-
1
-
-
0035839136
-
Translating the histone code
-
Jenuwein T., Allis C.D. Translating the histone code. Science 2001, 293:1074-1080.
-
(2001)
Science
, vol.293
, pp. 1074-1080
-
-
Jenuwein, T.1
Allis, C.D.2
-
3
-
-
33847076849
-
Chromatin modifications and their function
-
Kouzarides T. Chromatin modifications and their function. Cell 2007, 128:693-705.
-
(2007)
Cell
, vol.128
, pp. 693-705
-
-
Kouzarides, T.1
-
4
-
-
35848961668
-
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers
-
Taverna S.D., et al. How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nat. Struct. Mol. Biol. 2007, 14:1025-1040.
-
(2007)
Nat. Struct. Mol. Biol.
, vol.14
, pp. 1025-1040
-
-
Taverna, S.D.1
-
5
-
-
77049099785
-
Histone methyltransferases in cancer
-
Albert M., Helin K. Histone methyltransferases in cancer. Semin. Cell Dev. Biol. 2010, 21:209-220.
-
(2010)
Semin. Cell Dev. Biol.
, vol.21
, pp. 209-220
-
-
Albert, M.1
Helin, K.2
-
6
-
-
0037188911
-
Histone methylation: dynamic or static?
-
Bannister A.J., et al. Histone methylation: dynamic or static?. Cell 2002, 109:801-806.
-
(2002)
Cell
, vol.109
, pp. 801-806
-
-
Bannister, A.J.1
-
7
-
-
11144332565
-
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
-
Shi Y., et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 2004, 119:941-953.
-
(2004)
Cell
, vol.119
, pp. 941-953
-
-
Shi, Y.1
-
8
-
-
67650522886
-
A novel mammalian flavin-dependent histone demethylase
-
Karytinos A., et al. A novel mammalian flavin-dependent histone demethylase. J. Biol. Chem. 2009, 284:17775-17782.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 17775-17782
-
-
Karytinos, A.1
-
9
-
-
34047248915
-
S. pombe LSD1 homologs regulate heterochromatin propagation and euchromatic gene transcription
-
Lan F., et al. S. pombe LSD1 homologs regulate heterochromatin propagation and euchromatic gene transcription. Mol. Cell 2007, 26:89-101.
-
(2007)
Mol. Cell
, vol.26
, pp. 89-101
-
-
Lan, F.1
-
10
-
-
34250891702
-
Genome-wide studies of histone demethylation catalysed by the fission yeast homologues of mammalian LSD1
-
Opel M., et al. Genome-wide studies of histone demethylation catalysed by the fission yeast homologues of mammalian LSD1. PLoS One 2007, 2:e386.
-
(2007)
PLoS One
, vol.2
-
-
Opel, M.1
-
11
-
-
34147162969
-
Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3
-
Rudolph T., et al. Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3. Mol. Cell 2007, 26:103-115.
-
(2007)
Mol. Cell
, vol.26
, pp. 103-115
-
-
Rudolph, T.1
-
12
-
-
58149156264
-
The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation
-
Wang J., et al. The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation. Nat. Genet. 2009, 41:125-129.
-
(2009)
Nat. Genet.
, vol.41
, pp. 125-129
-
-
Wang, J.1
-
13
-
-
34247348215
-
Opposing LSD1 complexes function in developmental gene activation and repression programmes
-
Wang J., et al. Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature 2007, 446:882-887.
-
(2007)
Nature
, vol.446
, pp. 882-887
-
-
Wang, J.1
-
14
-
-
77950675541
-
The histone demethylase LSD1 regulates neural stem cell proliferation
-
Sun G., et al. The histone demethylase LSD1 regulates neural stem cell proliferation. Mol. Cell Biol. 2010, 30:1997-2005.
-
(2010)
Mol. Cell Biol.
, vol.30
, pp. 1997-2005
-
-
Sun, G.1
-
15
-
-
67649834041
-
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
-
Hu X., et al. LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:10141-10146.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 10141-10146
-
-
Hu, X.1
-
16
-
-
34547785073
-
Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1
-
Saleque S., et al. Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Mol. Cell 2007, 27:562-572.
