Histone lysine methyltransferase setd8 promotes carcinogenesis by deregulating PCNA expression

Cancer Research

Volumn 72, Issue 13, 2012, Pages 3217-3227

  Takawa, Masashi ^a,c   Cho, Hyun Soo ^a   Hayami, Shinya ^a   Toyokawa, Gouji ^a   Kogure, Masaharu ^a,c   Yamane, Yuka ^a   Iwai, Yukiko ^a   Maejima, Kazuhiro ^a   Ueda, Koji ^b   Masuda, Akiko ^b   Dohmae, Naoshi ^b   Field, Helen I ^e   Tsunoda, Tatsuhiko ^b   Kobayashi, Takaaki ^c   Akasu, Takayuki ^d   Sugiyama, Masanori ^c   Ohnuma, Shin Ichi ^f   Atomi, Yutaka ^c   Ponder, Bruce A J ^e   Nakamura, Yusuke ^a,g   Hamamoto, Ryuji ^a,e   more..

^a UNIVERSITY OF TOKYO   (Japan)

^b RIKEN   (Japan)

^c KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d NATIONAL CANCER CENTER HOSPITAL   (Japan)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f UNIVERSITY COLLEGE LONDON   (United Kingdom)

^g UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; ENDONUCLEASE FEN1; FLAP ENDONUCLEASE; HISTONE LYSINE METHYLTRANSFERASE; LYSINE; OKAZAKI FRAGMENT; PROTEIN SETD8; UNCLASSIFIED DRUG;

ADULT; AGED; AMINO ACID SUBSTITUTION; ARTICLE; BLADDER CANCER; CARCINOGENESIS; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; FEMALE; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; MUTANT; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METHYLATION; PROTEIN PROTEIN INTERACTION;

EID: 84863579070     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-11-3701     Document Type: Article

References (43)

