The Histone Demethylase RBP2 Is Overexpressed in Gastric Cancer and Its Inhibition Triggers Senescence of Cancer Cells

Gastroenterology

Volumn 138, Issue 3, 2010, Pages 981-992

  Zeng, Jiping ^a,b   Ge, Zheng ^a   Wang, Lixiang ^b   Li, Qiao ^a,b   Wang, Na ^a,b   Björkholm, Magnus ^a   Jia, Jihui ^b   Xu, Dawei ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b SHANDONG UNIVERSITY   (China)

Author keywords

Cellular Senescence; Histone Demethylation

Indexed keywords

BETA GALACTOSIDASE; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN DEPENDENT KINASE INHIBITOR 2A; HISTONE DEMETHYLASE RBP2; HISTONE H3; HISTONE H4; LUCIFERASE; PROTAMINE KINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER CELL; CHROMATIN IMMUNOPRECIPITATION; CLINICAL ARTICLE; CLONOGENESIS; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; METHYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SENESCENCE; STAINING; STOMACH CANCER; UPREGULATION;

EID: 77449088946     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2009.10.004     Document Type: Article

References (46)

1. Zheng L., Wang L., Ajani J., et al. Molecular basis of gastric cancer development and progression. Gastric Cancer 7 (2004) 61-77
2. Vogiatzi P., Vindigni C., Roviello F., et al. Deciphering the underlying genetic and epigenetic events leading to gastric carcinogenesis. J Cell Physiol 211 (2007) 287-295
3. Smith M.G., Hold G.L., Tahara E., et al. Cellular and molecular aspects of gastric cancer. World J Gastroenterol 12 (2006) 2979-2990
4. Correa P., and Houghton J. Carcinogenesis of Helicobacter pylori. Gastroenterology 133 (2007) 659-672
5. Li W., Ge Z., Liu C., et al. CIP2A is overexpressed in gastric cancer and its depletion leads to impaired clonogenicity, senescence, or differentiation of tumor cells. Clin Cancer Res 14 (2008) 3722-3728
6. Plummer M., van Doorn L.J., Franceschi S., et al. Helicobacter pylori cytotoxin-associated genotype and gastric precancerous lesions. J Natl Cancer Inst 99 (2007) 1328-1334
7. Berger S.L. The complex language of chromatin regulation during transcription. Nature 447 (2007) 407-412
8. Shi Y., and Whetstine J.R. Dynamic regulation of histone lysine methylation by demethylases. Mol Cell 25 (2007) 1-14
9. Christensen J., Agger K., Cloos P.A., et al. RBP2 belongs to a family of demethylases, specific for tri- and dimethylated lysine 4 on histone 3. Cell 128 (2007) 1063-1076
10. Secombe J., Li L., Carlos L., et al. The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth. Genes Dev 21 (2007) 537-551
11. Klose R.J., Yan Q., Tothova Z., et al. The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Cell 128 (2007) 889-900
12. Lopez-Bigas N., Kisiel T.A., Dewaal D.C., et al. Genome-wide analysis of the H3K4 histone demethylase RBP2 reveals a transcriptional program controlling differentiation. Mol Cell 31 (2008) 520-530
13. Pasini D., Hansen K.H., Christensen J., et al. Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2. Genes Dev 22 (2008) 1345-1355
14. van Oevelen C., Wang J., Asp P., et al. A role for mammalian Sin3 in permanent gene silencing. Mol Cell 32 (2008) 359-370
15. Cloos P.A., Christensen J., Agger K., et al. Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. Genes Dev 22 (2008) 1115-1140
16. Glozak M.A., and Seto E. Histone deacetylases and cancer. Oncogene 26 (2007) 5420-5432
17. Cloos P.A., Christensen J., Agger K., et al. The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3. Nature 442 (2006) 307-311
18. Hu N., Wang C., Hu Y., et al. Genome-wide association study in esophageal cancer using GeneChip mapping 10K array. Cancer Res 65 (2005) 2542-2546
19. Yamane K., Tateishi K., Klose R.J., et al. PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. Mol Cell 25 (2007) 801-812
