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Volumn 33, Issue 10, 2014, Pages 1207-1217

Context-specific regulation of cancer epigenomes by histone and transcription factor methylation

Author keywords

cancer epigenetics; histones; lysine methylation; transcription factors

Indexed keywords

HISTONE; HISTONE DEMETHYLASE; HISTONE METHYLTRANSFERASE; LYSINE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EZH2;

EID: 84895925247     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.87     Document Type: Review
Times cited : (30)

References (173)
  • 1
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • Kouzarides T. Chromatin modifications and their function. Cell 2007; 128: 693-705
    • (2007) Cell , vol.128 , pp. 693-705
    • Kouzarides, T.1
  • 2
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • Jenuwein T, Allis CD. Translating the histone code. Science 2001; 293: 1074-1080
    • (2001) Science , vol.293 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 3
    • 33947315736 scopus 로고    scopus 로고
    • Cancer epigenomics: DNA methylomes and histone-modification maps
    • Esteller M. Cancer epigenomics: DNA methylomes and histone-modification maps. Nat Rev Genet 2007; 8: 286-298
    • (2007) Nat Rev Genet , vol.8 , pp. 286-298
    • Esteller, M.1
  • 4
    • 35848951163 scopus 로고    scopus 로고
    • Covalent modifications of histones during development and disease pathogenesis
    • Bhaumik SR, Smith E, Shilatifard A. Covalent modifications of histones during development and disease pathogenesis. Nat Struct Mol Biol 2007; 14: 1008-1016
    • (2007) Nat Struct Mol Biol , vol.14 , pp. 1008-1016
    • Bhaumik, S.R.1    Smith, E.2    Shilatifard, A.3
  • 5
    • 34249299791 scopus 로고    scopus 로고
    • The complex language of chromatin regulation During transcription
    • Berger SL. The complex language of chromatin regulation During transcription. Nature 2007; 447: 407-412
    • (2007) Nature , vol.447 , pp. 407-412
    • Berger, S.L.1
  • 6
    • 34948839944 scopus 로고    scopus 로고
    • Facultative heterochromatin: Is there a distinctive molecular signature?
    • Trojer P, Reinberg D. Facultative heterochromatin: Is there a distinctive molecular signature?. Mol Cell 2007; 28: 1-13
    • (2007) Mol Cell , vol.28 , pp. 1-13
    • Trojer, P.1    Reinberg, D.2
  • 8
    • 0035282573 scopus 로고    scopus 로고
    • Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
    • Lachner M, O'Carroll D, Rea S, Mechtler K, Jenuwein T. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 2001; 410: 116-120
    • (2001) Nature , vol.410 , pp. 116-120
    • Lachner, M.1    O'Carroll, D.2    Rea, S.3    Mechtler, K.4    Jenuwein, T.5
  • 9
    • 77049099785 scopus 로고    scopus 로고
    • Histone methyltransferases in cancer
    • Albert M, Helin K. Histone methyltransferases in cancer. Semin Cell Dev Biol 2010; 21: 209-220
    • (2010) Semin Cell Dev Biol , vol.21 , pp. 209-220
    • Albert, M.1    Helin, K.2
  • 10
    • 0035839952 scopus 로고    scopus 로고
    • Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins
    • Ayton PM, Cleary ML. Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins. Oncogene 2001; 20: 5695-5707
    • (2001) Oncogene , vol.20 , pp. 5695-5707
    • Ayton, P.M.1    Cleary, M.L.2
  • 11
    • 35548934558 scopus 로고    scopus 로고
    • MLL translocations, histone modifications and leukaemia stem-cell development
    • Krivtsov AV, Armstrong SA. MLL translocations, histone modifications and leukaemia stem-cell development. Nat Rev Cancer 2007; 7: 823-833
    • (2007) Nat Rev Cancer , vol.7 , pp. 823-833
    • Krivtsov, A.V.1    Armstrong, S.A.2
  • 12
    • 55249114697 scopus 로고    scopus 로고
    • The Mll partial tandem duplication: Differential, tissue-specific activity in the presence or absence of the wild-type allele
    • Dorrance AM, Liu S, Chong A, Pulley B, Nemer D, Guimond M et al. The Mll partial tandem duplication: Differential, tissue-specific activity in the presence or absence of the wild-type allele. Blood 2008; 112: 2508-2511
    • (2008) Blood , vol.112 , pp. 2508-2511
    • Dorrance, A.M.1    Liu, S.2    Chong, A.3    Pulley, B.4    Nemer, D.5    Guimond, M.6
  • 13
    • 33749424957 scopus 로고    scopus 로고
    • Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations
    • Dorrance AM, Liu S, Yuan W, Becknell B, Arnoczky KJ, Guimond M et al. Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations. J Clin Invest 2006; 116: 2707-2716
    • (2006) J Clin Invest , vol.116 , pp. 2707-2716
    • Dorrance, A.M.1    Liu, S.2    Yuan, W.3    Becknell, B.4    Arnoczky, K.J.5    Guimond, M.6
  • 14
    • 52649089060 scopus 로고    scopus 로고
    • DNA hypermethylation and epigenetic silencing of the tumor suppressor gene, SLC5A8, in acute myeloid leukemia with the MLL partial tandem duplication
    • Whitman SP, Hackanson B, Liyanarachchi S, Liu S, Rush LJ, Maharry K et al. DNA hypermethylation and epigenetic silencing of the tumor suppressor gene, SLC5A8, in acute myeloid leukemia with the MLL partial tandem duplication. Blood 2008; 112: 2013-2016
    • (2008) Blood , vol.112 , pp. 2013-2016
    • Whitman, S.P.1    Hackanson, B.2    Liyanarachchi, S.3    Liu, S.4    Rush, L.J.5    Maharry, K.6
  • 15
    • 79251629946 scopus 로고    scopus 로고
    • The genetic landscape of the childhood cancer medulloblastoma
    • Parsons DW, Li M, Zhang X, Jones S, Leary RJ, Lin JC et al. The genetic landscape of the childhood cancer medulloblastoma. Science 2011; 331: 435-439
    • (2011) Science , vol.331 , pp. 435-439
    • Parsons, D.W.1    Li, M.2    Zhang, X.3    Jones, S.4    Leary, R.J.5    Lin, J.C.6
  • 17
    • 84863165348 scopus 로고    scopus 로고
    • Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27
    • McCabe MT, Graves AP, Ganji G, Diaz E, Halsey WS, Jiang Y et al. Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27). Proc Natl Acad Sci USA 2012; 109: 2989-2994
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 2989-2994
    • McCabe, M.T.1    Graves, A.P.2    Ganji, G.3    Diaz, E.4    Halsey, W.S.5    Jiang, Y.6
  • 18
    • 75749124332 scopus 로고    scopus 로고
    • Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
    • Morin RD, Johnson NA, Severson TM, Mungall AJ, An J, Goya R et al. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat Genet 2010; 42: 181-185
    • (2010) Nat Genet , vol.42 , pp. 181-185
    • Morin, R.D.1    Johnson, N.A.2    Severson, T.M.3    Mungall, A.J.4    An, J.5    Goya, R.6
  • 19
    • 77955085750 scopus 로고    scopus 로고
    • Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
    • Ernst T, Chase AJ, Score J, Hidalgo-Curtis CE, Bryant C, Jones AV et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat Genet 2010; 42: 722-726
    • (2010) Nat Genet , vol.42 , pp. 722-726
    • Ernst, T.1    Chase, A.J.2    Score, J.3    Hidalgo-Curtis, C.E.4    Bryant, C.5    Jones, A.V.6
  • 20
    • 0141816752 scopus 로고    scopus 로고
    • EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
    • Kleer CG, Cao Q, Varambally S, Shen R, Ota I, Tomlins SA et al. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci USA 2003; 100: 11606-11611
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 11606-11611
    • Kleer, C.G.1    Cao, Q.2    Varambally, S.3    Shen, R.4    Ota, I.5    Tomlins, S.A.6
  • 21
    • 33644765912 scopus 로고    scopus 로고
    • Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer
    • Collett K, Eide GE, Arnes J, Stefansson IM, Eide J, Braaten A et al. Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer. Clin Cancer Res 2006; 12: 1168-1174
    • (2006) Clin Cancer Res , vol.12 , pp. 1168-1174
    • Collett, K.1    Eide, G.E.2    Arnes, J.3    Stefansson, I.M.4    Eide, J.5    Braaten, A.6
  • 22
    • 29344439946 scopus 로고    scopus 로고
    • Expression levels of the EZH2 polycomb transcriptional repressor correlate with aggressiveness and invasive potential of bladder carcinomas