-
(2007)
Mol. Cell
, vol.27
, pp. 562-572
-
-
Saleque, S.1
-
17
-
-
62849102897
-
Involvement of histone demethylase LSD1 in Blimp-1-mediated gene repression during plasma cell differentiation
-
Su S.T., et al. Involvement of histone demethylase LSD1 in Blimp-1-mediated gene repression during plasma cell differentiation. Mol. Cell Biol. 2009, 29:1421-1431.
-
(2009)
Mol. Cell Biol.
, vol.29
, pp. 1421-1431
-
-
Su, S.T.1
-
18
-
-
33845762289
-
Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence
-
Kahl P., et al. Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence. Cancer Res. 2006, 66:11341-11347.
-
(2006)
Cancer Res.
, vol.66
, pp. 11341-11347
-
-
Kahl, P.1
-
19
-
-
77950868547
-
Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology
-
Lim S., et al. Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology. Carcinogenesis 2010, 31:512-520.
-
(2010)
Carcinogenesis
, vol.31
, pp. 512-520
-
-
Lim, S.1
-
20
-
-
24144462170
-
LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
-
Metzger E., et al. LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature 2005, 437:436-439.
-
(2005)
Nature
, vol.437
, pp. 436-439
-
-
Metzger, E.1
-
21
-
-
62449197931
-
Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy
-
Schulte J.H., et al. Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy. Cancer Res. 2009, 69:2065-2071.
-
(2009)
Cancer Res.
, vol.69
, pp. 2065-2071
-
-
Schulte, J.H.1
-
22
-
-
68749108259
-
LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer
-
Wang Y., et al. LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell 2009, 138:660-672.
-
(2009)
Cell
, vol.138
, pp. 660-672
-
-
Wang, Y.1
-
23
-
-
33846690407
-
Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors
-
Garcia-Bassets I., et al. Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors. Cell 2007, 128:505-518.
-
(2007)
Cell
, vol.128
, pp. 505-518
-
-
Garcia-Bassets, I.1
-
24
-
-
34548513035
-
P53 is regulated by the lysine demethylase LSD1
-
Huang J., et al. p53 is regulated by the lysine demethylase LSD1. Nature 2007, 449:105-108.
-
(2007)
Nature
, vol.449
, pp. 105-108
-
-
Huang, J.1
-
25
-
-
41549132495
-
LSD1: oxidative chemistry for multifaceted functions in chromatin regulation
-
Forneris F., et al. LSD1: oxidative chemistry for multifaceted functions in chromatin regulation. Trends Biochem. Sci. 2008, 33:181-189.
-
(2008)
Trends Biochem. Sci.
, vol.33
, pp. 181-189
-
-
Forneris, F.1
-
26
-
-
70349272130
-
KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints
-
Ciccone D.N., et al. KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints. Nature 2009, 461:415-418.
-
(2009)
Nature
, vol.461
, pp. 415-418
-
-
Ciccone, D.N.1
-
27
-
-
34247394225
-
Mutation of Drosophila Lsd1 disrupts H3-K4 methylation, resulting in tissue-specific defects during development
-
Di Stefano L., Ji J.Y., Moon N.S., Herr A., Dyson N. Mutation of Drosophila Lsd1 disrupts H3-K4 methylation, resulting in tissue-specific defects during development. Curr. Biol. 2007, 17:808-812.
-
(2007)
Curr. Biol.
, vol.17
, pp. 808-812
-
-
Di Stefano, L.1
Ji, J.Y.2
Moon, N.S.3
Herr, A.4
Dyson, N.5
-
28
-
-
64249166375
-
A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory
-
Katz D.J., et al. A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory. Cell 2009, 137:308-320.
-
(2009)
Cell
, vol.137
, pp. 308-320
-
-
Katz, D.J.1
-
29
-
-
32844454603
-
Histone demethylation by a family of JmjC domain-containing proteins
-
Tsukada Y., et al. Histone demethylation by a family of JmjC domain-containing proteins. Nature 2006, 439:811-816.
-
(2006)
Nature
, vol.439
, pp. 811-816
-
-
Tsukada, Y.1
-
30
-
-
55549147132
-
The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b)
-
He J., et al. The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b). Nat. Struct. Mol. Biol. 2008, 15:1169-1175.
-
(2008)
Nat. Struct. Mol. Biol.
, vol.15
, pp. 1169-1175
-
-
He, J.1
-
31
-
-
54349083294
-
DKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing
-
Lagarou A., et al. dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing. Genes Dev. 2008, 22:2799-2810.
