G9a and Glp methylate lysine 373 in the tumor suppressor p53

Journal of Biological Chemistry

Volumn 285, Issue 13, 2010, Pages 9636-9641

  Huang, Jing ^a,b   Dorsey, Jean ^b   Chuikov, Sergei ^e   Zhang, Xinyue ^a   Jenuwein, Thomas ^c,d   Reinberg, Danny ^e,f   Berger, Shelley L ^b,g  

^a NATIONAL CANCER INSTITUTE   (United States)

^b WISTAR INSTITUTE   (United States)

^c RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^d MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^e NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^g UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOTIC CELLS; CANCER TREATMENT; DATA BASE; DNA DAMAGES; NORMAL TISSUE; POST-TRANSLATIONAL MODIFICATIONS; TUMOR SUPPRESSORS;

ALKYLATION; METHYLATION; ONCOGENIC VIRUSES; TUMORS;

AMINO ACIDS;

G9A LIKE PROTEIN; HISTONE METHYLTRANSFERASE; LYSINE; PROTEIN G9A; PROTEIN P53; UNCLASSIFIED DRUG; EHMT2 PROTEIN, HUMAN; GOLGA6 PROTEIN, HUMAN; HISTOCOMPATIBILITY ANTIGEN; HISTONE LYSINE METHYLTRANSFERASE; PEPTIDE; PROTEIN; RECOMBINANT PROTEIN; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; ONCOGENE; PRIORITY JOURNAL; PROTEIN METHYLATION; PROTEIN PROCESSING; CHEMISTRY; DNA METHYLATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; METHYLATION; NEOPLASM; PHYSIOLOGY;

DNA DAMAGE; DNA METHYLATION; GENE EXPRESSION REGULATION; HISTOCOMPATIBILITY ANTIGENS; HISTONE-LYSINE N-METHYLTRANSFERASE; HUMANS; LYSINE; METHYLATION; NEOPLASMS; PEPTIDES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEINS; RECOMBINANT PROTEINS; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77951233574     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.062588     Document Type: Article

References (18)

1. Bode, A. M., and Dong, Z. (2004) Nat. Rev. Cancer 4, 793-805
2. Prives, C., and Manley, J. L. (2001) Cell 107, 815-818
3. Huang, J., and Berger, S. L. (2008) Curr. Opin. Genet. Dev. 18, 152-158
4. Schotta, G., Lachner, M., Sarma, Lys., Ebert, A., Sengupta, R., Reuter, G., Reinberg, D., and Jenuwein, T. (2004) Genes Dev. 18, 1251-1262
5. Huang, J., Perez-Burgos, L., Placek, B. J., Sengupta, R., Richter, M., Dorsey, J. A., Lysubicek, S., Opravil, S., Jenuwein, T., and Berger, S. L. (2006) Nature 444, 629-632
6. Chuikov, S., Lysurash, J., Lys., Wilson, J. R., Xiao, B., Justin, N., Ivanov, G. S., McLysinney, Lys., Tempst, P., Prives, C., Gamblin, S. J., Barlev, N. A., and Reinberg, D. (2004) Nature 432, 353-360
7. Shi, X., Lysachirskaia, I., Yamaguchi, H., West, L. E., Wen, H., Wang, E. W., Dutta, S., Appella, E., and Gozani, O. (2007) Mol. Cell 27, 636-646
8. Lysachirskaia, I., Shi, X., Yamaguchi, H., Tanoue, Lys., Wen, H., Wang, E. W., Appella, E., and Gozani, O. (2008) J. Biol. Chem. 283, 34660-34666
9. Huang, J., Sengupta, R., Espejo, A. B., Lee, M. G., Dorsey, J. A., Richter, M., Opravil, S., Shiekhattar, R., Bedford, M. T., Jenuwein, T., and Berger, S. L. (2007) Nature 449, 105-108
10. Tachibana, M., Sugimoto, Lys., Nozaki, M., Ueda, J., Ohta, T., Ohki, M., Fukuda, M., Takeda, N., Niida, H., Lysato, H., and Shinkai, Y. (2002) Genes Dev. 16, 1779-1791
11. Tachibana, M., Ueda, J., Fukuda, M., Takeda, N., Ohta, T., Iwanari, H., Sakihama, T., Lysodama, T., Hamakubo, T., and Shinkai, Y. (2005) Genes Dev. 19, 815-826
12. Rhodes, D. R., Yu, J., Shanker, Lys., Deshpande, N., Varambally, R., Ghosh, D., Barrette, T., Pandey, A., and Chinnaiyan, A. M. (2004) Neoplasia 6, 1-6
13. Toledo, F., and Wahl, G. M. (2006) Nat. Rev. Cancer 6, 909-923
14. Lysrummel, Lys., A., Lee, C. J., Toledo, F., and Wahl, G. M. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 10188-10193
15. Feng, L., Lin, T., Uranishi, H., Gu, W., and Xu, Y. (2005) Mol. Cell. Biol. 25, 5389-5395
16. Tang, Y., Zhao, W., Chen, Y., Zhao, Y., and Gu, W. (2008) Cell 133, 612-626
17. Schulte, J. H., Lim, S., Schramm, A., Friedrichs, N., Lysoster, J., Versteeg, R., Ora, I., Pajtler, Lys., Lyslein-Hitpass, L., Lysuhfittig-Lysulle, S., Metzger, E., Schüle, R., Eggert, A., Buettner, R., and Lysirfel, J. (2009) Cancer Res. 69, 2065-2071
18. Lysahl, P., Gullotti, L., Heukamp, L. C., Wolf, S., Friedrichs, N., Vorreuther, R., Solleder, G., Bastian, P. J., Ellinger, J., Metzger, E., Schüle, R., and Buettner, R. (2006) Cancer Res. 66, 11341-11347