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Volumn 208, Issue 4, 2006, Pages 554-563

Comprehensive genomic analysis of desmoplastic medulloblastomas: Identification of novel amplified genes and separate evaluation of the different histological components

Author keywords

Comparative genomic hybridization; Gene amplification; Medulloblatosma; Molecular genetics; RPS6KB1

Indexed keywords

AMYLOID PRECURSOR PROTEIN BINDING PROTEIN 2; BINDING PROTEIN; BREAST CARCINOMA AMPLIFIED SEQUENCE 3; DNA; MAGNESIUM DEPENDENT PHOSPHOPROTEIN PHOSPHATASE 1D; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN PATCHED; S6 KINASE; SONIC HEDGEHOG PROTEIN; T BOX TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 33644670527     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.1925     Document Type: Article
Times cited : (122)

References (66)
  • 2
    • 0034017036 scopus 로고    scopus 로고
    • Expression of the neurotrophin receptor p75NTR in medulloblastomas is correlated with distinct histological and clinical features: Evidence for a medulloblastoma subtype derived from the external granule cell layer
    • Buhren J, Christoph AH, Buslei R, Albrecht S, Wiestler OD, Pietsch T. Expression of the neurotrophin receptor p75NTR in medulloblastomas is correlated with distinct histological and clinical features: evidence for a medulloblastoma subtype derived from the external granule cell layer. J Neuropathol Exp Neurol 2000;59:229-240.
    • (2000) J Neuropathol Exp Neurol , vol.59 , pp. 229-240
    • Buhren, J.1    Christoph, A.H.2    Buslei, R.3    Albrecht, S.4    Wiestler, O.D.5    Pietsch, T.6
  • 3
    • 0029119268 scopus 로고
    • Prospective randomized trial of chemotherapy given before radiotherapy in childhood medulloblastoma
    • International Society of Paediatric Oncology (SIOP) and the (German) Society of Paediatric Oncology (GPO): SIOP II
    • Bailey CC, Gnekow A, Wellek S, Jones M, Round C, Brown J, et al. Prospective randomized trial of chemotherapy given before radiotherapy in childhood medulloblastoma. International Society of Paediatric Oncology (SIOP) and the (German) Society of Paediatric Oncology (GPO): SIOP II. Med Pediatr Oncol 1995;25:166-178.
    • (1995) Med Pediatr Oncol , vol.25 , pp. 166-178
    • Bailey, C.C.1    Gnekow, A.2    Wellek, S.3    Jones, M.4    Round, C.5    Brown, J.6
  • 4
    • 0028878530 scopus 로고
    • Staging, scoring and grading of medulloblastoma. A postoperative prognosis predicting system based on the cases of a single institute
    • Sure U, Berghorn WJ, Bertalanffy H, Wakabayashi T, Yoshida J, Sugita K, et al. Staging, scoring and grading of medulloblastoma. A postoperative prognosis predicting system based on the cases of a single institute. Acta Neurochir (Wien) 1995;132:59-65.
    • (1995) Acta Neurochir (Wien) , vol.132 , pp. 59-65
    • Sure, U.1    Berghorn, W.J.2    Bertalanffy, H.3    Wakabayashi, T.4    Yoshida, J.5    Sugita, K.6
  • 8
    • 0030913169 scopus 로고    scopus 로고
    • Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched
    • Pietsch T, Waha A, Koch A, Kraus J, Albrecht S, Tonn J, et al. Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched. Cancer Res 1997;57:2085-2088.
    • (1997) Cancer Res , vol.57 , pp. 2085-2088
    • Pietsch, T.1    Waha, A.2    Koch, A.3    Kraus, J.4    Albrecht, S.5    Tonn, J.6
  • 10
    • 0030738693 scopus 로고    scopus 로고
    • Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system
    • Wolter M, Reifenberger J, Sommer C, Ruzicka. T, Reifenberger G. Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res 1997;57:2581-2585.
