Instability of Foxp3 expression limits the ability of induced regulatory T cells to mitigate graft versus host disease

Clinical Cancer Research

Volumn 17, Issue 12, 2011, Pages 3969-3983

  Beres, Amy ^a   Komorowski, Richard ^a   Mihara, Masahiko ^b   Drobyski, William R ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; RETINOIC ACID; TRANSCRIPTION FACTOR FOXP3;

ADOPTIVE TRANSFER; ALLOGENIC BONE MARROW TRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL THERAPY; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE MODEL; DISEASE SEVERITY; EFFECTOR CELL; GRAFT VERSUS HOST REACTION; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE SUBPOPULATION; LYMPHOCYTE TRANSFER; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION;

ANIMALS; ANTIBODIES, BLOCKING; BONE MARROW TRANSPLANTATION; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; GRAFT VS HOST DISEASE; IMMUNOLOGIC FACTORS; INFLAMMATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PHENOTYPE; RECEPTORS, INTERLEUKIN-6; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY; TRETINOIN;

EID: 79959268660     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-10-3347     Document Type: Article

References (47)

1. Wing K, Sakaguchi S. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol 2010;11:7-13.
2. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol 1999;162:5317-26.
3. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor a chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995;160:1151-64.
4. McHugh RS, Whitters MJ, Piccirillo CA, Young DA, Shevach EM, Collins M, et al. CD4+ CD25+ immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoidinduced TNF receptor. Immunity 2002;16:311-23. (Pubitemid 34211969)
5. + regulatory T cells induced by an agonist self-peptide. Nat Immunol 2001;2:301-6.
6. + T cells. Immunity 2006;25: 249-59.
7. - precursors. Am J Transplant 2004;4:1614-27.
8. - T cells through Foxp3 induction and down regulation of Smad7. J Immunol 2004;172:5149-53.
9. + regulatory T cells from human peripheral blood. J Immunol 2001;166:7282-9.
10. + regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003;198:1875-86.
11. + regulatory T cells and for expansion of these cells. J Immunol 2007;178:2018-27.
12. Hill GR, Crawford JM, Cooke KR, Brinson YS, Pan L, Ferrara JL. Total body irradiation and acute graft versus host disease: the role of gastrointestinal damage and inflammatory cytokines. Blood 1997;90:3204-13. (Pubitemid 27444217)
13. Xun CQ, Thompson JS, Jennings CD, Brown SA, Widmer MB. Effect of total body irradiation, busulfan-cyclophosphamide, or cyclophosphamide conditioning on inflammatory cytokine release and development of acute and chronic graft versus host disease in H-2 incompatible transplanted SCID mice. Blood 1994;83:2360-67.
14. Ferrara JL, Reddy P. Pathophysiology of graft versus host disease. Semin Hematol 2006;43:3-10. (Pubitemid 43063330)
15. Miura Y, Thoburn CJ, Bright EC, Phelps ML, Shin T, Matsui EC, et al. Association of Foxp3 regulatory gene expression with graft versus host disease. Blood 2004;104:2187-93. (Pubitemid 39297878)
16. + regulatory T cells in patients with chronic graft versus host disease. Blood 2005;106:2903-11.
17. Rieger K, Loddenkemper C, Maul J, Fietz T, Wolff D, Terpe H, et al. Mucosal Foxp3+ regulatory T cells are numerically deficient in acute and chronic GVHD. Blood 2006;107:1717-23. (Pubitemid 43242414)
18. H17 cells is responsible for the autoimmune-mediated pathology in chronic graft versus host disease. Blood 2007;110:3804-13.
19. Hoffmann P, Ermann J, Edinger M, Fathman CG, Strober S. Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J Exp Med 2002;196:389-99. (Pubitemid 34875667)
20. Edinger M, Hoffmann P, Ermann J, Drago K, Fathman CG, Strober S, Negrin RS. CD4+CD25 +regulatory T cells preserve graft-versustumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med 2003;9:1144-50. (Pubitemid 37173698)
21. + T regulatory cells are potent inhibitors of GVHD and BM graft rejection. Blood 2004;104:3804-12.