-
(2008)
Genes Dev.
, vol.22
, pp. 2799-2810
-
-
Lagarou, A.1
-
32
-
-
36049022778
-
JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes
-
Frescas D., et al. JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes. Nature 2007, 450:309-313.
-
(2007)
Nature
, vol.450
, pp. 309-313
-
-
Frescas, D.1
-
33
-
-
62449276460
-
Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus
-
Tzatsos A., et al. Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:2641-2646.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 2641-2646
-
-
Tzatsos, A.1
-
34
-
-
33748641974
-
Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets
-
Gearhart M.D., et al. Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. Mol. Cell Biol. 2006, 26:6880-6889.
-
(2006)
Mol. Cell Biol.
, vol.26
, pp. 6880-6889
-
-
Gearhart, M.D.1
-
35
-
-
68249129007
-
BCOR regulates mesenchymal stem cell function by epigenetic mechanisms
-
Fan Z., et al. BCOR regulates mesenchymal stem cell function by epigenetic mechanisms. Nat. Cell Biol. 2009, 11:1002-1009.
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 1002-1009
-
-
Fan, Z.1
-
36
-
-
76249100563
-
Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65
-
Lu T., et al. Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:46-51.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 46-51
-
-
Lu, T.1
-
37
-
-
34548349350
-
The F-box protein Fbl10 is a novel transcriptional repressor of c-Jun
-
Koyama-Nasu R., et al. The F-box protein Fbl10 is a novel transcriptional repressor of c-Jun. Nat. Cell Biol. 2007, 9:1074-1080.
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 1074-1080
-
-
Koyama-Nasu, R.1
-
38
-
-
77950882645
-
CpG islands recruit a histone H3 lysine 36 demethylase
-
Blackledge N.P., et al. CpG islands recruit a histone H3 lysine 36 demethylase. Mol. Cell 2010, 38:179-190.
-
(2010)
Mol. Cell
, vol.38
, pp. 179-190
-
-
Blackledge, N.P.1
-
39
-
-
56449126497
-
KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state
-
Frescas D., et al. KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state. Cell Cycle 2008, 7:3539-3547.
-
(2008)
Cell Cycle
, vol.7
, pp. 3539-3547
-
-
Frescas, D.1
-
40
-
-
41149116609
-
Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process
-
Pfau R., et al. Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:1907-1912.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 1907-1912
-
-
Pfau, R.1
-
41
-
-
57349151485
-
The JmjC domain histone demethylase Ndy1 regulates redox homeostasis and protects cells from oxidative stress
-
Polytarchou C., et al. The JmjC domain histone demethylase Ndy1 regulates redox homeostasis and protects cells from oxidative stress. Mol. Cell Biol. 2008, 28:7451-7464.
-
(2008)
Mol. Cell Biol.
, vol.28
, pp. 7451-7464
-
-
Polytarchou, C.1
-
42
-
-
33746569501
-
Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice
-
Suzuki T., et al. Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice. EMBO J. 2006, 25:3422-3431.
-
(2006)
EMBO J.
, vol.25
, pp. 3422-3431
-
-
Suzuki, T.1
-
43
-
-
33646138230
-
JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor
-
Yamane K., et al. JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell 2006, 125:483-495.
-
(2006)
Cell
, vol.125
, pp. 483-495
-
-
Yamane, K.1
-
44
-
-
68049095260
-
Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice
-
Inagaki T., et al. Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice. Genes Cells 2009, 14:991-1001.
-
(2009)
Genes Cells
, vol.14
, pp. 991-1001
-
-
Inagaki, T.1
-
45
-
-
77449121100
-
Jmjd1a demethylase-regulated histone modification is essential for cAMP-response element modulator-regulated gene expression and spermatogenesis
-
Liu Z., et al. Jmjd1a demethylase-regulated histone modification is essential for cAMP-response element modulator-regulated gene expression and spermatogenesis. J. Biol. Chem. 2010, 285:2758-2770.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 2758-2770
-
-
Liu, Z.1
-
46
-
-
35948993829
-
Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis
-
Okada Y., et al. Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis. Nature 2007, 450:119-123.
-
(2007)
Nature
, vol.450
, pp. 119-123
-
-
Okada, Y.1
-
47
-
-
64749111074
-
Role of Jhdm2a in regulating metabolic gene expression and obesity resistance
-
Tateishi K., et al. Role of Jhdm2a in regulating metabolic gene expression and obesity resistance. Nature 2009, 458:757-761.