    • Weikert S, Christoph F, Kollermann J, Muller M, Schrader M, Miller K et al. Expression levels of the EZH2 polycomb transcriptional repressor correlate with aggressiveness and invasive potential of bladder carcinomas. Int J Mol Med 2005; 16: 349-353
    • (2005) Int J Mol Med , vol.16 , pp. 349-353
    • Weikert, S.1    Christoph, F.2    Kollermann, J.3    Muller, M.4    Schrader, M.5    Miller, K.6
  • 23
    • 33646596977 scopus 로고    scopus 로고
    • The gene for polycomb group protein enhancer of zeste homolog 2 (EZH2) is amplified in late-stage prostate cancer
    • Saramaki OR, Tammela TL, Martikainen PM, Vessella RL, Visakorpi T. The gene for polycomb group protein enhancer of zeste homolog 2 (EZH2) is amplified in late-stage prostate cancer. Genes Chromosomes Cancer 2006; 45: 639-645
    • (2006) Genes Chromosomes Cancer , vol.45 , pp. 639-645
    • Saramaki, O.R.1    Tammela, T.L.2    Martikainen, P.M.3    Vessella, R.L.4    Visakorpi, T.5
  • 24
    • 58149239686 scopus 로고    scopus 로고
    • Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer
    • Varambally S, Cao Q, Mani RS, Shankar S, Wang X, Ateeq B et al. Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science 2008; 322: 1695-1699
    • (2008) Science , vol.322 , pp. 1695-1699
    • Varambally, S.1    Cao, Q.2    Mani, R.S.3    Shankar, S.4    Wang, X.5    Ateeq, B.6
  • 26
    • 33644822360 scopus 로고    scopus 로고
    • EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast
    • Bachmann IM, Halvorsen OJ, Collett K, Stefansson IM, Straume O, Haukaas SA et al. EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast. J Clin Oncol 2006; 24: 268-273
    • (2006) J Clin Oncol , vol.24 , pp. 268-273
    • Bachmann, I.M.1    Halvorsen, O.J.2    Collett, K.3    Stefansson, I.M.4    Straume, O.5    Haukaas, S.A.6
  • 27
    • 0035877978 scopus 로고    scopus 로고
    • Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma
    • van Kemenade FJ, Raaphorst FM, Blokzijl T, Fieret E, Hamer KM, Satijn DP et al. Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma. Blood 2001; 97: 3896-3901
    • (2001) Blood , vol.97 , pp. 3896-3901
    • Van Kemenade, F.J.1    Raaphorst, F.M.2    Blokzijl, T.3    Fieret, E.4    Hamer, K.M.5    Satijn, D.P.6
  • 28
    • 61349112251 scopus 로고    scopus 로고
    • MYC stimulates EZH2 expression by repression of its negative regulator miR-26a
    • Sander S, Bullinger L, Klapproth K, Fiedler K, Kestler HA, Barth TF et al. MYC stimulates EZH2 expression by repression of its negative regulator miR-26a. Blood 2008; 112: 4202-4212
    • (2008) Blood , vol.112 , pp. 4202-4212
    • Sander, S.1    Bullinger, L.2    Klapproth, K.3    Fiedler, K.4    Kestler, H.A.5    Barth, T.F.6
  • 29
    • 41349104897 scopus 로고    scopus 로고
    • Enhancer of zeste homolog 2 downregulates E-cadherin by mediating histone H3 methylation in gastric cancer cells
    • Fujii S, Ochiai A. Enhancer of zeste homolog 2 downregulates E-cadherin by mediating histone H3 methylation in gastric cancer cells. Cancer Sci 2008; 99: 738-746
    • (2008) Cancer Sci , vol.99 , pp. 738-746
    • Fujii, S.1    Ochiai, A.2
  • 30
    • 34548645031 scopus 로고    scopus 로고
    • Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas
    • Kondo Y, Shen L, Suzuki S, Kurokawa T, Masuko K, Tanaka Y et al. Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas. Hepatol Res 2007; 37: 974-983
    • (2007) Hepatol Res , vol.37 , pp. 974-983
    • Kondo, Y.1    Shen, L.2    Suzuki, S.3    Kurokawa, T.4    Masuko, K.5    Tanaka, Y.6
  • 31
    • 0035883090 scopus 로고    scopus 로고
    • A novel gene NSD1 is fused to NUP98 in the t(5;11)(q35;p15.5) in De novo childhood acute myeloid leukemia
    • Jaju RJ, Fidler C, Haas OA, Strickson AJ, Watkins F, Clark K et al. A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in De novo childhood acute myeloid leukemia. Blood 2001; 98: 1264-1267
    • (2001) Blood , vol.98 , pp. 1264-1267
    • Jaju, R.J.1    Fidler, C.2    Haas, O.A.3    Strickson, A.J.4    Watkins, F.5    Clark, K.6
  • 32
    • 10744231835 scopus 로고    scopus 로고
    • Frequency of NUP98-NSD1 fusion transcript in childhood acute myeloid leukaemia
    • Cerveira N, Correia C, Doria S, Bizarro S, Rocha P, Gomes P et al. Frequency of NUP98-NSD1 fusion transcript in childhood acute myeloid leukaemia. Leukemia 2003; 17: 2244-2247
    • (2003) Leukemia , vol.17 , pp. 2244-2247
    • Cerveira, N.1    Correia, C.2    Doria, S.3    Bizarro, S.4    Rocha, P.5    Gomes, P.6
  • 33
    • 22544456244 scopus 로고    scopus 로고
    • Genotypephenotype associations in Sotos syndrome: An analysis of 266 individuals with NSD1 aberrations
    • Tatton-Brown K, Douglas J, Coleman K, Baujat G, Cole TR, Das S et al. Genotypephenotype associations in Sotos syndrome: An analysis of 266 individuals with NSD1 aberrations. Am J Hum Genet 2005; 77: 193-204
    • (2005) Am J Hum Genet , vol.77 , pp. 193-204
    • Tatton-Brown, K.1    Douglas, J.2    Coleman, K.3    Baujat, G.4    Cole, T.R.5    Das, S.6
  • 34
    • 76049084596 scopus 로고    scopus 로고
    • Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma
    • Berdasco M, Ropero S, Setien F, Fraga MF, Lapunzina P, Losson R et al. Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma. Proc Natl Acad Sci USA 2009; 106: 21830-21835
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 21830-21835
    • Berdasco, M.1    Ropero, S.2    Setien, F.3    Fraga, M.F.4    Lapunzina, P.5    Losson, R.6
  • 35
    • 58949087354 scopus 로고    scopus 로고
    • MMSET is overexpressed in cancers: Link with tumor aggressiveness
    • Kassambara A, Klein B, Moreaux J. MMSET is overexpressed in cancers: Link with tumor aggressiveness. Biochem Biophys Res Commun 2009; 379: 840-845
    • (2009) Biochem Biophys Res Commun , vol.379 , pp. 840-845
    • Kassambara, A.1    Klein, B.2    Moreaux, J.3
  • 36
    • 79955506975 scopus 로고    scopus 로고
    • The histone methyltransferase and putative oncoprotein MMSET is overexpressed in a large variety of human tumors
    • Hudlebusch HR, Santoni-Rugiu E, Simon R, Ralfkiaer E, Rossing HH, Johansen JV et al. The histone methyltransferase and putative oncoprotein MMSET is overexpressed in a large variety of human tumors. Clin Cancer Res 2011; 17: 2919-2933
    • (2011) Clin Cancer Res , vol.17 , pp. 2919-2933
    • Hudlebusch, H.R.1    Santoni-Rugiu, E.2    Simon, R.3    Ralfkiaer, E.4    Rossing, H.H.5    Johansen, J.V.6
  • 37
    • 0030922231 scopus 로고    scopus 로고
    • Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3
    • Chesi M, Nardini E, Brents LA, Schrock E, Ried T, Kuehl WM et al. Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3. Nat Genet 1997; 16: 260-264
    • (1997) Nat Genet , vol.16 , pp. 260-264
    • Chesi, M.1    Nardini, E.2    Brents, L.A.3    Schrock, E.4    Ried, T.5    Kuehl, W.M.6
  • 38
    • 0033887241 scopus 로고    scopus 로고
    • Detection of t(4;14)(p16.3;q32) chromosomal translocation in multiple myeloma by reverse transcription-polymerase chain reaction analysis of IGH-MMSET fusion transcripts
    • Malgeri U, Baldini L, Perfetti V, Fabris S, Vignarelli MC, Colombo G et al. Detection of t(4;14)(p16.3;q32) chromosomal translocation in multiple myeloma by reverse transcription-polymerase chain reaction analysis of IGH-MMSET fusion transcripts. Cancer Res 2000; 60: 4058-4061
    • (2000) Cancer Res , vol.60 , pp. 4058-4061
    • Malgeri, U.1    Baldini, L.2    Perfetti, V.3    Fabris, S.4    Vignarelli, M.C.5    Colombo, G.6
  • 39
    • 0037093259 scopus 로고    scopus 로고
    • NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)( p11.2;p15
    • Rosati R, La Starza R, Veronese A, Aventin A, Schwienbacher C, Vallespi T et al. NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15). Blood 2002; 99: 3857-3860
    • (2002) Blood , vol.99 , pp. 3857-3860
    • Rosati, R.1    La Starza, R.2    Veronese, A.3    Aventin, A.4    Schwienbacher, C.5    Vallespi, T.6
  • 40
    • 0035872769 scopus 로고    scopus 로고
    • NSD3 a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines
    • Angrand PO, Apiou F, Stewart AF, Dutrillaux B, Losson R, Chambon P. NSD3 a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines. Genomics 2001; 74: 79-88