22. Nguyen VH, Shashidhar S, Chang DS, Ho L, Kambham N, Bachmann M, et al. The impact of regulatory T cells on T cell immunity following hematopoietic cell transplantation. Blood 2008;111:945-53.
23. Nguyen VH, Zeiser R, Dasilva DL, Chang DS, Beilhack A, Contag CH, et al. In vivo dynamics of regulatory T cell trafficking and survival predict effective strategies to control graft versus host disease following allogeneic transplantation. Blood 2007;109:2649-56.
24. Riley JL, June CH, Blazar BR. Human T regulatory cell therapy: take a billion or so and call me in the morning. Immunity 2009;30:656-5.
25. Selvaraj RK, Geiger TL. A kinetic and dynamic analysis of Foxp3 induced in T cells by TGF-b. J Immunol 2007;178:7767-77.
26. Haribhai D, Lin W, Edwards B, Ziegelbauer J, Salzman NH, Carlson MR, et al. A central role for induced regulatory T cells in tolerance induction in experimental colitis. J Immunol 2009;182:3461-8.
27. + regulatory T cell dependent and independent control of allergic inflammation.Immunity 2008;29:114-26.
28. Chen X, Das R, Komorowski R, Beres A, Hessner MJ, Mihara M, Drobyski WR. Blockade of interleukin 6 signaling augments regulatory T cell reconstitution and attenuates the severity of graft versus host disease. Blood 2009;114:891-900.
29. Haribhai D, Lin W, Relland L, Truong N, Williams CB, Chatila TA. Regulatory T cells dynamically control the primary immune response to foreign antigen. J Immunol 2007;178:2961-72. (Pubitemid 46333175)
30. Das R, Chen X, Komorowski R, Hessner MJ, Drobyski WR. Interleukin 23 secretion by donor antigen presenting cells is critical for organ-specific pathology in graft versus host disease. Blood 2009;113:2352-62.
31. Yang XO, Nurieva R, Martinez GJ, Kang HS, Chung Y, Pappu BP, et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 2008;29:44-56.
32. + T cell lineage differentiation. Immunity 2009;30:646-55.
33. Zhou X, Bailey-Bucktrout SL, Jeker LT, Penaranda C, Martínez- Llordella M, Ashby M, et al. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol 2009;10:1000-7.
34. Schambach F, Schupp M, Lazar MA, Reiner SL. Activation of retinoic acid receptor-a favours regulatory T cell induction at the expense of IL-17-secreting T helper differentiation. Eur J Immunol 2007;37:2396-9. (Pubitemid 47423609)
35. + Treg cell conversion of naïve T cells. Immunity 2009;30:471-2.
36. Hill GR, Crawford JM, Cooke KR, Brinson YS, Pan L, Ferrara JL. Total body irradiation and acute graft versus host disease: the role of gastrointestinal damage and inflammatory cytokines. Blood 1997;90:3204-13. (Pubitemid 27444217)
37. Abu-Ghosh A, Goldman S, Slone V, van de Ven C, Suen Y, Murphy L, et al. Immunological reconstitution and correlation of circulating serum inflammatory mediators/cytokines with the incidence of acute graft versus host disease during the first 100 days following unrelated umbilical cord blood transplantation. Bone Marrow Transplant 1999;24:535-44. (Pubitemid 29423634)
38. Imamura M, Hashino S, Kobayashi H, Kubayashi S, Hirano S, Minagawa T, et al. Serum cytokine levels in bone marrow transplantation: synergistic interaction of interleukin 6, interferon gamma, and tumor necrosis factor alpha in graft versus host disease. Bone Marrow Transplant 1994;13:745-51. (Pubitemid 24195790)
39. - T regulatory cells. Clin Immunol 2009;133:22-6.
40. Brunstein CG, Miller JS, Cao Q, McKenna DH, Hippen KL, Curtsinger J, et al. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood 2011;117:1061-70.
41. H17 conversion by IL-6. J Immunol 2008;180:7112-6.
42. + Treg revert in vivo and do not protect from experimental GVHD. Eur J Immunol 2009;39:3091-6.
43. hi cells. Immunity 2008;29:758-70.
44. Benson MJ, Pino-Lagos K, Rosemblatt M, Noelle RJ. All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J Exp Med 2007;204:1765-74. (Pubitemid 47236315)
45. - T cells. J Immunol 2007; 179:2041-5.
46. Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006;441:235-8.
47. Horwitz DA, Zheng SG, Gray JD. Natural and TGF-B-induced Foxp3+ CD4+ CD25 +regulatory T cells are not mirror images of each other. Trends Immunol 2008;29:429-35.