-
(2009)
Nature
, vol.458
, pp. 757-761
-
-
Tateishi, K.1
-
48
-
-
73549088729
-
Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth
-
Krieg A.J., et al. Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Mol. Cell Biol. 2010, 30:344-353.
-
(2010)
Mol. Cell Biol.
, vol.30
, pp. 344-353
-
-
Krieg, A.J.1
-
49
-
-
35348982301
-
Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells
-
Loh Y.H., et al. Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells. Genes Dev. 2007, 21:2545-2557.
-
(2007)
Genes Dev.
, vol.21
, pp. 2545-2557
-
-
Loh, Y.H.1
-
50
-
-
33746332412
-
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3
-
Cloos P.A., et al. The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3. Nature 2006, 442:307-311.
-
(2006)
Nature
, vol.442
, pp. 307-311
-
-
Cloos, P.A.1
-
51
-
-
33745146571
-
Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells
-
Fodor B.D., et al. Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells. Genes Dev. 2006, 20:1557-1562.
-
(2006)
Genes Dev.
, vol.20
, pp. 1557-1562
-
-
Fodor, B.D.1
-
52
-
-
33745847680
-
The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36
-
Klose R.J., et al. The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36. Nature 2006, 442:312-316.
-
(2006)
Nature
, vol.442
, pp. 312-316
-
-
Klose, R.J.1
-
53
-
-
56849114113
-
Heterochromatin protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase
-
Lin C.H., et al. Heterochromatin protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase. Mol. Cell 2008, 32:696-706.
-
(2008)
Mol. Cell
, vol.32
, pp. 696-706
-
-
Lin, C.H.1
-
54
-
-
33646124469
-
Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases
-
Whetstine J.R., et al. Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell 2006, 125:467-481.
-
(2006)
Cell
, vol.125
, pp. 467-481
-
-
Whetstine, J.R.1
-
55
-
-
67649800263
-
Dynamic histone H1 isotype 4 methylation and demethylation by histone lysine methyltransferase G9a/KMT1C and the jumonji domain-containing JMJD2/KDM4 proteins
-
Trojer P., et al. Dynamic histone H1 isotype 4 methylation and demethylation by histone lysine methyltransferase G9a/KMT1C and the jumonji domain-containing JMJD2/KDM4 proteins. J. Biol. Chem. 2009, 284:8395-8405.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 8395-8405
-
-
Trojer, P.1
-
56
-
-
33644670527
-
Comprehensive genomic analysis of desmoplastic medulloblastomas: identification of novel amplified genes and separate evaluation of the different histological components
-
Ehrbrecht A., et al. Comprehensive genomic analysis of desmoplastic medulloblastomas: identification of novel amplified genes and separate evaluation of the different histological components. J. Pathol. 2006, 208:554-563.
-
(2006)
J. Pathol.
, vol.208
, pp. 554-563
-
-
Ehrbrecht, A.1
-
57
-
-
72449186524
-
Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer
-
Liu G., et al. Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer. Oncogene 2009, 28:4491-4500.
-
(2009)
Oncogene
, vol.28
, pp. 4491-4500
-
-
Liu, G.1
-
58
-
-
63449115501
-
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma
-
Northcott P.A., et al. Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. Nat. Genet. 2009, 41:465-472.
-
(2009)
Nat. Genet.
, vol.41
, pp. 465-472
-
-
Northcott, P.A.1
-
59
-
-
0034282790
-
Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines
-
Yang Z.Q., et al. Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines. Cancer Res. 2000, 60:4735-4739.
-
(2000)
Cancer Res.
, vol.60
, pp. 4735-4739
-
-
Yang, Z.Q.1
-
60
-
-
33847392500
-
Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression
-
Wissmann M., et al. Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat. Cell Biol. 2007, 9:347-353.
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 347-353
-
-
Wissmann, M.1
-
61
-
-
72449133771
-
The histone demethylase Dmel\Kdm4A controls genes required for life span and male-specific sex determination in Drosophila
-
Lorbeck M.T., et al. The histone demethylase Dmel\Kdm4A controls genes required for life span and male-specific sex determination in Drosophila. Gene 2010, 450:8-17.