    • (2001) Genomics , vol.74 , pp. 79-88
    • Angrand, P.O.1    Apiou, F.2    Stewart, A.F.3    Dutrillaux, B.4    Losson, R.5    Chambon, P.6
  • 41
    • 77953170322 scopus 로고    scopus 로고
    • Histone methyltransferase gene SETD2 is a novel tumor suppressor gene in clear cell renal cell carcinoma
    • Duns G, van Den Berg E, van Duivenbode I, Osinga J, Hollema H, Hofstra RM et al. Histone methyltransferase gene SETD2 is a novel tumor suppressor gene in clear cell renal cell carcinoma. Cancer Res 2010; 70: 4287-4291
    • (2010) Cancer Res , vol.70 , pp. 4287-4291
    • Duns, G.1    Van Den Berg, E.2    Van Duivenbode, I.3    Osinga, J.4    Hollema, H.5    Hofstra, R.M.6
  • 42
    • 75149188170 scopus 로고    scopus 로고
    • Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
    • Dalgliesh GL, Furge K, Greenman C, Chen L, Bignell G, Butler A et al. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature 2010; 463: 360-363
    • (2010) Nature , vol.463 , pp. 360-363
    • Dalgliesh, G.L.1    Furge, K.2    Greenman, C.3    Chen, L.4    Bignell, G.5    Butler, A.6
  • 43
    • 17944380227 scopus 로고    scopus 로고
    • Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability
    • Peters AH, O'Carroll D, Scherthan H, Mechtler K, Sauer S, Schofer C et al. Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Cell 2001; 107: 323-337
    • (2001) Cell , vol.107 , pp. 323-337
    • Peters, A.H.1    O'Carroll, D.2    Scherthan, H.3    Mechtler, K.4    Sauer, S.5    Schofer, C.6
  • 44
    • 63449115501 scopus 로고    scopus 로고
    • Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma
    • Northcott PA, Nakahara Y, Wu X, Feuk L, Ellison DW, Croul S et al. Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. Nat Genet 2009; 41: 465-472
    • (2009) Nat Genet , vol.41 , pp. 465-472
    • Northcott, P.A.1    Nakahara, Y.2    Wu, X.3    Feuk, L.4    Ellison, D.W.5    Croul, S.6
  • 45
    • 79953056443 scopus 로고    scopus 로고
    • The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset
    • Ceol CJ, Houvras Y, Jane-Valbuena J, Bilodeau S, Orlando DA, Battisti V et al. The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset. Nature 2011; 471: 513-517
    • (2011) Nature , vol.471 , pp. 513-517
    • Ceol, C.J.1    Houvras, Y.2    Jane-Valbuena, J.3    Bilodeau, S.4    Orlando, D.A.5    Battisti, V.6
  • 46
    • 42549092622 scopus 로고    scopus 로고
    • Gene expression profiling in hepatocellular carcinoma: Upregulation of genes in amplified chromosome regions
    • Skawran B, Steinemann D, Weigmann A, Flemming P, Becker T, Flik J et al. Gene expression profiling in hepatocellular carcinoma: Upregulation of genes in amplified chromosome regions. Mod Pathol 2008; 21: 505-516
    • (2008) Mod Pathol , vol.21 , pp. 505-516
    • Skawran, B.1    Steinemann, D.2    Weigmann, A.3    Flemming, P.4    Becker, T.5    Flik, J.6
  • 47
    • 67650102336 scopus 로고    scopus 로고
    • Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous cell carcinoma
    • Komatsu S, Imoto I, Tsuda H, Ki Kozaki, Muramatsu T, Shimada Y et al. Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous cell carcinoma. Carcinogenesis 2009; 30: 1139-1146
    • (2009) Carcinogenesis , vol.30 , pp. 1139-1146
    • Komatsu, S.1    Imoto, I.2    Tsuda, H.3    Ki Kozak, I.4    Muramatsu, T.5    Shimada, Y.6
  • 48
    • 4143074854 scopus 로고    scopus 로고
    • SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells
    • Hamamoto R, Furukawa Y, Morita M, Iimura Y, Silva FP, Li M et al. SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. Nat Cell Biol 2004; 6: 731-740
    • (2004) Nat Cell Biol , vol.6 , pp. 731-740
    • Hamamoto, R.1    Furukawa, Y.2    Morita, M.3    Iimura, Y.4    Silva, F.P.5    Li, M.6
  • 50
    • 65949117245 scopus 로고    scopus 로고
    • Identification of Smyd4 as a potential tumor suppressor gene involved in breast cancer development
    • Hu L, Zhu YT, Qi C, Zhu YJ. Identification of Smyd4 as a potential tumor suppressor gene involved in breast cancer development. Cancer Res 2009; 69: 4067-4072
    • (2009) Cancer Res , vol.69 , pp. 4067-4072
    • Hu, L.1    Zhu, Y.T.2    Qi, C.3    Zhu, Y.J.4
  • 51
    • 84863579070 scopus 로고    scopus 로고
    • Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression
    • Takawa M, Cho HS, Hayami S, Toyokawa G, Kogure M, Yamane Y et al. Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression. Cancer Res 2012; 72: 3217-3227
    • (2012) Cancer Res , vol.72 , pp. 3217-3227
    • Takawa, M.1    Cho, H.S.2    Hayami, S.3    Toyokawa, G.4    Kogure, M.5    Yamane, Y.6
  • 52
    • 17444375685 scopus 로고    scopus 로고
    • Hdot1l links histone methylation to leukemogenesis
    • Okada Y, Feng Q, Lin Y, Jiang Q, Li Y, Coffield VM et al. hDOT1L links histone methylation to leukemogenesis. Cell 2005; 121: 167-178
    • (2005) Cell , vol.121 , pp. 167-178
    • Okada, Y.1    Feng, Q.2    Lin, Y.3    Jiang, Q.4    Li, Y.5    Coffield, V.M.6
  • 54
    • 33748207226 scopus 로고    scopus 로고
    • Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L
    • Okada Y, Jiang Q, Lemieux M, Jeannotte L, Su L, Zhang Y. Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L. Nat Cell Biol 2006; 8: 1017-1024
    • (2006) Nat Cell Biol , vol.8 , pp. 1017-1024
    • Okada, Y.1    Jiang, Q.2    Lemieux, M.3    Jeannotte, L.4    Su, L.5    Zhang, Y.6
  • 55
    • 33646569453 scopus 로고    scopus 로고
    • Mutational analysis of PRDM1 indicates a tumor-suppressor role in Diffuse large B-cell lymphomas
    • Tam W, Gomez M, Chadburn A, Lee JW, Chan WC, Knowles DM. Mutational analysis of PRDM1 indicates a tumor-suppressor role in Diffuse large B-cell lymphomas. Blood 2006; 107: 4090-4100
    • (2006) Blood , vol.107 , pp. 4090-4100
    • Tam, W.1    Gomez, M.2    Chadburn, A.3    Lee, J.W.4    Chan, W.C.5    Knowles, D.M.6
  • 57
    • 46749136860 scopus 로고    scopus 로고
    • MicroRNA-mediated down-regulation of PRDM1/Blimp-1 in Hodgkin/Reed-Sternberg cells: A potential pathogenetic lesion in Hodgkin lymphomas
    • Nie K, Gomez M, Landgraf P, Garcia JF, Liu Y, Tan LH et al. MicroRNA-mediated down-regulation of PRDM1/Blimp-1 in Hodgkin/Reed-Sternberg cells: A potential pathogenetic lesion in Hodgkin lymphomas. Am J Pathol 2008; 173: 242-252
    • (2008) Am J Pathol , vol.173 , pp. 242-252
    • Nie, K.1    Gomez, M.2    Landgraf, P.3    Garcia, J.F.4    Liu, Y.5    Tan, L.H.6
  • 59
    • 0032188763 scopus 로고    scopus 로고
    • RIZ1, but not the alternative RIZ2 product of the same gene, is underexpressed in breast cancer, and forced RIZ1 expression causes G2-M cell cycle arrest and/or apoptosis
    • He L, Yu JX, Liu L, Buyse IM, Wang MS, Yang QC et al. RIZ1, but not the alternative RIZ2 product of the same gene, is underexpressed in breast cancer, and forced RIZ1 expression causes G2-M cell cycle arrest and/or apoptosis. Cancer Res 1998; 58: 4238-4244
    • (1998) Cancer Res , vol.58 , pp. 4238-4244
    • He, L.1    Yu, J.X.2    Liu, L.3    Buyse, I.M.4    Wang, M.S.5    Yang, Q.C.6
  • 60
    • 0035890771 scopus 로고    scopus 로고
    • Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily
    • Du Y, Carling T, Fang W, Piao Z, Sheu JC, Huang S. Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily. Cancer Res 2001; 61: 8094-8099
    • (2001) Cancer Res , vol.61 , pp. 8094-8099
    • Du, Y.1    Carling, T.2    Fang, W.3    Piao, Z.4    Sheu, J.C.5    Huang, S.6
  • 62
    • 0035449997 scopus 로고    scopus 로고
    • Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily
    • Steele-Perkins G, Fang W, Yang XH, Van Gele M, Carling T, Gu J et al. Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily. Genes Dev 2001; 15: 2250-2262
    • (2001) Genes Dev , vol.15 , pp. 2250-2262
    • Steele-Perkins, G.1    Fang, W.2    Yang, X.H.3    Van Gele, M.4    Carling, T.5    Gu, J.6
  • 63
    • 2342564968 scopus 로고    scopus 로고
    • Frequent epigenetic inactivation of RIZ1 by promoter hypermethylation in human gastric carcinoma