    • (1997) Cancer Res , vol.57 , pp. 2581-2585
    • Wolter, M.1    Reifenberger, J.2    Sommer, C.3    Ruzicka, T.4    Reifenberger, G.5
  • 12
    • 0032080853 scopus 로고    scopus 로고
    • Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system
    • Reifenberger J, Wolter M, Weber RG, Megahed M, Ruzicka T, Lichter P, et al. Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res 1998;58:1798-1803.
    • (1998) Cancer Res , vol.58 , pp. 1798-1803
    • Reifenberger, J.1    Wolter, M.2    Weber, R.G.3    Megahed, M.4    Ruzicka, T.5    Lichter, P.6
  • 14
    • 0035427076 scopus 로고    scopus 로고
    • Somatic mutations of WNT/wingless signalling pathway components in primitive neuroectodermal tumors
    • Koch A, Waha A, Tonn JC, Sorensen N, Berthold F, Wolter M, et al. Somatic mutations of WNT/wingless signalling pathway components in primitive neuroectodermal tumors. Int J Cancer 2001;93:445-449.
    • (2001) Int J Cancer , vol.93 , pp. 445-449
    • Koch, A.1    Waha, A.2    Tonn, J.C.3    Sorensen, N.4    Berthold, F.5    Wolter, M.6
  • 16
    • 0035477364 scopus 로고    scopus 로고
    • Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas
    • Dahmen RP, Koch A, Denkhaus D, Tonn JC, Sorensen N, Berthold F, et al. Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas. Cancer Res 2001;61:7039-7043.
    • (2001) Cancer Res , vol.61 , pp. 7039-7043
    • Dahmen, R.P.1    Koch, A.2    Denkhaus, D.3    Tonn, J.C.4    Sorensen, N.5    Berthold, F.6
  • 17
    • 0037473082 scopus 로고    scopus 로고
    • AXIN1 mutations but not deletions in cerebellar medulloblastomas
    • Baeza N, Masuoka J, Kleihues P, Ohgaki H. AXIN1 mutations but not deletions in cerebellar medulloblastomas. Oncogene 2003;22:632-636.
    • (2003) Oncogene , vol.22 , pp. 632-636
    • Baeza, N.1    Masuoka, J.2    Kleihues, P.3    Ohgaki, H.4
  • 18
    • 9144241696 scopus 로고    scopus 로고
    • Molecular pathogenesis of childhood brain tumors
    • Pietsch T, Taylor MD, Rutka JT. Molecular pathogenesis of childhood brain tumors. J Neurooncol 2004;70:203-215.
    • (2004) J Neurooncol , vol.70 , pp. 203-215
    • Pietsch, T.1    Taylor, M.D.2    Rutka, J.T.3
  • 19
    • 0032959871 scopus 로고    scopus 로고
    • Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog
    • Wechsler-Reya RJ, Scott MP. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron 1999;22:103-114.
    • (1999) Neuron , vol.22 , pp. 103-114
    • Wechsler-Reya, R.J.1    Scott, M.P.2
  • 20
    • 0036559186 scopus 로고    scopus 로고
    • Gli and hedgehog in cancer: Tumours, embryos and stem cells
    • Ruiz i Altaba A, Sanchez P, Dahmane N. Gli and hedgehog in cancer: tumours, embryos and stem cells. Nat Rev Cancer 2002;2:361-372.
    • (2002) Nat Rev Cancer , vol.2 , pp. 361-372
    • Ruiz i Altaba, A.1    Sanchez, P.2    Dahmane, N.3
  • 21
  • 22
    • 0027537408 scopus 로고
    • Detection of complete and partial chromosome gains and losses by comparative genomic in situ hybridization
    • du Manoir S, Speicher MR, Joos S, Schrock E, Popp S, Dohner H, et al. Detection of complete and partial chromosome gains and losses by comparative genomic in situ hybridization. Hum Genet 1993;90:590-610.
