REV-ERB and ROR nuclear receptors as drug targets

Nature Reviews Drug Discovery

Volumn 13, Issue 3, 2014, Pages 197-216

  Kojetin, Douglas J ^a   Burris, Thomas P ^b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ANTIDIABETIC AGENT; CELL NUCLEUS RECEPTOR; DIGOXIN; GSK 4112; INTERLEUKIN 6; ML 209; N (2,2,2 TRIFLUOROETHYL) N [4 (2,2,2 TRIFLUORO 1 HYDROXY 1 TRIFLUOROMETHYLETHYL)PHENYL]BENZENESULFONAMIDE; NUCLEAR RECEPTOR NR1D1; RECEPTOR BLOCKING AGENT; RETINOID RELATED ORPHAN RECEPTOR ALPHA; RETINOID RELATED ORPHAN RECEPTOR BETA; RETINOID RELATED ORPHAN RECEPTOR GAMMA; REV ERBBETA PROTEIN; SR 1001; SR 1078; SR 1555; SR 2211; SR 3335; SR 8278; SR 9009; SR 9011; STEROL; UNCLASSIFIED DRUG; URSOLIC ACID;

AREA UNDER THE CURVE; BINDING AFFINITY; CIRCADIAN RHYTHM; CYTOKINE PRODUCTION; DNA BINDING MOTIF; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; DRUG STRUCTURE; DRUG TARGETING; FEEDBACK SYSTEM; HUMAN; IMMUNOREGULATION; LIGAND BINDING; MAXIMUM PLASMA CONCENTRATION; METABOLIC REGULATION; MOLECULAR DYNAMICS; MOLECULAR SENSOR; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SEQUENCE HOMOLOGY;

ANIMALS; ATHEROSCLEROSIS; DIABETES MELLITUS; DRUG DELIVERY SYSTEMS; HUMANS; LIGANDS; NEOPLASMS; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP D, MEMBER 1; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 1; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, RETINOIC ACID; SIGNAL TRANSDUCTION;

EID: 84895801586     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd4100     Document Type: Review

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