    • Oshimo Y, Oue N, Mitani Y, Nakayama H, Kitadai Y, Yoshida K et al. Frequent epigenetic inactivation of RIZ1 by promoter hypermethylation in human gastric carcinoma. Int J Cancer 2004; 110: 212-218
    • (2004) Int J Cancer , vol.110 , pp. 212-218
    • Oshimo, Y.1    Oue, N.2    Mitani, Y.3    Nakayama, H.4    Kitadai, Y.5    Yoshida, K.6
  • 65
    • 54449098519 scopus 로고    scopus 로고
    • Hyper-methylation of RIZ1 tumor suppressor gene is involved in the early tumorigenesis of hepatocellular carcinoma
    • Piao GH, Piao WH, He Y, Zhang HH, Wang GQ, Piao Z. Hyper-methylation of RIZ1 tumor suppressor gene is involved in the early tumorigenesis of hepatocellular carcinoma. Histol Histopathol 2008; 23: 1171-1175
    • (2008) Histol Histopathol , vol.23 , pp. 1171-1175
    • Piao, G.H.1    Piao, W.H.2    He, Y.3    Zhang, H.H.4    Wang, G.Q.5    Piao, Z.6
  • 66
    • 0032880408 scopus 로고    scopus 로고
    • Decreased RIZ1 expression but not RIZ2 in hepatoma and suppression of hepatoma tumorigenicity by RIZ1
    • Jiang G, Liu L, Buyse IM, Simon D, Huang S. Decreased RIZ1 expression but not RIZ2 in hepatoma and suppression of hepatoma tumorigenicity by RIZ1. Int J Cancer 1999; 83: 541-546
    • (1999) Int J Cancer , vol.83 , pp. 541-546
    • Jiang, G.1    Liu, L.2    Buyse, I.M.3    Simon, D.4    Huang, S.5
  • 67
    • 3042722089 scopus 로고    scopus 로고
    • PRDM5 is silenced in human cancers and has growth suppressive activities
    • Deng Q, Huang S. PRDM5 is silenced in human cancers and has growth suppressive activities. Oncogene 2004; 23: 4903-4910
    • (2004) Oncogene , vol.23 , pp. 4903-4910
    • Deng, Q.1    Huang, S.2
  • 68
    • 34548083307 scopus 로고    scopus 로고
    • PRDM5 identified as a target of epigenetic silencing in colorectal and gastric cancer
    • Watanabe Y, Toyota M, Kondo Y, Suzuki H, Imai T, Ohe-Toyota M et al. PRDM5 identified as a target of epigenetic silencing in colorectal and gastric cancer. Clin Cancer Res 2007; 13: 4786-4794
    • (2007) Clin Cancer Res , vol.13 , pp. 4786-4794
    • Watanabe, Y.1    Toyota, M.2    Kondo, Y.3    Suzuki, H.4    Imai, T.5    Ohe-Toyota, M.6
  • 69
    • 0037766264 scopus 로고    scopus 로고
    • Quantitative PCR identifies a minimal deleted region of 120 kb extending from the Philadelphia chromosome ABL translocation breakpoint in chronic myeloid leukemia with poor outcome
    • Kolomietz E, Marrano P, Yee K, Thai B, Braude I, Kolomietz A et al. Quantitative PCR identifies a minimal deleted region of 120 kb extending from the Philadelphia chromosome ABL translocation breakpoint in chronic myeloid leukemia with poor outcome. Leukemia 2003; 17: 1313-1323
    • (2003) Leukemia , vol.17 , pp. 1313-1323
    • Kolomietz, E.1    Marrano, P.2    Yee, K.3    Thai, B.4    Braude, I.5    Kolomietz, A.6
  • 70
    • 0742272092 scopus 로고    scopus 로고
    • A potential role for PRDM12 in the pathogenesis of chronic myeloid leukaemia with derivative chromosome 9 deletion
    • Reid AG, Nacheva EP. A potential role for PRDM12 in the pathogenesis of chronic myeloid leukaemia with derivative chromosome 9 deletion. Leukemia 2004; 18: 178-180
    • (2004) Leukemia , vol.18 , pp. 178-180
    • Reid, A.G.1    Nacheva, E.P.2
  • 72
    • 18744410349 scopus 로고    scopus 로고
    • ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation
    • Nakamura T, Mori T, Tada S, Krajewski W, Rozovskaia T, Wassell R et al. ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. Mol Cell 2002; 10: 1119-1128
    • (2002) Mol Cell , vol.10 , pp. 1119-1128
    • Nakamura, T.1    Mori, T.2    Tada, S.3    Krajewski, W.4    Rozovskaia, T.5    Wassell, R.6
  • 73
    • 39649084473 scopus 로고    scopus 로고
    • A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification
    • Mueller D, Bach C, Zeisig D, Garcia-Cuellar MP, Monroe S, Sreekumar A et al. A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification. Blood 2007; 110: 4445-4454
    • (2007) Blood , vol.110 , pp. 4445-4454
    • Mueller, D.1    Bach, C.2    Zeisig, D.3    Garcia-Cuellar, M.P.4    Monroe, S.5    Sreekumar, A.6
  • 74
    • 70149123507 scopus 로고    scopus 로고
    • Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10-positive leukemias
    • Lin YH, Kakadia PM, Chen Y, Li YQ, Deshpande AJ, Buske C et al. Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10-positive leukemias. Blood 2009; 114: 651-658
    • (2009) Blood , vol.114 , pp. 651-658
    • Lin, Y.H.1    Kakadia, P.M.2    Chen, Y.3    Li, Y.Q.4    Deshpande, A.J.5    Buske, C.6
  • 75
    • 0037217478 scopus 로고    scopus 로고
    • NSD1 mutations are the major cause of Sotos syndrome and occur in some cases of Weaver syndrome but are rare in other overgrowth phenotypes
    • Douglas J, Hanks S, Temple IK, Davies S, Murray A, Upadhyaya M et al. NSD1 mutations are the major cause of Sotos syndrome and occur in some cases of Weaver syndrome but are rare in other overgrowth phenotypes. Am J Hum Genet 2003; 72: 132-143
    • (2003) Am J Hum Genet , vol.72 , pp. 132-143
    • Douglas, J.1    Hanks, S.2    Temple, I.K.3    Davies, S.4    Murray, A.5    Upadhyaya, M.6
  • 77
    • 78650978001 scopus 로고    scopus 로고
    • The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells
    • Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L et al. The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells. Blood 2011; 117: 211-220
    • (2011) Blood , vol.117 , pp. 211-220
    • Martinez-Garcia, E.1    Popovic, R.2    Min, D.J.3    Sweet, S.M.4    Thomas, P.M.5    Zamdborg, L.6
  • 78
    • 34047272162 scopus 로고    scopus 로고
    • The telomerase reverse transcriptase (hTERT) gene is a direct target of the histone methyltransferase SMYD3
    • Liu C, Fang X, Ge Z, Jalink M, Kyo S, Bjorkholm M et al. The telomerase reverse transcriptase (hTERT) gene is a direct target of the histone methyltransferase SMYD3. Cancer Res 2007; 67: 2626-2631
    • (2007) Cancer Res , vol.67 , pp. 2626-2631
    • Liu, C.1    Fang, X.2    Ge, Z.3    Jalink, M.4    Kyo, S.5    Bjorkholm, M.6
  • 79
    • 67749114645 scopus 로고    scopus 로고
    • Requirement of histone methyltransferase SMYD3 for estrogen receptor-mediated transcription
    • Kim H, Heo K, Kim JH, Kim K, Choi J, An W. Requirement of histone methyltransferase SMYD3 for estrogen receptor-mediated transcription. J Biol Chem 2009; 284: 19867-19877
    • (2009) J Biol Chem , vol.284 , pp. 19867-19877
    • Kim, H.1    Heo, K.2    Kim, J.H.3    Kim, K.4    Choi, J.5    An, W.6
  • 80
  • 81
    • 67650102336 scopus 로고    scopus 로고
    • Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous cell carcinoma
    • Komatsu S, Imoto I, Tsuda H, Kozaki KI, Muramatsu T, Shimada Y et al. Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous cell carcinoma. Carcinogenesis 2009; 30: 1139-1146
    • (2009) Carcinogenesis , vol.30 , pp. 1139-1146
    • Komatsu, S.1    Imoto, I.2    Tsuda, H.3    Kozaki, K.I.4    Muramatsu, T.5    Shimada, Y.6
  • 82
    • 33746832077 scopus 로고    scopus 로고
    • Identification and characterization of Smyd2: A split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex
    • Brown MA, Sims 3rd RJ, Gottlieb PD, Tucker PW. Identification and characterization of Smyd2: A split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex. Mol Cancer 2006; 5: 26
    • (2006) Mol Cancer , vol.5 , pp. 26
    • Brown, M.A.1    Sims III, R.J.2    Gottlieb, P.D.3    Tucker, P.W.4
  • 84
    • 18444392703 scopus 로고    scopus 로고
    • PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin
    • Nishioka K, Rice JC, Sarma K, Erdjument-Bromage H, Werner J, Wang Y et al. PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol Cell 2002; 9: 1201-1213
    • (2002) Mol Cell , vol.9 , pp. 1201-1213
    • Nishioka, K.1    Rice, J.C.2    Sarma, K.3    Erdjument-Bromage, H.4    Werner, J.5    Wang, Y.6
  • 85
    • 0036714189 scopus 로고    scopus 로고
    • Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes
    • Rice JC, Nishioka K, Sarma K, Steward R, Reinberg D, Allis CD. Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes. Genes Dev 2002; 16: 2225-2230