1. Jenuwein T, Allis CD. Translating the histone code. Science 2001;293:1074-80. (Pubitemid 32758077)
2. Volkel P, Angrand PO. The control of histone lysine methylation in epigenetic regulation. Biochimie 2007;89:1-20. (Pubitemid 44970511)
3. Stoimenov I, Helleday T. PCNA on the crossroad of cancer. Biochem Soc Trans 2009;37:605-13.
4. Miyachi K, Fritzler MJ, Tan EM. Autoantibody to a nuclear antigen in proliferating cells. J Immunol 1978;121:2228-34. (Pubitemid 9075187)
5. Bravo R, Fey SJ, Bellatin J, Larsen PM, Celis JE. Identification of a nuclear polypeptide ("cyclin") whose relative proportion is sensitive to changes in the rate of cell proliferation and to transformation. Prog Clin Biol Res 1982;85:235-48.
6. Celis JE, Bravo R, Larsen PM, Fey SJ. Cyclin: a nuclear protein whose level correlates directly with the proliferative state of normal as well as transformed cells. Leuk Res 1984;8:143-57. (Pubitemid 14149192)
7. Prelich G, Tan CK, Kostura M, Mathews MB, So AG, Downey KM, et al. Functional identity of proliferating cell nuclear antigen and a DNA polymerase-delta auxiliary protein. Nature 1987;326:517-20. (Pubitemid 17055499)
8. Tan CK, Castillo C, So AG, Downey KM. An auxiliary protein for DNA polymerase-delta from fetal calf thymus. J Biol Chem 1986;261:12310-6. (Pubitemid 17202800)
9. Hoege C, Pfander B, Moldovan GL, Pyrowolakis G, Jentsch S. RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature 2002;419:135-41. (Pubitemid 35025438)
10. Bailly V, Lauder S, Prakash S, Prakash L. Yeast DNA repair proteins Rad6 and Rad18 form a heterodimer that has ubiquitin conjugating, DNA binding, and ATP hydrolytic activities. J Biol Chem 1997;272:23360-5. (Pubitemid 27392476)
11. WangSC, Nakajima Y, Yu YL, Xia W, Chen CT, Yang CC, et al. Tyrosine phosphorylation controls PCNA function through protein stability. Nat Cell Biol 2006;8:1359-68. (Pubitemid 44835110)
12. Naryzhny SN, Lee H. The post-translational modifications of proliferating cell nuclear antigen: acetylation, not phosphorylation, plays an important role in the regulation of its function. J Biol Chem 2004;279:20194-9. (Pubitemid 38623464)
13. Windecker H, Ulrich HD. Architecture and assembly of poly-SUMO chains on PCNA in Saccharomyces cerevisiae. J Mol Biol 2008;376:221-31.
14. Hayami S, Kelly JD, Cho HS, Yoshimatsu M, Unoki M, Tsunoda T, et al. Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers. Int J Cancer 2011;128:574-86.
15. Hayami S, Yoshimatsu M, Veerakumarasivam A, Unoki M, Iwai Y, Tsunoda T, et al. Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. Mol Cancer 2010;9:59.
16. Wallard MJ, Pennington CJ, Veerakumarasivam A, Burtt G, Mills IG, Warren A, et al. Comprehensive profiling and localisation of the matrix metalloproteinases in urothelial carcinoma. Br J Cancer 2006;94:569-77. (Pubitemid 43289762)
17. Yoshimatsu M, Toyokawa G, Hayami S, Unoki M, Tsunoda T, Field HI, et al. Dysregulation of PRMT1 and PRMT6, type I arginine methyltransferases, is involved in various types of human cancers. Int J Cancer 2011;128:562-73.
18. Olsburgh J, Harnden P, Weeks R, Smith B, Joyce A, Hall G, et al. Uroplakin gene expression in normal human tissues and locally advanced bladder cancer. J Pathol 2003;199:41-9. (Pubitemid 36054728)
19. Huen MS, Sy SM, van Deursen JM, Chen J. Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication. J Biol Chem 2008;283:11073-7.
20. Jorgensen S, Elvers I, Trelle MB, Menzel T, Eskildsen M, Jensen ON, et al. The histone methyltransferase SET8 is required for S-phase progression. J Cell Biol 2007;179:1337-45.
21. Lieber MR. The FEN-1 family of structure-specific nucleases in eukaryotic DNA replication, recombination and repair. Bioessays 1997;19:233-40. (Pubitemid 27140647)
22. Waga S, Bauer G, Stillman B. Reconstitution of complete SV40 DNA replication with purified replication factors. J Biol Chem 1994;269:10923-34. (Pubitemid 24198307)
23. Reagan MS, Pittenger C, Siede W, Friedberg EC. Characterization of a mutant strain of Saccharomyces cerevisiae with a deletion of the RAD27 gene, a structural homolog of the RAD2 nucleotide excision repair gene. J Bacteriol 1995;177:364-71.
24. Zheng L, Dai H, Qiu J, Huang Q, Shen B. Disruption of the FEN-1/PCNA interaction results in DNA replication defects, pulmonary hypoplasia, pancytopenia, and newborn lethality in mice. Mol Cell Biol 2007;27:3176-86. (Pubitemid 46581328)
25. Henneke G, Koundrioukoff S, Hubscher U. Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation. Oncogene 2003;22:4301-13. (Pubitemid 36897962)
26. Soza S, Leva V, Vago R, Ferrari G, Mazzini G, Biamonti G, et al. DNA ligase I deficiency leads to replication-dependent DNA damage and impacts cell morphology without blocking cell cycle progression. Mol Cell Biol 2009;29:2032-41.
27. Tishkoff DX, Filosi N, Gaida GM, Kolodner RD. A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair. Cell 1997;88:253-63. (Pubitemid 28015874)
28. Hamamoto R, Furukawa Y, Morita M, Iimura Y, Silva FP, Li M, et al. SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. Nat Cell Biol 2004;6:731-40. (Pubitemid 39144478)
29. Hamamoto R, Silva FP, Tsuge M, Nishidate T, Katagiri T, Nakamura Y, et al. Enhanced SMYD3 expression is essential for the growth of breast cancer cells. Cancer Sci 2006;97:113-8. (Pubitemid 43379478)
30. McBride AE, Silver PA. State of the arg: protein methylation at arginine comes of age. Cell 2001;106:5-8. (Pubitemid 32709951)
31. Lachner M, Jenuwein T. The many faces of histone lysine methylation. Curr Opin Cell Biol 2002;14:286-98. (Pubitemid 34626966)
32. Kelman Z, O'Donnell M. Structural and functional similarities of prokaryotic and eukaryoticDNApolymerase sliding clamps. Nucleic Acids Res 1995;23:3613-20.
33. Wyman C, Botchan M. DNA replication. A familiar ring to DNA polymerase processivity. Curr Biol 1995;5:334-7.
34. Moldovan GL, Pfander B, Jentsch S. PCNA, the maestro of the replication fork. Cell 2007;129:665-79. (Pubitemid 46802385)
35. Arakawa H, Moldovan GL, Saribasak H, Saribasak NN, Jentsch S, Buerstedde JM. A role for PCNA ubiquitination in immunoglobulin hypermutation. PLoS Biol 2006;4:e366.
36. Leach CA, Michael WM. Ubiquitin/SUMO modification of PCNA promotes replication fork progression in Xenopus laevis egg extracts. J Cell Biol 2005;171:947-54. (Pubitemid 41815827)
37. Houston SI, McManus KJ, Adams MM, Sims JK, Carpenter PB, Hendzel MJ, et al. Catalytic function of the PR-Set7 histone H4 lysine 20 monomethyltransferase is essential for mitotic entry and genomic stability. J Biol Chem 2008;283:19478-88.
38. Tardat M, Murr R, Herceg Z, Sardet C, Julien E. PR-Set7-dependent lysine methylation ensures genome replication and stability through S-phase. J Cell Biol 2007;179:1413-26.
39. Azam N, Vairapandi M, Zhang W, Hoffman B, Liebermann DA. Interaction of CR6 (GADD45gamma) with proliferating cell nuclear antigen impedes negative growth control. J Biol Chem 2001;276:2766-74.
40. Vairapandi M, Balliet AG, Fornace AJ Jr, Hoffman B, Liebermann DA. The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1. Oncogene 1996;12:2579-94. (Pubitemid 26237787)
41. Chen U, Chen S, Saha P, Dutta A. p21Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex. Proc Natl Acad Sci U S A 1996;93:11597-602.
42. Zheng L, Jia J, Finger LD, Guo Z, Zer C, Shen B. Functional regulation of FEN1 nuclease and its link to cancer. Nucleic Acids Res 2011;39:781-94.
43. Guo Z, Zheng L, Xu H, Dai H, Zhou M, Pascua MR, et al. Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding. Nat Chem Biol 2010;6:766-73.