    • (1993) Hum Genet , vol.90 , pp. 590-610
    • du Manoir, S.1    Speicher, M.R.2    Joos, S.3    Schrock, E.4    Popp, S.5    Dohner, H.6
  • 24
    • 17344371740 scopus 로고    scopus 로고
    • High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays
    • Pinkel D, Segraves R, Sudar D, Clark S, Poole I, Kowbel D, et al. High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays. Nat Genet 1998;20:207-211.
    • (1998) Nat Genet , vol.20 , pp. 207-211
    • Pinkel, D.1    Segraves, R.2    Sudar, D.3    Clark, S.4    Poole, I.5    Kowbel, D.6
  • 26
    • 0042425741 scopus 로고    scopus 로고
    • Characterization of gene expression profiles associated with glioma progression using oligonucleotide-based microarray analysis and real-time reverse transcription-polymerase chain reaction
    • van den Boom J, Wolter M, Kuick R, Misek DE, Youkilis AS, Wechsler DS, et al. Characterization of gene expression profiles associated with glioma progression using oligonucleotide-based microarray analysis and real-time reverse transcription-polymerase chain reaction. Am J Pathol 2003;163:1033-1043.
    • (2003) Am J Pathol , vol.163 , pp. 1033-1043
    • van den Boom, J.1    Wolter, M.2    Kuick, R.3    Misek, D.E.4    Youkilis, A.S.5    Wechsler, D.S.6
  • 27
    • 0029800810 scopus 로고    scopus 로고
    • Refined mapping of 12ql3-ql5 amplicons in human malignant gliomas suggests CDK4/SAS and MDM2 as independent amplification targets
    • Reifenberger G, Ichimura K, Reifenberger J, Elkahloun AG, Meltzer PS, Collins VP. Refined mapping of 12ql3-ql5 amplicons in human malignant gliomas suggests CDK4/SAS and MDM2 as independent amplification targets. Cancer Res 1996;56:5141-5145.
    • (1996) Cancer Res , vol.56 , pp. 5141-5145
    • Reifenberger, G.1    Ichimura, K.2    Reifenberger, J.3    Elkahloun, A.G.4    Meltzer, P.S.5    Collins, V.P.6
  • 28
    • 0031847422 scopus 로고    scopus 로고
    • Recurrent chromosomal imbalances detected in biopsy material from oral premalignant and malignant lesions by combined tissue microdissection, universal DNA amplification, and comparative genomic hybridization
    • Weber RG, Scheer M, Born IA, Joos S, Cobbers JM, Hofele C, et al. Recurrent chromosomal imbalances detected in biopsy material from oral premalignant and malignant lesions by combined tissue microdissection, universal DNA amplification, and comparative genomic hybridization. Am J Pathol 1998; 153:295-303.
    • (1998) Am J Pathol , vol.153 , pp. 295-303
    • Weber, R.G.1    Scheer, M.2    Born, I.A.3    Joos, S.4    Cobbers, J.M.5    Hofele, C.6
  • 29
    • 0026736251 scopus 로고
    • Degenerate oligonucleotide-primed PCR: General amplification of target DNA by a single degenerate primer
    • Telenius H, Carter NP, Bebb CE, Nordenskjold M, Ponder BA, Turmacliffe A. Degenerate oligonucleotide-primed PCR: general amplification of target DNA by a single degenerate primer. Genomics 1992;13:718-725.
    • (1992) Genomics , vol.13 , pp. 718-725
    • Telenius, H.1    Carter, N.P.2    Bebb, C.E.3    Nordenskjold, M.4    Ponder, B.A.5    Turmacliffe, A.6
  • 30
    • 12944328014 scopus 로고    scopus 로고
    • Characteristic chromosomal imbalances in primary central nervous system lymphomas of the diffuse large B-cell type
    • Weber T, Weber RG, Kaulich K, Actor B, Meyer-Puttlitz B, Lampel S, et al. Characteristic chromosomal imbalances in primary central nervous system lymphomas of the diffuse large B-cell type. Brain Pathol 2000;10:73-84.