-
(2010)
Gene
, vol.450
, pp. 8-17
-
-
Lorbeck, M.T.1
-
62
-
-
33947245128
-
RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3
-
Christensen J., et al. RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3. Cell 2007, 128:1063-1076.
-
(2007)
Cell
, vol.128
, pp. 1063-1076
-
-
Christensen, J.1
-
63
-
-
33947302685
-
The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases
-
Iwase S., et al. The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell 2007, 128:1077-1088.
-
(2007)
Cell
, vol.128
, pp. 1077-1088
-
-
Iwase, S.1
-
64
-
-
33847401344
-
The retinoblastoma binding protein RBP2 is an H3K4 demethylase
-
Klose R.J., et al. The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Cell 2007, 128:889-900.
-
(2007)
Cell
, vol.128
, pp. 889-900
-
-
Klose, R.J.1
-
65
-
-
33847383585
-
Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein
-
Lee M.G., et al. Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein. Cell 2007, 128:877-887.
-
(2007)
Cell
, vol.128
, pp. 877-887
-
-
Lee, M.G.1
-
66
-
-
34249900454
-
The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation
-
Tahiliani M., et al. The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation. Nature 2007, 447:601-605.
-
(2007)
Nature
, vol.447
, pp. 601-605
-
-
Tahiliani, M.1
-
67
-
-
33947244845
-
PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation
-
Yamane K., et al. PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. Mol. Cell 2007, 25:801-812.
-
(2007)
Mol. Cell
, vol.25
, pp. 801-812
-
-
Yamane, K.1
-
68
-
-
0033786540
-
A screen for new trithorax group genes identified little imaginal discs, the Drosophila melanogaster homologue of human retinoblastoma binding protein 2
-
Gildea J.J., et al. A screen for new trithorax group genes identified little imaginal discs, the Drosophila melanogaster homologue of human retinoblastoma binding protein 2. Genetics 2000, 156:645-663.
-
(2000)
Genetics
, vol.156
, pp. 645-663
-
-
Gildea, J.J.1
-
69
-
-
34247260388
-
The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase
-
Lee N., et al. The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase. Nat. Struct. Mol. Biol. 2007, 14:341-343.
-
(2007)
Nat. Struct. Mol. Biol.
, vol.14
, pp. 341-343
-
-
Lee, N.1
-
70
-
-
33947152396
-
The trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth
-
Secombe J., et al. The trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth. Genes Dev. 2007, 21:537-551.
-
(2007)
Genes Dev.
, vol.21
, pp. 537-551
-
-
Secombe, J.1
-
71
-
-
70349183714
-
Histone chaperones ASF1 and NAP1 differentially modulate removal of active histone marks by LID-RPD3 complexes during NOTCH silencing
-
Moshkin Y.M., et al. Histone chaperones ASF1 and NAP1 differentially modulate removal of active histone marks by LID-RPD3 complexes during NOTCH silencing. Mol. Cell 2009, 35:782-793.
-
(2009)
Mol. Cell
, vol.35
, pp. 782-793
-
-
Moshkin, Y.M.1
-
72
-
-
62849096399
-
The H3K4 demethylase lid associates with and inhibits histone deacetylase Rpd3
-
Lee N., et al. The H3K4 demethylase lid associates with and inhibits histone deacetylase Rpd3. Mol. Cell Biol. 2009, 29:1401-1410.
-
(2009)
Mol. Cell Biol.
, vol.29
, pp. 1401-1410
-
-
Lee, N.1
-
73
-
-
20444429760
-
Binding of pRB to the PHD protein RBP2 promotes cellular differentiation
-
Benevolenskaya E.V., et al. Binding of pRB to the PHD protein RBP2 promotes cellular differentiation. Mol. Cell 2005, 18:623-635.
-
(2005)
Mol. Cell
, vol.18
, pp. 623-635
-
-
Benevolenskaya, E.V.1
-
74
-
-
49349114931
-
Genome-wide analysis of the H3K4 histone demethylase RBP2 reveals a transcriptional program controlling differentiation
-
Lopez-Bigas N., et al. Genome-wide analysis of the H3K4 histone demethylase RBP2 reveals a transcriptional program controlling differentiation. Mol. Cell 2008, 31:520-530.
-
(2008)
Mol. Cell
, vol.31
, pp. 520-530
-
-
Lopez-Bigas, N.1
-
75
-
-
43249116995
-
Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2
-
Pasini D., et al. Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2. Genes Dev. 2008, 22:1345-1355.
