Frequent epigenetic inactivation of RIZ1 by promoter hypermethylation in human gastric carcinoma

International Journal of Cancer

Volumn 110, Issue 2, 2004, Pages 212-218

  Oshimo, Yasuhiro ^a   Oue, Naohide ^a   Mitani, Yoshitsugu ^a   Nakayama, Hirofumi ^a   Kitadai, Yasuhiko ^a   Yoshida, Kazuhiro ^b   Chayama, Kazuaki ^a   Yasui, Wataru ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

CIMP; DNA methylation; Gastric carcinoma; p53; RIZ1

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; MESSENGER RNA; TRANSCRIPTION FACTOR;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; EPIGENETICS; GENE; GENE INACTIVATION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MINT1 GENE; MINT12 GENE; MINT2 GENE; MINT25 GENE; MINT31 GENE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN METHYLATION; RIZ1 GENE; SINGLE STRAND CONFORMATION POLYMORPHISM; STOMACH CARCINOMA; TRANSCRIPTION REGULATION; TUMOR CELL LINE;

CELL LINE, TUMOR; DNA METHYLATION; DNA-BINDING PROTEINS; GENES, P53; HUMANS; MUTATION; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; STOMACH NEOPLASMS; TRANSCRIPTION FACTORS;

EID: 2342564968     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.20090     Document Type: Article

References (49)

1. Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002;3:415-28.
2. Baylin SB, Herman JG, Graff JR, Vertino PM, Issa JP. Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res 1998;72:141-96.
3. Fleisher AS, Esteller M, Wang S, Tamura G, Suzuki H, Yin J, Zou TT, Abraham JM, Kong D, Smolinski KN, Shi YQ, Rhyu MG, et al. Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability. Cancer Res 1999;59:1090-5.
4. Leung SY, Yuen ST, Chung LP, Chu KM, Chan AS, Ho JC. hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability. Cancer Res 1999;59:159-64.
5. Shim YH, Kang GH, Ro JY. Correlation of p16 hypermethylation with p16 protein loss in sporadic gastric carcinomas. Lab Invest 2000;80:689-95.
6. Tamura G, Yin J, Wang S, Fleisher AS, Zou T, Abraham JM, Kong D, Smolinski KN, Wilson KT, James SP, Silverberg SG, Nishizuka S, et al. E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas. J Natl Cancer Inst 2000;92:569-73.
7. Kikuchi T, Itoh F, Toyota M, Suzuki H, Yamamoto H, Fujita M, Hosokawa M, Imai K. Aberrant methylation and histone deacetylation of cyclooxygenase 2 in gastric cancer. Int J Cancer 2002;97:272-7.
8. Song SH, Jong HS, Choi HH, Inoue H, Tanabe T, Kim NK, Bang YJ. Transcriptional silencing of cyclooxygenase-2 by hyper-methylation of the 5′ CpG island in human gastric carcinoma cells. Cancer Res 2001;61:4628-35.
9. Byun DS, Lee MG, Chae KS, Ryu BG, Chi SG. Frequent epigenetic inactivation of RASSF1A by aberrant promoter hypermethylation in human gastric adenocarcinoma. Cancer Res 2001;61:7034-8.
10. Kang YH, Lee HS, Kim WH. Promoter methylation and silencing of PTEN in gastric carcinoma. Lab Invest 2002;82:285-91.
11. Sato K, Tamura G, Tsuchiya T, Endoh Y, Usuba O, Kimura W, Motoyama T. Frequent loss of expression without sequence mutations of the DCC gene in primary gastric cancer. Br J Cancer 2001;85:199-203.
12. Kaneda A, Kaminishi M, Nakanishi Y, Sugimura T, Ushijima T. Reduced expression of the insulin-induced protein 1 and p41 Arp2/3 complex genes in human gastric cancers. Int J Cancer 2002;100:57-62.
13. Kaneda A, Kaminishi M, Yanagihara K, Sugimura T, Ushijima T. Identification of silencing of nine genes in human gastric cancers. Cancer Res 2002;62:6645-50.
14. Oue N, Shigeishi H, Kuniyasu H, Yokozaki H, Kuraoka K, Ito R, Yasui, W. Promoter hypermethylation of MGMT is associated with protein loss in gastric carcinoma. Int J Cancer 2001;93:805-9.
15. Oue N, Motoshita J, Yokozaki H, Hayashi K, Tahara E, Taniyama K, Matsusaki K, Yasui W. Distinct promoter hypermethylation of p16INK4a, CDH1, and RAR-beta in intestinal, diffuse-adherent, and diffuse-scattered type gastric carcinomas. J Pathol 2002;198:55-9.
16. Oue N, Matsumura S, Nakayama H, Kitadai Y, Taniyama K, Matsusaki K, Yasui W. Reduced expression of the TSP1 gene and its association with promoter hypermethylation in gastric carcinoma. Oncology 2003;64:423-9.
17. Hamai H, Oue N, Mitani Y, Nakayama H, Ito R, Matsusaki K, Yoshida K, Toge T, Yasui W. DNA hypermethylation and histone hypo acetylation of the HLTF gene are associated with reduced expression in gastric carcinoma. Cancer Sci 2003;94:692-8.
18. Oshimo Y, Nakayama H, Ito R, Kitadai Y, Yoshida K, Chyama K, Yasui W. Promotor methylation of cyclin D2 gene in gastric carcinoma. Int J Oncol 2003;23:1663-70.
19. Buyse IM, Shao G, Huang S. The retinoblastoma protein binds to RIZ, a zinc finger protein that shares an epitope with the adenovirus EIA protein. Proc Natl Acad Sci USA 1995;92:4467-71.
20. Huang S, Shao G, Liu L. The PR domain of the Rb-binding zinc finger protein RIZ1 is a protein binding interface and is related to the SET domain functioning in chromatin-mediated gene expression. J Biol Chem 1997;272:2984-91.
21. Jiang GL, Huang S. The yin-yang of PR domain family genes in tumorigenesis. Histol Histopathol 2000;15:109-17.
22. Liu L, Shao G, Steel-Perkins G, Huang S. The retinoblastoma interacting zinc finger gene RIZ produces a PR domain lacking product through an internal promoter. J Biol Chem 1997;272:2984-91.
23. Weith A, Brodeur GM, Bruns GA, Matise TC, Mischke D, Nizetic D, Seldin MF, van Roy N, Vance J. Report of the second international workshop on human chromosome 1 mapping 1995. Cytogenet Cell Genet 1996;72:114-44.
24. Koizumi Y, Tanaka S, Mou R, Koganei H, Kokawa A, Kitamura R, Yamauchi H, Ookubo K, Saito T, Tominaga S, Matsumura K, Shimada H, et al. Changes in DNA copy number in primary gastric carcinomas by comparative genomic hybridization. Clin Cancer Res 1997;3:1067-76.