    • (2002) Genes Dev , vol.16 , pp. 2225-2230
    • Rice, J.C.1    Nishioka, K.2    Sarma, K.3    Steward, R.4    Reinberg, D.5    Allis, C.D.6
  • 86
    • 78149423004 scopus 로고    scopus 로고
    • Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation During DNA damage
    • Oda H, Hubner MR, Beck DB, Vermeulen M, Hurwitz J, Spector DL et al. Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation During DNA damage. Mol Cell 2010; 40: 364-376
    • (2010) Mol Cell , vol.40 , pp. 364-376
    • Oda, H.1    Hubner, M.R.2    Beck, D.B.3    Vermeulen, M.4    Hurwitz, J.5    Spector, D.L.6
  • 87
    • 64749106929 scopus 로고    scopus 로고
    • Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development
    • Oda H, Okamoto I, Murphy N, Chu J, Price SM, Shen MM et al. Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development. Mol Cell Biol 2009; 29: 2278-2295
    • (2009) Mol Cell Biol , vol.29 , pp. 2278-2295
    • Oda, H.1    Okamoto, I.2    Murphy, N.3    Chu, J.4    Price, S.M.5    Shen, M.M.6
  • 89
    • 78349272437 scopus 로고    scopus 로고
    • Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression
    • Wu S, Wang W, Kong X, Congdon LM, Yokomori K, Kirschner MW et al. Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression. Genes Dev 2010; 24: 2531-2542
    • (2010) Genes Dev , vol.24 , pp. 2531-2542
    • Wu, S.1    Wang, W.2    Kong, X.3    Congdon, L.M.4    Yokomori, K.5    Kirschner, M.W.6
  • 90
    • 84855340668 scopus 로고    scopus 로고
    • SET8 promotes epithelialmesenchymal transition and confers TWIST dual transcriptional activities
    • Yang F, Sun L, Li Q, Han X, Lei L, Zhang H et al. SET8 promotes epithelialmesenchymal transition and confers TWIST dual transcriptional activities. EMBO J 2012; 31: 110-123
    • (2012) EMBO J , vol.31 , pp. 110-123
    • Yang, F.1    Sun, L.2    Li, Q.3    Han, X.4    Lei, L.5    Zhang, H.6
  • 91
    • 84865687580 scopus 로고    scopus 로고
    • Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery
    • Towbin BD, Gonzalez-Aguilera C, Sack R, Gaidatzis D, Kalck V, Meister P et al. Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery. Cell 2012; 150: 934-947
    • (2012) Cell , vol.150 , pp. 934-947
    • Towbin, B.D.1    Gonzalez-Aguilera, C.2    Sack, R.3    Gaidatzis, D.4    Kalck, V.5    Meister, P.6
  • 93
    • 33947134834 scopus 로고    scopus 로고
    • The polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
    • Bracken AP, Kleine-Kohlbrecher D, Dietrich N, Pasini D, Gargiulo G, Beekman C et al. The polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev 2007; 21: 525-530
    • (2007) Genes Dev , vol.21 , pp. 525-530
    • Bracken, A.P.1    Kleine-Kohlbrecher, D.2    Dietrich, N.3    Pasini, D.4    Gargiulo, G.5    Beekman, C.6
  • 94
    • 33947576177 scopus 로고    scopus 로고
    • Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus
    • Dietrich N, Bracken AP, Trinh E, Schjerling CK, Koseki H, Rappsilber J et al. Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. EMBO J 2007; 26: 1637-1648
    • (2007) EMBO J , vol.26 , pp. 1637-1648
    • Dietrich, N.1    Bracken, A.P.2    Trinh, E.3    Schjerling, C.K.4    Koseki, H.5    Rappsilber, J.6
  • 95
    • 34447125133 scopus 로고    scopus 로고
    • The gene encoding the prostatic tumor suppressor PSP94 is a target for repression by the Polycomb group protein EZH2
    • Beke L, Nuytten M, Van Eynde A, Beullens M, Bollen M. The gene encoding the prostatic tumor suppressor PSP94 is a target for repression by the Polycomb group protein EZH2. Oncogene 2007; 26: 4590-4595
    • (2007) Oncogene , vol.26 , pp. 4590-4595
    • Beke, L.1    Nuytten, M.2    Van Eynde, A.3    Beullens, M.4    Bollen, M.5
  • 96
    • 35748937338 scopus 로고    scopus 로고
    • Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancer
    • Yu J, Cao Q, Mehra R, Laxman B, Tomlins SA, Creighton CJ et al. Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancer. Cancer Cell 2007; 12: 419-431
    • (2007) Cancer Cell , vol.12 , pp. 419-431
    • Yu, J.1    Cao, Q.2    Mehra, R.3    Laxman, B.4    Tomlins, S.A.5    Creighton, C.J.6
  • 97
    • 37349067098 scopus 로고    scopus 로고
    • Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells
    • Lee J, Son MJ, Woolard K, Donin NM, Li A, Cheng CH et al. Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell 2008; 13: 69-80
    • (2008) Cancer Cell , vol.13 , pp. 69-80
    • Lee, J.1    Son, M.J.2    Woolard, K.3    Donin, N.M.4    Li, A.5    Cheng, C.H.6
  • 98
    • 79952766783 scopus 로고    scopus 로고
    • Histone methyltransferase EZH2 induces Akt-dependent genomic instability and BRCA1 inhibition in breast cancer
    • Gonzalez ME, DuPrie ML, Krueger H, Merajver SD, Ventura AC, Toy KA et al. Histone methyltransferase EZH2 induces Akt-dependent genomic instability and BRCA1 inhibition in breast cancer. Cancer Res 2011; 71: 2360-2370
    • (2011) Cancer Res , vol.71 , pp. 2360-2370
    • Gonzalez, M.E.1    DuPrie, M.L.2    Krueger, H.3    Merajver, S.D.4    Ventura, A.C.5    Toy, K.A.6
  • 99
    • 57649124289 scopus 로고    scopus 로고
    • Repression of E-cadherin by the polycomb group protein EZH2 in cancer
    • Cao Q, Yu J, Dhanasekaran SM, Kim JH, Mani RS, Tomlins SA et al. Repression of E-cadherin by the polycomb group protein EZH2 in cancer. Oncogene 2008; 27: 7274-7284
    • (2008) Oncogene , vol.27 , pp. 7274-7284
    • Cao, Q.1    Yu, J.2    Dhanasekaran, S.M.3    Kim, J.H.4    Mani, R.S.5    Tomlins, S.A.6
  • 100
    • 0142105414 scopus 로고    scopus 로고
    • EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer
    • Bracken AP, Pasini D, Capra M, Prosperini E, Colli E, Helin K. EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J 2003; 22: 5323-5335
    • (2003) EMBO J , vol.22 , pp. 5323-5335
    • Bracken, A.P.1    Pasini, D.2    Capra, M.3    Prosperini, E.4    Colli, E.5    Helin, K.6
  • 101
    • 80052222327 scopus 로고    scopus 로고
    • Context-specific regulation of NF-kappaB target gene expression by EZH2 in breast cancers
    • Lee ST, Li Z, Wu Z, Aau M, Guan P, Karuturi RK et al. Context-specific regulation of NF-kappaB target gene expression by EZH2 in breast cancers. Mol Cell 2011; 43: 798-810
    • (2011) Mol Cell , vol.43 , pp. 798-810
    • Lee, S.T.1    Li, Z.2    Wu, Z.3    Aau, M.4    Guan, P.5    Karuturi, R.K.6
  • 102
    • 84871052080 scopus 로고    scopus 로고
    • EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent
    • Xu K, Wu ZJ, Groner AC, He HH, Cai C, Lis RT et al. EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent. Science 2012; 338: 1465-1469
    • (2012) Science , vol.338 , pp. 1465-1469
    • Xu, K.1    Wu, Z.J.2    Groner, A.C.3    He, H.H.4    Cai, C.5    Lis, R.T.6
  • 103
    • 84872269688 scopus 로고    scopus 로고
    • Characterization of the EZH2-MMSET histone methyltransferase regulatory axis in cancer
    • Asangani IA, Ateeq B, Cao Q, Dodson L, Pandhi M, Kunju LP et al. Characterization of the EZH2-MMSET histone methyltransferase regulatory axis in cancer. Mol Cell 2012; 49: 80-93
    • (2012) Mol Cell , vol.49 , pp. 80-93
    • Asangani, I.A.1    Ateeq, B.2    Cao, Q.3    Dodson, L.4    Pandhi, M.5    Kunju, L.P.6
  • 104
    • 80051513341 scopus 로고    scopus 로고
    • An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated selfrenewal program as essential for leukemia maintenance
    • Zuber J, Rappaport AR, Luo W, Wang E, Chen C, Vaseva AV et al. An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated selfrenewal program as essential for leukemia maintenance. Genes Dev 2011; 25: 1628-1640
    • (2011) Genes Dev , vol.25 , pp. 1628-1640
    • Zuber, J.1    Rappaport, A.R.2    Luo, W.3    Wang, E.4    Chen, C.5    Vaseva, A.V.6
  • 105
    • 78049286684 scopus 로고    scopus 로고
    • Histone demethylases in Development and disease
    • Pedersen MT, Helin K. Histone demethylases in Development and disease. Trends Cell Biol 2010; 20: 662-671
    • (2010) Trends Cell Biol , vol.20 , pp. 662-671
    • Pedersen, M.T.1    Helin, K.2
  • 106
    • 68749108259 scopus 로고    scopus 로고
    • LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer
    • Wang Y, Zhang H, Chen Y, Sun Y, Yang F, Yu W et al. LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell 2009; 138: 660-672
    • (2009) Cell , vol.138 , pp. 660-672
    • Wang, Y.1    Zhang, H.2    Chen, Y.3    Sun, Y.4    Yang, F.5    Yu, W.6
  • 107
    • 77950868547 scopus 로고    scopus 로고
    • Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology
    • Lim S, Janzer A, Becker A, Zimmer A, Schule R, Buettner R et al. Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology. Carcinogenesis 2010; 31: 512-520
    • (2010) Carcinogenesis , vol.31 , pp. 512-520
    • Lim, S.1    Janzer, A.2    Becker, A.3    Zimmer, A.4    Schule, R.5    Buettner, R.6
  • 108
    • 78649815150 scopus 로고    scopus 로고
    • Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers
    • Hayami S, Kelly JD, Cho HS, Yoshimatsu M, Unoki M, Tsunoda T et al. Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers. Int J Cancer 2011; 128: 574-586
    • (2011) Int J Cancer , vol.128 , pp. 574-586
    • Hayami, S.1    Kelly, J.D.2    Cho, H.S.3    Yoshimatsu, M.4    Unoki, M.5    Tsunoda, T.6
  • 109
    • 33845762289 scopus 로고    scopus 로고
    • Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence
    • Kahl P, Gullotti L, Heukamp LC, Wolf S, Friedrichs N, Vorreuther R et al. Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence. Cancer Res 2006; 66: 11341-11347
    • (2006) Cancer Res , vol.66 , pp. 11341-11347
    • Kahl, P.1    Gullotti, L.2    Heukamp, L.C.3    Wolf, S.4    Friedrichs, N.5    Vorreuther, R.6
  • 110
    • 62449197931 scopus 로고    scopus 로고
    • Lysinespecific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: Implications for therapy
    • Schulte JH, Lim S, Schramm A, Friedrichs N, Koster J, Versteeg R et al. Lysinespecific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: Implications for therapy. Cancer Res 2009; 69: 2065-2071
    • (2009) Cancer Res , vol.69 , pp. 2065-2071
    • Schulte, J.H.1    Lim, S.2    Schramm, A.3    Friedrichs, N.4    Koster, J.5    Versteeg, R.6
  • 111
    • 73749085827 scopus 로고    scopus 로고
    • H3K4 dimethylation in hepatocellular carcinoma is rare compared with other hepatobiliary and gastrointestinal carcinomas and correlates with expression of the methylase Ash2 and the demethylase LSD1
    • Magerl C, Ellinger J, Braunschweig T, Kremmer E, Koch LK, Holler T et al. H3K4 dimethylation in hepatocellular carcinoma is rare compared with other hepatobiliary and gastrointestinal carcinomas and correlates with expression of the methylase Ash2 and the demethylase LSD1. Hum Pathol 2010; 41: 181-189
    • (2010) Hum Pathol , vol.41 , pp. 181-189
    • Magerl, C.1    Ellinger, J.2    Braunschweig, T.3    Kremmer, E.4    Koch, L.K.5    Holler, T.6
  • 112
    • 36049022778 scopus 로고    scopus 로고
    • Jhdm1b/ fbxl10 is a nucleolar protein that represses transcription of ribosomal rna genes
    • Frescas D, Guardavaccaro D, Bassermann F, Koyama-Nasu R, Pagano M. JHDM1B/ FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes. Nature 2007; 450: 309-313
    • (2007) Nature , vol.450 , pp. 309-313
    • Frescas, D.1    Guardavaccaro, D.2    Bassermann, F.3    Koyama-Nasu, R.4    Pagano, M.5
  • 113
    • 56449126497 scopus 로고    scopus 로고
    • KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state
    • Frescas D, Guardavaccaro D, Kuchay SM, Kato H, Poleshko A, Basrur V et al. KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state. Cell Cycle 2008; 7: 3539-3547
    • (2008) Cell Cycle , vol.7 , pp. 3539-3547
    • Frescas, D.1    Guardavaccaro, D.2    Kuchay, S.M.3    Kato, H.4    Poleshko, A.5    Basrur, V.6
  • 114
    • 41149116609 scopus 로고    scopus 로고
    • Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process
    • Pfau R, Tzatsos A, Kampranis SC, Serebrennikova OB, Bear SE, Tsichlis PN. Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process. Proc Natl Acad Sci USA 2008; 105: 1907-1912
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 1907-1912
    • Pfau, R.1    Tzatsos, A.2    Kampranis, S.C.3    Serebrennikova, O.B.4    Bear, S.E.5    Tsichlis, P.N.6
  • 115
    • 84861574307 scopus 로고    scopus 로고
    • The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene
    • Cho HS, Toyokawa G, Daigo Y, Hayami S, Masuda K, Ikawa N et al. The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene. Int J Cancer 2012; 131: E179-E189
    • (2012) Int J Cancer , vol.131
    • Cho, H.S.1    Toyokawa, G.2    Daigo, Y.3    Hayami, S.4    Masuda, K.5    Ikawa, N.6
  • 116
    • 84855876194 scopus 로고    scopus 로고
    • Histone demethylase JMJD2B is required for tumor cell proliferation and survival and is overexpressed in gastric cancer
    • Li W, Zhao L, Zang W, Liu Z, Chen L, Liu T et al. Histone demethylase JMJD2B is required for tumor cell proliferation and survival and is overexpressed in gastric cancer. Biochem Biophys Res Commun 2011; 416: 372-378
    • (2011) Biochem Biophys Res Commun , vol.416 , pp. 372-378
    • Li, W.1    Zhao, L.2    Zang, W.3    Liu, Z.4    Chen, L.5    Liu, T.6
  • 118
    • 33746332412 scopus 로고    scopus 로고
    • The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3
    • Cloos PA, Christensen J, Agger K, Maiolica A, Rappsilber J, Antal T et al. The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3. Nature 2006; 442: 307-311
    • (2006) Nature , vol.442 , pp. 307-311
    • Cloos, P.A.1    Christensen, J.2    Agger, K.3    Maiolica, A.4    Rappsilber, J.5    Antal, T.6
  • 119
    • 33644670527 scopus 로고    scopus 로고
    • Comprehensive genomic analysis of desmoplastic medulloblastomas: Identification of novel amplified genes and separate evaluation of the different histological components
    • Ehrbrecht A, Muller U, Wolter M, Hoischen A, Koch A, Radlwimmer B et al. Comprehensive genomic analysis of desmoplastic medulloblastomas: Identification of novel amplified genes and separate evaluation of the different histological components. J Pathol 2006; 208: 554-563
    • (2006) J Pathol , vol.208 , pp. 554-563
    • Ehrbrecht, A.1    Muller, U.2    Wolter, M.3    Hoischen, A.4    Koch, A.5    Radlwimmer, B.6
  • 120
    • 33646826162 scopus 로고    scopus 로고
    • Molecular cytogenetic characterization of a metastatic lung sarcomatoid carcinoma: 9p23 neocentromere and 9p23-p24 amplification including JAK2 and JMJD2C
    • Italiano A, Attias R, Aurias A, Perot G, Burel-Vandenbos F, Otto J et al. Molecular cytogenetic characterization of a metastatic lung sarcomatoid carcinoma: 9p23 neocentromere and 9p23-p24 amplification including JAK2 and JMJD2C. Cancer Genet Cytogenet 2006; 167: 122-130
    • (2006) Cancer Genet Cytogenet , vol.167 , pp. 122-130
    • Italiano, A.1    Attias, R.2    Aurias, A.3    Perot, G.4    Burel-Vandenbos, F.5    Otto, J.6
  • 121
    • 77449088946 scopus 로고    scopus 로고
    • The histone demethylase RBP2 Is overexpressed in gastric cancer and its inhibition triggers senescence of cancer cells
    • Zeng J, Ge Z, Wang L, Li Q, Wang N, Bjorkholm M et al. The histone demethylase RBP2 Is overexpressed in gastric cancer and its inhibition triggers senescence of cancer cells. Gastroenterology 2010; 138: 981-992
    • (2010) Gastroenterology , vol.138 , pp. 981-992
    • Zeng, J.1    Ge, Z.2    Wang, L.3    Li, Q.4    Wang, N.5    Bjorkholm, M.6
  • 122
    • 37649023563 scopus 로고    scopus 로고
    • JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer
    • Xiang Y, Zhu Z, Han G, Ye X, Xu B, Peng Z et al. JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer. Proc Natl Acad Sci USA 2007; 104: 19226-19231
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 19226-19231
    • Xiang, Y.1    Zhu, Z.2    Han, G.3    Ye, X.4    Xu, B.5    Peng, Z.6
  • 123
    • 0038748632 scopus 로고    scopus 로고
    • A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer
    • Lu PJ, Sundquist K, Baeckstrom D, Poulsom R, Hanby A, Meier-Ewert S et al. A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer. J Biol Chem 1999; 274: 15633-15645