20. Barrett A., Madsen B., Copier J., et al. PLU-1 nuclear protein, which is upregulated in breast cancer, shows restricted expression in normal human adult tissues: a new cancer/testis antigen?. Int J Cancer 101 (2002) 581-588
21. Xiang Y., Zhu Z., Han G., et al. JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer. Proc Natl Acad Sci U S A 104 (2007) 19226-19231
22. Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 (2000) 57-70
23. Beausejour C.M., and Campisi J. Ageing: balancing regeneration and cancer. Nature 443 (2006) 404-405
24. Campisi J. Aging and cancer cell biology, 2007. Aging Cell 6 (2007) 261-263
25. Braig M., Lee S., Loddenkemper C., et al. Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 436 (2005) 660-665
26. Chen Z., Trotman L.C., Shaffer D., et al. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436 (2005) 725-730
27. Shay J.W., and Roninson I.B. Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 23 (2004) 2919-2933
28. Schmitt C.A., Fridman J.S., Yang M., et al. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell 109 (2002) 335-346
29. Tai A.W., and Chung R.T. p53 restoration leads to tumor senescence and regression: implications for cancer therapy. Gastroenterology 133 (2007) 722-723
30. Xue W., Zender L., Miething C., et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 445 (2007) 656-660
31. Acosta J.C., O'Loghlen A., Banito A., et al. Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell 133 (2008) 1006-1018
32. Kuilman T., Michaloglou C., Vredeveld L.C., et al. Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell 133 (2008) 1019-1031
33. Zeng J., Wang L., Li Q., et al. FoxM1 is up-regulated in gastric cancer and its inhibition leads to cellular senescence partially dependent on p27. J Pathol 218 (2009) 419-427
34. Ge Z., Liu C., Bjorkholm M., et al. Mitogen-activated protein kinase cascade-mediated histone H3 phosphorylation is critical for telomerase reverse transcriptase expression/telomerase activation induced by proliferation. Mol Cell Biol 26 (2006) 230-237
35. Lindvall C., Hou M., Komurasaki T., et al. Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling: activation of the epiregulin gene. Cancer Res 63 (2003) 1743-1747
36. Dimri G.P., Lee X., Basile G., et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A 92 (1995) 9363-9367
37. Pang P.H., Lin Y.H., Lee Y.H., et al. Molecular mechanisms of p21 and p27 induction by 3-methylcholanthrene, an aryl-hydrocarbon receptor agonist, involved in antiproliferation of human umbilical vascular endothelial cells. J Cell Physiol 215 (2008) 161-171
38. Sowa Y., Orita T., Minamikawa-Hiranabe S., et al. Sp3, but not Sp1, mediates the transcriptional activation of the p21/WAF1/Cip1 gene promoter by histone deacetylase inhibitor. Cancer Res 59 (1999) 4266-4270
39. Ohtani N., Zebedee Z., Huot T.J., et al. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence. Nature 409 (2001) 1067-1070
40. Young A.P., Schlisio S., Minamishima Y.A., et al. VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400. Nat Cell Biol 10 (2008) 361-369
41. Majumder P.K., Grisanzio C., O'Connell F., et al. A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression. Cancer Cell 14 (2008) 146-155
42. Fattaey A.R., Helin K., Dembski M.S., et al. Characterization of the retinoblastoma binding proteins RBP1 and RBP2. Oncogene 8 (1993) 3149-3156
43. Tu S., Teng Y.C., Yuan C., et al. The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif. Nat Struct Mol Biol 15 (2008) 419-421
44. Hayakawa T., Ohtani Y., Hayakawa N., et al. RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation. Genes Cells 12 (2007) 811-826
45. Iwase S., Lan F., Bayliss P., et al. The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell 128 (2007) 1077-1088
46. Roesch A., Mueller A.M., Stempfl T., et al. RBP2-H1/JARID1B is a transcriptional regulator with a tumor suppressive potential in melanoma cells. Int J Cancer 122 (2008) 1047-1057