25. He L, Yu JX, Liu L, Buyse IM, Wang MS, Yang QC, Nakagawara A, Brodeur GM, Shi YE, Huang S. RIZ1, but not the alternative RIZ2 product of the same gene, is underexpressed in breast cancer, and forced RIZ1 expression causes G2-M cell cycle arrest and/or apoptosis. Cancer Res 1998;58:4238-44.
26. Jiang GL, Liu L, Buyse IM, Simon D, Huang S. Decreased RIZ1 expression but not RIZ2 in hepatoma and suppression of hepatoma tumorigenicity by RIZ1. Int J Cancer 1999;83:541-7.
27. Chadwick RB, Jiang GL, Bennington GA, Yuan B, Johnson CK, Stevens MW, Niemann TH, Peltomaki P, Huang S, de la Chapelle A. Candidate tumor suppressor RIZ1 is frequently involved in colorectal carcinogenesis. Proc Natl Acad Sci USA 2000;97:2662-7.
28. Piao Z, fang W, Malkhosyan S, Kim H, Horii A, Perucho M, Huang S. Frameshift mutations of RIZ in human gastrointestinal and endometrial carcinomas with microsatellite instability. Cancer Res 2000; 60:4701-4.
29. Sakurada K, Furukawa T, Kato Y, Kayama T, Huang S, Horii A. RIZ, the retinoblastoma protein interacting zinc finger gene, is mutated in genetically unstable cancers of the pancreas, stomach, and colorectum. Genes Chromosomes Cancer 2001;30:207-11.
30. Steele-Perkins G, Fang W, Yang XH, Van Gele M, Carling T, Gu J, Buyse IM, Fletcher JA, Liu J, Bronson R, Chadwick RB, de la Chapella A, et al. Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily. Genes Dev 2001;15;2250-62.
31. Jiang GL, Huang S. Adenovirus expressing RIZ1 in tumor suppressor gene therapy of microsatellite-unstable colorectal cancers. Cancer Res 2001;61:1796-8.
32. Du Y, Carling T, Fang W, Piao Z, Sheu JC, Huang S. Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily. Cancer Res 2001; 61:8094-9.
33. Toyota M, Ahuja N, Suzuki H, Itoh F, Ohe-Toyota M, Imai K, Baylin SB, Issa J P. Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype. Cancer Res 1999;59:5438-42.
34. Oue N, Oshimo Y, Nakayama H, Ito R, Yoshida K, Matsusaki K, Yasui W. DNA methylation of multiple genes in gastric carcinoma; association with histological type and CpG island methylator phenotype. Cancer Sci 2003,94:901-5.
35. Whitehall VLJ, Wynter CVA, Walsh MD, Simms LA, Purdie D, Pandeya N, Young J, Meltzer SJ, Leggett BA, Jass JR. Morphological and molecular heterogeneity within nonmicrosatellite instability-high colorectal cancer. Cancer Res 2002;62:6011-4.
36. Waki T, Tamura G, Tsuchiya T, Sato K, Nishizuka S, Motoyama T. Promoter methylation status of E-cadherin, hMLH1, and p16 genes in nonneoplastic gastric epithelia. Am J Pathol 2002;161:399-403.
37. Ahuja N, Issa JP, Aging, methylation and cancer. Histol Histopathol 2000;15:835-42.
38. Ochiai A, Yasui W, Tahara E. Growth-promoting effect of gastrin on human gastric carcinoma cell line TMK-1. Jpn J Cancer Res 1995; 76:1064-71.
39. Lauren P. The two histological main types of gastric carcinoma. Diffuse and so-called intestinal type carcinoma: an attempt at histological classification. Acta Pathol Microbiol Scand 1965;64:31-49.
40. Shimoyama Y, Hirohashi S. Expression of E- and P-Cadherin in gastric carcinomas. Cancer Res 1991;51:2185-92.
41. Stelzner S, Emmrich P. The mixed type in Lauren's classification of gastric carcinoma. Histologic description and biologic behavior. Gen Diagn Pathol 1997;143:39-48.
42. Sobin LH, Wittekind CH, eds. TNM classification of malignant tumors, 6th ed. New York: Wiley-Liss Inc, 2002. pp 65-8.
43. Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996;93:9821-6.
44. Yokozaki H. Molecular characteristics of eight gastric cancer cell lines established in Japan. Pathol Int 2000;50:767-77.
45. Kang GH, Shim YH, Jung HY, Kim WH, Ro JY, Rhyu MG. CpG island methylation in premalignant stages of gastric carcinoma. Cancer Res 2001;61:2847-51.
46. To KF, Leung WK, Lee TL, Yu J, Tong JH, Chan MW, Ng EK, Chung SC, Sung JJ. Promoter hypermethylation of tumor-related genes in gastric intestinal metaplasia of patients with and without gastric cancer. Int J Cancer 2002;102:623-8.
47. Iacopetta BJ, Soong R, House AK, Hamelin R. Gastric carcinomas with microsatellite instability: clinical features and mutations to the TGF-beta type II receptor, IGFII receptor, and BAX genes. J Pathol 1999;187:428-32.
48. Fang DC, Wang RQ, Yang SM, Yang JM, Liu HF, Peng GY, Xiao TL, Luo YH. Mutation and methylation of hMLH1 in gastric carcinomas with microsatellite instability. World J Gastroenterol 2003;9: 655-9.
49. Ko LJ, Prives C. p53: puzzle and paradigm. Genes Dev 1996;10: 1054-72.