    • (2000) Brain Pathol , vol.10 , pp. 73-84
    • Weber, T.1    Weber, R.G.2    Kaulich, K.3    Actor, B.4    Meyer-Puttlitz, B.5    Lampel, S.6
  • 31
    • 0029128936 scopus 로고
    • Detection of chromosomal aberrations by means of molecular cytogenetics: Painting of chromosomes and chromosomal subregions and comparative genomic hybridization
    • Lichter P, Bentz M, Joos S. Detection of chromosomal aberrations by means of molecular cytogenetics: painting of chromosomes and chromosomal subregions and comparative genomic hybridization. Methods Enzymol 1995;254:334-359.
    • (1995) Methods Enzymol , vol.254 , pp. 334-359
    • Lichter, P.1    Bentz, M.2    Joos, S.3
  • 33
    • 0033851883 scopus 로고    scopus 로고
    • An optimized set of human telomere clones for studying telomere integrity and architecture
    • Knight SJ, Lese CM, Precht KS, Kuc J, Ning Y, Lucas S, et al. An optimized set of human telomere clones for studying telomere integrity and architecture. Am J Hum Genet 2000;67:320-332.
    • (2000) Am J Hum Genet , vol.67 , pp. 320-332
    • Knight, S.J.1    Lese, C.M.2    Precht, K.S.3    Kuc, J.4    Ning, Y.5    Lucas, S.6
  • 34
    • 0037376804 scopus 로고    scopus 로고
    • DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones
    • Fiegler H, Carr P, Douglas EJ, Burford DC, Hunt S, Scott CE, et al. DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones. Genes Chromosomes Cancer 2003;36:361-374.
    • (2003) Genes Chromosomes Cancer , vol.36 , pp. 361-374
    • Fiegler, H.1    Carr, P.2    Douglas, E.J.3    Burford, D.C.4    Hunt, S.5    Scott, C.E.6
  • 35
    • 10744225365 scopus 로고    scopus 로고
    • Automated array-based genomic profiling in chronic lymphocytic leukemia: Development of a clinical tool and discovery of recurrent genomic alterations
    • Schwaenen C, Nessling M, Wessendorf S, Salvi T, Wrobel G, Radlwimmer B, et al. Automated array-based genomic profiling in chronic lymphocytic leukemia: development of a clinical tool and discovery of recurrent genomic alterations. Proc Natl Acad Sci USA 2004;101:1039-1044.
    • (2004) Proc. Natl Acad Sci USA , vol.101 , pp. 1039-1044
    • Schwaenen, C.1    Nessling, M.2    Wessendorf, S.3    Salvi, T.4    Wrobel, G.5    Radlwimmer, B.6
  • 36
    • 0036143687 scopus 로고    scopus 로고
    • Automated screening for genomic imbalances using matrix-based comparative genomic hybridization
    • Wessendorf S, Fritz B, Wrobel G, Nessling M, Lampel S, Goettel D, et al. Automated screening for genomic imbalances using matrix-based comparative genomic hybridization. Lab Invest 2002;82:47-60.
    • (2002) Lab Invest , vol.82 , pp. 47-60
    • Wessendorf, S.1    Fritz, B.2    Wrobel, G.3    Nessling, M.4    Lampel, S.5    Goettel, D.6
  • 38
    • 0035205570 scopus 로고    scopus 로고
    • Oligodendroglial tumors frequently demonstrate hypermethylation of the CDKN2A (MTS1, p16INK4a), p14ARF, and CDKN2B (MTS2, p15INK4b) tumor suppressor genes
    • Wolter M, Reifenberger J, Blaschke B, Ichimura. K, Schmidt EE, Collins VP, et al. Oligodendroglial tumors frequently demonstrate hypermethylation of the CDKN2A (MTS1, p16INK4a), p14ARF, and CDKN2B (MTS2, p15INK4b) tumor suppressor genes. J Neuropathol Exp Neurol 2001;60:1170-1180.