    • (1999) J Biol Chem , vol.274 , pp. 15633-15645
    • Lu, P.J.1    Sundquist, K.2    Baeckstrom, D.3    Poulsom, R.4    Hanby, A.5    Meier-Ewert, S.6
  • 124
    • 84856955226 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C
    • Niu X, Zhang T, Liao L, Zhou L, Lindner DJ, Zhou M et al. The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C. Oncogene 2012; 31: 776-786
    • (2012) Oncogene , vol.31 , pp. 776-786
    • Niu, X.1    Zhang, T.2    Liao, L.3    Zhou, L.4    Lindner, D.J.5    Zhou, M.6
  • 127
    • 79955470771 scopus 로고    scopus 로고
    • The H3K27me3 demethylase, KDM6B, is induced by Epstein-Barr virus and overexpressed in Hodgkin's Lymphoma
    • Anderton JA, Bose S, Vockerodt M, Vrzalikova K, Wei W, Kuo M et al. The H3K27me3 demethylase, KDM6B, is induced by Epstein-Barr virus and overexpressed in Hodgkin's Lymphoma. Oncogene 2011; 30: 2037-2043
    • (2011) Oncogene , vol.30 , pp. 2037-2043
    • Anderton, J.A.1    Bose, S.2    Vockerodt, M.3    Vrzalikova, K.4    Wei, W.5    Kuo, M.6
  • 128
    • 66149138053 scopus 로고    scopus 로고
    • The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence
    • Agger K, Cloos PA, Rudkjaer L, Williams K, Andersen G, Christensen J et al. The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence. Genes Dev 2009; 23: 1171-1176
    • (2009) Genes Dev , vol.23 , pp. 1171-1176
    • Agger, K.1    Cloos, P.A.2    Rudkjaer, L.3    Williams, K.4    Andersen, G.5    Christensen, J.6
  • 129
    • 11144332565 scopus 로고    scopus 로고
    • Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
    • Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 2004; 119: 941-953
    • (2004) Cell , vol.119 , pp. 941-953
    • Shi, Y.1    Lan, F.2    Matson, C.3    Mulligan, P.4    Whetstine, J.R.5    Cole, P.A.6
  • 130
    • 24144462170 scopus 로고    scopus 로고
    • LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
    • Metzger E, Wissmann M, Yin N, Muller JM, Schneider R, Peters AH et al. LSD1 demethylates repressive histone marks to promote androgen-receptor- dependent transcription. Nature 2005; 437: 436-439
    • (2005) Nature , vol.437 , pp. 436-439
    • Metzger, E.1    Wissmann, M.2    Yin, N.3    Muller, J.M.4    Schneider, R.5    Peters, A.H.6
  • 131
    • 33847392500 scopus 로고    scopus 로고
    • Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptordependent gene expression
    • Wissmann M, Yin N, Muller JM, Greschik H, Fodor BD, Jenuwein T et al. Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptordependent gene expression. Nat Cell Biol 2007; 9: 347-353
    • (2007) Nat Cell Biol , vol.9 , pp. 347-353
    • Wissmann, M.1    Yin, N.2    Muller, J.M.3    Greschik, H.4    Fodor, B.D.5    Jenuwein, T.6
  • 132
    • 80255137124 scopus 로고    scopus 로고
    • Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer
    • Kauffman EC, Robinson BD, Downes MJ, Powell LG, Lee MM, Scherr DS et al. Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer. Mol Carcinog 2011; 50: 931-944
    • (2011) Mol Carcinog , vol.50 , pp. 931-944
    • Kauffman, E.C.1    Robinson, B.D.2    Downes, M.J.3    Powell, L.G.4    Lee, M.M.5    Scherr, D.S.6
  • 133
    • 84864127389 scopus 로고    scopus 로고
    • Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERalpha-dependent and -independent manners
    • Pollock JA, Larrea MD, Jasper JS, McDonnell DP, McCafferty DG. Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERalpha-dependent and -independent manners. ACS Chem Biol 2012; 7: 1221-1231
    • (2012) ACS Chem Biol , vol.7 , pp. 1221-1231
    • Pollock, J.A.1    Larrea, M.D.2    Jasper, J.S.3    McDonnell, D.P.4    McCafferty, D.G.5
  • 134
    • 77953107054 scopus 로고    scopus 로고
    • The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1
    • Lin Y, Wu Y, Li J, Dong C, Ye X, Chi YI et al. The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1. EMBO J 2010; 29: 1803-1816
    • (2010) EMBO J , vol.29 , pp. 1803-1816
    • Lin, Y.1    Wu, Y.2    Li, J.3    Dong, C.4    Ye, X.5    Chi, Y.I.6
  • 135
    • 80155131102 scopus 로고    scopus 로고
    • Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14
    • Li Q, Shi L, Gui B, Yu W, Wang J, Zhang D et al. Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14. Cancer Res 2011; 71: 6899-6908
    • (2011) Cancer Res , vol.71 , pp. 6899-6908
    • Li, Q.1    Shi, L.2    Gui, B.3    Yu, W.4    Wang, J.5    Zhang, D.6
  • 136
    • 55549147132 scopus 로고    scopus 로고
    • The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b
    • He J, Kallin EM, Tsukada Y, Zhang Y. The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b). Nat Struct Mol Biol 2008; 15: 1169-1175
    • (2008) Nat Struct Mol Biol , vol.15 , pp. 1169-1175
    • He, J.1    Kallin, E.M.2    Tsukada, Y.3    Zhang, Y.4
  • 137
    • 62449276460 scopus 로고    scopus 로고
    • Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus
    • Tzatsos A, Pfau R, Kampranis SC, Tsichlis PN. Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus. Proc Natl Acad Sci USA 2009; 106: 2641-2646
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 2641-2646
    • Tzatsos, A.1    Pfau, R.2    Kampranis, S.C.3    Tsichlis, P.N.4
  • 138
    • 66149135288 scopus 로고    scopus 로고
    • Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS
    • Barradas M, Anderton E, Acosta JC, Li S, Banito A, Rodriguez-Niedenfuhr M et al. Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS. Genes Dev 2009; 23: 1177-1182
    • (2009) Genes Dev , vol.23 , pp. 1177-1182
    • Barradas, M.1    Anderton, E.2    Acosta, J.C.3    Li, S.4    Banito, A.5    Rodriguez-Niedenfuhr, M.6
  • 139
    • 79952140358 scopus 로고    scopus 로고
    • Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming
    • McLaughlin-Drubin ME, Crum CP, Munger K. Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming. Proc Natl Acad Sci USA 2011; 108: 2130-2135
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 2130-2135
    • McLaughlin-Drubin, M.E.1    Crum, C.P.2    Munger, K.3
  • 140
    • 1942534675 scopus 로고    scopus 로고
    • Gene-specific modulation of TAF10 function by SET9-mediated methylation
    • Kouskouti A, Scheer E, Staub A, Tora L, Talianidis I. Gene-specific modulation of TAF10 function by SET9-mediated methylation. Mol Cell 2004; 14: 175-182
    • (2004) Mol Cell , vol.14 , pp. 175-182
    • Kouskouti, A.1    Scheer, E.2    Staub, A.3    Tora, L.4    Talianidis, I.5
  • 143
    • 77950642805 scopus 로고    scopus 로고
    • Functional interplay between acetylation and methylation of the RelA subunit of NF-kappaB
    • Yang XD, Tajkhorshid E, Chen LF. Functional interplay between acetylation and methylation of the RelA subunit of NF-kappaB. Mol Cell Biol 2010; 30: 2170-2180
    • (2010) Mol Cell Biol , vol.30 , pp. 2170-2180
    • Yang, X.D.1    Tajkhorshid, E.2    Chen, L.F.3
  • 144
    • 67349285384 scopus 로고    scopus 로고
    • Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit
    • Yang XD, Huang B, Li M, Lamb A, Kelleher NL, Chen LF. Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit. EMBO J 2009; 28: 1055-1066
    • (2009) EMBO J , vol.28 , pp. 1055-1066
    • Yang, X.D.1    Huang, B.2    Li, M.3    Lamb, A.4    Kelleher, N.L.5    Chen, L.F.6
  • 145
    • 73149099403 scopus 로고    scopus 로고
    • Regulation of NF-kappaB activity through lysine monomethylation of p65
    • Ea CK, Baltimore D. Regulation of NF-kappaB activity through lysine monomethylation of p65. Proc Natl Acad Sci USA 2009; 106: 18972-18977
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 18972-18977
    • Ea, C.K.1    Baltimore, D.2
  • 146
    • 78650717706 scopus 로고    scopus 로고
    • Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes
    • Yang J, Huang J, Dasgupta M, Sears N, Miyagi M, Wang B et al. Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes. Proc Natl Acad Sci USA 2010; 107: 21499-21504
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 21499-21504
    • Yang, J.1    Huang, J.2    Dasgupta, M.3    Sears, N.4    Miyagi, M.5    Wang, B.6
  • 147
    • 77958485923 scopus 로고    scopus 로고
