Reduced exposure to calcineurin inhibitors in renal transplantation

New England Journal of Medicine

Volumn 357, Issue 25, 2007, Pages 2562-2575

  Ekberg, Henrik ^a,n   Tedesco Silva, Helio ^b   Demirbas, Alper ^c   Vítko, Štefan ^d   Nashan, Björn ^e   Gürkan, Alp ^f   Margreiter, Raimund ^g   Hugo, Christian ^h   Grinyó, Josep M ⁱ   Frei, Ulrich ^j   Vanrenterghem, Yves ^k   Daloze, Pierre ^l   Halloran, Philip F ^m  

^a LUND UNIVERSITY   (Sweden)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c AKDENIZ UNIVERSITY   (Turkey)

^d INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE   (Czech Republic)

^e HANNOVER MEDICAL SCHOOL   (Germany)

^f SB Tepecik Hospital   (Turkey)

^g UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

^h UNIVERSITY HOSPITAL ERLANGEN   (Germany)

ⁱ Ciutat Universitaria de Bellvitge   (Spain)

^j CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^k UNIVERSITY OF LEUVEN   (Belgium)

^l NOTRE DAME HOSPITAL   (Canada)

^m UNIVERSITY OF ALBERTA   (Canada)

ⁿ University Hospital   (Sweden)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN INHIBITOR; CORTICOSTEROID; CYCLOSPORIN A; DACLIZUMAB; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; RAPAMYCIN; TACROLIMUS;

ABDOMINAL PAIN; ACUTE GRAFT REJECTION; ADULT; ANEMIA; ARTICLE; CANDIDIASIS; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CYTOMEGALOVIRUS INFECTION; DIABETES MELLITUS; DIARRHEA; DRUG DOSE COMPARISON; DRUG DOSE REDUCTION; DRUG WITHDRAWAL; FEMALE; FEVER; GASTROINTESTINAL TOXICITY; GLOMERULUS FILTRATION RATE; GRAFT SURVIVAL; HEADACHE; HEMATURIA; HERPES; HUMAN; HYPERCHOLESTEROLEMIA; HYPERGLYCEMIA; HYPERLIPIDEMIA; HYPERTENSION; HYPERTRIGLYCERIDEMIA; HYPERURICEMIA; HYPOPHOSPHATEMIA; IMMUNOSUPPRESSIVE TREATMENT; INFESTATION; KAPLAN MEIER METHOD; KIDNEY ALLOGRAFT; KIDNEY ALLOGRAFT REJECTION; KIDNEY FUNCTION; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; LEUKOPENIA; LOW DRUG DOSE; LYMPHOCELE; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; MULTICENTER STUDY; OPPORTUNISTIC INFECTION; ORGAN TRANSPLANTATION; PATIENT COMPLIANCE; PERIPHERAL EDEMA; PNEUMONIA; PRIORITY JOURNAL; PROTEINURIA; RANDOMIZED CONTROLLED TRIAL; RHINOPHARYNGITIS; SIDE EFFECT; TREATMENT FAILURE; TREATMENT OUTCOME; URINARY TRACT INFECTION; VOMITING; WOUND HEALING IMPAIRMENT;

EID: 37349034394     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa067411     Document Type: Article

References (21)

1. Pascual M, Theruvath T, Kawai T, Tolkoff-Rubin N, Cosimi AB. Strategies to improve long-term outcomes after renal transplantation. N Engl J Med 2002;346:580-90.
2. Burdmann EA, Andoh TF, Yu L, Bennett WM. Cyclosporine nephrotoxicity. Semin Nephrol 2003;23:465-76.
3. Curtis JJ. Hypertensinogenic mechanism of the calcineurin inhibitors. Curr Hypertens Rep 2002;4:377-80.
4. 4. Idem. Hypertension following kidney transplantation. Am J Kidney Dis 1994;23:471-5.
5. Kobashigawa JA, Kasiske BL. Hyperlipidemia in solid transplantation. Transplantation 1997;63:331-8.
6. Luke RG. Mechanism of cyclosporine-induced hypertension. Am J Hypertens 1991;4:468-71.
7. Nankivell BJ, Borrows RJ, Fung CL, O'Connell PJ, Chapman JR, Allen RD. Calcineurin inhibitor nephrotoxicity: longitudinal assessment by protocol histology. Transplantation 2004;78:557-65.
8. Webster AC, Woodroffe RC, Taylor RS, Chapman JR, Craig JC. Tacrolimus versus ciclosporin as primary immunosuppression for kidney transplant recipients: meta-analysis and meta-regression of randomised trial data. BMJ 2005;331:810.
9. Margreiter R. Efficacy and safety of tacrolimus compared with ciclosporin microemulsion in renal transplantation: a randomised multicentre study. Lancet 2002;359:741-6.
10. Sperschneider H. A large, multicentre trial to compare the efficacy and safety of tacrolimus with cyclosporine microemulsion following renal transplantation. Transplant Proc 2001;33:1279-81.
11. Groth CG, Bäckman L, Morales JM, et al. Sirolimus (rapamycin)-based therapy in human renal transplantation: similar efficacy and different toxicity compared with cyclosporine. Transplantation 1999;67:1036-42.
12. Kreis H, Cisterne JM, Land W, et al. Sirolimus in association with mycophenolate mofetil induction for the prevention of acute graft rejection in renal allograft recipients. Transplantation 2000;69:1252-60.
13. Dean PG, Lund WJ, Larson TS, et al. Wound-healing complications after kidney transplantation: a prospective, randomized comparison of sirolimus and tacrolimus. Transplantation 2004;77:1555-61.
14. Langer RM, Kahan BD. Incidence, therapy, and consequences of lymphocele after sirolimus-cyclosporine-prednisone immunosuppression in renal transplant recipients. Transplantation 2002;74:804-8.
15. Rosengard BR, Feng S, Alfrey EJ, et al. Report of the Crystal City meeting to maximize the use of organs recovered from the cadaver donor. Am J Transplant 2002;2:701-11.
16. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976;16:31-41.
17. Vincenti F, Ramos E, Brattstrom C, et al. Multicenter trial exploring calcineurin inhibitors avoidance in renal transplantation. Transplantation 2001;71:1282-7.
18. Ekberg H, Grinyó J, Nashan B, et al. Cyclosporine sparing with mycophenolate mofetil, daclizumab and corticosteroids in renal allograft recipients: the CAESAR Study. Am J Transplant 2007;7:560-70.
19. Flechner SM, Kurian SM, Solez K, et al. De novo kidney transplantation without use of calcineurin inhibitors preserves renal structure and function at two years. Am J Transplant 2004;4:1776-85.
20. Association of a Rapamune (sirolimus) containing immunosuppressant regimen with a high rate of acute rejection in de novo renal transplant patients. Markham, ON, Canada: Wyeth Pharmaceuticals, August 18, 2006. (Accessed November 21, 2007 at: http://www.hc-sc.gc.ca/dhp-mps/medeff/advisories-avis/ prof/2006/rapamune_3_hpc-cps_e.html.)
21. Rostaing L, Cantarovich D, Mourad G, et al. Corticosteroid-free immunosuppression with tacrolimus, mycophenolate mofetil, and daclizumab induction in renal transplantation. Transplantation 2005;79:807-14.