    • (2001) J Neuropathol Exp Neurol , vol.60 , pp. 1170-1180
    • Wolter, M.1    Reifenberger, J.2    Blaschke, B.3    Ichimura, K.4    Schmidt, E.E.5    Collins, V.P.6
  • 41
    • 0033565715 scopus 로고    scopus 로고
    • Comparative genomic hybridization in patients with supratentorial and infratentorial primitive neuroectodermal tumors
    • Russo C, Pellarin M, Tingby O, Bollen AW, Lamborn KR, Mohapatra G, et al. Comparative genomic hybridization in patients with supratentorial and infratentorial primitive neuroectodermal tumors. Cancer 1999;86:331-339.
    • (1999) Cancer , vol.86 , pp. 331-339
    • Russo, C.1    Pellarin, M.2    Tingby, O.3    Bollen, A.W.4    Lamborn, K.R.5    Mohapatra, G.6
  • 42
    • 0032970323 scopus 로고    scopus 로고
    • Comparative genomic hybridization detects many recurrent imbalances in central nervous system primitive neuroectodermal tumours in children
    • Avet-Loiseau H, Venuat AM, Terrier-Lacombe MJ, Lellouch-Tubiana A, Zerah M, Vassal G. Comparative genomic hybridization detects many recurrent imbalances in central nervous system primitive neuroectodermal tumours in children. Br J Cancer 1999;79:1843-1847.
    • (1999) Br J Cancer , vol.79 , pp. 1843-1847
    • Avet-Loiseau, H.1    Venuat, A.M.2    Terrier-Lacombe, M.J.3    Lellouch-Tubiana, A.4    Zerah, M.5    Vassal, G.6
  • 43
    • 0028172248 scopus 로고
    • p53 gene mutation and mdm2 gene amplification are uncommon in medulloblastoma
    • Adesina AM, Nalbantoglu J, Cavenee WK. p53 gene mutation and mdm2 gene amplification are uncommon in medulloblastoma. Cancer Res 1994;54:5649-5651.
    • (1994) Cancer Res , vol.54 , pp. 5649-5651
    • Adesina, A.M.1    Nalbantoglu, J.2    Cavenee, W.K.3
  • 45
    • 0029900741 scopus 로고    scopus 로고
    • Mapping of chromosomal gains and losses in primitive neuroectodermal tumors by comparative genomic hybridization
    • Schutz BR, Scheurlen W, Krauss J, du Manoir S, Joos S, Bentz M, et al. Mapping of chromosomal gains and losses in primitive neuroectodermal tumors by comparative genomic hybridization. Genes Chromosomes Cancer 1996;16:196-203.
    • (1996) Genes Chromosomes Cancer , vol.16 , pp. 196-203
    • Schutz, B.R.1    Scheurlen, W.2    Krauss, J.3    du Manoir, S.4    Joos, S.5    Bentz, M.6
  • 47
    • 0036245047 scopus 로고    scopus 로고
    • MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group
    • Aldosari N, Bigner SH, Burger PC, Becker L, Kepner JL, Friedman HS, et al. MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group. Arch Pathol Lab Med 2002;126:540-544.
    • (2002) Arch Pathol Lab Med , vol.126 , pp. 540-544
    • Aldosari, N.1    Bigner, S.H.2    Burger, P.C.3    Becker, L.4    Kepner, J.L.5    Friedman, H.S.6
  • 49
    • 0942290729 scopus 로고    scopus 로고
    • Detection of oncogene amplifications in medulloblastomas by comparative genomic hybridization and array-based comparative genomic hybridization
    • Tong CY, Hui AB, Yin XL, Pang JC, Zhu XL, Poon WS, et al. Detection of oncogene amplifications in medulloblastomas by comparative genomic hybridization and array-based comparative genomic hybridization. J Neurosurg Spine 2004;100: 187-193.