    • Cross-talk between post-translational modifications regulate life or death decisions by E2F1
    • Kontaki H, Talianidis I. Cross-talk between post-translational modifications regulate life or death decisions by E2F1. Cell Cycle 2010; 9: 3836-3837
    • (2010) Cell Cycle , vol.9 , pp. 3836-3837
    • Kontaki, H.1    Talianidis, I.2
  • 148
    • 77954274181 scopus 로고    scopus 로고
    • Lysine methylation regulates E2F1-induced cell death
    • Kontaki H, Talianidis I. Lysine methylation regulates E2F1-induced cell death. Mol Cell 2010; 39: 152-160
    • (2010) Mol Cell , vol.39 , pp. 152-160
    • Kontaki, H.1    Talianidis, I.2
  • 149
    • 77951623834 scopus 로고    scopus 로고
    • Lysine methylation regulates the pRb tumour suppressor protein
    • Munro S, Khaire N, Inche A, Carr S, La Thangue NB. Lysine methylation regulates the pRb tumour suppressor protein. Oncogene 2010; 29: 2357-2367
    • (2010) Oncogene , vol.29 , pp. 2357-2367
    • Munro, S.1    Khaire, N.2    Inche, A.3    Carr, S.4    La Thangue, N.B.5
  • 150
    • 78751629039 scopus 로고    scopus 로고
    • Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein
    • Carr SM, Munro S, Kessler B, Oppermann U, La Thangue NB. Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein. EMBO J 2011; 30: 317-327
    • (2011) EMBO J , vol.30 , pp. 317-327
    • Carr, S.M.1    Munro, S.2    Kessler, B.3    Oppermann, U.4    La Thangue, N.B.5
  • 153
    • 79952155998 scopus 로고    scopus 로고
    • Lysine methylation and functional modulation of androgen receptor by Set9 methyltransferase
    • Ko S, Ahn J, Song CS, Kim S, Knapczyk-Stwora K, Chatterjee B. Lysine methylation and functional modulation of androgen receptor by Set9 methyltransferase. Mol Endocrinol 2011; 25: 433-444
    • (2011) Mol Endocrinol , vol.25 , pp. 433-444
    • Ko, S.1    Ahn, J.2    Song, C.S.3    Kim, S.4    Knapczyk-Stwora, K.5    Chatterjee, B.6
  • 154
    • 78650981194 scopus 로고    scopus 로고
    • A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability
    • Esteve PO, Chang Y, Samaranayake M, Upadhyay AK, Horton JR, Feehery GR et al. A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability. Nat Struct Mol Biol 2011; 18: 42-48
    • (2011) Nat Struct Mol Biol , vol.18 , pp. 42-48
    • Esteve, P.O.1    Chang, Y.2    Samaranayake, M.3    Upadhyay, A.K.4    Horton, J.R.5    Feehery, G.R.6
  • 156
    • 58149156264 scopus 로고    scopus 로고
    • The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation
    • Wang J, Hevi S, Kurash JK, Lei H, Gay F, Bajko J et al. The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation. Nat Genet 2009; 41: 125-129
    • (2009) Nat Genet , vol.41 , pp. 125-129
    • Wang, J.1    Hevi, S.2    Kurash, J.K.3    Lei, H.4    Gay, F.5    Bajko, J.6
  • 157
    • 79952124926 scopus 로고    scopus 로고
    • Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1
    • Liu X, Wang D, Zhao Y, Tu B, Zheng Z, Wang L et al. Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1). Proc Natl Acad Sci USA 2011; 108: 1925-1930
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 1925-1930
    • Liu, X.1    Wang, D.2    Zhao, Y.3    Tu, B.4    Zheng, Z.5    Wang, L.6
  • 158
    • 84862777054 scopus 로고    scopus 로고
    • Lysine methylation of FOXO3 regulates oxidative stress-induced neuronal cell death
    • Xie Q, Hao Y, Tao L, Peng S, Rao C, Chen H et al. Lysine methylation of FOXO3 regulates oxidative stress-induced neuronal cell death. EMBO Rep 2012; 13: 371-377
    • (2012) EMBO Rep , vol.13 , pp. 371-377
    • Xie, Q.1    Hao, Y.2    Tao, L.3    Peng, S.4    Rao, C.5    Chen, H.6
  • 160
    • 34547809957 scopus 로고    scopus 로고
    • Modulation of p53 function by SET8-mediated methylation at lysine 382
    • Shi X, Kachirskaia I, Yamaguchi H, West LE, Wen H, Wang EW et al. Modulation of p53 function by SET8-mediated methylation at lysine 382. Mol Cell 2007; 27: 636-646
    • (2007) Mol Cell , vol.27 , pp. 636-646
    • Shi, X.1    Kachirskaia, I.2    Yamaguchi, H.3    West, L.E.4    Wen, H.5    Wang, E.W.6
  • 163
    • 78650308842 scopus 로고    scopus 로고
    • Lysine methylation of the NF-kappaB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-kappaB signaling
    • Levy D, Kuo AJ, Chang Y, Schaefer U, Kitson C, Cheung P et al. Lysine methylation of the NF-kappaB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-kappaB signaling. Nat Immunol 2011; 12: 29-36
    • (2011) Nat Immunol , vol.12 , pp. 29-36
    • Levy, D.1    Kuo, A.J.2    Chang, Y.3    Schaefer, U.4    Kitson, C.5    Cheung, P.6
  • 164
    • 76249100563 scopus 로고    scopus 로고
    • Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65
    • Lu T, Jackson MW, Wang B, Yang M, Chance MR, Miyagi M et al. Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65. Proc Natl Acad Sci USA 2010; 107: 46-51
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 46-51
    • Lu, T.1    Jackson, M.W.2    Wang, B.3    Yang, M.4    Chance, M.R.5    Miyagi, M.6
  • 165
    • 84863011942 scopus 로고    scopus 로고
    • Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiation
    • Ling BM, Bharathy N, Chung TK, Kok WK, Li S, Tan YH et al. Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiation. Proc Natl Acad Sci USA 2012; 109: 841-846
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 841-846
    • Ling, B.M.1    Bharathy, N.2    Chung, T.K.3    Kok, W.K.4    Li, S.5    Tan, Y.H.6
  • 166
    • 55549089655 scopus 로고    scopus 로고
    • G9a-mediated lysine methylation alters the function of CCAAT/enhancerbinding protein-beta
    • Pless O, Kowenz-Leutz E, Knoblich M, Lausen J, Beyermann M, Walsh MJ et al. G9a-mediated lysine methylation alters the function of CCAAT/enhancerbinding protein-beta. J Biol Chem 2008; 283: 26357-26363
    • (2008) J Biol Chem , vol.283 , pp. 26357-26363
    • Pless, O.1    Kowenz-Leutz, E.2    Knoblich, M.3    Lausen, J.4    Beyermann, M.5    Walsh, M.J.6
  • 167
    • 34547751917 scopus 로고    scopus 로고
    • Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly
    • Sampath SC, Marazzi I, Yap KL, Krutchinsky AN, Mecklenbrauker I, Viale A et al. Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly. Mol Cell 2007; 27: 596-608
    • (2007) Mol Cell , vol.27 , pp. 596-608
    • Sampath, S.C.1    Marazzi, I.2    Yap, K.L.3    Krutchinsky, A.N.4    Mecklenbrauker, I.5    Viale, A.6
  • 169
    • 81055140863 scopus 로고    scopus 로고
    • Ncrna- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs
    • Yang L, Lin C, Liu W, Zhang J, Ohgi KA, Grinstein JD et al. ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs. Cell 2011; 147: 773-788
    • (2011) Cell , vol.147 , pp. 773-788
    • Yang, L.1    Lin, C.2    Liu, W.3    Zhang, J.4    Ohgi, K.A.5    Grinstein, J.D.6
  • 170
    • 84870308969 scopus 로고    scopus 로고
    • EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex
    • Lee JM, Lee JS, Kim H, Kim K, Park H, Kim JY et al. EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex. Mol Cell 2012; 48: 572-586
    • (2012) Mol Cell , vol.48 , pp. 572-586
    • Lee, J.M.1    Lee, J.S.2    Kim, H.3    Kim, K.4    Park, H.5    Kim, J.Y.6
  • 171
    • 58049203867 scopus 로고    scopus 로고
    • Role for 53BP1 Tudor domain recognition of p53 dimethylated at lysine 382 in DNA damage signaling
    • Kachirskaia I, Shi X, Yamaguchi H, Tanoue K, Wen H, Wang EW et al. Role for 53BP1 Tudor domain recognition of p53 dimethylated at lysine 382 in DNA damage signaling. J Biol Chem 2008; 283: 34660-34666
    • (2008) J Biol Chem , vol.283 , pp. 34660-34666
    • Kachirskaia, I.1    Shi, X.2    Yamaguchi, H.3    Tanoue, K.4    Wen, H.5    Wang, E.W.6
  • 173
    • 75149136735 scopus 로고    scopus 로고
    • SET domains of histone methyltransferases recognize ISWI-remodeled nucleosomal species
    • Krajewski WA, Reese JC. SET domains of histone methyltransferases recognize ISWI-remodeled nucleosomal species. Mol Cell Biol 2009; 30: 552-564
    • (2009) Mol Cell Biol , vol.30 , pp. 552-564
    • Krajewski, W.A.1    Reese, J.C.2


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