration and modulate RAC/CDC42 pathways. J Immunol 2008 180 : 8057 8065.
25. Mellor AL, Munn DH. IDO expression by dendritic cells: Tolerance and tryptophan catabolism. Nat Rev Immunol 2004 4 : 762 774.
26. Jain R, Tartar DM, Gregg RK et al. Innocuous IFNgamma induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production. J Exp Med 2008 205 : 207 218.
27. Harrington LE, Hatton RD, Mangan PR et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005 6 : 1123 1132.
28. Wei B, da Rocha Dias S, Wang H, Rudd CE. CTL-associated antigen-4 ligation induces rapid T cell polarization that depends on phosphatidylinositol 3-kinase, Vav-1, Cdc42, and myosin light chain kinase. J Immunol 2007 179 : 400 408.