    • (2004) J Neurosurg Spine , vol.100 , pp. 187-193
    • Tong, C.Y.1    Hui, A.B.2    Yin, X.L.3    Pang, J.C.4    Zhu, X.L.5    Poon, W.S.6
  • 50
    • 0025812930 scopus 로고
    • Analysis of N-ras gene mutations in medulloblastomas by polymerase chain reaction and oligonucleotide probes in formalin-fixed, paraffin-embedded tissues
    • Iolascon A, Lania A, Badiali M, Pession A, Saglio G, Giangaspero F, et al. Analysis of N-ras gene mutations in medulloblastomas by polymerase chain reaction and oligonucleotide probes in formalin-fixed, paraffin-embedded tissues. Med Pediatr Oncol 1991;19:240-245.
    • (1991) Med Pediatr Oncol , vol.19 , pp. 240-245
    • Iolascon, A.1    Lania, A.2    Badiali, M.3    Pession, A.4    Saglio, G.5    Giangaspero, F.6
  • 51
    • 0032694006 scopus 로고    scopus 로고
    • Genetic alterations in pediatric medulloblastomas detected by comparative genomic hybridization
    • Nishizaki T, Harada K, Kubota H, Ozaki S, Ito H, Sasaki K. Genetic alterations in pediatric medulloblastomas detected by comparative genomic hybridization. Pediatr Neurosurg 1999;31:27-32.
    • (1999) Pediatr Neurosurg , vol.31 , pp. 27-32
    • Nishizaki, T.1    Harada, K.2    Kubota, H.3    Ozaki, S.4    Ito, H.5    Sasaki, K.6
  • 52
    • 0036132648 scopus 로고    scopus 로고
    • Comparative genomic hybridization detects an increased number of chromosomal alterations in large cell/anaplastic medulloblastomas
    • Eberhart CG, Kratz JE, Schuster A, Goldthwaite P, Cohen KJ, Perlman EJ, et al. Comparative genomic hybridization detects an increased number of chromosomal alterations in large cell/anaplastic medulloblastomas. Brain Pathol 2002;12:36-44.
    • (2002) Brain Pathol , vol.12 , pp. 36-44
    • Eberhart, C.G.1    Kratz, J.E.2    Schuster, A.3    Goldthwaite, P.4    Cohen, K.J.5    Perlman, E.J.6
  • 53
    • 0242499482 scopus 로고    scopus 로고
    • Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3′-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas
    • Knobbe CB, Reifenberger G. Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3′-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas. Brain Pathol 2003;13:507-518.
    • (2003) Brain Pathol , vol.13 , pp. 507-518
    • Knobbe, C.B.1    Reifenberger, G.2
  • 54
    • 0038244014 scopus 로고    scopus 로고
    • hTERT ne amplification and increased mRNA expression in central nervous system embryonal tumors
    • Fan X, Wang Y, Kratz J, Brat DJ, Robitaille Y, Moghrabi A, et al. hTERT ne amplification and increased mRNA expression in central nervous system embryonal tumors. Am J Pathol 2003;162:1763-1769.
    • (2003) Am J Pathol , vol.162 , pp. 1763-1769
    • Fan, X.1    Wang, Y.2    Kratz, J.3    Brat, D.J.4    Robitaille, Y.5    Moghrabi, A.6
  • 56
    • 0034282790 scopus 로고    scopus 로고
    • Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in oesophageal cancer cell lines
    • Yang ZQ, Imoto I, Fukuda Y, Pimkhaokham A, Shimada Y, Imamura M, et al. Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in oesophageal cancer cell lines. Cancer Res 2000;60:4735-4739.