-
(2008)
Genes Dev.
, vol.22
, pp. 1345-1355
-
-
Pasini, D.1
-
76
-
-
55049117906
-
A role for mammalian Sin3 in permanent gene silencing
-
van Oevelen C., et al. A role for mammalian Sin3 in permanent gene silencing. Mol. Cell 2008, 32:359-370.
-
(2008)
Mol. Cell
, vol.32
, pp. 359-370
-
-
van Oevelen, C.1
-
77
-
-
77449088946
-
The histone demethylase RBP2 Is overexpressed in gastric cancer and its inhibition triggers senescence of cancer cells
-
Zeng J., et al. The histone demethylase RBP2 Is overexpressed in gastric cancer and its inhibition triggers senescence of cancer cells. Gastroenterology 2010, 138:981-992.
-
(2010)
Gastroenterology
, vol.138
, pp. 981-992
-
-
Zeng, J.1
-
78
-
-
77949366450
-
Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex
-
Liefke R., et al. Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex. Genes Dev. 2010, 24:590-601.
-
(2010)
Genes Dev.
, vol.24
, pp. 590-601
-
-
Liefke, R.1
-
79
-
-
0025808021
-
Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product
-
Defeo-Jones D., et al. Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product. Nature 1991, 352:251-254.
-
(1991)
Nature
, vol.352
, pp. 251-254
-
-
Defeo-Jones, D.1
-
80
-
-
67449091504
-
The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor
-
Zhou W., et al. The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor. BMB Rep. 2009, 42:154-159.
-
(2009)
BMB Rep.
, vol.42
, pp. 154-159
-
-
Zhou, W.1
-
81
-
-
0038748632
-
A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer
-
Lu P.J., et al. A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer. J. Biol. Chem. 1999, 274:15633-15645.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 15633-15645
-
-
Lu, P.J.1
-
82
-
-
37649023563
-
JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer
-
Xiang Y., et al. JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:19226-19231.
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 19226-19231
-
-
Xiang, Y.1
-
83
-
-
35148835080
-
Functional analysis of the transcription repressor PLU-1/JARID1B
-
Scibetta A.G., et al. Functional analysis of the transcription repressor PLU-1/JARID1B. Mol. Cell Biol. 2007, 27:7220-7235.
-
(2007)
Mol. Cell Biol.
, vol.27
, pp. 7220-7235
-
-
Scibetta, A.G.1
-
84
-
-
19944430270
-
Mutations in the JARID1C gene, which is involved in transcriptional regulation and chromatin remodeling, cause X-linked mental retardation
-
Jensen L.R., et al. Mutations in the JARID1C gene, which is involved in transcriptional regulation and chromatin remodeling, cause X-linked mental retardation. Am. J. Hum. Genet. 2005, 76:227-236.
-
(2005)
Am. J. Hum. Genet.
, vol.76
, pp. 227-236
-
-
Jensen, L.R.1
-
85
-
-
35148867907
-
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development
-
Agger K., et al. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature 2007, 449:731-734.
-
(2007)
Nature
, vol.449
, pp. 731-734
-
-
Agger, K.1
-
86
-
-
34548644772
-
The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing
-
De Santa F., et al. The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell 2007, 130:1083-1094.
-
(2007)
Cell
, vol.130
, pp. 1083-1094
-
-
De Santa, F.1
-
87
-
-
35148898348
-
A histone H3 lysine 27 demethylase regulates animal posterior development
-
Lan F., et al. A histone H3 lysine 27 demethylase regulates animal posterior development. Nature 2007, 449:689-694.
-
(2007)
Nature
, vol.449
, pp. 689-694
-
-
Lan, F.1
-
88
-
-
35348993743
-
Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination
-
Lee M.G., et al. Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science 2007, 318:447-450.
-
(2007)
Science
, vol.318
, pp. 447-450
-
-
Lee, M.G.1
-
89
-
-
76749139057
-
The histone demethylase UTX enables RB-dependent cell fate control
-
Wang J.K., et al. The histone demethylase UTX enables RB-dependent cell fate control. Genes Dev. 2010, 24:327-332.
-
(2010)
Genes Dev.
