Detection of t(4;14)(p16.3;q32) Chromosomal translocation in multiple myeloma by reverse transcription-polymerase chain reaction analysis of IGH-MMSET fusion transcripts

Cancer Research

Volumn 60, Issue 15, 2000, Pages 4058-4061

  Malgeri, U ^a   Baldini, L ^a   Perfetti, V ^a   Fabris, S ^a   Vignarelli, M C ^a   Colombo, G ^a   Lotti, V ^a   Compasso, S ^a   Bogni, S ^a   Lombardi, L ^a   Maiolo, A T ^a   Neri, A ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA;

ADULT; AGED; ARTICLE; CHIMERA; CHROMOSOME TRANSLOCATION; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MONOCLONAL IMMUNOGLOBULINEMIA; MULTIPLE MYELOMA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; AGED; CHROMOSOMES, HUMAN, PAIR 14; CHROMOSOMES, HUMAN, PAIR 4; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MIDDLE AGED; MULTIPLE MYELOMA; ONCOGENE PROTEINS, FUSION; PARAPROTEINEMIAS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSLOCATION, GENETIC;

EID: 0033887241     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Multiple myeloma: Increasing evidence for a multistep transformation process
2. Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma
3. The lg heavy chain gene is frequently involved in chromosomal translocations in multiple myeloma and plasma cell leukemia as detected by in situ hybridization
4. A novel chromosomal translocation t(4;14)(p16.3;q32) in multiple myeloma involves the fibroblast growth-factor receptor 3 gene
5. High incidence of translocations t(11;14)(q13;q32) and t(4;14)(p16;q32) in patients with plasma cell malignancies
6. Molecular analysis of 11q13 breakpoints in multiple myeloma
7. Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3
8. Detection of t(4;14)(p16.3;q32) chromosomal translocation in multiple myeloma by double-color fluorescent in situ hybridization
9. The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts
10. Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma
11. Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma
12. A gene encoding a fibroblast growth factor receptor isolated from the Huntington disease gene region of human chromosome 4
13. WHSCl, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma
14. Structural and functional diversity in the fgf receptor multigene family
15. FGFR3 gene mutations associated with human skeletal disorders are rarely involved in multiple myeloma
16. A clinical staging system for multiple myeloma
17. A cosmid conting and high resolution restriction map of the 2 megabase region containing the Huntington's disease gene
18. Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma
19. 14q32 Translocations and monosomy 13 observed in monoclonal gammopathy of undetermined significance delineate a multistep process for the oncogenesis of multiple myeloma