Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORγt protein

Journal of Biological Chemistry

Volumn 286, Issue 26, 2011, Pages 22707-22710

  Xu, Tao ^a   Wang, Xiaohu ^b   Zhong, Bo ^b   Nurieva, Roza I ^b   Ding, Sheng ^a   Dong, Chen ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOIMMUNE DISEASE; CYTOKINE PRODUCTION; CYTOKINES; DRUG CANDIDATES; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; HERBAL MEDICINES; INFLAMMATORY DISEASE; INTERLEUKIN-17; SMALL MOLECULES; URSOLIC ACID;

DISEASES;

INTERLEUKIN 17; RETINOID RELATED ORPHAN RECEPTOR GAMMA; URSOLIC ACID;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MATURATION; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS INHIBITION; TH17 CELL;

ANIMALS; ANTI-INFECTIVE AGENTS; CELL DIFFERENTIATION; CELL LINE; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-17; MICE; NEOPLASMS; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; TH17 CELLS; TRITERPENES;

EID: 79959538387     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C111.250407     Document Type: Article

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