, vol.24
, pp. 327-332
-
-
Wang, J.K.1
-
90
-
-
34547122520
-
PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex
-
Cho Y.W., et al. PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J. Biol. Chem. 2007, 282:20395-20406.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 20395-20406
-
-
Cho, Y.W.1
-
91
-
-
33847219608
-
Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth
-
Issaeva I., et al. Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth. Mol. Cell Biol. 2007, 27:1889-1903.
-
(2007)
Mol. Cell Biol.
, vol.27
, pp. 1889-1903
-
-
Issaeva, I.1
-
92
-
-
51849102077
-
The histone H3 lysine 27-specific demethylase Jmjd3 is required for neural commitment
-
Burgold T., et al. The histone H3 lysine 27-specific demethylase Jmjd3 is required for neural commitment. PLoS ONE 2008, 3:e3034.
-
(2008)
PLoS ONE
, vol.3
-
-
Burgold, T.1
-
93
-
-
36248990248
-
SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron
-
Jepsen K., et al. SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Nature 2007, 450:415-419.
-
(2007)
Nature
, vol.450
, pp. 415-419
-
-
Jepsen, K.1
-
94
-
-
47549105128
-
Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3
-
Sen G.L., et al. Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3. Genes Dev. 2008, 22:1865-1870.
-
(2008)
Genes Dev.
, vol.22
, pp. 1865-1870
-
-
Sen, G.L.1
-
95
-
-
66149138053
-
The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence
-
Agger K., et al. The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence. Genes Dev. 2009, 23:1171-1176.
-
(2009)
Genes Dev.
, vol.23
, pp. 1171-1176
-
-
Agger, K.1
-
96
-
-
66149135288
-
Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS
-
Barradas M., et al. Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS. Genes Dev. 2009, 23:1177-1182.
-
(2009)
Genes Dev.
, vol.23
, pp. 1177-1182
-
-
Barradas, M.1
-
97
-
-
75149188170
-
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
-
Dalgliesh G.L., et al. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature 2010, 463:360-363.
-
(2010)
Nature
, vol.463
, pp. 360-363
-
-
Dalgliesh, G.L.1
-
98
-
-
67349203626
-
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
-
van Haaften G., et al. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat. Genet. 2009, 41:521-523.
-
(2009)
Nat. Genet.
, vol.41
, pp. 521-523
-
-
van Haaften, G.1
-
99
-
-
77449127237
-
Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases
-
Horton J.R., et al. Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases. Nat. Struct. Mol. Biol. 2010, 17:38-43.
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 38-43
-
-
Horton, J.R.1
-
100
-
-
77950893589
-
A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation
-
Kleine-Kohlbrecher D., et al. A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation. Mol. Cell 2010, 38:165-178.
-
(2010)
Mol. Cell
, vol.38
, pp. 165-178
-
-
Kleine-Kohlbrecher, D.1
-
101
-
-
77949432014
-
PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase
-
Loenarz C., et al. PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase. Hum. Mol. Genet. 2010, 19:217-222.
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. 217-222
-
-
Loenarz, C.1
-
102
-
-
76449093977
-
Structural insights into a novel histone demethylase PHF8
-
Yu L., et al. Structural insights into a novel histone demethylase PHF8. Cell Res. 2010, 20:166-173.
-
(2010)
Cell Res.
, vol.20
, pp. 166-173
-
-
Yu, L.1
-
103
-
-
76449085537
-
Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4
-
Huang C., et al. Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4. Cell Res. 2010, 20:154-165.
-
(2010)
Cell Res.
, vol.20
, pp. 154-165
-
-
Huang, C.1
-
104
-
-
77649152293
-
KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development
-
Tsukada Y., et al. KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development. Genes Dev. 2010, 24:432-437.
-
(2010)
Genes Dev.
, vol.24
, pp. 432-437
-
-
Tsukada, Y.1
-
105
-
-
77951240318
-
Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation
-
Wen H., et al. Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation. J. Biol. Chem. 2010, 285:9322-9326.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 9322-9326
-
-
Wen, H.1
-
106
-
-
34347341762
-
A novel mutation in the PHF8 gene is associated with X-linked mental retardation with cleft lip/cleft palate
-
Abidi F.E., et al. A novel mutation in the PHF8 gene is associated with X-linked mental retardation with cleft lip/cleft palate. Clin. Genet. 2007, 72:19-22.
-
(2007)
Clin. Genet.