    • (2000) Cancer Res , vol.60 , pp. 4735-4739
    • Yang, Z.Q.1    Imoto, I.2    Fukuda, Y.3    Pimkhaokham, A.4    Shimada, Y.5    Imamura, M.6
  • 58
    • 0035015609 scopus 로고    scopus 로고
    • A novel amplification at 17q21-23 in ovarian cancer cell lines detected by comparative genon-& hybridization
    • Watanabe T, Imoto I, Kosugi Y, Ishiwata I, Inoue S, Takayama M, et al. A novel amplification at 17q21-23 in ovarian cancer cell lines detected by comparative genon-& hybridization. Gynecol Oncol 2001;81:172-177.
    • (2001) Gynecol Oncol , vol.81 , pp. 172-177
    • Watanabe, T.1    Imoto, I.2    Kosugi, Y.3    Ishiwata, I.4    Inoue, S.5    Takayama, M.6
  • 59
    • 0031461605 scopus 로고    scopus 로고
    • Analysis of genomic alterations in benign, atypical, and anaplastic meningiomas: Toward a genetic model of meningionta progression
    • Weber RG, Bostrom J, Wolter M, Baudis M, Collins VP, Reifenberger G, et al. Analysis of genomic alterations in benign, atypical, and anaplastic meningiomas: toward a genetic model of meningionta progression. Proc Natl Acad Sci USA 1997;94:14719-14724.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 14719-14724
    • Weber, R.G.1    Bostrom, J.2    Wolter, M.3    Baudis, M.4    Collins, V.P.5    Reifenberger, G.6
  • 60
    • 0032102198 scopus 로고    scopus 로고
    • Detection of gains and losses in 18 meningiomas by comparative genomic hybridization
    • Khan J, Parsa NZ, Harada T, Meltzer PS, Carter NP. Detection of gains and losses in 18 meningiomas by comparative genomic hybridization. Cancer Genet Cytogenet 1998;103:95-100.
    • (1998) Cancer Genet Cytogenet , vol.103 , pp. 95-100
    • Khan, J.1    Parsa, N.Z.2    Harada, T.3    Meltzer, P.S.4    Carter, N.P.5
  • 62
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002;296:1655-1657.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 63
    • 3442878125 scopus 로고    scopus 로고
    • Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas
    • Broderick DK, Di C, Parrett TJ, Samuels YR, Cummins JM, McLendon RE, et al. Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas. Cancer Res 2004;64:5048-5050.
    • (2004) Cancer Res , vol.64 , pp. 5048-5050
    • Broderick, D.K.1    Di, C.2    Parrett, T.J.3    Samuels, Y.R.4    Cummins, J.M.5    McLendon, R.E.6
  • 64
    • 0035866358 scopus 로고    scopus 로고
    • Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy
    • Geoerger B, Kerr K, Tang CB, Fung KM, Powell B, Sutton LN, et al. Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy. Cancer Res 2001;61:1527-1532.
    • (2001) Cancer Res , vol.61 , pp. 1527-1532
    • Geoerger, B.1    Kerr, K.2    Tang, C.B.3    Fung, K.M.4    Powell, B.5    Sutton, L.N.6
  • 65
    • 1642474000 scopus 로고    scopus 로고
    • Hedgehog and PI-3 kinase signalling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors
    • Kenney AM, Widlund HR, Rowitch DH. Hedgehog and PI-3 kinase signalling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors. Development 2004;131:217-228.
    • (2004) Development , vol.131 , pp. 217-228
    • Kenney, A.M.1    Widlund, H.R.2    Rowitch, D.H.3
  • 66
    • 4444273153 scopus 로고    scopus 로고
    • Sonic hedgehog and insulin-like growth factor signalling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice
    • Rao G, Pedone CA, Valle LD, Reiss K, Holland EC, Fults DW. Sonic hedgehog and insulin-like growth factor signalling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice. Oncogene 2004;23:6156-6162.
    • (2004) Oncogene , vol.23 , pp. 6156-6162
    • Rao, G.1    Pedone, C.A.2    Valle, L.D.3    Reiss, K.4    Holland, E.C.5    Fults, D.W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.