Optimized chemical probes for REV-ERBα

Journal of Medicinal Chemistry

Volumn 56, Issue 11, 2013, Pages 4729-4737

  Trump, Ryan P ^a   Bresciani, Stefano ^b   Cooper, Anthony W J ^c   Tellam, James P ^b   Wojno, Justyna ^b   Blaikley, John ^d   Orband Miller, Lisa A ^a   Kashatus, Jennifer A ^a   Boudjelal, Mohamed ^c   Dawson, Helen C ^a   Loudon, Andrew ^e   Ray, David ^d   Grant, Daniel ^a   Farrow, Stuart N ^c   Willson, Timothy M ^a   Tomkinson, Nicholas C O ^b  

^a GLAXOSMITHKLINE   (United States)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^c GLAXOSMITHKLINE   (United Kingdom)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

^e UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 BROMO 5 METHYLTHIOPHEN 2 YL) N (4 CHLOROBENZYL) N (PYRIDIN 3 YLMETHYL)METHANAMINE; 1 (BENZO[ B]THIOPHEN 2 YL) N (4 CHLOROBENZYL) N (PYRIDIN 3 YLMETHYL)METHANAMINE; 1 [3 (1H PYRROL 1 YL)THIOPHEN 2 YL] N (4 CHLOROBENZYL) N (PYRIDIN 3 YLMETHYL)METHANAMINE; 5 [[(4 CHLOROBENZYL)(PYRIDIN 3 YLMETHYL)AMINO]METHYL]THIOPHENE 2 CARBONITRILE; 5 [[(4 FLUOROBENZYL)(PYRIDIN 3 YLMETHYL)AMINO]METHYL]THIOPHENE 2 CARBONITRILE; GSK 0999; GSK 2667; GSK 2945; GSK 4112; GSK 5072; INTERLEUKIN 6; MISCELLANEOUS DRUGS AND AGENTS; N (2 METHYLBENZYL) 1 (5 NITROTHIOPHEN 2 YL) N (PYRIDIN 3YLMETHYL)METHANAMINE HYDROCHLORIDE SALT; N (3 METHOXYBENZYL) 1 (5 NITROTHIOPHEN 2 YL) N (PYRIDINV3 YLMETHYL)METHANAMINE HYDROCHLORIDE SALT; N (3 METHYLBENZYL) 1 (5 NITROTHIOPHEN 2 YL) N (PYRIDIN 3YLMETHYL)METHANAMINE HYDROCHLORIDE SALT; N (3 TRIFLUROMETHYLBENZYL) 1 (5 NITROTHIOPHEN 2 YL) N (PYRIDIN 3 YLMETHYL)METHANAMINE HYDROCHLORIDE SALT; N (4 CHLORO 2 METHYLBENZYL) N (4 CHLOROBENZYL) 1 (5 NITROTHIOPHEN 2 YL)METHANAMINE; N (4 CHLOROBENZYL) 1 (5 NITROTHIOPHEN 2 YL) N (PYRIDIN 3 YLMETHYL)METHANAMINE HYDROCHLORIDE SALT; N (4 CHLOROBENZYL) 1 (PYRIDIN 3 YL) N (THIAZOL 2 YLMETHYL)METHANAMINE; N (4 CHLOROBENZYL) 3 METHYL N [(5 NITROTHIOPHEN 2 YL)METHYL)BUTAN 1 AMINE HYDROCHLORIDE SALT; N (4 CHLOROBENZYL) N (2 FLUOROBENZYL) 1 (5 NITROTHIOPHEN 2 YL)METHANAMINE HYDROCHLORIDE SALT; N (4 FLUOROBENZYL) 1 (5 NITROTHIOPHEN 2 YL) N (PYRIDIN 3 YLMETHYL)METHANAMINE; N (4 METHOXYBENZYL) 1 (5 NITROTHIOPHEN 2 YL) N (PYRIDIN 3YLMETHYL)METHANAMINE HYDROCHLORIDE SALT; N (4 METHYLBENZYL) 1 (5 NITROTHIOPHEN 2 YL) N (PYRIDIN 3 YLMETHYL)METHANAMINE HYDROCHLORIDE SALT; N [(1H IMIDAZOL 2 YL)METHYL] N (4 CHLOROBENZYL) 1 (PYRIDIN 3 YL)METHANAMINE; N BENZYL N (4 CHLOROBENZYL) 1 (5 NITROTHIOPHEN 2 YL)METHANAMINE; NUCLEAR RECEPTOR NR1D1; NUCLEAR RECEPTOR NR1D1 AGONIST; TRANSCRIPTION FACTOR ARNTL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CHOLESTEROL METABOLISM; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; INFLAMMATION; INSULIN RESISTANCE; LIPOPHILICITY; MICROWAVE IRRADIATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

AMINES; ANIMALS; BIOLOGICAL AVAILABILITY; CARRIER PROTEINS; CELL LINE; CIRCADIAN RHYTHM; GLYCINE; HUMANS; MICE; MICE, INBRED C57BL; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP D, MEMBER 1; ORPHAN NUCLEAR RECEPTORS; PEPTIDE FRAGMENTS; RADIOLIGAND ASSAY; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 84879044621     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400458q     Document Type: Article

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