, vol.72
, pp. 19-22
-
-
Abidi, F.E.1
-
107
-
-
34547862845
-
Screening of mutations in the PHF8 gene and identification of a novel mutation in a Finnish family with XLMR and cleft lip/cleft palate
-
Koivisto A.M., et al. Screening of mutations in the PHF8 gene and identification of a novel mutation in a Finnish family with XLMR and cleft lip/cleft palate. Clin. Genet. 2007, 72:145-149.
-
(2007)
Clin. Genet.
, vol.72
, pp. 145-149
-
-
Koivisto, A.M.1
-
108
-
-
26944461197
-
Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate
-
Laumonnier F., et al. Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate. J. Med. Genet. 2005, 42:780-786.
-
(2005)
J. Med. Genet.
, vol.42
, pp. 780-786
-
-
Laumonnier, F.1
-
109
-
-
35348938519
-
JMJD6 is a histone arginine demethylase
-
Chang B., et al. JMJD6 is a histone arginine demethylase. Science 2007, 318:444-447.
-
(2007)
Science
, vol.318
, pp. 444-447
-
-
Chang, B.1
-
110
-
-
67650072604
-
Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing
-
Webby C.J., et al. Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. Science 2009, 325:90-93.
-
(2009)
Science
, vol.325
, pp. 90-93
-
-
Webby, C.J.1
-
111
-
-
34247890161
-
Changing story of the receptor for phosphatidylserine-dependent clearance of apoptotic cells
-
Wolf A., et al. Changing story of the receptor for phosphatidylserine-dependent clearance of apoptotic cells. EMBO Rep. 2007, 8:465-469.
-
(2007)
EMBO Rep.
, vol.8
, pp. 465-469
-
-
Wolf, A.1
-
112
-
-
67349266612
-
Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger
-
Wang G.G., et al. Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature 2009, 459:847-851.
-
(2009)
Nature
, vol.459
, pp. 847-851
-
-
Wang, G.G.1
-
113
-
-
53549088904
-
Lid2 is required for coordinating H3K4 and H3K9 methylation of heterochromatin and euchromatin
-
Li F., et al. Lid2 is required for coordinating H3K4 and H3K9 methylation of heterochromatin and euchromatin. Cell 2008, 135:272-283.
-
(2008)
Cell
, vol.135
, pp. 272-283
-
-
Li, F.1
-
114
-
-
23044433837
-
The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal
-
Bose J., et al. The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal. J. Biol. 2004, 3:15.
-
(2004)
J. Biol.
, vol.3
, pp. 15
-
-
Bose, J.1
-
115
-
-
9444237436
-
Phosphatidylserine receptor is required for the engulfment of dead apoptotic cells and for normal embryonic development in zebrafish
-
Hong J.R., et al. Phosphatidylserine receptor is required for the engulfment of dead apoptotic cells and for normal embryonic development in zebrafish. Development 2004, 131:5417-5427.
-
(2004)
Development
, vol.131
, pp. 5417-5427
-
-
Hong, J.R.1
-
116
-
-
34447527656
-
The Drosophila homolog of the putative phosphatidylserine receptor functions to inhibit apoptosis
-
Krieser R.J., et al. The Drosophila homolog of the putative phosphatidylserine receptor functions to inhibit apoptosis. Development 2007, 134:2407-2414.
-
(2007)
Development
, vol.134
, pp. 2407-2414
-
-
Krieser, R.J.1
-
117
-
-
1942489369
-
Defective fetal liver erythropoiesis and T lymphopoiesis in mice lacking the phosphatidylserine receptor
-
Kunisaki Y., et al. Defective fetal liver erythropoiesis and T lymphopoiesis in mice lacking the phosphatidylserine receptor. Blood 2004, 103:3362-3364.
-
(2004)
Blood
, vol.103
, pp. 3362-3364
-
-
Kunisaki, Y.1
-
118
-
-
0345374586
-
Phosphatidylserine receptor is required for clearance of apoptotic cells
-
Li M.O., et al. Phosphatidylserine receptor is required for clearance of apoptotic cells. Science 2003, 302:1560-1563.
-
(2003)
Science
, vol.302
, pp. 1560-1563
-
-
Li, M.O.1
-
119
-
-
0345374587
-
Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12
-
Wang X., et al. Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12. Science 2003, 302:1563-1566.
-
(2003)
Science
, vol.302
, pp. 1563-1566
-
-
Wang, X.1
|